Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of Syzygium.By consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to...Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of Syzygium.By consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological activity.These articles show that L.japonica has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant effects.These activities have important applications in the pharmaceutical,food,and fragrance industries.This review focuses on the chemical composition and pharmacological effects of L.japonicae,which is of great significance to the development of new drugs and therapeutic methods.展开更多
Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colit...Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.展开更多
Denervation-induced skeletal muscle atrophy can potentially cause the decline in the quality of life of patients and an increased risk of mortality.Complex pathophysiological mechanisms with dynamic alterations have b...Denervation-induced skeletal muscle atrophy can potentially cause the decline in the quality of life of patients and an increased risk of mortality.Complex pathophysiological mechanisms with dynamic alterations have been documented in skeletal muscle atrophy resulting from innervation loss.Hence,an in-depth comprehension of the key mechanisms and molecules governing skeletal muscle atrophy at varying stages,along with targeted treatment and protection,becomes essential for effective atrophy management.Our preliminary research categorizes the skeletal muscle atrophy process into four stages using microarray analysis.This review extensively discusses the pathways and molecules potentially implicated in regulating the four stages of denervation and muscle atrophy.Notably,drugs targeting the reactivare oxygen species stage and the inflammation stage assume critical roles.Timely intervention during the initial atrophy stages can expedite protection against skeletal muscle atrophy.Additionally,pharmaceutical intervention in the ubiquitin-proteasome pathway associated with atrophy and autophagy lysosomes can effectively slow down skeletal muscle atrophy.Key molecules within this stage encompass MuRF1,MAFbx,LC3II,p62/SQSTM1,etc.This review also compiles a profile of drugs with protective effects against skeletal muscle atrophy at distinct postdenervation stages,thereby augmenting the evidence base for denervation-induced skeletal muscle atrophy treatment.展开更多
As a traditional Chinese medicine, Pueraria lobata has been widely recorded in Chinese herbal works of the past dynasties. Modern studies have found that its main chemical components are isoflavones, triterpenoids, sa...As a traditional Chinese medicine, Pueraria lobata has been widely recorded in Chinese herbal works of the past dynasties. Modern studies have found that its main chemical components are isoflavones, triterpenoids, saponins, etc., which have antipyretic, anti⁃inflammatory, anti⁃infection, blood pressure, blood sugar, blood lipid, and pharmacological effects such as improving reproductive function. Clinically, it is used in the treatment of diabetic diseases, gastrointestinal diseases, cardiovascular diseases, etc. in the form of traditional Chinese medicine compound prescriptions. This reseach aims to summarize related articles of Pueraria lobata in the past 5 years, focusing on its pharmacological effects and clinical application of the compound, and provide references for its further development and utilization.展开更多
Osthole has various pharmacological effects such as anti-cancer,anti-inflammation,prevention and treatment of cardiovascular diseases and neuroprotection.This paper reviews the advances in the research of the pharmaco...Osthole has various pharmacological effects such as anti-cancer,anti-inflammation,prevention and treatment of cardiovascular diseases and neuroprotection.This paper reviews the advances in the research of the pharmacological effects and molecular mechanisms of osthole,in order to provide new ideas for further research and clinical application of osthole.展开更多
Lycoris radiata,a Chinese herbal medicine,is a plant of Amaryllidaceae family,which has the antidotal,expectorant,diuretic,emetic and insecticidal effects.Lycorine hydrochloride is an alkaloid extracted from the bulb ...Lycoris radiata,a Chinese herbal medicine,is a plant of Amaryllidaceae family,which has the antidotal,expectorant,diuretic,emetic and insecticidal effects.Lycorine hydrochloride is an alkaloid extracted from the bulb of L.radiata.Studies have shown that lycorine hydrochloride has many pharmacological effects(anti-fungal,anti-viral and anti-tumor).In this paper,the related research on pharmacological effects and mechanism of lycorine hydrochloride is systematically summarized in order to provide a theoretical basis for further research and application of lycorine hydrochloride.展开更多
Celosia L. is richly distributed in China and there are about 60 species in the world. The chemical constituents of Celosia L. include flavonoids, triterpenoid saponins, steroids, organic acids, and cyclic peptides. W...Celosia L. is richly distributed in China and there are about 60 species in the world. The chemical constituents of Celosia L. include flavonoids, triterpenoid saponins, steroids, organic acids, and cyclic peptides. Which have a variety of effects such as antimicrobial, hepatoprotective and antitumour. To provide a scientific foundation for the subsequent phase of research and development for Celosia L., 30 years of pertinent global literature is summarized, analyzed, and categorized. An overview of 75 chemical constituents, pharmacological activities, and clinical applications is provided.展开更多
Red jujube(Ziziphus jujuba Mill.),as a traditional Chinese medicine and edible plant,has a long history and extensive uses.Red jujubes are not only widely used in the food industry and traditional Chinese medicine pre...Red jujube(Ziziphus jujuba Mill.),as a traditional Chinese medicine and edible plant,has a long history and extensive uses.Red jujubes are not only widely used in the food industry and traditional Chinese medicine preparations,but also have attracted widespread research interest due to their rich functional components and various pharmacological effects.This paper reviewed the main functional components of jujubes,including polysaccharides,triterpenoid saponins,organic acids and alkaloids,and discussed in detail the pharmacological effects of these components such as blood sugar-regulating,antioxidant,anti-inflammatory and anti-tumor effects.Furthermore,the paper also summarized the safety issues such as drug interactions and toxic side effects of jujubes,and prospected the future development direction of jujube research.展开更多
Synephrine hydrochloride,an alkaloid compound extracted from immature bitter orange,has many pharmacological effects such as anticancer effect,antioxidant effect and antidepression effect.In this paper,the pharmacolog...Synephrine hydrochloride,an alkaloid compound extracted from immature bitter orange,has many pharmacological effects such as anticancer effect,antioxidant effect and antidepression effect.In this paper,the pharmacological effects and mechanism of synephrine hydrochloride were reviewed in order to provide a theoretical basis for the development and application of synephrine hydrochloride.展开更多
Gynostemma pentaphyllum(G.pentaphyllum)is a traditional medicinal plant with medicinal and economic value.With in-depth research on the chemical compositions and pharmacological effects,the applications of G.pentaphyl...Gynostemma pentaphyllum(G.pentaphyllum)is a traditional medicinal plant with medicinal and economic value.With in-depth research on the chemical compositions and pharmacological effects,the applications of G.pentaphyllum have been expanded.G.pentaphyllum has the effects of clearing heat and detoxification,relieving cough and phlegm,nourishing heart,tranquilizing nerves,and can be used to treat gastroenteritis,tracheitis,pharyngitis,hyperlipidemia,and arteriosclerosis.It can also be used to alleviate symptoms such as migraines,insufficient sleep,and white hair.In recent years,G.pentaphyllum has also been used for clinical adjuvant treatment of various cancers.In this study,the chemical constituents and pharmacological effects on G.pentaphyllum in recent years were reviewed.This review could provide reference for further development and utilization of G.pentaphyllum.展开更多
Elephantopus tomentosus,belonging to the genus Elephantopus,is widely distributed in the coastal areas of southern China and tropical regions,used locally as traditional folk medicine.Previous phytochemistry studies o...Elephantopus tomentosus,belonging to the genus Elephantopus,is widely distributed in the coastal areas of southern China and tropical regions,used locally as traditional folk medicine.Previous phytochemistry studies on Elephantopus tomentosus led to the isolation of sesquiterpenoids,triterpenoids,flavonoids and other compounds.Research has shown that these compounds possess multiple biological activities,which have attracted great attention of researchers worldwide.This study reviews the chemical constituents and biological activities of the Elephantopus tomentosus in order to better explore and utilize Elephantopus tomentosus.展开更多
Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate...Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate of E.ulmoides Oliv.is still very low,only bark has been used as medicine and other parts of Eucommia ulmoides Oliv.cannot be fully utilized,even the leaves have been well utilized in food products in Japan in the past decades.In order to improve the comprehensive utilization efficiency of E.ulmoides Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of E.ulmoides Oliv.The findings suggest that other parts of E.ulmoides Oliv.could replace the bark of E.ulmoides Oliv.to some extent besides of their respective applications.The unique and extensive physiological functions between different parts of E.ulmoides Oliv.indicate that the comprehensive utilization of E.ulmoides Oliv.has a wide space to develop,which is also an effective way to protect E.ulmoides Oliv.resources and improve its the utilization rate.展开更多
Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,...Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and flavonoids.Pharmacological effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and anti-inflammatory.This paper summarized chemical constituents and pharmacological effects of Lilium.展开更多
This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many ...This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many aspects,including anti-inflammation,anti-oxidation,anti-thrombosis,anti-tumor and so on.In particular,more than ten saponins have been found to have good anti-tumor activity and have potential research value,which can provide reference for the full development and utilization of Ardisia gigantifolia Stapf resources.展开更多
Ginsenoside Rb3(G-Rb3)is one of the primary active compounds isolated from Panax ginseng Meyer,which belongs to protopanaxadiol ginsenosides(PPD).Based on the structure-activity relationship(SAR)of ginsenosides,the pe...Ginsenoside Rb3(G-Rb3)is one of the primary active compounds isolated from Panax ginseng Meyer,which belongs to protopanaxadiol ginsenosides(PPD).Based on the structure-activity relationship(SAR)of ginsenosides,the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain extent.However,pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins,such as Compound K,F2,etc.A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials,which was achieved by diminishing oxidative stress and apoptosis.Therefore,more systematic and in-depth studies are needed to complete the pharmaceutical value and to promote its clinical applications.This article highlights the multiple pharmacological effects and mechanisms of G-Rb3 and prospects for its development.展开更多
Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps sinensis.Its main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and polysaccharides....Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps sinensis.Its main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and polysaccharides.Due to the huge development potential of P.hepiali in the field of food and medicine,it has been developed into a variety of products that cater to the needs of the public.In this paper,the chemical constituents and their pharmacological effects of P.hepiali are reviewed,which can provide reference for the development and application of P.hepiali.展开更多
Laportea bulbifera(Sieb.et Zucc.)Wedd.is a perennial herb of Laportea in Urticaceae.At present,more than 90 compounds have been isolated from L.bulbifera,mainly including flavonoids,coumarins,phenolic acids,esters,ket...Laportea bulbifera(Sieb.et Zucc.)Wedd.is a perennial herb of Laportea in Urticaceae.At present,more than 90 compounds have been isolated from L.bulbifera,mainly including flavonoids,coumarins,phenolic acids,esters,ketones,phenylpropanoids and steroids,which have anti-inflammatory and analgesic,immunosuppressive,anti-oxidant,hypoglycemic and lipid-lowering pharmacological effects.This article summarized the research progress of the pharmacological effects and the chemical constituents of L.bulbifera in recent years,hoping to provide references for its further research and development.展开更多
In this paper,the pharmacological effects of aucubin include anti-inflammatory effect,anti-tumor effect,neuroprotective effect,anti-cardiovascular disease effect,hepatoprotective effect,anti-oxidation effect and anti-...In this paper,the pharmacological effects of aucubin include anti-inflammatory effect,anti-tumor effect,neuroprotective effect,anti-cardiovascular disease effect,hepatoprotective effect,anti-oxidation effect and anti-aging effect,antibacterial effect,anti-diabetes effect and bone protection.The purpose of this study is to provide theoretical basis for the development and clinical application of aucubin.展开更多
Harmaine hydrochloride is an important alkaloid compound and mainly exists in the roots,stems,leaves and seeds of the plant Peganum harmala L.(family Zygophyllaceae).Harmaine hydrochloride not only has good anti-bacte...Harmaine hydrochloride is an important alkaloid compound and mainly exists in the roots,stems,leaves and seeds of the plant Peganum harmala L.(family Zygophyllaceae).Harmaine hydrochloride not only has good anti-bacterial,anti-plasmodium,anti-Parkinson's disease,anti-fungal,anti-oxidation and anti-tumor activities,but also has the characteristics of small adverse reactions and low toxicity,thus it has attracted wide attention from scholars and researchers.This paper reviews the pharmacological effects and mechanisms of harmine hydrochloride in recent years,and is intended to provide a theoretical basis for the clinical application of harmine hydrochloride.展开更多
Daurisoline is an important bisbenzylisoquinoline alkaloid and mainly exists in the rhizome of Menispermum dauricum DC.,a plant of the family Menispermaceae.Due to its pharmacological effects such as anti-arrhythmia,a...Daurisoline is an important bisbenzylisoquinoline alkaloid and mainly exists in the rhizome of Menispermum dauricum DC.,a plant of the family Menispermaceae.Due to its pharmacological effects such as anti-arrhythmia,anti-ischemia and anti-cancer,daurisoline has attracted wide attention of researchers.In this paper,the pharmacological effects and action mechanism of daurisoline were reviewed in combination with relevant research literature,to provide a theoretical basis for the development and clinical application of daurisoline.展开更多
基金supported by National Nature Science Foundation of China (81973284)Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944)Jiangsu Province Capability Improvement Project through Science,Technology and Education (ZDXYS202207).
文摘Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of Syzygium.By consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological activity.These articles show that L.japonica has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant effects.These activities have important applications in the pharmaceutical,food,and fragrance industries.This review focuses on the chemical composition and pharmacological effects of L.japonicae,which is of great significance to the development of new drugs and therapeutic methods.
基金supported by National Nature Science Foundation of China (81973284)Scientific Research Foundation of the Education Department of Liaoning Province (LJKZ0944).
文摘Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.
基金supported by the National Natural Science Foundation of China(Grant No.32200940)Science and Technology Bureau of Nantong(Grant Nos.JC2020101,JC2021085)Municipal Health Commission of Nantong(Grant No.MA2020019).
文摘Denervation-induced skeletal muscle atrophy can potentially cause the decline in the quality of life of patients and an increased risk of mortality.Complex pathophysiological mechanisms with dynamic alterations have been documented in skeletal muscle atrophy resulting from innervation loss.Hence,an in-depth comprehension of the key mechanisms and molecules governing skeletal muscle atrophy at varying stages,along with targeted treatment and protection,becomes essential for effective atrophy management.Our preliminary research categorizes the skeletal muscle atrophy process into four stages using microarray analysis.This review extensively discusses the pathways and molecules potentially implicated in regulating the four stages of denervation and muscle atrophy.Notably,drugs targeting the reactivare oxygen species stage and the inflammation stage assume critical roles.Timely intervention during the initial atrophy stages can expedite protection against skeletal muscle atrophy.Additionally,pharmaceutical intervention in the ubiquitin-proteasome pathway associated with atrophy and autophagy lysosomes can effectively slow down skeletal muscle atrophy.Key molecules within this stage encompass MuRF1,MAFbx,LC3II,p62/SQSTM1,etc.This review also compiles a profile of drugs with protective effects against skeletal muscle atrophy at distinct postdenervation stages,thereby augmenting the evidence base for denervation-induced skeletal muscle atrophy treatment.
基金National Natural Science Foundation of China(81774304)。
文摘As a traditional Chinese medicine, Pueraria lobata has been widely recorded in Chinese herbal works of the past dynasties. Modern studies have found that its main chemical components are isoflavones, triterpenoids, saponins, etc., which have antipyretic, anti⁃inflammatory, anti⁃infection, blood pressure, blood sugar, blood lipid, and pharmacological effects such as improving reproductive function. Clinically, it is used in the treatment of diabetic diseases, gastrointestinal diseases, cardiovascular diseases, etc. in the form of traditional Chinese medicine compound prescriptions. This reseach aims to summarize related articles of Pueraria lobata in the past 5 years, focusing on its pharmacological effects and clinical application of the compound, and provide references for its further development and utilization.
基金Supported by the Talent Training Program for the Reform and Development of Local Colleges and University of the Central Government(2020GSP16)Postgraduate Innovative Research Project of Heilongjiang Bayi Agricultural University(YJSCX2022-Y59)。
文摘Osthole has various pharmacological effects such as anti-cancer,anti-inflammation,prevention and treatment of cardiovascular diseases and neuroprotection.This paper reviews the advances in the research of the pharmacological effects and molecular mechanisms of osthole,in order to provide new ideas for further research and clinical application of osthole.
基金Supported by the Talent Training Program for the Reform and Development of Local Colleges and University of the Central Government(2020GSP16)。
文摘Lycoris radiata,a Chinese herbal medicine,is a plant of Amaryllidaceae family,which has the antidotal,expectorant,diuretic,emetic and insecticidal effects.Lycorine hydrochloride is an alkaloid extracted from the bulb of L.radiata.Studies have shown that lycorine hydrochloride has many pharmacological effects(anti-fungal,anti-viral and anti-tumor).In this paper,the related research on pharmacological effects and mechanism of lycorine hydrochloride is systematically summarized in order to provide a theoretical basis for further research and application of lycorine hydrochloride.
文摘Celosia L. is richly distributed in China and there are about 60 species in the world. The chemical constituents of Celosia L. include flavonoids, triterpenoid saponins, steroids, organic acids, and cyclic peptides. Which have a variety of effects such as antimicrobial, hepatoprotective and antitumour. To provide a scientific foundation for the subsequent phase of research and development for Celosia L., 30 years of pertinent global literature is summarized, analyzed, and categorized. An overview of 75 chemical constituents, pharmacological activities, and clinical applications is provided.
基金Supported by Guizhou Provincial Science and Technology Support Plan Program (QKHFQ[2021]).
文摘Red jujube(Ziziphus jujuba Mill.),as a traditional Chinese medicine and edible plant,has a long history and extensive uses.Red jujubes are not only widely used in the food industry and traditional Chinese medicine preparations,but also have attracted widespread research interest due to their rich functional components and various pharmacological effects.This paper reviewed the main functional components of jujubes,including polysaccharides,triterpenoid saponins,organic acids and alkaloids,and discussed in detail the pharmacological effects of these components such as blood sugar-regulating,antioxidant,anti-inflammatory and anti-tumor effects.Furthermore,the paper also summarized the safety issues such as drug interactions and toxic side effects of jujubes,and prospected the future development direction of jujube research.
基金Supported by the Talent Training Program for the Reform and Development of Local Colleges and Universities of the Central Government(2020GSP16)Heilongjiang Province Key Research and Development Plan Guidance Project(GZ20220039)Innovation and Entrepreneurship Training Program for College Students in Heilongjiang Province(202210223010).
文摘Synephrine hydrochloride,an alkaloid compound extracted from immature bitter orange,has many pharmacological effects such as anticancer effect,antioxidant effect and antidepression effect.In this paper,the pharmacological effects and mechanism of synephrine hydrochloride were reviewed in order to provide a theoretical basis for the development and application of synephrine hydrochloride.
基金This work was financially supported by National Nature Science Foundation of China(81973284)Scientific Research Foundation of the Education Department of Liaoning Province(LJKZ0944).
文摘Gynostemma pentaphyllum(G.pentaphyllum)is a traditional medicinal plant with medicinal and economic value.With in-depth research on the chemical compositions and pharmacological effects,the applications of G.pentaphyllum have been expanded.G.pentaphyllum has the effects of clearing heat and detoxification,relieving cough and phlegm,nourishing heart,tranquilizing nerves,and can be used to treat gastroenteritis,tracheitis,pharyngitis,hyperlipidemia,and arteriosclerosis.It can also be used to alleviate symptoms such as migraines,insufficient sleep,and white hair.In recent years,G.pentaphyllum has also been used for clinical adjuvant treatment of various cancers.In this study,the chemical constituents and pharmacological effects on G.pentaphyllum in recent years were reviewed.This review could provide reference for further development and utilization of G.pentaphyllum.
文摘Elephantopus tomentosus,belonging to the genus Elephantopus,is widely distributed in the coastal areas of southern China and tropical regions,used locally as traditional folk medicine.Previous phytochemistry studies on Elephantopus tomentosus led to the isolation of sesquiterpenoids,triterpenoids,flavonoids and other compounds.Research has shown that these compounds possess multiple biological activities,which have attracted great attention of researchers worldwide.This study reviews the chemical constituents and biological activities of the Elephantopus tomentosus in order to better explore and utilize Elephantopus tomentosus.
基金the National Key Research and Development Plan,China(2016YFD0400203-4).
文摘Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate of E.ulmoides Oliv.is still very low,only bark has been used as medicine and other parts of Eucommia ulmoides Oliv.cannot be fully utilized,even the leaves have been well utilized in food products in Japan in the past decades.In order to improve the comprehensive utilization efficiency of E.ulmoides Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of E.ulmoides Oliv.The findings suggest that other parts of E.ulmoides Oliv.could replace the bark of E.ulmoides Oliv.to some extent besides of their respective applications.The unique and extensive physiological functions between different parts of E.ulmoides Oliv.indicate that the comprehensive utilization of E.ulmoides Oliv.has a wide space to develop,which is also an effective way to protect E.ulmoides Oliv.resources and improve its the utilization rate.
基金Science and Technology Development Program of Henan Province(192102110112)Science and Technology Project of Kaifeng(1908005).
文摘Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and flavonoids.Pharmacological effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and anti-inflammatory.This paper summarized chemical constituents and pharmacological effects of Lilium.
基金Project of Guangdong Provincial Bureau of Chinese Medicine(20201371)Guangdong Medical Research Foundation(A2020170)Science and Technology Plan of Zhongshan City,Guangdong Province(2019B1014).
文摘This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many aspects,including anti-inflammation,anti-oxidation,anti-thrombosis,anti-tumor and so on.In particular,more than ten saponins have been found to have good anti-tumor activity and have potential research value,which can provide reference for the full development and utilization of Ardisia gigantifolia Stapf resources.
基金This work was funded by the grant of Jilin Science&Technology Development Plan(No.20200301037RQ).
文摘Ginsenoside Rb3(G-Rb3)is one of the primary active compounds isolated from Panax ginseng Meyer,which belongs to protopanaxadiol ginsenosides(PPD).Based on the structure-activity relationship(SAR)of ginsenosides,the pentose structure of G-Rb3 limited itself to possess more pharmacological activity to a certain extent.However,pharmacokinetics show that G-Rb3 is processed through deglycosylation in the intestinal tract and converted into more active rare saponins,such as Compound K,F2,etc.A series of studies focused on neuroprotection and the cardiovascular system demonstrating its therapeutic potentials,which was achieved by diminishing oxidative stress and apoptosis.Therefore,more systematic and in-depth studies are needed to complete the pharmaceutical value and to promote its clinical applications.This article highlights the multiple pharmacological effects and mechanisms of G-Rb3 and prospects for its development.
基金This work was financially supported by the Natural Science Foundation of Fujian Province of China(Grant No:2019J05032).
文摘Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps sinensis.Its main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and polysaccharides.Due to the huge development potential of P.hepiali in the field of food and medicine,it has been developed into a variety of products that cater to the needs of the public.In this paper,the chemical constituents and their pharmacological effects of P.hepiali are reviewed,which can provide reference for the development and application of P.hepiali.
基金Research Fund of Guangxi Colleges and Universities(YB2014192)Guangxi Key R&D Program(GK AB19110027)High-level Innovation Team and Outstanding Scholars Project of Guangxi Colleges and Universities:Zhuang Medical Foundation and Clinical Innovation Team(GJR[2014]07).
文摘Laportea bulbifera(Sieb.et Zucc.)Wedd.is a perennial herb of Laportea in Urticaceae.At present,more than 90 compounds have been isolated from L.bulbifera,mainly including flavonoids,coumarins,phenolic acids,esters,ketones,phenylpropanoids and steroids,which have anti-inflammatory and analgesic,immunosuppressive,anti-oxidant,hypoglycemic and lipid-lowering pharmacological effects.This article summarized the research progress of the pharmacological effects and the chemical constituents of L.bulbifera in recent years,hoping to provide references for its further research and development.
基金Talent Training Program by the Central Government for the Reform and Development of Local Universities(2020GSP16)Innovation and Entrepreneurship Project for College Students(202110223003).
文摘In this paper,the pharmacological effects of aucubin include anti-inflammatory effect,anti-tumor effect,neuroprotective effect,anti-cardiovascular disease effect,hepatoprotective effect,anti-oxidation effect and anti-aging effect,antibacterial effect,anti-diabetes effect and bone protection.The purpose of this study is to provide theoretical basis for the development and clinical application of aucubin.
基金Central Government Supporting Local University Reform and Development Fund Talent Training Project(2020GSP16).
文摘Harmaine hydrochloride is an important alkaloid compound and mainly exists in the roots,stems,leaves and seeds of the plant Peganum harmala L.(family Zygophyllaceae).Harmaine hydrochloride not only has good anti-bacterial,anti-plasmodium,anti-Parkinson's disease,anti-fungal,anti-oxidation and anti-tumor activities,but also has the characteristics of small adverse reactions and low toxicity,thus it has attracted wide attention from scholars and researchers.This paper reviews the pharmacological effects and mechanisms of harmine hydrochloride in recent years,and is intended to provide a theoretical basis for the clinical application of harmine hydrochloride.
基金Supported by Central Government Supporting Local College Reform and Development Fund Talent Training Project (2020GSP16)
文摘Daurisoline is an important bisbenzylisoquinoline alkaloid and mainly exists in the rhizome of Menispermum dauricum DC.,a plant of the family Menispermaceae.Due to its pharmacological effects such as anti-arrhythmia,anti-ischemia and anti-cancer,daurisoline has attracted wide attention of researchers.In this paper,the pharmacological effects and action mechanism of daurisoline were reviewed in combination with relevant research literature,to provide a theoretical basis for the development and clinical application of daurisoline.
