Background:Patients undergoing hemodialysis suffer from deteriorating physical health,impaired physical function,and have a low quality of life,that explained by insufficient metabolic clearance.To overcome these obst...Background:Patients undergoing hemodialysis suffer from deteriorating physical health,impaired physical function,and have a low quality of life,that explained by insufficient metabolic clearance.To overcome these obstacles,cost-effective strategies must be developed,including exercise as a complement to hemodialysis therapy.Objective:To determine the effectiveness of exercise therapy on functional balance,physical performance,and quality of life among patients undergoing hemodialysis:a randomized controlled trial.Methods:This randomized controlled trial study was carried out on 68 patients with chronic kidney disease undergoing hemodialysis for at least six months and had a medically stable condition who were randomly divided into training(n=32)exercise therapy and(n=31)control,groups.The training group participated in 8-week(3 sessions per week)resistance exercise therapy in three sets of 10 repetitions of knee extension,hip flexion,and hip abduction with the use of an elastic band under the supervision of a training physiotherapist and researcher during the first hour of the three routine hemodialysis treatment session per week.But the control group did not experience any intervention.To analyze the data,two-way analysis of variance and Bonferroni statistical tests were used at the significant level of(P=0.05).Results:6 Minute-Walk Test(6MWT)(0.013),and in the Physical Activity Scale for the Elderly(PASE)(0.014),and Short Survey Form 36(SF-36)questionnaires and health-related quality of life(HRQOL)(0.001)had significant improvements in the training group in comparison to the control group from pre to post-test,also physical performance(0.001)was improving as compared with control group(0.89)at(P=0.05).Conclusion:Resistance exercise therapy interventions for eight weeks effectively improve the physical function and performance,activity levels,and health-related quality of life of patients with chronic kidney disease and undergoing regular hemodialysis compared with a control group.展开更多
Background:Hemodialysis is the major treatment option for patients with chronic kidney disease.With the increase in the number of maintenance hemodialysis patients,debilitating conditions of muscle willing and atrophy...Background:Hemodialysis is the major treatment option for patients with chronic kidney disease.With the increase in the number of maintenance hemodialysis patients,debilitating conditions of muscle willing and atrophy and numerous health problems associated with chronic kidney disease and hemodialysis have become the most significant concerns.Methods:This randomized controlled trial study design will be conducted at Al-Najaf city in the southern region of Iraq and carried out on 68 patients with chronic kidney disease undergoing hemodialysis for at least six months and who had a medically stable condition,which will be randomly divided into training group;exercise therapy and control,groups.The training group participated in 8-week(3 sessions per week)resistance exercise therapy in three sets of 10 repetitions of knee extension,hip flexion,and hip abduction with the use of an elastic band under the supervision of a training physiotherapist and researcher during the first hour of the three routine hemodialysis treatment session per week.But the control group did not experience any intervention.To analyze the data,two-way analysis of variance and Bonferroni statistical tests will be used at the significant level of(P=0.05).Discussion:Important features of this study include the randomization procedures,double-blind,large sample size,and a standardized protocol for resistance exercise training on the physical performance of hemodialysis patients.This study aims to determine the effectiveness of resistance exercise for the patient with chronic kidney disease and undergoing hemodialysis.Therefore,our results will be useful for patients with chronic kidney diseases,medical staff,and healthcare decision-makers.展开更多
The spacecraequipment layout optimization design(SELOD)problems with complicated performance con-straints and diversity are studied in this paper.The previous literature uses the gradient-based algorithm to obtain op...The spacecraequipment layout optimization design(SELOD)problems with complicated performance con-straints and diversity are studied in this paper.The previous literature uses the gradient-based algorithm to obtain optimized non-overlap layout schemes from randomly initialized cases eectively.However,these local optimal solutions are too dicult to jump out of their current relative geometry relationships,signicantly limiting their further improvement in performance indicators.Therefore,considering the geometric diversity of layout schemes is put forward to alleviate this limitation.First,similarity measures,including modied cosine similarity and gaussian kernel function similarity,are introduced into the layout optimization process.Then the optimization produces a set of feasible layout candidates with the most remarkable dierence in geometric distribution and the most representative schemes are sampled.Finally,these feasible geometric solutions are used as initial solutions to optimize the physical performance indicators of the spacecra,and diversied layout schemes of spacecraequipment are generated for the engineering practice.The validity and eectiveness of the proposed methodology are demonstrated by two SELOD applications.展开更多
BACKGROUND Sarcopenia is a clinical condition associated with several liver diseases and it includes non-alcoholic fatty liver disease(NAFLD)in its broad spectrum as steatosis,steatohepatitis and fibrosis.However,the ...BACKGROUND Sarcopenia is a clinical condition associated with several liver diseases and it includes non-alcoholic fatty liver disease(NAFLD)in its broad spectrum as steatosis,steatohepatitis and fibrosis.However,the criteria to define sarcopenia are diverse,and even those established in consensus have been discussed regarding their performance in making an accurate diagnosis.AIM To evaluate the prevalence of sarcopenia,using different methods,in patients with NAFLD,and its association with clinical-anthropometric parameters.METHODS This was an observational study of outpatients with NAFLD.Sarcopenia was defined by the European Working Group Consensus on Sarcopenia in Older People of 2010(EWGSOP1)and 2018(EWGSOP2).The skeletal muscle index was used to estimate muscle mass,handgrip strength was assessed using the dynamometer and physical performance by walking a distance of four meters at usual walking speed.The non-invasive fibrosis scores,fibrosis-4(FIB-4)index and Aspartate aminotransferase to platelet ratio index(APRI),were used to assess the absence and presence of fibrosis.RESULTS Fifty-seven individuals with NAFLD were evaluated,the mean age(SD)was 52.7(11.3)years and 75.4%were female.Fibrosis assessed by FIB-4 and APRI was observed in 3.7%and 16.6%of patients with NAFLD,respectively.The diagnosis of sarcopenia was identified only by EWGSOP1 in 3.5%of NAFLD patients,and the prevalence of probable/pre-sarcopenia was higher using the EWGSOP2 consensus at 26.3%,when compared to 1.8%with EWGSOP1.Sarcopenia defined by EWGSOP1,was associated with grade I steatosis,but without overweight(P<0.05).An association between sarcopenia and fibrosis was not observed(P>0.05).EWGSOP2 showed a greater number of patients with probable sarcopenia,and who were overweight(12(80.0%)),with a higher degree of steatosis[11(73.3%)and presence of fibrosis(1(6.7%),FIB-4 and 3(20.0%),APRI]compared to EWGSOP1[1(100%),0(0.0%),0(0.0%),FIB-4 and 0(0.0%),APRI,respectively].CONCLUSION The present study showed that sarcopenia in NAFLD was not predominant in patients without fibrosis,by both diagnostic methods.In addition,the prevalence of probable sarcopenia also depends on the method applied.展开更多
BACKGROUND Although the prognostic relevance of sarcopenia has been increasingly recognised in the context of liver disease,there is a paucity of data evaluating body composition in patients with chronic hepatitis B(C...BACKGROUND Although the prognostic relevance of sarcopenia has been increasingly recognised in the context of liver disease,there is a paucity of data evaluating body composition in patients with chronic hepatitis B(CHB).Beyond virus-related factors,nutritional and metabolic aspects can be associated with skeletal muscle abnormalities in these patients and should not be disregarded.AIM To evaluate the association between components of sarcopenia and demographic,clinical,lifestyle,nutritional,and biochemical variables in CHB patients.METHODS Dual-energy X-ray absorptiometry(DXA)was used to assess muscle mass by quantifying appendicular lean mass(ALM)adjusted for body mass index(ALMBMI).Muscle function was evaluated by hand grip strength(HGS)and the timed up and go test.Metabolic-associated fatty liver disease(MAFLD)was defined according to the criteria proposed by an international expert panel.A body shape index and the International Physical Activity Questionnaire were used to assess central obesity and physical activity level,respectively.RESULTS This cross-sectional study included 105 CHB outpatients followed at the tertiary care ambulatory centre(mean age,48.5±12.0 years;58.1%males;76.2%without cirrhosis;23.8%with compensated cirrhosis).The DXA-derived fat mass percentage was inversely correlated with the ALMBMI(r=-0.87)and HGS(r=-0.63).In the multivariable analysis,MAFLD,sedentarism and central obesity were positively and independently associated with low ALMBMI.MAFLD and central obesity were independently associated with low HGS.CONCLUSION MAFLD and central obesity were associated with low muscle mass and strength in patients with chronic hepatitis B,independent of the liver disease stage.展开更多
This study aimed to evaluate the efficacy of an individualized remote exercise program on the improvement of body composition and physical fitness of a heterogeneous group of patients who completed breast cancer treat...This study aimed to evaluate the efficacy of an individualized remote exercise program on the improvement of body composition and physical fitness of a heterogeneous group of patients who completed breast cancer treatment.This prospective study included 107 women aged 18 to 60,shortly after curative treatment for localized breast cancer,at the Erasto Gaertner Cancer Hospital(HEG)in Curitiba,PR,Brazil.Body composition,maximal oxygen consumption,and muscle resistance were evaluated after nine months of intervention while considering adherence to the program,level of physical activity,presence of binge eating disorder,tumor classification,and treatment type.Seventy-eight women(72.8%)adhered to the training program.Adherent participants showed significant changes in body mass([-4.3±3.6]kg;p<0.0001),body mass index([-1.6±1.5]kg·m^(−2);p<0.0001),body fat(−3.4%±3.1%;p<0.0001),maximal oxygen consumption([7.5±2.0]ml·kg^(−1)·min^(−1));p<0.0001),and abdominal resistance([11.2±2.8]reps;p<0.0001).In contrast,these variables did not change significantly in the non-adherent group.Among the adherent participants,those subclassified in the severe binge group showed a more noticeable reduction in body mass,body mass index,and body fat(p<0.05)than those in the non-binge group.Individualized remotely-guided physical exercise programs can improve the body composition and physical fitness of women undergoing post-breast cancer surveillance,regardless of pathological history or treatment.展开更多
In this paper,we proposed a quality of transmission(QoT)prediction technique for the quality of service(QoS)link setup based on machine learning classifiers,with synthetic data generated using the transmission equatio...In this paper,we proposed a quality of transmission(QoT)prediction technique for the quality of service(QoS)link setup based on machine learning classifiers,with synthetic data generated using the transmission equations instead of the Gaussian noise(GN)model.The proposed technique uses some link and signal characteristics as input features.The bit error rate(BER)of the signals was compared with the forward error correction threshold BER,and the comparison results were employed as labels.The transmission equations approach is a better alternative to the GN model(or other similar margin-based models)in the absence of real data(i.e.,at the deployment stage of a network)or the case that real data are scarce(i.e.,for enriching the dataset/reducing probing lightpaths);furthermore,the three classifiers trained using the data of the transmission equations are more reliable and practical than those trained using the data of the GN model.Meanwhile,we noted that the priority of the three classifiers should be support vector machine(SVM)>K nearest neighbor(KNN)>logistic regression(LR)as shown in the results obtained by the transmission equations,instead of SVM>LR>KNN as in the results of the GN model.展开更多
This randomized,double-blind,clinical trial was designed to compare the endurance capacity(ergogenic property)in healthy athletes after consumption of apple cider vinegar(ACV)and a commercial sports drink(CSD)before a...This randomized,double-blind,clinical trial was designed to compare the endurance capacity(ergogenic property)in healthy athletes after consumption of apple cider vinegar(ACV)and a commercial sports drink(CSD)before and during endurance exercise.Fourteen healthy participants were enrolled in this trial and were divided into two groups as ACV and CSD with seven participants in each.Participants were requested to consume 500 mL of either commercial ACV or CSD 1 h before endurance exercise(bicycle ergometer).Blood samples were collected at baseline,0,20,40,60 min until exhaustion to assess glucose,lactate,ammonia and non-esterified fatty acids(NEFA).Respiratory exchange rate(RER)score was measured every 15 min and the heart rate(HR)was measured every 5 min.The outcome of the present trial clearly showed that no significant differences were observed between ACV and CSD except in the blood level of ammonia(only at exhaustion time).Thus,these results show that ACV and the CSD both possessing the ergogenic property,enhanced blood glucose,NEFA,and suppress the production of lactate as well as maintains normal RER score,and HR throughout the endurance exercise.Overall this trial showcases that ACV did not significantly improve the ergogenic activity over the CSD.展开更多
文摘Background:Patients undergoing hemodialysis suffer from deteriorating physical health,impaired physical function,and have a low quality of life,that explained by insufficient metabolic clearance.To overcome these obstacles,cost-effective strategies must be developed,including exercise as a complement to hemodialysis therapy.Objective:To determine the effectiveness of exercise therapy on functional balance,physical performance,and quality of life among patients undergoing hemodialysis:a randomized controlled trial.Methods:This randomized controlled trial study was carried out on 68 patients with chronic kidney disease undergoing hemodialysis for at least six months and had a medically stable condition who were randomly divided into training(n=32)exercise therapy and(n=31)control,groups.The training group participated in 8-week(3 sessions per week)resistance exercise therapy in three sets of 10 repetitions of knee extension,hip flexion,and hip abduction with the use of an elastic band under the supervision of a training physiotherapist and researcher during the first hour of the three routine hemodialysis treatment session per week.But the control group did not experience any intervention.To analyze the data,two-way analysis of variance and Bonferroni statistical tests were used at the significant level of(P=0.05).Results:6 Minute-Walk Test(6MWT)(0.013),and in the Physical Activity Scale for the Elderly(PASE)(0.014),and Short Survey Form 36(SF-36)questionnaires and health-related quality of life(HRQOL)(0.001)had significant improvements in the training group in comparison to the control group from pre to post-test,also physical performance(0.001)was improving as compared with control group(0.89)at(P=0.05).Conclusion:Resistance exercise therapy interventions for eight weeks effectively improve the physical function and performance,activity levels,and health-related quality of life of patients with chronic kidney disease and undergoing regular hemodialysis compared with a control group.
文摘Background:Hemodialysis is the major treatment option for patients with chronic kidney disease.With the increase in the number of maintenance hemodialysis patients,debilitating conditions of muscle willing and atrophy and numerous health problems associated with chronic kidney disease and hemodialysis have become the most significant concerns.Methods:This randomized controlled trial study design will be conducted at Al-Najaf city in the southern region of Iraq and carried out on 68 patients with chronic kidney disease undergoing hemodialysis for at least six months and who had a medically stable condition,which will be randomly divided into training group;exercise therapy and control,groups.The training group participated in 8-week(3 sessions per week)resistance exercise therapy in three sets of 10 repetitions of knee extension,hip flexion,and hip abduction with the use of an elastic band under the supervision of a training physiotherapist and researcher during the first hour of the three routine hemodialysis treatment session per week.But the control group did not experience any intervention.To analyze the data,two-way analysis of variance and Bonferroni statistical tests will be used at the significant level of(P=0.05).Discussion:Important features of this study include the randomization procedures,double-blind,large sample size,and a standardized protocol for resistance exercise training on the physical performance of hemodialysis patients.This study aims to determine the effectiveness of resistance exercise for the patient with chronic kidney disease and undergoing hemodialysis.Therefore,our results will be useful for patients with chronic kidney diseases,medical staff,and healthcare decision-makers.
基金supported by Aerospace Frontier Inspiration Project (Grant No.KY0505072113) from College of Aerospace Science and Engineering,NUDT,which are gratefully acknowledged by the authors.
文摘The spacecraequipment layout optimization design(SELOD)problems with complicated performance con-straints and diversity are studied in this paper.The previous literature uses the gradient-based algorithm to obtain optimized non-overlap layout schemes from randomly initialized cases eectively.However,these local optimal solutions are too dicult to jump out of their current relative geometry relationships,signicantly limiting their further improvement in performance indicators.Therefore,considering the geometric diversity of layout schemes is put forward to alleviate this limitation.First,similarity measures,including modied cosine similarity and gaussian kernel function similarity,are introduced into the layout optimization process.Then the optimization produces a set of feasible layout candidates with the most remarkable dierence in geometric distribution and the most representative schemes are sampled.Finally,these feasible geometric solutions are used as initial solutions to optimize the physical performance indicators of the spacecra,and diversied layout schemes of spacecraequipment are generated for the engineering practice.The validity and eectiveness of the proposed methodology are demonstrated by two SELOD applications.
基金Fundacao de Amparo à Pesquisa do Estado da Bahia (FAPESB)Coordenacao de Aperfeicoamento de Pessoal de Nível Superior (CAPES)+2 种基金Programa Institucional de Bolsas de Iniciacao Científica (PIBIC)Coordenacao de Aperfei?oamento de Pessoal de Nível Superior (CNPq)Programa Permanecer.
文摘BACKGROUND Sarcopenia is a clinical condition associated with several liver diseases and it includes non-alcoholic fatty liver disease(NAFLD)in its broad spectrum as steatosis,steatohepatitis and fibrosis.However,the criteria to define sarcopenia are diverse,and even those established in consensus have been discussed regarding their performance in making an accurate diagnosis.AIM To evaluate the prevalence of sarcopenia,using different methods,in patients with NAFLD,and its association with clinical-anthropometric parameters.METHODS This was an observational study of outpatients with NAFLD.Sarcopenia was defined by the European Working Group Consensus on Sarcopenia in Older People of 2010(EWGSOP1)and 2018(EWGSOP2).The skeletal muscle index was used to estimate muscle mass,handgrip strength was assessed using the dynamometer and physical performance by walking a distance of four meters at usual walking speed.The non-invasive fibrosis scores,fibrosis-4(FIB-4)index and Aspartate aminotransferase to platelet ratio index(APRI),were used to assess the absence and presence of fibrosis.RESULTS Fifty-seven individuals with NAFLD were evaluated,the mean age(SD)was 52.7(11.3)years and 75.4%were female.Fibrosis assessed by FIB-4 and APRI was observed in 3.7%and 16.6%of patients with NAFLD,respectively.The diagnosis of sarcopenia was identified only by EWGSOP1 in 3.5%of NAFLD patients,and the prevalence of probable/pre-sarcopenia was higher using the EWGSOP2 consensus at 26.3%,when compared to 1.8%with EWGSOP1.Sarcopenia defined by EWGSOP1,was associated with grade I steatosis,but without overweight(P<0.05).An association between sarcopenia and fibrosis was not observed(P>0.05).EWGSOP2 showed a greater number of patients with probable sarcopenia,and who were overweight(12(80.0%)),with a higher degree of steatosis[11(73.3%)and presence of fibrosis(1(6.7%),FIB-4 and 3(20.0%),APRI]compared to EWGSOP1[1(100%),0(0.0%),0(0.0%),FIB-4 and 0(0.0%),APRI,respectively].CONCLUSION The present study showed that sarcopenia in NAFLD was not predominant in patients without fibrosis,by both diagnostic methods.In addition,the prevalence of probable sarcopenia also depends on the method applied.
基金Supported by the Funda??o de AmparoàPesquisa do Estado de Minas Gerais,No.APQ-02320-18。
文摘BACKGROUND Although the prognostic relevance of sarcopenia has been increasingly recognised in the context of liver disease,there is a paucity of data evaluating body composition in patients with chronic hepatitis B(CHB).Beyond virus-related factors,nutritional and metabolic aspects can be associated with skeletal muscle abnormalities in these patients and should not be disregarded.AIM To evaluate the association between components of sarcopenia and demographic,clinical,lifestyle,nutritional,and biochemical variables in CHB patients.METHODS Dual-energy X-ray absorptiometry(DXA)was used to assess muscle mass by quantifying appendicular lean mass(ALM)adjusted for body mass index(ALMBMI).Muscle function was evaluated by hand grip strength(HGS)and the timed up and go test.Metabolic-associated fatty liver disease(MAFLD)was defined according to the criteria proposed by an international expert panel.A body shape index and the International Physical Activity Questionnaire were used to assess central obesity and physical activity level,respectively.RESULTS This cross-sectional study included 105 CHB outpatients followed at the tertiary care ambulatory centre(mean age,48.5±12.0 years;58.1%males;76.2%without cirrhosis;23.8%with compensated cirrhosis).The DXA-derived fat mass percentage was inversely correlated with the ALMBMI(r=-0.87)and HGS(r=-0.63).In the multivariable analysis,MAFLD,sedentarism and central obesity were positively and independently associated with low ALMBMI.MAFLD and central obesity were independently associated with low HGS.CONCLUSION MAFLD and central obesity were associated with low muscle mass and strength in patients with chronic hepatitis B,independent of the liver disease stage.
文摘This study aimed to evaluate the efficacy of an individualized remote exercise program on the improvement of body composition and physical fitness of a heterogeneous group of patients who completed breast cancer treatment.This prospective study included 107 women aged 18 to 60,shortly after curative treatment for localized breast cancer,at the Erasto Gaertner Cancer Hospital(HEG)in Curitiba,PR,Brazil.Body composition,maximal oxygen consumption,and muscle resistance were evaluated after nine months of intervention while considering adherence to the program,level of physical activity,presence of binge eating disorder,tumor classification,and treatment type.Seventy-eight women(72.8%)adhered to the training program.Adherent participants showed significant changes in body mass([-4.3±3.6]kg;p<0.0001),body mass index([-1.6±1.5]kg·m^(−2);p<0.0001),body fat(−3.4%±3.1%;p<0.0001),maximal oxygen consumption([7.5±2.0]ml·kg^(−1)·min^(−1));p<0.0001),and abdominal resistance([11.2±2.8]reps;p<0.0001).In contrast,these variables did not change significantly in the non-adherent group.Among the adherent participants,those subclassified in the severe binge group showed a more noticeable reduction in body mass,body mass index,and body fat(p<0.05)than those in the non-binge group.Individualized remotely-guided physical exercise programs can improve the body composition and physical fitness of women undergoing post-breast cancer surveillance,regardless of pathological history or treatment.
文摘In this paper,we proposed a quality of transmission(QoT)prediction technique for the quality of service(QoS)link setup based on machine learning classifiers,with synthetic data generated using the transmission equations instead of the Gaussian noise(GN)model.The proposed technique uses some link and signal characteristics as input features.The bit error rate(BER)of the signals was compared with the forward error correction threshold BER,and the comparison results were employed as labels.The transmission equations approach is a better alternative to the GN model(or other similar margin-based models)in the absence of real data(i.e.,at the deployment stage of a network)or the case that real data are scarce(i.e.,for enriching the dataset/reducing probing lightpaths);furthermore,the three classifiers trained using the data of the transmission equations are more reliable and practical than those trained using the data of the GN model.Meanwhile,we noted that the priority of the three classifiers should be support vector machine(SVM)>K nearest neighbor(KNN)>logistic regression(LR)as shown in the results obtained by the transmission equations,instead of SVM>LR>KNN as in the results of the GN model.
文摘This randomized,double-blind,clinical trial was designed to compare the endurance capacity(ergogenic property)in healthy athletes after consumption of apple cider vinegar(ACV)and a commercial sports drink(CSD)before and during endurance exercise.Fourteen healthy participants were enrolled in this trial and were divided into two groups as ACV and CSD with seven participants in each.Participants were requested to consume 500 mL of either commercial ACV or CSD 1 h before endurance exercise(bicycle ergometer).Blood samples were collected at baseline,0,20,40,60 min until exhaustion to assess glucose,lactate,ammonia and non-esterified fatty acids(NEFA).Respiratory exchange rate(RER)score was measured every 15 min and the heart rate(HR)was measured every 5 min.The outcome of the present trial clearly showed that no significant differences were observed between ACV and CSD except in the blood level of ammonia(only at exhaustion time).Thus,these results show that ACV and the CSD both possessing the ergogenic property,enhanced blood glucose,NEFA,and suppress the production of lactate as well as maintains normal RER score,and HR throughout the endurance exercise.Overall this trial showcases that ACV did not significantly improve the ergogenic activity over the CSD.
