Objective To investigate the effects of different doses of atorvastatin on plasma endothelin and platelet function in acute ST-segment elevation myocardial infarction(STEMI)patients after emergency percutaneous corona...Objective To investigate the effects of different doses of atorvastatin on plasma endothelin and platelet function in acute ST-segment elevation myocardial infarction(STEMI)patients after emergency percutaneous coronary intervention(PCI).Methods A total of 120 patients with acute STEMI treated with emergency PCI were enrolled and randomly divided into 20 mg of atorvastatin treatment group(standard group,n=60),and 40 mg of atorvastatin treatment group(intensive group,n=60).展开更多
目的:观察七龙天对低氧性肺动脉高压(HPH)大鼠内皮素-1(ET-1)、血管内皮细胞一氧化氮合成酶(NOS)的影响。方法:雄性SD大鼠随机分为6组:空白对照组(A)、模型组(B)、波生坦组(C)、七龙天低剂量组(D)、七龙天中剂量组(E)、七龙天高剂量组(F...目的:观察七龙天对低氧性肺动脉高压(HPH)大鼠内皮素-1(ET-1)、血管内皮细胞一氧化氮合成酶(NOS)的影响。方法:雄性SD大鼠随机分为6组:空白对照组(A)、模型组(B)、波生坦组(C)、七龙天低剂量组(D)、七龙天中剂量组(E)、七龙天高剂量组(F)。A组大鼠置于正常环境中饲养,B、C、D、E、F组均造模。采用常压低氧法制模,从制模第1天始给药,连续3周,A、B两组均给予蒸馏水3 m L/(只·d)。在直视下行右心导管术测定肺血流动力学参数,及RT-PCR法检测肺组织中NOS、ET-1 mRNA表达。结果:七龙天及波生坦均可明显降低大鼠肺动脉高压,且以七龙天高剂量组效果为佳,疗效呈药物剂量依赖表现。各组NOS、ET-1表达量与肺动脉压具有相关性,但二者在高剂量七龙天调节至正常范围时,肺动脉压仍未恢复正常水平。结论:不同剂量七龙天均可降低肺动脉高压,且高剂量七龙天疗效优于波生坦。其降压机制与降低NOS及ET-1表达量有关,但仍可能受其他炎症因子及血管新生因子影响。展开更多
文摘Objective To investigate the effects of different doses of atorvastatin on plasma endothelin and platelet function in acute ST-segment elevation myocardial infarction(STEMI)patients after emergency percutaneous coronary intervention(PCI).Methods A total of 120 patients with acute STEMI treated with emergency PCI were enrolled and randomly divided into 20 mg of atorvastatin treatment group(standard group,n=60),and 40 mg of atorvastatin treatment group(intensive group,n=60).
文摘目的:观察七龙天对低氧性肺动脉高压(HPH)大鼠内皮素-1(ET-1)、血管内皮细胞一氧化氮合成酶(NOS)的影响。方法:雄性SD大鼠随机分为6组:空白对照组(A)、模型组(B)、波生坦组(C)、七龙天低剂量组(D)、七龙天中剂量组(E)、七龙天高剂量组(F)。A组大鼠置于正常环境中饲养,B、C、D、E、F组均造模。采用常压低氧法制模,从制模第1天始给药,连续3周,A、B两组均给予蒸馏水3 m L/(只·d)。在直视下行右心导管术测定肺血流动力学参数,及RT-PCR法检测肺组织中NOS、ET-1 mRNA表达。结果:七龙天及波生坦均可明显降低大鼠肺动脉高压,且以七龙天高剂量组效果为佳,疗效呈药物剂量依赖表现。各组NOS、ET-1表达量与肺动脉压具有相关性,但二者在高剂量七龙天调节至正常范围时,肺动脉压仍未恢复正常水平。结论:不同剂量七龙天均可降低肺动脉高压,且高剂量七龙天疗效优于波生坦。其降压机制与降低NOS及ET-1表达量有关,但仍可能受其他炎症因子及血管新生因子影响。
基金Natural Science Foundation of Liaoning Province(20062102)Scientific and technological project in Liaoning Province(2007225004-3)+1 种基金Shenyang Municipal Science and Technology Project (1071162-9-00)Educational Department of Liaoning Province Project(051494)
