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The relationship of plasma homocysteine level and apolipoprotein E gene polymorphism with Alzheimer's disease
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作者 陈英 《China Medical Abstracts(Internal Medicine)》 2016年第3期192-,共1页
Objective To investigate the correlations of plasma homocysteine(Hcy)level and apolipoprotein E gene polymorphism with Alzheimer’s disease(AD)and mild cognitive impairment(MCI).Methods A case-control study in 66 AD p... Objective To investigate the correlations of plasma homocysteine(Hcy)level and apolipoprotein E gene polymorphism with Alzheimer’s disease(AD)and mild cognitive impairment(MCI).Methods A case-control study in 66 AD patients(AD group),64 MCI patients(MCI group)and 54 healthy controls(control group)was conducted.Plasma Hcy level and Apo E polymorphism 展开更多
关键词 HCY MCI The relationship of plasma homocysteine level and apolipoprotein E gene polymorphism with Alzheimer’s disease gene
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Effect of N,N-Dimethylglycine on Homocysteine Metabolism in Rats Fed Folate-Sufficient and Folate-Deficient Diets 被引量:1
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作者 LIU Yi Qun HUANG Ling He +7 位作者 LIU Pei Pei XING Qing Bin HAN Feng WANG Qin CHEN Shu Rong SUGIYAMA Kimio XIANG Xue Song HUANG Zhen Wu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2021年第5期356-363,共8页
Objective This study aimed to investigate the effects of N,N-dimethylglycine(DMG) on the concentration and metabolism of plasma homocysteine(pHcy) in folate-sufficient and folate-deficient rats.Methods In this study, ... Objective This study aimed to investigate the effects of N,N-dimethylglycine(DMG) on the concentration and metabolism of plasma homocysteine(pHcy) in folate-sufficient and folate-deficient rats.Methods In this study, 0.1% DMG was supplemented in 20% casein diets that were either folatesufficient(20 C) or folate-deficient(20 CFD). Blood and liver of rats were subjected to assays of Hcy and its metabolites. Hcy and its related metabolite concentrations were determined using a liquid chromatographic system.Results Folate deprivation significantly increased pHcy concentration in rats fed 20 C diet(from 14.19 ±0.39 μmol/L to 28.49 ± 0.50 μmol/L;P < 0.05). When supplemented with DMG, pHcy concentration was significantly decreased(12.23 ± 0.18 μmol/L) in rats fed 20 C diet but significantly increased(31.56 ±0.59 μmol/L) in rats fed 20 CFD. The hepatic methionine synthase activity in the 20 CFD group was significantly lower than that in the 20 C group;enzyme activity was unaffected by DMG supplementation regardless of folate sufficiency. The activity of hepatic cystathionine β-synthase(CBS) in the 20 CFD group was decreased but not in the 20 C group;DMG supplementation enhanced hepatic CBS activity in both groups, in which the effect was significant in the 20 C group but not in the other group.Conclusion DMG supplementation exhibited hypohomocysteinemic effects under folate-sufficient conditions. By contrast, the combination of folate deficiency and DMG supplementation has deleterious effect on pHcy concentration. 展开更多
关键词 Folate deficiency N N-Dimethylglycine 5-methyltetrahydrofolate plasma homocysteine
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