Objective: To analyze the effect of psychological nursing combined with breathing exercises on lung function of patients with pneumoconiosis, and to analyze the methods. A total of 64 cases of pneumoconiosis admitted ...Objective: To analyze the effect of psychological nursing combined with breathing exercises on lung function of patients with pneumoconiosis, and to analyze the methods. A total of 64 cases of pneumoconiosis admitted from January 2020 to December 2022 were divided into the reference group and the experimental group by random numerical table. On the basis of symptomatic treatment, the control group was combined with conventional nursing measures and breathing exercises, while the experimental group was treated with psychological nursing on the basis of the control group, and the pulmonary function indexes and adverse mood of the two groups before and after nursing were compared. Results: There was no difference in SAS score, SDS score and pulmonary function indexes between the two groups before intervention (P > 0.05), and the SAS score in the experimental group was the SDS score was lower than that of the control group, and FEV1, FEV1% and FEV1/FVC were higher than those of the control group, and the P < 0.05 was lower.展开更多
[Objectives]This study was conducted to explore the X-ray manifestations of pneumoconiosis patients and differentiation from pulmonary tuberculosis.[Methods]Retrospective analysis was conducted on 103 patients who und...[Objectives]This study was conducted to explore the X-ray manifestations of pneumoconiosis patients and differentiation from pulmonary tuberculosis.[Methods]Retrospective analysis was conducted on 103 patients who underwent lung examinations,including 47 cases of pneumoconiosis and 56 cases of pulmonary tuberculosis.The differences in nodule characteristics and accompanying cavity sign between pneumoconiosis and pulmonary tuberculosis were compared.[Results]The X-ray manifestations of pneumoconiosis patients mainly included various forms of lung images,which were uneven in density,and had blurry edges,and sometimes thickening of lung markings and reduction of lung volume could be observed.The acinar nodules observed in X-ray films of patients with hematogenous disseminated pulmonary tuberculosis appeared petal like.The uniformity of nodule appearance such as nodule distribution,nodule density,and nodule size was significantly lower in pneumoconiosis than in hematogenous disseminated pulmonary tuberculosis,showing a statistical significance(P<0.05).The diameter of cavities in patients with pneumoconiosis accompanied by cavity sign[(0.64±0.13 vs 3.37±0.95)cm]was lower than that in patients with secondary pulmonary tuberculosis accompanied by cavity sign.There was a significant difference in the thickness of the cavity wall between the two diseases,and patients with pneumoconiosis accompanied by cavity sign had a higher rate of thick wall cavities(>3 mm).The X-ray manifestations of pneumoconiosis and tuberculosis were relatively similar,but the distribution,density and size of nodules in pneumoconiosis were relatively uneven,and the patients accompanied by cavity sign had smaller cavity diameter and higher rate of thick-walled cavities.[Conclusions]This study provides a reference for the clinical differential diagnosis of pneumoconiosis and pulmonary tuberculosis.展开更多
Objective To evaluate the alterations of biomarkers in the development and progression of coal workers＇ pneumoconiosis （CWP）. Methods The type and number of cells, and the levels of tumor necrosis factor-alpha （T...Objective To evaluate the alterations of biomarkers in the development and progression of coal workers＇ pneumoconiosis （CWP）. Methods The type and number of cells, and the levels of tumor necrosis factor-alpha （TNF-α）, pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1. Results Compared to active coal miners without CWP （8,23μg/mL）, TNF-α concentration was gradually decreased when dust exposure was stopped （5.90 μg/mL）. Elevated surfactant protein A （SP-A） level and phosphatidylglycerol （PG） to phosphatidylinositol （PI） ratio were found in miners actively exposed to coal dust （6528 μg/mL for SP-A and 10. for PG/P1）, and both parameters decreased when CWP progressed from CWP （0/1） （3419μg/mL for SP-A and 5.9 for PG/PI） to CWP （1/1） （1654 μg/mL for SP-A and 5.5 for PG/PI）. Conclusion Biomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers＇ pneumoconiosis.展开更多
Pneumoconiosis is a restrictive lung disease mostly caused by occupational exposure to dust,including silica dust,asbestos,and other fibers.Inhalable particles smaller than 10μm can enter the bronchioles,injure lung ...Pneumoconiosis is a restrictive lung disease mostly caused by occupational exposure to dust,including silica dust,asbestos,and other fibers.Inhalable particles smaller than 10μm can enter the bronchioles,injure lung cells,and induce lung fibrosis.This hard-to-cure disease places a substantial burden on patients and society[1].展开更多
The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis（PTB） among coal workers＇ pneumoconiosis（CWP） patients. A match...The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis（PTB） among coal workers＇ pneumoconiosis（CWP） patients. A matched case-control study was conducted in 86 CWP patients with active PTB and 86 CWP controls without TB. A standardized questionnaire was used for risk factors assessment. Conditioned logistic regression analysis was used to identify associations between the risk factors and active PTB among CWP patients. The results showed that the stage of CWP, poor workplace ventilation, family history of TB, and exposure to TB were independent risk factors for active PTB in patients with CWP with which recommendations for improving work environments, and for case finding activities in patients with CWP could be made.展开更多
BACKGROUND Rapidly progressive pneumoconiosis(RPP) occasionally occurs in coal workers, particularly those with high exposure to silica. Here, we report the case of a 64-year-old male miller with RPP. CASE SUMMARY The...BACKGROUND Rapidly progressive pneumoconiosis(RPP) occasionally occurs in coal workers, particularly those with high exposure to silica. Here, we report the case of a 64-year-old male miller with RPP. CASE SUMMARY The patient had a persistent cough for one month and had been clinically diagnosed with pulmonary tuberculosis in 2011. He worked in a stone processing factory from the ages of 20 through 37 and has owned his own mill for the past 25 years. His chest radiograph showed significant increases in the size and number of lung nodules since his last follow-up in 2013. By percutaneous needle lung biopsy, the nodular lesions showed diffuse infiltration of phagocytic macrophages and birefringent crystals by polarizing microscopy. He was finally diagnosed with RPP of mixed dust pneumoconiosis combined with silicosis. CONCLUSION In this case, mixed dust pneumoconiosis with silicosis might be accelerated by persistent exposure to graindust from working in a mill environment.展开更多
Objective： The aim of this case-control study was to explore whether five tagging single nucleotide poly- morphisms （tSNPs） within the transforming growth factor-ill （TGF-fll） gene were involved in manifestation ...Objective： The aim of this case-control study was to explore whether five tagging single nucleotide poly- morphisms （tSNPs） within the transforming growth factor-ill （TGF-fll） gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers pneumoconiosis （CWP）. Methods： The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group. Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method. Results： The single SNP analysis showed that the genotype frequencies of SNP2 （rs1800470, ＋869T/C, extron 1） and SNP5 （rs11466345, intron 5） in CWP cases were significantly different from those in controls. Multivariate logistic regression analysis revealed that SNP2 （rs1800470） CC genotype was associated with decreased risk of CWP （OR = 0.50, 95% CI = 0.32-0.78）, which was evident among subgroups of those never smoke （OR = 0.40, 95%CI = 0.24-0.66）, cases with stage Ⅱ（OR = 0.41, 95%CI = 0.22-0.76） and exposure period （〈 28 y： OR = 0.54, 95%CI = 0.31-0.95; ≥ 28 y： OR = 0.52, 95%CI = 0.32-0.96）. However, the SNP5 （rs11466345） GG genotype was associated with an increased risk of CWP （OR = 2.5, 95%CI = 1.36-4.57）, and further stratification analysis showed that the risk of CWP was increased in both smoking and nonsmoking groups, shorter and longer exposure groups, while the risk of CWP was only increased in patients with stage I and Ⅱ. Conclusion： This study suggests that TGF-β1 polymorphisms may contribute to susceptibility of CWP.展开更多
In the United States,an unexpected and severe increase in coal miners’lung diseases in the late 1990s prompted researchers to investigate the causes of the disease resurgence.This study aims to scrutinize the effects...In the United States,an unexpected and severe increase in coal miners’lung diseases in the late 1990s prompted researchers to investigate the causes of the disease resurgence.This study aims to scrutinize the effects of various mining parameters,including coal rank,mine size,mine operation type,coal seam height,and geographical location on the prevalence of coal worker’s pneumoconiosis(CWP)in surface and underground coal mines.A comprehensive dataset was created using the U.S.Mine Safety and Health Administration(MSHA)Employment and Accident/Injury databases.The information was merged based on the mine ID by utilizing SQL data management software.A total number of 123,589 mine-year observations were included in the statistical analysis.Generalized Estimating Equation(GEE)model was used to conduct a statistical analysis on a total of 29,707,and 32,643 mine-year observations for underground and surface coal mines,respectively.The results of the econometrics approach revealed that coal workers in underground coal mines are at a greater risk of CWP comparing to those of surface coal operations.Furthermore,underground coal mines in the Appalachia and Interior regions are at a higher risk of CWP prevalence than the Western region.Surface coal mines in the Appalachian coal region are more likely to CWP development than miners in the Western region.The analysis also indicated that coal workers working in smaller mines are more vulnerable to CWP than those in large mine sizes.Furthermore,coal workers in thin-seam underground mine operations are more likely to develop CWP.展开更多
Three hundred and ninety five residents in a desert area were examined with chest radiographs and 28 cases with siliceous pneumoconiosis were found. The prevalence of siliceous pneumoconiosis was 7.09%, and that over ...Three hundred and ninety five residents in a desert area were examined with chest radiographs and 28 cases with siliceous pneumoconiosis were found. The prevalence of siliceous pneumoconiosis was 7.09%, and that over 40 years of age was 21%. The histological findings of lungs from a camel living in that area for 20 years also confirmed to have siliceous pneumoconiosis.展开更多
The Residual Volume (RV) and Functional ResidualCapacity (FRC) were measured in 49 male workers exposedto cement dust (group A) and 50 male patients with pneu-moconiosis (group B). These data were compared withthose i...The Residual Volume (RV) and Functional ResidualCapacity (FRC) were measured in 49 male workers exposedto cement dust (group A) and 50 male patients with pneu-moconiosis (group B). These data were compared withthose in 84 healthy workers (group C). Data from groupA, B exhibited mixed or obstructed ventilation dysfunction.The means of RV%, FRC% in group A were 31.2～35.6%and 56.7～59.3% respectively. These values were not onlysignificantly higher than those of the group C, but alsohigher than those of group B. The individual abnormaldetecting rates of RV% in group A, B were 26.5% and52.0% respectively, remarkably higher than 9.5% in thegroup C. It seems that RV% can be used as an individualscreening test in clinical practice. In physiologic terms,It has been recognized that FRC might more objectively.reflect the changes in quasi-static mechanics in community.The impact factors of RV might be related to quasi-staticmechanics other than to those of strength of respiratorymuscles, resistance of airway and collapsibility of bron-chial walls.展开更多
Objective: To study the relationship between the polymorphism of drug resistant gene rpoB and drug resistance against rifampicin(RFP) of M. tuberculosis L-forms, and to evaluate its clinical application. Methods: A to...Objective: To study the relationship between the polymorphism of drug resistant gene rpoB and drug resistance against rifampicin(RFP) of M. tuberculosis L-forms, and to evaluate its clinical application. Methods: A total of 52 clinical isolated strains of M. tuberculosis L-forms were collected. rpoB gene polymorphism was analyzed by polymerase chain reaction and single-strand conformation polymorphism (PCR-SSCP) and conventional antimicrobial susceptibility test (AST). Their results were compared. Results: AST results showed that 38 of 52 clinical isolated strains were drug resistance (73.08％),while PCR-SSCP indicated 65.38％ (32/52) rpoB gene polymorphism. There was no statistic significance(χ2= 2.4914) between the 2 methods. Conclusion:Combined the application of PCR-SSCP with AST in detecting rpoB drug resistant gene polymorphism of M. tuberculosis L-form from pneumoconiosis patients with tuberculosis may have advantages at earlier diagnosis and guidance of clinical medications.展开更多
Objective:To analyze the rule of prescribing traditional Chinese medicine for treating pneumoconiosis,so as to provide reference for differential diagnosis and treatment of pneumoconiosis as well as for the developmen...Objective:To analyze the rule of prescribing traditional Chinese medicine for treating pneumoconiosis,so as to provide reference for differential diagnosis and treatment of pneumoconiosis as well as for the development of new drugs for treatingthe disease.Methods:We searched China National Knowledge Infrastructure,Wanfang Database and VIP Chinese PublicationDatabase to retrieve relevant literatures which were then screened according to the enrollment criteria to establish a prescriptiondatabase of traditional Chinese medicine for the treatment of pneumoconiosis.The inheritance calculation platform of traditionalChinese medicine was used to analyze the prescribing rule of traditional Chinese medicine in the treatment of pneumoconiosisbased on association rules,k-means clustering algorithm and regression model analysis.Results:A total of 131 related literature were preliminarily selected,from which 97 prescriptions of traditional Chinese medicine with a total of 195 herbs were included.The most frequently prescribed herbs included Radix astragali,Platycodon grandiflorum,Pinellia ternata,licorice,Codonopsispilosula,Salvia miltiorrhiza,bitter almond etc.A total of 14 association rules,13 high-frequency herb pairs were found and 5groups of formulas were revealed by cluster analysis.Conclusion:The prescriptions for the treatment of pneumoconiosis are mainly composed of herbs for tonifying deficiency,resolving phlegm,relieving cough and asthma,activating blood circulation and removingblood stasis,which are supplemented with herbs for clearing heat,relieving appearance,regulating qi,promoting waterand permeating dampness,etc.,The prescribing rules reflect the basic pathological characteristics of lung deficiency and collateral arthralgia in pneumoconiosis,which provides some ideas for the clinical differentiation and treatment of pneumoconiosis in traditionalChinese medicine.It also provides reference for the research and development of new treatment methods.展开更多
Objective：To study the relationship between mutation in the katG gene and drug resistance of INH in Mycobacterium tuberculosis L-forms among patients of pneumoconiosis complicated with pulmonary tuberculosis, and to ...Objective：To study the relationship between mutation in the katG gene and drug resistance of INH in Mycobacterium tuberculosis L-forms among patients of pneumoconiosis complicated with pulmonary tuberculosis, and to explore the clinical application of PCR-SSCP. Methods： A total of 52 clinical isolated strains of Mycobacterium tuberculosis L-forms were collected. Mutation in the katG genes was detected by PCR-SSCP and traditional antimicrobial susceptibility test （AST）. Results： The results by AST showed that there were 40 persisters in 52 clinical isolated strains. The drug resistant rate was 76.92%（40/52）, and the gene mutation rate of katG was 57.70%（30/52）by PCR-SSCP, the difference was no quite significance （X^2 = 2.8507, P 〉 0.05）. The coincidence rate of two methods was 75.00% （30/40）. Conclusion： The detectionrate of katG resistant strains in Mycobacterium tuberculosis L-forms was high by PCR-SSCP. The combined application of PCR-SSCP and traditional antimicrobial susceptibility test can improve the detecting rate.展开更多
Silicosis is one of the most serious occupational diseases which affect many workers' health in China. Under the guidance of policies from the Chinese Government, the industries, hcalth care institutions, scientis...Silicosis is one of the most serious occupational diseases which affect many workers' health in China. Under the guidance of policies from the Chinese Government, the industries, hcalth care institutions, scientists and workers were organized and have made great efforts in plevention and treatment of silicosis as well as pneumoconiosis. Since the 1960s, the national health standards and chest X-ray diagnosis criteria for silicosis were established and have been revised recently.A nationwide epidemiological survey revealed that the cumulative pneumoconiosis cases were about 4 800 000 (1949-1992). The high prevalence rate has been the motivation to search for anti-silicotic drugs. Several kinds of anti-silicotic drugs were studied and found to be able to retard progression of silicosis and cause changes in X-ray picture. The mechanism of drug efficiency and the development of silicosis have attracted the interest of scientists in this fields and fruitful results have been obtained. For prevention of dust hazards, the systematic design for facilities of dust collection and the isolation of dust source appropriate to township industries have been worked out and used widely. Recently,under the supervision of the Ministry of Public Health, China, a pilot study on countermeasure for industrial hazards and health care service in township industries has been instituted展开更多
Pneumoconiosis (PNC) is a major occupational disease that develops as a result of occupational exposure to dust via inhalation. In addition to its harmful effects on the respiratory system, PNC can increase vulnerabil...Pneumoconiosis (PNC) is a major occupational disease that develops as a result of occupational exposure to dust via inhalation. In addition to its harmful effects on the respiratory system, PNC can increase vulnerability to coronary heart disease (CHD)—the leading cause of death in the United States and in the world. Currently, two types of cardiovascular intervention procedures for CHD treatment are percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). The objective of this study was to investigate comparative effectiveness of the two major cardiovascular intervention procedures—PCI and CABG—in PNC patients with CHD. Data from 1094 hospitalizations of adult patients with PNC and CHD (CHD-PNC patients) and 534,120 hospi-talizations of CHD patients without PNC (CHD-nonPNC) were investigated. Adjusted odds ratios for in-hospital death in relation to the type of procedure, adjusted for patient socio-demographic and clinical characteristics and hospital characteristics, were calculated using multivariable logistic regression. Men constituted 97.8% of CHD-PNC patients and 68.6% of CHD-nonPNC patients. Within the CHD-PNC group, crude (unadjusted) in-hospital mortality after CABG and PCI did not differ significantly (1.35% vs. 2.00%, p = 0.425) and remained insignificant in the multivariable analysis, adjusted for patient and hospital characteristics (adjusted OR = 0.714, 95% CI 0.220 - 2.323, p = 0.576). But in the CHD-nonPNC group, in-hospital mortality after CABG was significantly higher than after PCI both in crude analysis (2.83% vs. 1.28%,展开更多
Objective:To evaluate the efficacy of transbronchoscopic large volume lung lavage in the treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease(COPD).Methods:The clinical data of 80 patient...Objective:To evaluate the efficacy of transbronchoscopic large volume lung lavage in the treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease(COPD).Methods:The clinical data of 80 patients with pneumoconiosis complicated with COPD admitted to our hospital from June 2017 to January 2019 were retrospectively analyzed.40 patients in the control group were treated with conventional drugs and 40 patients in the observation group treated with conventional drugs plus transbronchoscopic large-volume lung lavage.Dyspnea score and healthy quality of life were compared between the two groups.Results:the scores of dyspnea in the observation group were significantly lower than those in the control group at 12,24 and 48 weeks after treatment,and the(SGRQ)scores of George’s respiratory problems questionnaire in the observation group were significantly lower than those in the control group at 12,24 and 48 weeks after treatment.Conclusion:Thetransbronchoscopic large volume of lung lavage has a significant effect on the treatment of pneumoconiosis patients with COPD,which can effectively reduce the degree of dyspnea and improve the quality of life.展开更多
Objective:To explore the effect of respiratory rehabilitation training on the quality of life of pneumoconiosis patients.Methods:76 pneumoconiosis patients who were treated in our hospital from April 2017 to December ...Objective:To explore the effect of respiratory rehabilitation training on the quality of life of pneumoconiosis patients.Methods:76 pneumoconiosis patients who were treated in our hospital from April 2017 to December 2019 were selected as the research object,and randomly divided into 2 groups according to the order of admission by coin tossing,38 cases in each group.The control group carried out health knowledge education on the basis of conventiona1 treatment,and the observation group combined with respiratory rehabilitation training on the basis of the control group to compare the quality of life and lung function of the two groups of patients.Results:After 2 months of nursing care,scores of GQOLI-74 scale and pulmonary ventilation function indexes in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Respiratory rehabilitation training can improve pulmonary ventilation function of pneumoconiosis patients,improve the quality of life of patients,has good clinical application value.展开更多
Pneumoconiosis is a disease characterized by pulmonary tissue deposition caused by dust exposure in the workplace.In China,due to the large number and wide distribution of pneumoconiosis patients,there is a high deman...Pneumoconiosis is a disease characterized by pulmonary tissue deposition caused by dust exposure in the workplace.In China,due to the large number and wide distribution of pneumoconiosis patients,there is a high demand for the case data of lung biopsy during the diagnosis of pneumoconiosis.This text studied the application of medical image detection technology in pneumoconiosis diagnosis based on deep learning(DL).A medical image detection and convolution neural network(CNN)based on DL was analyzed,and the application of DL medical image technology in pneumoconiosis diagnosis was researched.The experimental results in this paper showed that in the last round of testing,the accuracy of ResNet model including deconvolution structure reached 95.2%.The area under curve(AUC)value of the working characteristics of the subject is 0.987.The sensitivity was 99.66%,and the specificity was 88.61%.The non staging diagnosis of pneumoconiosis improved the diagnostic sensitivity while ensuring high specificity.At the same time,Delong test method was used to conduct AUC analysis on the three models,and the results showed that model C was more effective than model A and model B.There is no significant difference between model A and model B,and there is no significant difference in diagnostic efficiency.In a word,the diagnosis of the model has high sensitivity and low probability of missed diagnosis,which can greatly reduce the working pressure of diagnostic doctors and effectively improve the efficiency of diagnosis.展开更多
Background:Pneumoconiosis is the most widely distributed occupational disease worldwide.China is currently the largest coal producer and consumer and the country with the most coal miners and cases of coal workers’pn...Background:Pneumoconiosis is the most widely distributed occupational disease worldwide.China is currently the largest coal producer and consumer and the country with the most coal miners and cases of coal workers’pneumoconiosis(CWP).Despite more than 70 years of effort,the problem of CWP and silicosis remains serious.There is a lack of analysis of direct data on coal miners’pneumoconiosis from all over the country.This study aimed to describe the epidemiology of coal miners’pneumoconiosis and reveal some important clues regarding its social determinants.Methods:The annual incidence rate,20-year prevalence rate,and incidence rate of coal miners’pneumoconiosis per million tons in China from 1949 to 2021 were calculated by using the data of annual number of coal miners’pneumoconiosis diagnosed and reported from the coal mining and dressing industry,the number of coal miners,and the raw coal production,and the relationship between the incident cases of coal miners’pneumoconiosis and the death toll from coal mine safety accidents was analyzed using Pearson correlation analysis,with the aim of exploring the relationship between the incident cases of coal miners’pneumoconiosis and its social determinants with an ecological study.Results:From 1949 to 2021,there have been more than 462,000 patients with coal miners’pneumoconio-sis in China,showing double U-shaped distributions with an increasing trend,accounting for about 50.5%(462,000/915,000)of all diagnosed pneumoconiosis in China,while the incidencet rate of coal miners’pneu-moconiosis presents a large W shaped distribution with three peaks over a time span of more than 50 years.From 1949 to 1986,there was a strong correlation between the incident cases of coal miners’pneumoconiosis and raw coal production,the number of coal miners,and the number of deaths from coal mine accidents(r=0.849,P<0.001;r=0.817,P<0.001;r=0.697,P<0.001,respectively),but there was no such correlation found from 1987 to 2006.It was estimated that the annual incidence rate of coal miners’pneumoconiosis in China from 2016 to 2020 was 3.4‰(95%CI:2.6-4.3‰),and the prevalence rate across the recent 20-year observation period was 4.8%(95%CI:4.6-4.9%),both measured at the peak or around the peak over the 70 years.In particular,1963,1986,2006,and 2009 were the four important turning points in time.Conclusion:There was a sustained high level of incident cases of coal miners’pneumoconiosis with double U-shaped curve in China,which may be affected by a variety of social determinants and risk factors.展开更多
Objective To understand the social security situation of current cases of pneumoconiosis in non-coal mine industries in Jiangsu Province,and to provide reference for the treatment and security work of pneumoconiosis p...Objective To understand the social security situation of current cases of pneumoconiosis in non-coal mine industries in Jiangsu Province,and to provide reference for the treatment and security work of pneumoconiosis patients.Methods From January to October 2020,a follow-up survey was conducted on4038 cases of pneumoconiosis in non-coal mine industries of the province from October 1949 to December 2019.展开更多
文摘Objective: To analyze the effect of psychological nursing combined with breathing exercises on lung function of patients with pneumoconiosis, and to analyze the methods. A total of 64 cases of pneumoconiosis admitted from January 2020 to December 2022 were divided into the reference group and the experimental group by random numerical table. On the basis of symptomatic treatment, the control group was combined with conventional nursing measures and breathing exercises, while the experimental group was treated with psychological nursing on the basis of the control group, and the pulmonary function indexes and adverse mood of the two groups before and after nursing were compared. Results: There was no difference in SAS score, SDS score and pulmonary function indexes between the two groups before intervention (P > 0.05), and the SAS score in the experimental group was the SDS score was lower than that of the control group, and FEV1, FEV1% and FEV1/FVC were higher than those of the control group, and the P < 0.05 was lower.
基金Supported by Science and Technology Fund of Guizhou Health and Health Committee(gzwjkj2020-1-184)。
文摘[Objectives]This study was conducted to explore the X-ray manifestations of pneumoconiosis patients and differentiation from pulmonary tuberculosis.[Methods]Retrospective analysis was conducted on 103 patients who underwent lung examinations,including 47 cases of pneumoconiosis and 56 cases of pulmonary tuberculosis.The differences in nodule characteristics and accompanying cavity sign between pneumoconiosis and pulmonary tuberculosis were compared.[Results]The X-ray manifestations of pneumoconiosis patients mainly included various forms of lung images,which were uneven in density,and had blurry edges,and sometimes thickening of lung markings and reduction of lung volume could be observed.The acinar nodules observed in X-ray films of patients with hematogenous disseminated pulmonary tuberculosis appeared petal like.The uniformity of nodule appearance such as nodule distribution,nodule density,and nodule size was significantly lower in pneumoconiosis than in hematogenous disseminated pulmonary tuberculosis,showing a statistical significance(P<0.05).The diameter of cavities in patients with pneumoconiosis accompanied by cavity sign[(0.64±0.13 vs 3.37±0.95)cm]was lower than that in patients with secondary pulmonary tuberculosis accompanied by cavity sign.There was a significant difference in the thickness of the cavity wall between the two diseases,and patients with pneumoconiosis accompanied by cavity sign had a higher rate of thick wall cavities(>3 mm).The X-ray manifestations of pneumoconiosis and tuberculosis were relatively similar,but the distribution,density and size of nodules in pneumoconiosis were relatively uneven,and the patients accompanied by cavity sign had smaller cavity diameter and higher rate of thick-walled cavities.[Conclusions]This study provides a reference for the clinical differential diagnosis of pneumoconiosis and pulmonary tuberculosis.
基金This research was supported by University of Essen in Germany and Xishan Coal & Power Company
文摘Objective To evaluate the alterations of biomarkers in the development and progression of coal workers＇ pneumoconiosis （CWP）. Methods The type and number of cells, and the levels of tumor necrosis factor-alpha （TNF-α）, pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1. Results Compared to active coal miners without CWP （8,23μg/mL）, TNF-α concentration was gradually decreased when dust exposure was stopped （5.90 μg/mL）. Elevated surfactant protein A （SP-A） level and phosphatidylglycerol （PG） to phosphatidylinositol （PI） ratio were found in miners actively exposed to coal dust （6528 μg/mL for SP-A and 10. for PG/P1）, and both parameters decreased when CWP progressed from CWP （0/1） （3419μg/mL for SP-A and 5.9 for PG/PI） to CWP （1/1） （1654 μg/mL for SP-A and 5.5 for PG/PI）. Conclusion Biomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers＇ pneumoconiosis.
基金supported by Guangdong Provincial Science and Technology Plan Provincial International Cooperation Project[No.2011B050700001].
文摘Pneumoconiosis is a restrictive lung disease mostly caused by occupational exposure to dust,including silica dust,asbestos,and other fibers.Inhalable particles smaller than 10μm can enter the bronchioles,injure lung cells,and induce lung fibrosis.This hard-to-cure disease places a substantial burden on patients and society[1].
基金supported by the Research program on occupational poisoning and occupational lung disease[2014BAI12B01]
文摘The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis（PTB） among coal workers＇ pneumoconiosis（CWP） patients. A matched case-control study was conducted in 86 CWP patients with active PTB and 86 CWP controls without TB. A standardized questionnaire was used for risk factors assessment. Conditioned logistic regression analysis was used to identify associations between the risk factors and active PTB among CWP patients. The results showed that the stage of CWP, poor workplace ventilation, family history of TB, and exposure to TB were independent risk factors for active PTB in patients with CWP with which recommendations for improving work environments, and for case finding activities in patients with CWP could be made.
文摘BACKGROUND Rapidly progressive pneumoconiosis(RPP) occasionally occurs in coal workers, particularly those with high exposure to silica. Here, we report the case of a 64-year-old male miller with RPP. CASE SUMMARY The patient had a persistent cough for one month and had been clinically diagnosed with pulmonary tuberculosis in 2011. He worked in a stone processing factory from the ages of 20 through 37 and has owned his own mill for the past 25 years. His chest radiograph showed significant increases in the size and number of lung nodules since his last follow-up in 2013. By percutaneous needle lung biopsy, the nodular lesions showed diffuse infiltration of phagocytic macrophages and birefringent crystals by polarizing microscopy. He was finally diagnosed with RPP of mixed dust pneumoconiosis combined with silicosis. CONCLUSION In this case, mixed dust pneumoconiosis with silicosis might be accelerated by persistent exposure to graindust from working in a mill environment.
基金supported by the National Natural Science Foundation of China(No.30872093)Research Foundation of Health Department of Jiangsu Province(No.H200628)
文摘Objective： The aim of this case-control study was to explore whether five tagging single nucleotide poly- morphisms （tSNPs） within the transforming growth factor-ill （TGF-fll） gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers pneumoconiosis （CWP）. Methods： The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group. Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method. Results： The single SNP analysis showed that the genotype frequencies of SNP2 （rs1800470, ＋869T/C, extron 1） and SNP5 （rs11466345, intron 5） in CWP cases were significantly different from those in controls. Multivariate logistic regression analysis revealed that SNP2 （rs1800470） CC genotype was associated with decreased risk of CWP （OR = 0.50, 95% CI = 0.32-0.78）, which was evident among subgroups of those never smoke （OR = 0.40, 95%CI = 0.24-0.66）, cases with stage Ⅱ（OR = 0.41, 95%CI = 0.22-0.76） and exposure period （〈 28 y： OR = 0.54, 95%CI = 0.31-0.95; ≥ 28 y： OR = 0.52, 95%CI = 0.32-0.96）. However, the SNP5 （rs11466345） GG genotype was associated with an increased risk of CWP （OR = 2.5, 95%CI = 1.36-4.57）, and further stratification analysis showed that the risk of CWP was increased in both smoking and nonsmoking groups, shorter and longer exposure groups, while the risk of CWP was only increased in patients with stage I and Ⅱ. Conclusion： This study suggests that TGF-β1 polymorphisms may contribute to susceptibility of CWP.
基金This study is funded by the National Institute for Occupational Safety and Health(NIOSH)[75D30119C06390].The authors would like to thank Dr.Arvin Ebrahimkhanlou for all precise technical comments related to statistical analysis.
文摘In the United States,an unexpected and severe increase in coal miners’lung diseases in the late 1990s prompted researchers to investigate the causes of the disease resurgence.This study aims to scrutinize the effects of various mining parameters,including coal rank,mine size,mine operation type,coal seam height,and geographical location on the prevalence of coal worker’s pneumoconiosis(CWP)in surface and underground coal mines.A comprehensive dataset was created using the U.S.Mine Safety and Health Administration(MSHA)Employment and Accident/Injury databases.The information was merged based on the mine ID by utilizing SQL data management software.A total number of 123,589 mine-year observations were included in the statistical analysis.Generalized Estimating Equation(GEE)model was used to conduct a statistical analysis on a total of 29,707,and 32,643 mine-year observations for underground and surface coal mines,respectively.The results of the econometrics approach revealed that coal workers in underground coal mines are at a greater risk of CWP comparing to those of surface coal operations.Furthermore,underground coal mines in the Appalachia and Interior regions are at a higher risk of CWP prevalence than the Western region.Surface coal mines in the Appalachian coal region are more likely to CWP development than miners in the Western region.The analysis also indicated that coal workers working in smaller mines are more vulnerable to CWP than those in large mine sizes.Furthermore,coal workers in thin-seam underground mine operations are more likely to develop CWP.
文摘Three hundred and ninety five residents in a desert area were examined with chest radiographs and 28 cases with siliceous pneumoconiosis were found. The prevalence of siliceous pneumoconiosis was 7.09%, and that over 40 years of age was 21%. The histological findings of lungs from a camel living in that area for 20 years also confirmed to have siliceous pneumoconiosis.
文摘The Residual Volume (RV) and Functional ResidualCapacity (FRC) were measured in 49 male workers exposedto cement dust (group A) and 50 male patients with pneu-moconiosis (group B). These data were compared withthose in 84 healthy workers (group C). Data from groupA, B exhibited mixed or obstructed ventilation dysfunction.The means of RV%, FRC% in group A were 31.2～35.6%and 56.7～59.3% respectively. These values were not onlysignificantly higher than those of the group C, but alsohigher than those of group B. The individual abnormaldetecting rates of RV% in group A, B were 26.5% and52.0% respectively, remarkably higher than 9.5% in thegroup C. It seems that RV% can be used as an individualscreening test in clinical practice. In physiologic terms,It has been recognized that FRC might more objectively.reflect the changes in quasi-static mechanics in community.The impact factors of RV might be related to quasi-staticmechanics other than to those of strength of respiratorymuscles, resistance of airway and collapsibility of bron-chial walls.
文摘Objective: To study the relationship between the polymorphism of drug resistant gene rpoB and drug resistance against rifampicin(RFP) of M. tuberculosis L-forms, and to evaluate its clinical application. Methods: A total of 52 clinical isolated strains of M. tuberculosis L-forms were collected. rpoB gene polymorphism was analyzed by polymerase chain reaction and single-strand conformation polymorphism (PCR-SSCP) and conventional antimicrobial susceptibility test (AST). Their results were compared. Results: AST results showed that 38 of 52 clinical isolated strains were drug resistance (73.08％),while PCR-SSCP indicated 65.38％ (32/52) rpoB gene polymorphism. There was no statistic significance(χ2= 2.4914) between the 2 methods. Conclusion:Combined the application of PCR-SSCP with AST in detecting rpoB drug resistant gene polymorphism of M. tuberculosis L-form from pneumoconiosis patients with tuberculosis may have advantages at earlier diagnosis and guidance of clinical medications.
基金General Project of National Natural Science Foundation of China(No.81573970)BeijingMunicipal Natural Science Foundation(No.7202118)。
文摘Objective:To analyze the rule of prescribing traditional Chinese medicine for treating pneumoconiosis,so as to provide reference for differential diagnosis and treatment of pneumoconiosis as well as for the development of new drugs for treatingthe disease.Methods:We searched China National Knowledge Infrastructure,Wanfang Database and VIP Chinese PublicationDatabase to retrieve relevant literatures which were then screened according to the enrollment criteria to establish a prescriptiondatabase of traditional Chinese medicine for the treatment of pneumoconiosis.The inheritance calculation platform of traditionalChinese medicine was used to analyze the prescribing rule of traditional Chinese medicine in the treatment of pneumoconiosisbased on association rules,k-means clustering algorithm and regression model analysis.Results:A total of 131 related literature were preliminarily selected,from which 97 prescriptions of traditional Chinese medicine with a total of 195 herbs were included.The most frequently prescribed herbs included Radix astragali,Platycodon grandiflorum,Pinellia ternata,licorice,Codonopsispilosula,Salvia miltiorrhiza,bitter almond etc.A total of 14 association rules,13 high-frequency herb pairs were found and 5groups of formulas were revealed by cluster analysis.Conclusion:The prescriptions for the treatment of pneumoconiosis are mainly composed of herbs for tonifying deficiency,resolving phlegm,relieving cough and asthma,activating blood circulation and removingblood stasis,which are supplemented with herbs for clearing heat,relieving appearance,regulating qi,promoting waterand permeating dampness,etc.,The prescribing rules reflect the basic pathological characteristics of lung deficiency and collateral arthralgia in pneumoconiosis,which provides some ideas for the clinical differentiation and treatment of pneumoconiosis in traditionalChinese medicine.It also provides reference for the research and development of new treatment methods.
基金National Science Foundation Youth fund of Anhui University of Science & Technology(200537)
文摘Objective：To study the relationship between mutation in the katG gene and drug resistance of INH in Mycobacterium tuberculosis L-forms among patients of pneumoconiosis complicated with pulmonary tuberculosis, and to explore the clinical application of PCR-SSCP. Methods： A total of 52 clinical isolated strains of Mycobacterium tuberculosis L-forms were collected. Mutation in the katG genes was detected by PCR-SSCP and traditional antimicrobial susceptibility test （AST）. Results： The results by AST showed that there were 40 persisters in 52 clinical isolated strains. The drug resistant rate was 76.92%（40/52）, and the gene mutation rate of katG was 57.70%（30/52）by PCR-SSCP, the difference was no quite significance （X^2 = 2.8507, P 〉 0.05）. The coincidence rate of two methods was 75.00% （30/40）. Conclusion： The detectionrate of katG resistant strains in Mycobacterium tuberculosis L-forms was high by PCR-SSCP. The combined application of PCR-SSCP and traditional antimicrobial susceptibility test can improve the detecting rate.
文摘Silicosis is one of the most serious occupational diseases which affect many workers' health in China. Under the guidance of policies from the Chinese Government, the industries, hcalth care institutions, scientists and workers were organized and have made great efforts in plevention and treatment of silicosis as well as pneumoconiosis. Since the 1960s, the national health standards and chest X-ray diagnosis criteria for silicosis were established and have been revised recently.A nationwide epidemiological survey revealed that the cumulative pneumoconiosis cases were about 4 800 000 (1949-1992). The high prevalence rate has been the motivation to search for anti-silicotic drugs. Several kinds of anti-silicotic drugs were studied and found to be able to retard progression of silicosis and cause changes in X-ray picture. The mechanism of drug efficiency and the development of silicosis have attracted the interest of scientists in this fields and fruitful results have been obtained. For prevention of dust hazards, the systematic design for facilities of dust collection and the isolation of dust source appropriate to township industries have been worked out and used widely. Recently,under the supervision of the Ministry of Public Health, China, a pilot study on countermeasure for industrial hazards and health care service in township industries has been instituted
文摘Pneumoconiosis (PNC) is a major occupational disease that develops as a result of occupational exposure to dust via inhalation. In addition to its harmful effects on the respiratory system, PNC can increase vulnerability to coronary heart disease (CHD)—the leading cause of death in the United States and in the world. Currently, two types of cardiovascular intervention procedures for CHD treatment are percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). The objective of this study was to investigate comparative effectiveness of the two major cardiovascular intervention procedures—PCI and CABG—in PNC patients with CHD. Data from 1094 hospitalizations of adult patients with PNC and CHD (CHD-PNC patients) and 534,120 hospi-talizations of CHD patients without PNC (CHD-nonPNC) were investigated. Adjusted odds ratios for in-hospital death in relation to the type of procedure, adjusted for patient socio-demographic and clinical characteristics and hospital characteristics, were calculated using multivariable logistic regression. Men constituted 97.8% of CHD-PNC patients and 68.6% of CHD-nonPNC patients. Within the CHD-PNC group, crude (unadjusted) in-hospital mortality after CABG and PCI did not differ significantly (1.35% vs. 2.00%, p = 0.425) and remained insignificant in the multivariable analysis, adjusted for patient and hospital characteristics (adjusted OR = 0.714, 95% CI 0.220 - 2.323, p = 0.576). But in the CHD-nonPNC group, in-hospital mortality after CABG was significantly higher than after PCI both in crude analysis (2.83% vs. 1.28%,
基金Social Benefiting Project by Science and Technology for Ningxia Hui Autonomous Region:Comprehensive Demonstration of Integrated Prevention and Control Technology of Pneumoconiosis in Ningdong Coal Mine(Project No.:KJHM201503)。
文摘Objective:To evaluate the efficacy of transbronchoscopic large volume lung lavage in the treatment of pneumoconiosis complicated with chronic obstructive pulmonary disease(COPD).Methods:The clinical data of 80 patients with pneumoconiosis complicated with COPD admitted to our hospital from June 2017 to January 2019 were retrospectively analyzed.40 patients in the control group were treated with conventional drugs and 40 patients in the observation group treated with conventional drugs plus transbronchoscopic large-volume lung lavage.Dyspnea score and healthy quality of life were compared between the two groups.Results:the scores of dyspnea in the observation group were significantly lower than those in the control group at 12,24 and 48 weeks after treatment,and the(SGRQ)scores of George’s respiratory problems questionnaire in the observation group were significantly lower than those in the control group at 12,24 and 48 weeks after treatment.Conclusion:Thetransbronchoscopic large volume of lung lavage has a significant effect on the treatment of pneumoconiosis patients with COPD,which can effectively reduce the degree of dyspnea and improve the quality of life.
基金Ningxia Hui Autonomous Region Science and Teclnology Huimin Plan Project:Integrated demonstration of integrated prevention and control technology for pneumoconiosis in Ningdong Coal Mine(No.KJHM201503).
文摘Objective:To explore the effect of respiratory rehabilitation training on the quality of life of pneumoconiosis patients.Methods:76 pneumoconiosis patients who were treated in our hospital from April 2017 to December 2019 were selected as the research object,and randomly divided into 2 groups according to the order of admission by coin tossing,38 cases in each group.The control group carried out health knowledge education on the basis of conventiona1 treatment,and the observation group combined with respiratory rehabilitation training on the basis of the control group to compare the quality of life and lung function of the two groups of patients.Results:After 2 months of nursing care,scores of GQOLI-74 scale and pulmonary ventilation function indexes in the observation group were higher than those in the control group,with statistically significant differences(P<0.05).Conclusion:Respiratory rehabilitation training can improve pulmonary ventilation function of pneumoconiosis patients,improve the quality of life of patients,has good clinical application value.
文摘Pneumoconiosis is a disease characterized by pulmonary tissue deposition caused by dust exposure in the workplace.In China,due to the large number and wide distribution of pneumoconiosis patients,there is a high demand for the case data of lung biopsy during the diagnosis of pneumoconiosis.This text studied the application of medical image detection technology in pneumoconiosis diagnosis based on deep learning(DL).A medical image detection and convolution neural network(CNN)based on DL was analyzed,and the application of DL medical image technology in pneumoconiosis diagnosis was researched.The experimental results in this paper showed that in the last round of testing,the accuracy of ResNet model including deconvolution structure reached 95.2%.The area under curve(AUC)value of the working characteristics of the subject is 0.987.The sensitivity was 99.66%,and the specificity was 88.61%.The non staging diagnosis of pneumoconiosis improved the diagnostic sensitivity while ensuring high specificity.At the same time,Delong test method was used to conduct AUC analysis on the three models,and the results showed that model C was more effective than model A and model B.There is no significant difference between model A and model B,and there is no significant difference in diagnostic efficiency.In a word,the diagnosis of the model has high sensitivity and low probability of missed diagnosis,which can greatly reduce the working pressure of diagnostic doctors and effectively improve the efficiency of diagnosis.
基金This work was supported by the Advisory Research Project of the Chinese Academy of Engineering in 2019(No.2019-XZ-70).
文摘Background:Pneumoconiosis is the most widely distributed occupational disease worldwide.China is currently the largest coal producer and consumer and the country with the most coal miners and cases of coal workers’pneumoconiosis(CWP).Despite more than 70 years of effort,the problem of CWP and silicosis remains serious.There is a lack of analysis of direct data on coal miners’pneumoconiosis from all over the country.This study aimed to describe the epidemiology of coal miners’pneumoconiosis and reveal some important clues regarding its social determinants.Methods:The annual incidence rate,20-year prevalence rate,and incidence rate of coal miners’pneumoconiosis per million tons in China from 1949 to 2021 were calculated by using the data of annual number of coal miners’pneumoconiosis diagnosed and reported from the coal mining and dressing industry,the number of coal miners,and the raw coal production,and the relationship between the incident cases of coal miners’pneumoconiosis and the death toll from coal mine safety accidents was analyzed using Pearson correlation analysis,with the aim of exploring the relationship between the incident cases of coal miners’pneumoconiosis and its social determinants with an ecological study.Results:From 1949 to 2021,there have been more than 462,000 patients with coal miners’pneumoconio-sis in China,showing double U-shaped distributions with an increasing trend,accounting for about 50.5%(462,000/915,000)of all diagnosed pneumoconiosis in China,while the incidencet rate of coal miners’pneu-moconiosis presents a large W shaped distribution with three peaks over a time span of more than 50 years.From 1949 to 1986,there was a strong correlation between the incident cases of coal miners’pneumoconiosis and raw coal production,the number of coal miners,and the number of deaths from coal mine accidents(r=0.849,P<0.001;r=0.817,P<0.001;r=0.697,P<0.001,respectively),but there was no such correlation found from 1987 to 2006.It was estimated that the annual incidence rate of coal miners’pneumoconiosis in China from 2016 to 2020 was 3.4‰(95%CI:2.6-4.3‰),and the prevalence rate across the recent 20-year observation period was 4.8%(95%CI:4.6-4.9%),both measured at the peak or around the peak over the 70 years.In particular,1963,1986,2006,and 2009 were the four important turning points in time.Conclusion:There was a sustained high level of incident cases of coal miners’pneumoconiosis with double U-shaped curve in China,which may be affected by a variety of social determinants and risk factors.
文摘Objective To understand the social security situation of current cases of pneumoconiosis in non-coal mine industries in Jiangsu Province,and to provide reference for the treatment and security work of pneumoconiosis patients.Methods From January to October 2020,a follow-up survey was conducted on4038 cases of pneumoconiosis in non-coal mine industries of the province from October 1949 to December 2019.
