Phosphate residue is a kind of hazardous solid waste and if not properly disposed of, could cause serious environmental contaminations. The abundant iron salt available in phosphate residue can be used to prepare phot...Phosphate residue is a kind of hazardous solid waste and if not properly disposed of, could cause serious environmental contaminations. The abundant iron salt available in phosphate residue can be used to prepare photo-Fenton catalytic reagent for wastewater treatment. In this study, the phosphate residue was effectively purified by a hydrothermal recrystallization method, reaching an iron phosphate purity of 94.2%. The particles of iron phosphate were further processed with ball milling with their average size reduced from 19.4 to 1.6 μm. By hydrothermal crystallization of iron phosphate and thermal decomposition of oxalate precursor, porous iron hydroxy phosphate was prepared. The modified porous iron hydroxy phosphate(m-PIHP) of higher surface area with iron oxalate on its surface can degrade 98.87% of Rhodamine B in 15 min. Cyclic experiment showed that the catalyst still had a good catalytic activity after six cycles( > 40%). The X-ray photoelectron spectroscopy results showed that the iron oxalate complex on the catalyst surface decomposed to produce ferrous ions and accelerated the rate of · OH production. The current work demonstrated that the m-PIHP synthesized from phosphate residue and modified with iron oxalate can be used as an effective dye wastewater treatment agent.展开更多
3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomi...3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomic layer deposition technique was used to deposit nanometer-thick zinc oxide(ZnO)layer onto the skeleton of 3D porous Fe scaffolds with interconnected open pores.The effect of ZnO thin film on the in vitro degradation behavior,antibacterial activity and cytocompatibility of 3D porous Fe scaffolds was systematically evaluated.The results showed that a dense ZnO thin film with a thickness of 76 nm was uniformly deposited on the skeleton of the porous Fe scaffolds.The thickness of ZnO thin film could be easily controlled by the deposition cycles.The deposited ZnO thin film significantly reduced the degradation rate of porous Fe scaffolds and the fabricated ZnO coated porous Fe scaffolds demonstrated strong antibacterial ability against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus,while did not significantly affect cytocompatibility and could also promote cell adhesion.展开更多
Electrochemical nitrogen reduction reaction(NRR)under ambient conditions is highly desirable to achieve sustainable ammonia(NH3)production via an alternative carbon free strategy.Single-atom catalysts(SACs)with super ...Electrochemical nitrogen reduction reaction(NRR)under ambient conditions is highly desirable to achieve sustainable ammonia(NH3)production via an alternative carbon free strategy.Single-atom catalysts(SACs)with super high atomic utilization and catalytic efficiency exhibit great potential for NRR.Herein,a high-performance NRR SAC is facilely prepared via a simple deposition method to anchor Au single atoms onto porousβ-FeOOH nanotubes.The resulting Au-SA/FeOOH can efficiently drive NRR under ambient conditions,and the NH3 yield reaches as high as 2,860μg·h^(-1)·mg_(Au)^(-1)at-0.4 V vs.reversible hydrogen electrode(RHE)with 14.2%faradaic efficiency,much superior to those of all the reported Au-based electrocatalysts.Systematic investigations demonstrate that the synergy of much enhanced N_(2)adsorption,directional electron export,and mass transfer ability in Au-SA/FeOOH greatly contributes to the superior NRR activity.This work highlights a new insight into the design of high efficient NRR electrocatalysts by combination of porous metal oxide matrix and highly active single-atom sites.展开更多
The integration of photothermal therapy(PTT)with gene therapy(GT)in a single nanoscale platform demonstrates great potential in cancer therapy.Porous iron oxide nanoagents(PIONs)are widely used as magnetic nanoagents ...The integration of photothermal therapy(PTT)with gene therapy(GT)in a single nanoscale platform demonstrates great potential in cancer therapy.Porous iron oxide nanoagents(PIONs)are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal therapy.However,the therapeutic efficacy of PIONs-mediated GT has not been studied.The long noncoding RNA(lncRNA)CRYBG3(LNC CRYBG3),a lncRNA induced by heavy ion irradiation in lung cancer cells,has been reported to directly bind to globular actin(G-actin)and cause degradation of cytoskeleton and blocking of cytokinesis,thus indicating its potential for use in GT by simulating the effect of heavy ion irradiation and functioning as an antitumor drug.In the present study,we investigated the possibility of combining PIONs-mediated PTT and LNC CRYBG3-mediated GT to destroy non-small cell lung cancer(NSCLC)cells both in vitro and in vivo.The combination therapy showed a high cancer cell killing efficacy,and the cure rate was better than that achieved using PTT or GT alone.Moreover,as a type of magnetic nanoagent,PIONs can be used for magnetic resonance imaging(MRI)and photoacoustic imaging(PAI)both in vitro and in vivo.These findings indicate that the new combination therapy has high potential for cancer treatment.展开更多
基金supported by the Science and Technology Development Foundation of Pudong New Area (No. PKJ2014-Z03)Dawn Program of Shanghai (No. 09SG54 )Material Science and Engineering Key Subject of Shanghai Polytechnic University (No. XXKZD1601)。
文摘Phosphate residue is a kind of hazardous solid waste and if not properly disposed of, could cause serious environmental contaminations. The abundant iron salt available in phosphate residue can be used to prepare photo-Fenton catalytic reagent for wastewater treatment. In this study, the phosphate residue was effectively purified by a hydrothermal recrystallization method, reaching an iron phosphate purity of 94.2%. The particles of iron phosphate were further processed with ball milling with their average size reduced from 19.4 to 1.6 μm. By hydrothermal crystallization of iron phosphate and thermal decomposition of oxalate precursor, porous iron hydroxy phosphate was prepared. The modified porous iron hydroxy phosphate(m-PIHP) of higher surface area with iron oxalate on its surface can degrade 98.87% of Rhodamine B in 15 min. Cyclic experiment showed that the catalyst still had a good catalytic activity after six cycles( > 40%). The X-ray photoelectron spectroscopy results showed that the iron oxalate complex on the catalyst surface decomposed to produce ferrous ions and accelerated the rate of · OH production. The current work demonstrated that the m-PIHP synthesized from phosphate residue and modified with iron oxalate can be used as an effective dye wastewater treatment agent.
基金This work was financially supported by the Natural Science Foundation of Guangdong(No.2019A1515011755)China.The authors acknowledge the assistance of SUSTech Core Research Facilities that receives support from Presidential Fund and Development and Reform Commission of Shenzhen Municipality.
文摘3D porous iron(Fe)scaffolds with interconnected open pores are promising candidates for bone repair.However,the bare 3D porous Fe scaffolds lack of antibacterial activity and the ability for cell adhesion.Herein,atomic layer deposition technique was used to deposit nanometer-thick zinc oxide(ZnO)layer onto the skeleton of 3D porous Fe scaffolds with interconnected open pores.The effect of ZnO thin film on the in vitro degradation behavior,antibacterial activity and cytocompatibility of 3D porous Fe scaffolds was systematically evaluated.The results showed that a dense ZnO thin film with a thickness of 76 nm was uniformly deposited on the skeleton of the porous Fe scaffolds.The thickness of ZnO thin film could be easily controlled by the deposition cycles.The deposited ZnO thin film significantly reduced the degradation rate of porous Fe scaffolds and the fabricated ZnO coated porous Fe scaffolds demonstrated strong antibacterial ability against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus,while did not significantly affect cytocompatibility and could also promote cell adhesion.
基金This work was supported by the Natural Science Foundation of Tianjin City of China(No.18JCJQJC47700)the Key Laboratory of Resource Chemistry of Chinese Ministry of Education(No.KLRC_ME1902)+2 种基金the Opening Project of Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Chinese Ministry of Education,the National Natural Science Foundation of China(No.21701168)Dalian high level talent innovation project(No.2019RQ063)the Open Project Foundation of State Key Laboratory of Structural Chemistry,and Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences(No.20200021).
文摘Electrochemical nitrogen reduction reaction(NRR)under ambient conditions is highly desirable to achieve sustainable ammonia(NH3)production via an alternative carbon free strategy.Single-atom catalysts(SACs)with super high atomic utilization and catalytic efficiency exhibit great potential for NRR.Herein,a high-performance NRR SAC is facilely prepared via a simple deposition method to anchor Au single atoms onto porousβ-FeOOH nanotubes.The resulting Au-SA/FeOOH can efficiently drive NRR under ambient conditions,and the NH3 yield reaches as high as 2,860μg·h^(-1)·mg_(Au)^(-1)at-0.4 V vs.reversible hydrogen electrode(RHE)with 14.2%faradaic efficiency,much superior to those of all the reported Au-based electrocatalysts.Systematic investigations demonstrate that the synergy of much enhanced N_(2)adsorption,directional electron export,and mass transfer ability in Au-SA/FeOOH greatly contributes to the superior NRR activity.This work highlights a new insight into the design of high efficient NRR electrocatalysts by combination of porous metal oxide matrix and highly active single-atom sites.
基金This work was supported by the National Key R&D program of China(2018YFC0115704,2018YFB1105700)the Guangdong Science and Technology Department(2020B1212060018,2020B1212030004)+1 种基金the Guangdong Basic and Applied Basic Research Foundation for Distinguished Young Scholars(2020B1515020027)the grant from Guangzhou Science and Technology Bureau(202002020070,202102010181,202102010007).
文摘The integration of photothermal therapy(PTT)with gene therapy(GT)in a single nanoscale platform demonstrates great potential in cancer therapy.Porous iron oxide nanoagents(PIONs)are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal therapy.However,the therapeutic efficacy of PIONs-mediated GT has not been studied.The long noncoding RNA(lncRNA)CRYBG3(LNC CRYBG3),a lncRNA induced by heavy ion irradiation in lung cancer cells,has been reported to directly bind to globular actin(G-actin)and cause degradation of cytoskeleton and blocking of cytokinesis,thus indicating its potential for use in GT by simulating the effect of heavy ion irradiation and functioning as an antitumor drug.In the present study,we investigated the possibility of combining PIONs-mediated PTT and LNC CRYBG3-mediated GT to destroy non-small cell lung cancer(NSCLC)cells both in vitro and in vivo.The combination therapy showed a high cancer cell killing efficacy,and the cure rate was better than that achieved using PTT or GT alone.Moreover,as a type of magnetic nanoagent,PIONs can be used for magnetic resonance imaging(MRI)and photoacoustic imaging(PAI)both in vitro and in vivo.These findings indicate that the new combination therapy has high potential for cancer treatment.
