Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this condition.The aims of this study were to...Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this condition.The aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive impairment.We found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic stroke.In addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic stroke.Serum phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic stroke.Furthermore,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein levels.Although ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein levels.Taken together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.展开更多
Background: The mechanisms by which acupuncture affects poststroke cognitive impairment (PSCI) remain unclear. Objective: To investigate brain functional network (BFN) changes in patients with PSCI after acupuncture t...Background: The mechanisms by which acupuncture affects poststroke cognitive impairment (PSCI) remain unclear. Objective: To investigate brain functional network (BFN) changes in patients with PSCI after acupuncture therapy. Methods: Twenty-two PSCI patients who underwent acupuncture therapy in our hospital were enrolled as research subjects. Another 14 people matched for age, sex, and education level were included in the normal control (HC) group. All the subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans;the PSCI patients underwent one scan before acupuncture therapy and another after. The network metric difference between PSCI patients and HCs was analyzed via the independent-sample t test, whereas the paired-sample t test was employed to analyze the network metric changes in PSCI patients before vs. after treatment. Results: Small-world network attributes were observed in both groups for sparsities between 0.1 and 0.28. Compared with the HC group, the PSCI group presented significantly lower values for the global topological properties (γ, Cp, and Eloc) of the brain;significantly greater values for the nodal attributes of betweenness centrality in the CUN. L and the HES. R, degree centrality in the SFGdor. L, PCG. L, IPL. L, and HES. R, and nodal local efficiency in the ORBsup. R, ORBsupmed. R, DCG. L, SMG. R, and TPOsup. L;and decreased degree centrality in the MFG. R, IFGoperc. R, and SOG. R. After treatment, PSCI patients presented increased degree centrality in the LING.L, LING.R, and IOG. L and nodal local efficiency in PHG. L, IOG. R, FFG. L, and the HES. L, and decreased betweenness centrality in the PCG. L and CUN. L, degree centrality in the ORBsupmed. R, and nodal local efficiency in ANG. R. Conclusion: Cognitive decline in PSCI patients may be related to BFN disorders;acupuncture therapy may modulate the topological properties of the BFNs of PSCI patients.展开更多
OBJECTIVE： To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL： We retr...OBJECTIVE： To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL： We retrieved data from the Chinese National Knowledge Infrastructure （1979-2012）, Wanfang （1980-2012）, VIP （1989-2012）, Chinese Biomedical Literature （1975- 2012）, PubMed （1966-2012）, Ovid Lww （-2012）, and Cochrane Library （-2012） Database using the internet. SELECTION CRITERIA： Randomized controlled trials on filiform needle acupuncture versus antidepressant drugs for treatment of poststroke depression were included. Moreover, the in- cluded articles scored at least 4 points on the Jadad scale. Exclusion criteria： other acupuncture therapies as treatment group, not stroke-induced depression patients, score 〈 4 points, non-ran- domized controlled trials, or animal trials. MAIN OUTCOME MEASURES： These were the Hamilton Depression Scale scores, clinical ef- fective rate, Self-Rating Depression Scale scores, Side Effect Rating Scale scores, and incidence of adverse reaction and events. RESULTS： A total of 17 randomized controlled clinical trials were included. Meta-analysis results displayed that after 4 weeks of treatment, clinical effective rate was better in patients treated with fill- form needle acupuncture than those treated with simple antidepressant drugs [relative risk = 1.11, 95% confidence interval （C/）： 1.03-1.21, P = 0.01]. At 6 weeks, clinical effective rate was similar between filiform needle acupuncture and antidepressant drug groups. At 2 weeks after filiform needle acupuncture, Hamilton Depression Scale （17 items） scores were lower than in the antide- pressant drug group （mean difference = -2.34, 95%CI： -3.46 to -1.22, P 〈 0.000,1）. At 4 weeks, Hamilton Depression Scale （24 items） scores were similar between filiform needle acupuncture and antidepressant drug groups. Self-Rating Depression Scale scores were lower in filiform needle acupuncture group than in the antidepressant drug group. Side Effect Rating Scale was used in only two articles, and no meta-analysis was conducted. Safety evaluation of the 17 arti- cles showed that gastrointestinal tract reactions such as nausea and vomiting were very common in the antidepressant drug group. Incidence of adverse reaction and events was very low in the filiform needle acupuncture group. CONCLUSION： Early filiform needle acupuncture for poststroke depression can perfectly con- trol depression. Filiform needle acupuncture is safe and reliable. Therapeutic effects of filiform needle acupuncture were better than those of antidepressant drugs.展开更多
To the editor, I read with interest the recent report on ＂filiform needle acupuncture for poststroke depression＂ （Zhang et al., 2014）. Zhang et al. （2014） performed a meta-analysis and conclud- ed that ＂early ...To the editor, I read with interest the recent report on ＂filiform needle acupuncture for poststroke depression＂ （Zhang et al., 2014）. Zhang et al. （2014） performed a meta-analysis and conclud- ed that ＂early filiform needle acupuncture for poststroke depression can perfectly control depression：＇ In fact, the in- cluded meta-analysis might support the clinical effectiveness of filariform needle acupuncture for poststroke depression. However, there are several concerns. First, the hospital infection due to acupuncture manipulation with filiform is a big topic to be addressed. As Gang et al. （2012） noted, ＂aseptic technic principles aren＇t strictly followed; disinfection and isolation systems are unsound;展开更多
Objective: To explore the effect of zopiclone combined with Deanxit on cytokines and neurotransmitters in patients with poststroke depression. Methods: A total of 78 patients with poststroke depression who were treate...Objective: To explore the effect of zopiclone combined with Deanxit on cytokines and neurotransmitters in patients with poststroke depression. Methods: A total of 78 patients with poststroke depression who were treated in Zaozhuang Mining Group Dongjiao Hospital between January 2015 and February 2017 were divided into control group (n=41, receiving conventional Deanxit therapy) and zopiclone group (n=37, receiving zopiclone combined with Deanxit therapy). The differences in serum nerve injury marker, inflammatory cytokine and monoamine neurotransmitter levels were compared between the two groups before treatment and after 12 weeks of treatment. Results: Before treatment, serum levels of nerve injury markers, inflammatory cytokines and monoamine neurotransmitters were not significantly different between the two groups. After 12 weeks of treatment, serum nerve injury markers NSE and S100B levels of zopiclone group were lower than those of control group whereas BDNF level was higher than that of control group;serum inflammatory cytokines IL-1, IL-2, IL-23 and TNF-α levels of zopiclone group were lower than those of control group;serum monoamine neurotransmitters NE, 5-HT and DA levels of zopiclone group were higher than those of control group. Conclusion: Zopiclone combined with Deanxit therapy can effectively optimize the neurological function, reduce the inflammatory response and increase the secretion of monoamine neurotransmitters in patients with poststroke depression.展开更多
Background： The pathophysiology of poststroke depression （PSD） remains elusive because of its proposed multifactorial nature. Accumulating evidence suggests that brain-derived neurotrophic factor （BDNF） plays a k...Background： The pathophysiology of poststroke depression （PSD） remains elusive because of its proposed multifactorial nature. Accumulating evidence suggests that brain-derived neurotrophic factor （BDNF） plays a key role in the pathophysiology of depression and PSD. And the cerebellar dysfunction may be important in the etiology of depression; it is not clear whether it also has a major effect on the risk of PSD. This study aimed to explore the expression of BDNF and high-affinity receptors tyrosine kinase B （TrkB） in the cerebellum of rats with PSD. Methods： The rat models with focal cerebral ischemic were made using a thread embolization method. PSD rat models were established with comprehensive separate breeding and unpredicted chronic mild stress （UCMS） on this basis. A normal control group, depression group, and a stroke group were used to compare with the PSD group. Thirteen rats were used in each group. Immunohistochemistry and reverse transcription-polymerase chain reaction （RT-PCR） for detecting the expression of BDNF and TrkB protein and mRNA in the cerebellum were used at the 29th day following the UCMS. Results： Compared with the normal control group and the stroke group, the number of BDNF immunoreactive （IR） positive neurons was less in the PSD group （P 〈 0.05）. Furthermore, the number ofTrkB 1R positive cells was significantly less in the PSD group than that in the normal control group （P 〈 0.05）. The gene expression of BDNF and TrkB in the cerebellum of PSD rats also decreased compared to the normal control group （P 〈 0.05）. Conclusions： These findings suggested a possible association between expression of BDNF and TrkB in the cerebellum and the pathogeuesis of PSD.展开更多
Acupuncture and rehabilitation therapies were used to treat 40 cases of shoulder-hand syndrome, the results show that integration of acupuncture and rehabilitation can increase therapeutic effects and shorten treatmen...Acupuncture and rehabilitation therapies were used to treat 40 cases of shoulder-hand syndrome, the results show that integration of acupuncture and rehabilitation can increase therapeutic effects and shorten treatment courses to accelerate recovery.展开更多
Objective： To observe the clinical efficacy of puncturing Renying （ST 9） in the treatment of poststroke dysphagia. Methods： Sixty cases of poststroke dysphagia were randomized into two groups, a control group in w...Objective： To observe the clinical efficacy of puncturing Renying （ST 9） in the treatment of poststroke dysphagia. Methods： Sixty cases of poststroke dysphagia were randomized into two groups, a control group in which 30 cases were given rehabilitation training, and a treatment group in which 30 cases were treated by puncturing Renying （ST 9） and rehabilitation training, with a course of four weeks. Results： The total effective rate for dysphagia was higher in the treatment group than in the control group （P〈0.05）. Conclusion： Puncturing Renying （ST 9） is quite effective for poststroke dysphagia.展开更多
Objective:This study aimed to systematically evaluate the clinical efficiency and safety of moxibustion for the treatment of poststroke insomnia(PSI).Methods:We searched PubMed,the Cochrane Library,Embase,China Nation...Objective:This study aimed to systematically evaluate the clinical efficiency and safety of moxibustion for the treatment of poststroke insomnia(PSI).Methods:We searched PubMed,the Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and clinical rial for trandomized controlled trials on moxibustion as a treatment for PSI,including results from the creation of all databases until December 12,2020.The functional languages used were Chinese and English.Two reviewers independently performed the literature search,data extraction,and quality evaluation.The primary and secondary outcome measures were the effective rate and adverse events,respectively.The meta-analysis was carried out using RevMan5.4 software and Stata15.Results:Of the 11 trials,996 patients in China's Mainland were included.Compared to the control group,the combination of single moxibustion therapy or moxibustion combined with acupuncture in the treatment of DN could reduce the sleep quality score(SQS)(mean difference[MD]=-0.50,95%confidence interval[CI][-0.89,-0.11],Z=2.51,P=0.01),time to falling asleep score(MD=-0.39,95%CI[-0.49,-0.29],Z=7.79,P<0.00001),sleep time score(MD=-0.34,95%CI[-0.59,-0.09],Z=2.64,P=0.008),sleep efficiency score(MD=-0.30,95%CI[-0.52,-0.08],Z=2.69,P=0.007),sleep disorder score(MD=-0.29,95%CI[-0.49,-0.09],Z=2.85,P=0.004),daily function disturbance score(MD=-0.54,95%CI[-0.82,-0.26],Z=3.78,P=0.0002),Pittsburgh Sleep Quality Index aggregate score(MD=-2.30,95%CI[-2.97,-1.63],Z=6.71,P<0.00001),SPIEGEL aggregate score(MD=-7.62,95%CI[-8.12,-7.12],Z=29.75,P<0.00001),and stroke-specific quality of life aggregate score(MD=12.68,95%CI[0.92,24.44],Z=2.11,P=0.03).Conclusion:This study indicates that moxibustion contributes to the treatment of PSI.Nevertheless,more extensive trials are required to validate the results due to the small sample sizes,few reports on adverse effects,and high risk of bias in the included studies.展开更多
The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small do...The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac.展开更多
A number of studies have assessed the influence of depression on the risk of cardiovascular disease. A growing literature indicates a link between depression and cerebrovascular events, although the direction of this ...A number of studies have assessed the influence of depression on the risk of cardiovascular disease. A growing literature indicates a link between depression and cerebrovascular events, although the direction of this association remains unclear. Numerous data have emerged suggesting an association between depressive symptoms and subsequent risk of stroke, thus leading to the hypothesis that a direct causality between depression and stroke exists. Notwithstanding, how depression may act as a risk factor for stroke is still unclear. Depression might be linked to stroke via neuroendocrine and inflammation effects, through correlation with major comorbidities such as hypertensionand diabetes or by intervention of lifestyle behavioral mediators. Finally, antidepressant medications have recently drawn attention for a possible association with increased risk of stroke, although such findings remain uncertain. Depression has been also established as an important consequence after stroke, exerting a significant adverse impact on the course of motor recovery, social functioning and, overall, on quality of life. Post stroke depression occurs in nearly one third of stroke cases, but the exact mechanism leading to depression after stroke is still incompletely understood. In this article, we will review contemporary epidemiologic studies, discuss potential mechanisms and specific aspects of the complex relation between depression and stroke.展开更多
The differences between the“Tong Guan Li Qiao”acupuncture therapy and the conventional and current other acupuncture methods for poststroke dysphagia are as follows:first,it adheres to the basic idea of "Xing N...The differences between the“Tong Guan Li Qiao”acupuncture therapy and the conventional and current other acupuncture methods for poststroke dysphagia are as follows:first,it adheres to the basic idea of "Xing Nao Kai Qiao"acupuncture therapy in selecting and combining acupoints,centers on the brain,and combines the dysphagia symptoms of the mouth,tongue,and throat-related orifices with the root cause of"brain";second,thereare strictand standard requirements intheacupuncture operation,that is,manipulation quantification.In addition to standardized twirling,lifting,and thrusting,the techniques of deep needling on the acupoints in the neck region,blood-letting puncturing at the posterior wallof the pharynx,and theneedling sensation of"like a fishbone getting stuck in the throat"are all unique.展开更多
Objective:To observe the clinical efficacy of body acupuncture combined with FANG’s scalp acupuncture in treating limb dysfunction in the remission stage of stroke and explore the mechanism.Methods:Sixty patients in ...Objective:To observe the clinical efficacy of body acupuncture combined with FANG’s scalp acupuncture in treating limb dysfunction in the remission stage of stroke and explore the mechanism.Methods:Sixty patients in the remission stage of stroke with limb dysfunction were divided into a control group and a treatment group using the random number table method,with 30 cases in each group.The control group was treated with ordinary acupuncture based on the conventional rehabilitation treatment,and the treatment group was additionally offered FANG’s scalp acupuncture.The interventions were conducted once daily with 10 sessions as 1 course.The Fugl-Meyer assessment(FMA)and Barthel index(BI)scores and serum malondialdehyde(MDA)and superoxide dismutase(SOD)levels were compared after 2 treatment courses,and the clinical efficacy was evaluated.Results:After treatment,the FMA and BI scores increased in both groups(P<0.05)and were higher in the treatment group than in the control group(P<0.05).Both groups showed a decreased MDA level and an increased SOD level after the intervention,all showing statistical significance(P<0.05);there were significant differences between the two groups(P<0.05).Conclusion:Based on the conventional rehabilitation treatment,ordinary acupuncture used alone or in combination with FANG’s scalp acupuncture can lower the oxidative stress level and improve limb function in treating limb dysfunction in the remission stage of stroke;body acupuncture plus FANG’s scalp acupuncture can produce better results.展开更多
Stroke is the leading cause of neurological diseases globally.Remarkably,epilepsy is a common complication of stroke,which greatly impairs the quality of life of patients and poses a significant clinical challenge.The...Stroke is the leading cause of neurological diseases globally.Remarkably,epilepsy is a common complication of stroke,which greatly impairs the quality of life of patients and poses a significant clinical challenge.Therefore,a better understanding of the risk factors for poststroke epilepsy is crucial.A recent study published in JAMA Neurology studied the brain network associated with poststroke epilepsy in a group of 76 patients compared to a cohort of 625 control patients using lesion mapping techniques.The results showed that negative functional connectivity between lesion locations and regions in the basal ganglia and cerebellum confers a higher risk of developing epilepsy after stroke.The lesion network nodes associated with epilepsy were identical across different lesion types including hematomas,traumas,tumors,and tubers.Furthermore,the poststroke epilepsy brain network has potential therapeutic relevance to deep brain stimulation(DBS).In a cohort of 30 patients,the functional connectivity between anterior thalamic DBS sites and the lesion network nodes was found to correlate with seizure control after DBS.In summary,the finding provides a novel method for predicting the risk of poststroke epilepsy in patients and may guide brain stimulation treatments for epilepsy.展开更多
Objective： To observe the effect of warm joint needling plus rehabilitation techniques on the balance function and quality of life （QOL） of patients with spastic hemiplegia after ischemic cerebral stroke. Methods：...Objective： To observe the effect of warm joint needling plus rehabilitation techniques on the balance function and quality of life （QOL） of patients with spastic hemiplegia after ischemic cerebral stroke. Methods： Ninety patients with spastic hemiplegia after ischemic cerebral stroke were randomized into a rehabilitation group, a warm joint needling group and an observation group, with 30 cases in each group. The rehabilitation group was intervened by Bobath therapy, the warm joint needling group was treated with joint needling on the affected side plus warm needling, and the observation group was given the same rehabilitation treatment as the rehabilitation group together with the same warm joint needling as the warm joint needling group. The three groups were treated once another day, 1 month as a treatment course for 6 months. Before the treatment, and respectively after 2-week, 1-month, 3-month, and 6-month treatment, the modified Ashworth scale （MAS） was used to measure the anti-spasm ability of the lower limb, the Berg balance scale （BBS） was adopted to evaluate the balance function, and the stroke-specific quality of life scale （SS-QOL） was employed to estimate the QOL. Results： After 3-month and 6-month treatment, the lower-limb MAS scores in the observation group were significantly better than those in the rehabilitation group and the warm joint needling group （all P〈0.05）. After 1-month, B-month and 6-month treatment, the BBS scores in the observation group were significantly better than those in the rehabilitation group and the warm joint needling group （all P〈0.05）. After 2-week, 1-month, 3-month and 6-month treatment, the SS-QOL scores in the observation group were markedly better than those in the rehabilitation group and the warm joint needling group （all P〈0.05）. Conclusion： Warm joint needling plus rehabilitation can effectively improve the lower-limb spasticity state, balance function and QOL in patients with spastic hemiplegia after ischemic cerebral stroke.展开更多
OBJECTIVE:Acupuncture has often been used for aphasia rehabilitation in China.The purpose of this paper was to:1) provide a historic overview of acupuncture for aphasia due to stroke;2) summarize the commonly used acu...OBJECTIVE:Acupuncture has often been used for aphasia rehabilitation in China.The purpose of this paper was to:1) provide a historic overview of acupuncture for aphasia due to stroke;2) summarize the commonly used acupuncture approaches;and 3) objectively comment on the effectiveness of acupuncture for the rehabilitation of this type of disorder.METHODS:The Elsevier database and a Chinese database(CNKI) were searched through December,2010 with the key words "aphasia,acupuncture" in English and Chinese,respectively.Case reports,uncontrolled clinical observations and controlled clinical trials were all included if acupuncture was the sole treatment or the main component of complex intervention for the rehabilitation of aphasia caused by cerebrovascular disease.RESULTS:More than 100 relevant articles were found.After analyzing these articles,we found that acupuncture for apoplectic aphasia most often included tongue,scalp,body and combination acupuncture.Tongue bleeding,deep insertion and strong stimulation were adopted by many practitioners.The ten most frequently used acupoints(or areas) were Lianquan(RN 23),Jinjin(EX-HN 12),Yuye(EX-HN 13),Tongli(HT 5),Fengchi(GB 20),Neiguan(PC 6),Baihui(DU 20),No.1,2 and 3 language sections,Sanyinjiao(SP 6) and Yamen(DU 15).CONCLUSIONS:Controlled clinical studies and a systematic literature review demonstrate that acupuncture has therapeutic effects on aphasia after stroke.展开更多
Objective： To observe the effect of applying tuina to exterior-interiorly connected meridians for post-stroke upper limb spasticity. Methods： A total of 150 patients with post-stroke upper limb spasticity were rando...Objective： To observe the effect of applying tuina to exterior-interiorly connected meridians for post-stroke upper limb spasticity. Methods： A total of 150 patients with post-stroke upper limb spasticity were randomly allocated into a treatment group （n=75） and a control group （n=75） by the random number table. Patients in the treatment group received tuina on exterior-interiorly connected meridians, whereas patients in the control group received standard rehabilitation therapy. The therapeutic efficacies in both groups were observed after 3 weeks of treatment. Results： The total effective rate in the treatment group was 89.3%, versus 61.3% in the control group, showing a statistically significant difference （P〈0.05）. After the treatment, the muscle tones by the modified Ashworth scale （MAS） were significantly improved in both groups （both P〈0.05）; and the improvement of muscle tone was more significant in the treatment group than that in the control group （P〈0.05）. Conclusion： Applying tuina to exterior-interiorly connected meridians can obtain an exact efficacy for post-stroke upper limb spasticity.展开更多
Objective： To observe the clinical efficacy of acupuncture plus motor therapy for postapoplectic spastic hemiplegia and provide reference for rehabilitation care of patients with spastic hemiplegia after stroke. Meth...Objective： To observe the clinical efficacy of acupuncture plus motor therapy for postapoplectic spastic hemiplegia and provide reference for rehabilitation care of patients with spastic hemiplegia after stroke. Methods： A total of 87 cases with postapoplectic spastic hemiplegia were randomly allocated into a treatment group and a control group. Patients in both groups received basic treatments to control blood pressure, blood sugar, blood fat and improve circulation. The 43 cases in the treatment group received acupuncture combined with motor therapy, whereas the 44 cases in the control group received motor therapy alone（same as the treatment group）. The treatment was conducted once a day, for a total of 3 sessions. One session consisted of 10 times and there was a 1-day interval between two sessions. Then the changes in modified Ashworth scale（MAS） score and Fugl-Meyer assessment scale（FMA） score and clinical efficacy were observed. Results： After treatment, the MAS scores were significantly decreased in both groups, showing intra-group statistical differences（P〈0.01）. The MAS score in the treatment group was significantly lower than that in the control group, showing a between-group statistical difference（P〈0.01）. The total effective rate was 69.8% in the treatment group, versus 45.5% in the control group, showing a between-group statistical difference（P〈0.05）. After treatment, the FMA scores were significantly increased in both groups, showing intra-group statistical differences（P〈0.01）; and the FMA score in the treatment group was significantly higher than that in the control group, showing a between-group statistical difference（P〈0.05）. Conclusion： Acupuncture combined with motor therapy is better than motor therapy alone in alleviating postapoplectic limb spasticity, improving the limb motor function and increasing the activities of daily living（ADL）.展开更多
Objective：To observe the therapeutic efficacy of acupuncture plus Tai Ji Quan （Tai Chi） in recovering the neurological function and treating depression state in post-stroke depression patients,together with a 12-mo...Objective：To observe the therapeutic efficacy of acupuncture plus Tai Ji Quan （Tai Chi） in recovering the neurological function and treating depression state in post-stroke depression patients,together with a 12-month follow-up.Methods：A total of 105 eligible post-stroke depression patients were randomized into an acupuncture plus Tai Ji group （53 cases） and a control group （52 cases） based on their visiting sequence.The patients all received routine treatment and rehabilitation training for stroke.In addition,the control group was given oral administration of citalopram hydrobromide tablets,1 month as a course of treatment,for 3 courses in total.Meanwhile,the acupuncture plus Tai Ji group received acupuncture and practiced Tai Ji Quan,for 1 month and 12 months respectively.Before the intervention,after 1-month intervention and 12 months later,the National Institute of Health stroke scale （NIHSS）,Barthel index （BI） and Hamilton depression rating scale （HAMD） were adopted for efficacy evaluation.Results：Prior to the intervention,there were no significant differences in HAMD,NIHSS and BI scores between the two groups （all P〉0.05）;after 1-month intervention,there were significant between-group differences in NIHSS,BI and HAMD scores （P〈0.05 or P〈0.01）;the 12-month follow-up revealed significant between-group differences in NIHSS,BI and HAMD scores （all P〈0.01）.In the treatment of stroke,the total effective rate was 84.4% in the acupuncture plus Tai Ji group,significantly higher than 68.9% in the control group （P〈0.05）;in the treatment of depression,the total effective rate was 86.7% in the acupuncture plus Tai Ji group,significantly higher than 77.8% in the control group （P〈0.05）.Conclusion：Acupuncture plus Tai Ji Quan can produce a significant efficacy in improving the limb motor function and depression in post-stroke depression patients.展开更多
Objective: To observe the clinical efficacy of traditional tuina plus modern rehabilitation in the treatment of lower limb extensor spasticity during stroke recovery. Methods: A total of 93 stroke patients who met the...Objective: To observe the clinical efficacy of traditional tuina plus modern rehabilitation in the treatment of lower limb extensor spasticity during stroke recovery. Methods: A total of 93 stroke patients who met the inclusion criteria were randomly divided into an observation group and a control group. Forty-four patients in the observation group were treated with traditional tuina plus modern rehabilitation, and 49 patients in the control group were treated with modern rehabilitation. The modified Ashworth scale (MAS), the Fugl-Meyer assessment scale (FMA) and the modified Barthel index (MBI) were used to evaluate the knee extensors state, lower limb motor function and activities of daily living (ADL) of the two groups. Results: After treatment, the overall efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the MAS scores of both groups were significantly lower, FMA and MBI scores were significantly higher, and the differences were statistically significant in each group (P<0.01). After treatment, the MAS score of the observation group was lower than that of the control group, and the differenee between the groups was statistically significant (P<0.01). The MBI score of the observation group was higher than that of the control group, and the differenee between the two groups was statistically significant (P<0.05). There were significant differences in the post-treatment changes in MAS, FMA and MBI scores between the two groups (all P<0.05). Conclusion: Traditional tuina plus modern rehabilitation therapy can effectively alleviate or prevent lower limb extensor spasticity after stroke, and improve limb mobility and ADL. Hence, it is worthy of clinical promotion.展开更多
基金supported by the Scientific Research Project of China Rehabilitation Research Center,No.2021zx-23the National Natural Science Foundation of China,No.32100925the Beijing Nova Program,No.Z211100002121038。
文摘Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this condition.The aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive impairment.We found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic stroke.In addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic stroke.Serum phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic stroke.Furthermore,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein levels.Although ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein levels.Taken together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.
文摘Background: The mechanisms by which acupuncture affects poststroke cognitive impairment (PSCI) remain unclear. Objective: To investigate brain functional network (BFN) changes in patients with PSCI after acupuncture therapy. Methods: Twenty-two PSCI patients who underwent acupuncture therapy in our hospital were enrolled as research subjects. Another 14 people matched for age, sex, and education level were included in the normal control (HC) group. All the subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans;the PSCI patients underwent one scan before acupuncture therapy and another after. The network metric difference between PSCI patients and HCs was analyzed via the independent-sample t test, whereas the paired-sample t test was employed to analyze the network metric changes in PSCI patients before vs. after treatment. Results: Small-world network attributes were observed in both groups for sparsities between 0.1 and 0.28. Compared with the HC group, the PSCI group presented significantly lower values for the global topological properties (γ, Cp, and Eloc) of the brain;significantly greater values for the nodal attributes of betweenness centrality in the CUN. L and the HES. R, degree centrality in the SFGdor. L, PCG. L, IPL. L, and HES. R, and nodal local efficiency in the ORBsup. R, ORBsupmed. R, DCG. L, SMG. R, and TPOsup. L;and decreased degree centrality in the MFG. R, IFGoperc. R, and SOG. R. After treatment, PSCI patients presented increased degree centrality in the LING.L, LING.R, and IOG. L and nodal local efficiency in PHG. L, IOG. R, FFG. L, and the HES. L, and decreased betweenness centrality in the PCG. L and CUN. L, degree centrality in the ORBsupmed. R, and nodal local efficiency in ANG. R. Conclusion: Cognitive decline in PSCI patients may be related to BFN disorders;acupuncture therapy may modulate the topological properties of the BFNs of PSCI patients.
基金supported by the Guangdong Provincial"211 Engineering"Stage-III Key Disciplines Construction Project in China,No.Yue 2009431
文摘OBJECTIVE： To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL： We retrieved data from the Chinese National Knowledge Infrastructure （1979-2012）, Wanfang （1980-2012）, VIP （1989-2012）, Chinese Biomedical Literature （1975- 2012）, PubMed （1966-2012）, Ovid Lww （-2012）, and Cochrane Library （-2012） Database using the internet. SELECTION CRITERIA： Randomized controlled trials on filiform needle acupuncture versus antidepressant drugs for treatment of poststroke depression were included. Moreover, the in- cluded articles scored at least 4 points on the Jadad scale. Exclusion criteria： other acupuncture therapies as treatment group, not stroke-induced depression patients, score 〈 4 points, non-ran- domized controlled trials, or animal trials. MAIN OUTCOME MEASURES： These were the Hamilton Depression Scale scores, clinical ef- fective rate, Self-Rating Depression Scale scores, Side Effect Rating Scale scores, and incidence of adverse reaction and events. RESULTS： A total of 17 randomized controlled clinical trials were included. Meta-analysis results displayed that after 4 weeks of treatment, clinical effective rate was better in patients treated with fill- form needle acupuncture than those treated with simple antidepressant drugs [relative risk = 1.11, 95% confidence interval （C/）： 1.03-1.21, P = 0.01]. At 6 weeks, clinical effective rate was similar between filiform needle acupuncture and antidepressant drug groups. At 2 weeks after filiform needle acupuncture, Hamilton Depression Scale （17 items） scores were lower than in the antide- pressant drug group （mean difference = -2.34, 95%CI： -3.46 to -1.22, P 〈 0.000,1）. At 4 weeks, Hamilton Depression Scale （24 items） scores were similar between filiform needle acupuncture and antidepressant drug groups. Self-Rating Depression Scale scores were lower in filiform needle acupuncture group than in the antidepressant drug group. Side Effect Rating Scale was used in only two articles, and no meta-analysis was conducted. Safety evaluation of the 17 arti- cles showed that gastrointestinal tract reactions such as nausea and vomiting were very common in the antidepressant drug group. Incidence of adverse reaction and events was very low in the filiform needle acupuncture group. CONCLUSION： Early filiform needle acupuncture for poststroke depression can perfectly con- trol depression. Filiform needle acupuncture is safe and reliable. Therapeutic effects of filiform needle acupuncture were better than those of antidepressant drugs.
文摘To the editor, I read with interest the recent report on ＂filiform needle acupuncture for poststroke depression＂ （Zhang et al., 2014）. Zhang et al. （2014） performed a meta-analysis and conclud- ed that ＂early filiform needle acupuncture for poststroke depression can perfectly control depression：＇ In fact, the in- cluded meta-analysis might support the clinical effectiveness of filariform needle acupuncture for poststroke depression. However, there are several concerns. First, the hospital infection due to acupuncture manipulation with filiform is a big topic to be addressed. As Gang et al. （2012） noted, ＂aseptic technic principles aren＇t strictly followed; disinfection and isolation systems are unsound;
基金Shandong Provincial Natural Science Foundation Project(Grant No.81471371).
文摘Objective: To explore the effect of zopiclone combined with Deanxit on cytokines and neurotransmitters in patients with poststroke depression. Methods: A total of 78 patients with poststroke depression who were treated in Zaozhuang Mining Group Dongjiao Hospital between January 2015 and February 2017 were divided into control group (n=41, receiving conventional Deanxit therapy) and zopiclone group (n=37, receiving zopiclone combined with Deanxit therapy). The differences in serum nerve injury marker, inflammatory cytokine and monoamine neurotransmitter levels were compared between the two groups before treatment and after 12 weeks of treatment. Results: Before treatment, serum levels of nerve injury markers, inflammatory cytokines and monoamine neurotransmitters were not significantly different between the two groups. After 12 weeks of treatment, serum nerve injury markers NSE and S100B levels of zopiclone group were lower than those of control group whereas BDNF level was higher than that of control group;serum inflammatory cytokines IL-1, IL-2, IL-23 and TNF-α levels of zopiclone group were lower than those of control group;serum monoamine neurotransmitters NE, 5-HT and DA levels of zopiclone group were higher than those of control group. Conclusion: Zopiclone combined with Deanxit therapy can effectively optimize the neurological function, reduce the inflammatory response and increase the secretion of monoamine neurotransmitters in patients with poststroke depression.
基金Acknowledgments We would like to thank Dr. Tricia for her invaluable comments in the writing of this manuscript. I This research- was supported by a grant from the Yunnan Natural Science Foundation （No. 2009ZC126M）.
文摘Background： The pathophysiology of poststroke depression （PSD） remains elusive because of its proposed multifactorial nature. Accumulating evidence suggests that brain-derived neurotrophic factor （BDNF） plays a key role in the pathophysiology of depression and PSD. And the cerebellar dysfunction may be important in the etiology of depression; it is not clear whether it also has a major effect on the risk of PSD. This study aimed to explore the expression of BDNF and high-affinity receptors tyrosine kinase B （TrkB） in the cerebellum of rats with PSD. Methods： The rat models with focal cerebral ischemic were made using a thread embolization method. PSD rat models were established with comprehensive separate breeding and unpredicted chronic mild stress （UCMS） on this basis. A normal control group, depression group, and a stroke group were used to compare with the PSD group. Thirteen rats were used in each group. Immunohistochemistry and reverse transcription-polymerase chain reaction （RT-PCR） for detecting the expression of BDNF and TrkB protein and mRNA in the cerebellum were used at the 29th day following the UCMS. Results： Compared with the normal control group and the stroke group, the number of BDNF immunoreactive （IR） positive neurons was less in the PSD group （P 〈 0.05）. Furthermore, the number ofTrkB 1R positive cells was significantly less in the PSD group than that in the normal control group （P 〈 0.05）. The gene expression of BDNF and TrkB in the cerebellum of PSD rats also decreased compared to the normal control group （P 〈 0.05）. Conclusions： These findings suggested a possible association between expression of BDNF and TrkB in the cerebellum and the pathogeuesis of PSD.
文摘Acupuncture and rehabilitation therapies were used to treat 40 cases of shoulder-hand syndrome, the results show that integration of acupuncture and rehabilitation can increase therapeutic effects and shorten treatment courses to accelerate recovery.
文摘Objective： To observe the clinical efficacy of puncturing Renying （ST 9） in the treatment of poststroke dysphagia. Methods： Sixty cases of poststroke dysphagia were randomized into two groups, a control group in which 30 cases were given rehabilitation training, and a treatment group in which 30 cases were treated by puncturing Renying （ST 9） and rehabilitation training, with a course of four weeks. Results： The total effective rate for dysphagia was higher in the treatment group than in the control group （P〈0.05）. Conclusion： Puncturing Renying （ST 9） is quite effective for poststroke dysphagia.
基金supported by the Special Research Project of the Traditional Chinese Medicine Industry(201107006)the School-level Scientific Research Project of Tianjin University of Traditional Chinese Medicine(XJ201801)。
文摘Objective:This study aimed to systematically evaluate the clinical efficiency and safety of moxibustion for the treatment of poststroke insomnia(PSI).Methods:We searched PubMed,the Cochrane Library,Embase,China National Knowledge Infrastructure(CNKI),Wanfang Data Knowledge Service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and clinical rial for trandomized controlled trials on moxibustion as a treatment for PSI,including results from the creation of all databases until December 12,2020.The functional languages used were Chinese and English.Two reviewers independently performed the literature search,data extraction,and quality evaluation.The primary and secondary outcome measures were the effective rate and adverse events,respectively.The meta-analysis was carried out using RevMan5.4 software and Stata15.Results:Of the 11 trials,996 patients in China's Mainland were included.Compared to the control group,the combination of single moxibustion therapy or moxibustion combined with acupuncture in the treatment of DN could reduce the sleep quality score(SQS)(mean difference[MD]=-0.50,95%confidence interval[CI][-0.89,-0.11],Z=2.51,P=0.01),time to falling asleep score(MD=-0.39,95%CI[-0.49,-0.29],Z=7.79,P<0.00001),sleep time score(MD=-0.34,95%CI[-0.59,-0.09],Z=2.64,P=0.008),sleep efficiency score(MD=-0.30,95%CI[-0.52,-0.08],Z=2.69,P=0.007),sleep disorder score(MD=-0.29,95%CI[-0.49,-0.09],Z=2.85,P=0.004),daily function disturbance score(MD=-0.54,95%CI[-0.82,-0.26],Z=3.78,P=0.0002),Pittsburgh Sleep Quality Index aggregate score(MD=-2.30,95%CI[-2.97,-1.63],Z=6.71,P<0.00001),SPIEGEL aggregate score(MD=-7.62,95%CI[-8.12,-7.12],Z=29.75,P<0.00001),and stroke-specific quality of life aggregate score(MD=12.68,95%CI[0.92,24.44],Z=2.11,P=0.03).Conclusion:This study indicates that moxibustion contributes to the treatment of PSI.Nevertheless,more extensive trials are required to validate the results due to the small sample sizes,few reports on adverse effects,and high risk of bias in the included studies.
基金supported by the Major Program of "13115" Science and Technology Innovation Project (Preclinical study of Xingnao Jieyu capsule), No. 2010ZDKG-65
文摘The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac.
文摘A number of studies have assessed the influence of depression on the risk of cardiovascular disease. A growing literature indicates a link between depression and cerebrovascular events, although the direction of this association remains unclear. Numerous data have emerged suggesting an association between depressive symptoms and subsequent risk of stroke, thus leading to the hypothesis that a direct causality between depression and stroke exists. Notwithstanding, how depression may act as a risk factor for stroke is still unclear. Depression might be linked to stroke via neuroendocrine and inflammation effects, through correlation with major comorbidities such as hypertensionand diabetes or by intervention of lifestyle behavioral mediators. Finally, antidepressant medications have recently drawn attention for a possible association with increased risk of stroke, although such findings remain uncertain. Depression has been also established as an important consequence after stroke, exerting a significant adverse impact on the course of motor recovery, social functioning and, overall, on quality of life. Post stroke depression occurs in nearly one third of stroke cases, but the exact mechanism leading to depression after stroke is still incompletely understood. In this article, we will review contemporary epidemiologic studies, discuss potential mechanisms and specific aspects of the complex relation between depression and stroke.
基金Registry on Acupuncture and Moxibustion Therapy in Stroke Patients(2019YFC0840709).
文摘The differences between the“Tong Guan Li Qiao”acupuncture therapy and the conventional and current other acupuncture methods for poststroke dysphagia are as follows:first,it adheres to the basic idea of "Xing Nao Kai Qiao"acupuncture therapy in selecting and combining acupoints,centers on the brain,and combines the dysphagia symptoms of the mouth,tongue,and throat-related orifices with the root cause of"brain";second,thereare strictand standard requirements intheacupuncture operation,that is,manipulation quantification.In addition to standardized twirling,lifting,and thrusting,the techniques of deep needling on the acupoints in the neck region,blood-letting puncturing at the posterior wallof the pharynx,and theneedling sensation of"like a fishbone getting stuck in the throat"are all unique.
文摘Objective:To observe the clinical efficacy of body acupuncture combined with FANG’s scalp acupuncture in treating limb dysfunction in the remission stage of stroke and explore the mechanism.Methods:Sixty patients in the remission stage of stroke with limb dysfunction were divided into a control group and a treatment group using the random number table method,with 30 cases in each group.The control group was treated with ordinary acupuncture based on the conventional rehabilitation treatment,and the treatment group was additionally offered FANG’s scalp acupuncture.The interventions were conducted once daily with 10 sessions as 1 course.The Fugl-Meyer assessment(FMA)and Barthel index(BI)scores and serum malondialdehyde(MDA)and superoxide dismutase(SOD)levels were compared after 2 treatment courses,and the clinical efficacy was evaluated.Results:After treatment,the FMA and BI scores increased in both groups(P<0.05)and were higher in the treatment group than in the control group(P<0.05).Both groups showed a decreased MDA level and an increased SOD level after the intervention,all showing statistical significance(P<0.05);there were significant differences between the two groups(P<0.05).Conclusion:Based on the conventional rehabilitation treatment,ordinary acupuncture used alone or in combination with FANG’s scalp acupuncture can lower the oxidative stress level and improve limb function in treating limb dysfunction in the remission stage of stroke;body acupuncture plus FANG’s scalp acupuncture can produce better results.
基金supported by the National Key R&D Program of China(2022YFC2503800)the National Natural Science Foundation of China(82071454)Beijing Municipal Science&Technology Commission(Z211100002921032).
文摘Stroke is the leading cause of neurological diseases globally.Remarkably,epilepsy is a common complication of stroke,which greatly impairs the quality of life of patients and poses a significant clinical challenge.Therefore,a better understanding of the risk factors for poststroke epilepsy is crucial.A recent study published in JAMA Neurology studied the brain network associated with poststroke epilepsy in a group of 76 patients compared to a cohort of 625 control patients using lesion mapping techniques.The results showed that negative functional connectivity between lesion locations and regions in the basal ganglia and cerebellum confers a higher risk of developing epilepsy after stroke.The lesion network nodes associated with epilepsy were identical across different lesion types including hematomas,traumas,tumors,and tubers.Furthermore,the poststroke epilepsy brain network has potential therapeutic relevance to deep brain stimulation(DBS).In a cohort of 30 patients,the functional connectivity between anterior thalamic DBS sites and the lesion network nodes was found to correlate with seizure control after DBS.In summary,the finding provides a novel method for predicting the risk of poststroke epilepsy in patients and may guide brain stimulation treatments for epilepsy.
文摘Objective： To observe the effect of warm joint needling plus rehabilitation techniques on the balance function and quality of life （QOL） of patients with spastic hemiplegia after ischemic cerebral stroke. Methods： Ninety patients with spastic hemiplegia after ischemic cerebral stroke were randomized into a rehabilitation group, a warm joint needling group and an observation group, with 30 cases in each group. The rehabilitation group was intervened by Bobath therapy, the warm joint needling group was treated with joint needling on the affected side plus warm needling, and the observation group was given the same rehabilitation treatment as the rehabilitation group together with the same warm joint needling as the warm joint needling group. The three groups were treated once another day, 1 month as a treatment course for 6 months. Before the treatment, and respectively after 2-week, 1-month, 3-month, and 6-month treatment, the modified Ashworth scale （MAS） was used to measure the anti-spasm ability of the lower limb, the Berg balance scale （BBS） was adopted to evaluate the balance function, and the stroke-specific quality of life scale （SS-QOL） was employed to estimate the QOL. Results： After 3-month and 6-month treatment, the lower-limb MAS scores in the observation group were significantly better than those in the rehabilitation group and the warm joint needling group （all P〈0.05）. After 1-month, B-month and 6-month treatment, the BBS scores in the observation group were significantly better than those in the rehabilitation group and the warm joint needling group （all P〈0.05）. After 2-week, 1-month, 3-month and 6-month treatment, the SS-QOL scores in the observation group were markedly better than those in the rehabilitation group and the warm joint needling group （all P〈0.05）. Conclusion： Warm joint needling plus rehabilitation can effectively improve the lower-limb spasticity state, balance function and QOL in patients with spastic hemiplegia after ischemic cerebral stroke.
文摘OBJECTIVE:Acupuncture has often been used for aphasia rehabilitation in China.The purpose of this paper was to:1) provide a historic overview of acupuncture for aphasia due to stroke;2) summarize the commonly used acupuncture approaches;and 3) objectively comment on the effectiveness of acupuncture for the rehabilitation of this type of disorder.METHODS:The Elsevier database and a Chinese database(CNKI) were searched through December,2010 with the key words "aphasia,acupuncture" in English and Chinese,respectively.Case reports,uncontrolled clinical observations and controlled clinical trials were all included if acupuncture was the sole treatment or the main component of complex intervention for the rehabilitation of aphasia caused by cerebrovascular disease.RESULTS:More than 100 relevant articles were found.After analyzing these articles,we found that acupuncture for apoplectic aphasia most often included tongue,scalp,body and combination acupuncture.Tongue bleeding,deep insertion and strong stimulation were adopted by many practitioners.The ten most frequently used acupoints(or areas) were Lianquan(RN 23),Jinjin(EX-HN 12),Yuye(EX-HN 13),Tongli(HT 5),Fengchi(GB 20),Neiguan(PC 6),Baihui(DU 20),No.1,2 and 3 language sections,Sanyinjiao(SP 6) and Yamen(DU 15).CONCLUSIONS:Controlled clinical studies and a systematic literature review demonstrate that acupuncture has therapeutic effects on aphasia after stroke.
基金supported by Science-technology Support Plan Project of Hebei Province,No.11276168~~
文摘Objective： To observe the effect of applying tuina to exterior-interiorly connected meridians for post-stroke upper limb spasticity. Methods： A total of 150 patients with post-stroke upper limb spasticity were randomly allocated into a treatment group （n=75） and a control group （n=75） by the random number table. Patients in the treatment group received tuina on exterior-interiorly connected meridians, whereas patients in the control group received standard rehabilitation therapy. The therapeutic efficacies in both groups were observed after 3 weeks of treatment. Results： The total effective rate in the treatment group was 89.3%, versus 61.3% in the control group, showing a statistically significant difference （P〈0.05）. After the treatment, the muscle tones by the modified Ashworth scale （MAS） were significantly improved in both groups （both P〈0.05）; and the improvement of muscle tone was more significant in the treatment group than that in the control group （P〈0.05）. Conclusion： Applying tuina to exterior-interiorly connected meridians can obtain an exact efficacy for post-stroke upper limb spasticity.
文摘Objective： To observe the clinical efficacy of acupuncture plus motor therapy for postapoplectic spastic hemiplegia and provide reference for rehabilitation care of patients with spastic hemiplegia after stroke. Methods： A total of 87 cases with postapoplectic spastic hemiplegia were randomly allocated into a treatment group and a control group. Patients in both groups received basic treatments to control blood pressure, blood sugar, blood fat and improve circulation. The 43 cases in the treatment group received acupuncture combined with motor therapy, whereas the 44 cases in the control group received motor therapy alone（same as the treatment group）. The treatment was conducted once a day, for a total of 3 sessions. One session consisted of 10 times and there was a 1-day interval between two sessions. Then the changes in modified Ashworth scale（MAS） score and Fugl-Meyer assessment scale（FMA） score and clinical efficacy were observed. Results： After treatment, the MAS scores were significantly decreased in both groups, showing intra-group statistical differences（P〈0.01）. The MAS score in the treatment group was significantly lower than that in the control group, showing a between-group statistical difference（P〈0.01）. The total effective rate was 69.8% in the treatment group, versus 45.5% in the control group, showing a between-group statistical difference（P〈0.05）. After treatment, the FMA scores were significantly increased in both groups, showing intra-group statistical differences（P〈0.01）; and the FMA score in the treatment group was significantly higher than that in the control group, showing a between-group statistical difference（P〈0.05）. Conclusion： Acupuncture combined with motor therapy is better than motor therapy alone in alleviating postapoplectic limb spasticity, improving the limb motor function and increasing the activities of daily living（ADL）.
文摘Objective：To observe the therapeutic efficacy of acupuncture plus Tai Ji Quan （Tai Chi） in recovering the neurological function and treating depression state in post-stroke depression patients,together with a 12-month follow-up.Methods：A total of 105 eligible post-stroke depression patients were randomized into an acupuncture plus Tai Ji group （53 cases） and a control group （52 cases） based on their visiting sequence.The patients all received routine treatment and rehabilitation training for stroke.In addition,the control group was given oral administration of citalopram hydrobromide tablets,1 month as a course of treatment,for 3 courses in total.Meanwhile,the acupuncture plus Tai Ji group received acupuncture and practiced Tai Ji Quan,for 1 month and 12 months respectively.Before the intervention,after 1-month intervention and 12 months later,the National Institute of Health stroke scale （NIHSS）,Barthel index （BI） and Hamilton depression rating scale （HAMD） were adopted for efficacy evaluation.Results：Prior to the intervention,there were no significant differences in HAMD,NIHSS and BI scores between the two groups （all P〉0.05）;after 1-month intervention,there were significant between-group differences in NIHSS,BI and HAMD scores （P〈0.05 or P〈0.01）;the 12-month follow-up revealed significant between-group differences in NIHSS,BI and HAMD scores （all P〈0.01）.In the treatment of stroke,the total effective rate was 84.4% in the acupuncture plus Tai Ji group,significantly higher than 68.9% in the control group （P〈0.05）;in the treatment of depression,the total effective rate was 86.7% in the acupuncture plus Tai Ji group,significantly higher than 77.8% in the control group （P〈0.05）.Conclusion：Acupuncture plus Tai Ji Quan can produce a significant efficacy in improving the limb motor function and depression in post-stroke depression patients.
文摘Objective: To observe the clinical efficacy of traditional tuina plus modern rehabilitation in the treatment of lower limb extensor spasticity during stroke recovery. Methods: A total of 93 stroke patients who met the inclusion criteria were randomly divided into an observation group and a control group. Forty-four patients in the observation group were treated with traditional tuina plus modern rehabilitation, and 49 patients in the control group were treated with modern rehabilitation. The modified Ashworth scale (MAS), the Fugl-Meyer assessment scale (FMA) and the modified Barthel index (MBI) were used to evaluate the knee extensors state, lower limb motor function and activities of daily living (ADL) of the two groups. Results: After treatment, the overall efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P<0.05). After treatment, the MAS scores of both groups were significantly lower, FMA and MBI scores were significantly higher, and the differences were statistically significant in each group (P<0.01). After treatment, the MAS score of the observation group was lower than that of the control group, and the differenee between the groups was statistically significant (P<0.01). The MBI score of the observation group was higher than that of the control group, and the differenee between the two groups was statistically significant (P<0.05). There were significant differences in the post-treatment changes in MAS, FMA and MBI scores between the two groups (all P<0.05). Conclusion: Traditional tuina plus modern rehabilitation therapy can effectively alleviate or prevent lower limb extensor spasticity after stroke, and improve limb mobility and ADL. Hence, it is worthy of clinical promotion.
