Temporary plugging agent(TPA)is widely used in many fields of petroleum reservoir drilling and production,such as temporary plugging while drilling and petroleum well stimulation by diverting in acidizing or fracturin...Temporary plugging agent(TPA)is widely used in many fields of petroleum reservoir drilling and production,such as temporary plugging while drilling and petroleum well stimulation by diverting in acidizing or fracturing operations.The commonly used TPA mainly includes hard particles,fibers,gels,and composite systems.However,current particles have many limitations in applications,such as insufficient plugging strength and slow degradation rate.In this paper,a degradable pre-formed particle gel(DPPG)was developed.Experimental results show that the DPPG has an excellent static swelling effect and self-degradation performance.With a decrease in the concentration of total monomers or cross-linker,the swelling volume of the synthesized DPPG gradually increases.However,the entire self-degradation time gradually decreases.The increase in 2-acrylamide-2-methylpropanesulfonic acid(AMPS)in the DPPG composition can significantly increase its swelling ratio and shorten the self-degradation time.Moreover,DPPG has excellent high-temperature resistance(150°C)and high-salinity resistance(200,000 mg/L NaCl).Core displacement results show that the DPPG has a perfect plugging effect in the porous media(the plugging pressure gradient was as high as 21.12 MPa),and the damage to the formation after degradation is incredibly minor.Therefore,the DPPG can be used as an up-and-coming TPA in oil fields.展开更多
The deformation and failure mechanism of cylindrical shells and square plate with pre-formed holes under blast loading were investigated numerically by employing the Ansys 17.0 and Ls-Dyna 971.To calibrate the numeric...The deformation and failure mechanism of cylindrical shells and square plate with pre-formed holes under blast loading were investigated numerically by employing the Ansys 17.0 and Ls-Dyna 971.To calibrate the numerical model,the experiments of square plates with pre-formed circle holes were modeled and the numerical results have a good agreement with the experiment data.The calibrated numerical model was used to study the deformation and failure mechanism of cylindrical shells with pre-formed circle holes subjected to blast loading.The structure response and stress field changing process has been divided into four specific stages and the deformation mechanism has been discussed systematically.The local and global deformation curves,degree of damage,change of stress status and failure modes of cylindrical shell and square plate with pre-formed circular holes are obtained,compared and analyzed,it can be concluded as:(1)The transition of tensile stress fields is due to the geometrical characteristic of pre-formed holes and cylindrical shell with arch configuration;(2)The existence of preformed holes not only lead to the increasing of stress concentration around the holes,but also release the stress concentration during whole response process;(3)There are three and two kinds of failure modes for square plate and cylindrical shell with pre-formed holes,respectively.and the standoff distance has a key influence on the forming location of the crack initiating point and the locus of crack propagation;(4)The square plate with pre-formed holes has a better performance than cylindrical shell on blast-resistant capability at a smaller standoff distance,while the influence of pre-formed holes on the reduction of blast-resistant capability of square plate is bigger than that of cylindrical shell.展开更多
In Iwamoto-Harada model the whole phase space is full of fermions. When the momentum distributions of the exciton states are taken into account, the pre-formation probability of light composite particles could be impr...In Iwamoto-Harada model the whole phase space is full of fermions. When the momentum distributions of the exciton states are taken into account, the pre-formation probability of light composite particles could be improved, and the exciton state-dependent pre-formation probability has been proposed. The calculated results indicate that the consideration of the momentum distribution enhances the pre-formation probability of [1, m] configuration, and suppresses that of [ι 〉 1, m] configurations seriously.展开更多
The present work is focused on the performance of three types of coal-oil agglomerates on recovery of liberated gold from gold bearing materials. Pre-formed agglomerates developed using bio-diesel, castor oil and mine...The present work is focused on the performance of three types of coal-oil agglomerates on recovery of liberated gold from gold bearing materials. Pre-formed agglomerates developed using bio-diesel, castor oil and mineral diesel as liquid hydrophobic phases were used in the study. The influence of the type of liquid hydrophobic phase on the degree of gold recovery and the effect of factors such as gold particle concentration, viscosity, agglomerate size, agglomerate/ore ratios and particle penetration into agglomerates have been studied as a function of time. It is shown that gold recovery rate can be increased by an increase in agglomerate loading, surface area and the viscosity of the hydrophobic phase and high recoveries are attained up to 98.5%. Increase in concentration of gold particles per unit volume of slurry increased attachment rate but did not change the final recoveries attained. It is shown that gold particle penetration occurs mainly in the coarse agglomerates if contact is prolonged beyond 60 minutes. Examination of sections of gold-loaded agglomerates under reflected light microscope showed gold and some silicate particles penetrated in few cracked agglomerates and only gold particles were observed inside the uncracked agglomerates suggesting the possibility of gold selectivity during particles penetration. It was shown that the increase in gold recovery attained at prolonged contact time is due to both gold penetration and oleophilic attachment.展开更多
Pre-formed V7-type short amylose(SA)could interact with curcumin to form inclusion complex(IC)thereby to improve the stability of curcumin.However,the complexation mechanism of V7-type SA and curcumin is not clear,whi...Pre-formed V7-type short amylose(SA)could interact with curcumin to form inclusion complex(IC)thereby to improve the stability of curcumin.However,the complexation mechanism of V7-type SA and curcumin is not clear,which limit the improvement of inclusion efficiency.To obtain a starch nanocarrier with high loading capacity,the encapsulation process and interaction parameters of V7-type SA-curcumin IC was studied.The analysis results demonstrated that stoichiometric ratio value of the SA-curcumin complex was around 1.V7-type SA performed excellently in the delivery of curcumin attributing to their high loading capacity(over 20%).It was found that curcumin could enter into the pre-formed helical cavity of SA to form an IC.The conformation change of SA caused the reduction in the interaction ratio in the last 20 ns of simulation.However,SA and curcumin always remained complexation status during the simulation.Hydrogen bonds(H-bonds)and hydrophobic interaction were the most critical acting forces involved in the formation and stability of V7-type SA-curcumin complex.Molecular docking presented that H-bonds interaction between curcumin ligand and V7-type SA chain(O3 at the 25th glucose unit,and O6 at the 17th and 20th glucose units)were found.Furthermore,the hydrophobic interactions were discovered between curcumin ligand and SA chain(18th,19th,21st,22nd and 23rd glucose units).展开更多
Parkinson's disease(PD)is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity,and when these symptoms respond to dopaminergic medications.Yet in the last years there was a greater recognition ...Parkinson's disease(PD)is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity,and when these symptoms respond to dopaminergic medications.Yet in the last years there was a greater recognition of additional aspects of the disease including non-motor symptoms and prodromal states with associated pathology in various regions of the nervous system.In this review we discuss current concepts of two major alterations found during the course of the disease:cytoplasmic aggregates of the protein a-synuclein and the degeneration of dopaminergic neurons.We provide an overview of new approaches in this field based on current concepts and latest literature.In many areas,translational research on PD has advanced the understanding of the disease but there is still a need for more effective therapeutic options based on the insights into the basic biological phenomena.展开更多
基金This work was supported by the Research Foundation of China University of Petroleum-Beijing at Karamay(No.XQZX20200010)the Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2019D01B57)+3 种基金the University Scientific Research Project of Xinjiang Uygur Autonomous Region(No.XJEDU2019Y067)the Xinjiang Uygur Autonomous Region Innovation Environment Construction Project(No.2019Q025)the Sichuan Province Regional Innovation Cooperation Project(No.2020YFQ0036)the CNPC Strategic Cooperation Science and Technology Project(ZLZX2020-01-04-04)。
文摘Temporary plugging agent(TPA)is widely used in many fields of petroleum reservoir drilling and production,such as temporary plugging while drilling and petroleum well stimulation by diverting in acidizing or fracturing operations.The commonly used TPA mainly includes hard particles,fibers,gels,and composite systems.However,current particles have many limitations in applications,such as insufficient plugging strength and slow degradation rate.In this paper,a degradable pre-formed particle gel(DPPG)was developed.Experimental results show that the DPPG has an excellent static swelling effect and self-degradation performance.With a decrease in the concentration of total monomers or cross-linker,the swelling volume of the synthesized DPPG gradually increases.However,the entire self-degradation time gradually decreases.The increase in 2-acrylamide-2-methylpropanesulfonic acid(AMPS)in the DPPG composition can significantly increase its swelling ratio and shorten the self-degradation time.Moreover,DPPG has excellent high-temperature resistance(150°C)and high-salinity resistance(200,000 mg/L NaCl).Core displacement results show that the DPPG has a perfect plugging effect in the porous media(the plugging pressure gradient was as high as 21.12 MPa),and the damage to the formation after degradation is incredibly minor.Therefore,the DPPG can be used as an up-and-coming TPA in oil fields.
基金The reported research is financially supported by The National Natural Science Foundation of China under Grant No.11902310 and No.11802292.
文摘The deformation and failure mechanism of cylindrical shells and square plate with pre-formed holes under blast loading were investigated numerically by employing the Ansys 17.0 and Ls-Dyna 971.To calibrate the numerical model,the experiments of square plates with pre-formed circle holes were modeled and the numerical results have a good agreement with the experiment data.The calibrated numerical model was used to study the deformation and failure mechanism of cylindrical shells with pre-formed circle holes subjected to blast loading.The structure response and stress field changing process has been divided into four specific stages and the deformation mechanism has been discussed systematically.The local and global deformation curves,degree of damage,change of stress status and failure modes of cylindrical shell and square plate with pre-formed circular holes are obtained,compared and analyzed,it can be concluded as:(1)The transition of tensile stress fields is due to the geometrical characteristic of pre-formed holes and cylindrical shell with arch configuration;(2)The existence of preformed holes not only lead to the increasing of stress concentration around the holes,but also release the stress concentration during whole response process;(3)There are three and two kinds of failure modes for square plate and cylindrical shell with pre-formed holes,respectively.and the standoff distance has a key influence on the forming location of the crack initiating point and the locus of crack propagation;(4)The square plate with pre-formed holes has a better performance than cylindrical shell on blast-resistant capability at a smaller standoff distance,while the influence of pre-formed holes on the reduction of blast-resistant capability of square plate is bigger than that of cylindrical shell.
文摘In Iwamoto-Harada model the whole phase space is full of fermions. When the momentum distributions of the exciton states are taken into account, the pre-formation probability of light composite particles could be improved, and the exciton state-dependent pre-formation probability has been proposed. The calculated results indicate that the consideration of the momentum distribution enhances the pre-formation probability of [1, m] configuration, and suppresses that of [ι 〉 1, m] configurations seriously.
文摘The present work is focused on the performance of three types of coal-oil agglomerates on recovery of liberated gold from gold bearing materials. Pre-formed agglomerates developed using bio-diesel, castor oil and mineral diesel as liquid hydrophobic phases were used in the study. The influence of the type of liquid hydrophobic phase on the degree of gold recovery and the effect of factors such as gold particle concentration, viscosity, agglomerate size, agglomerate/ore ratios and particle penetration into agglomerates have been studied as a function of time. It is shown that gold recovery rate can be increased by an increase in agglomerate loading, surface area and the viscosity of the hydrophobic phase and high recoveries are attained up to 98.5%. Increase in concentration of gold particles per unit volume of slurry increased attachment rate but did not change the final recoveries attained. It is shown that gold particle penetration occurs mainly in the coarse agglomerates if contact is prolonged beyond 60 minutes. Examination of sections of gold-loaded agglomerates under reflected light microscope showed gold and some silicate particles penetrated in few cracked agglomerates and only gold particles were observed inside the uncracked agglomerates suggesting the possibility of gold selectivity during particles penetration. It was shown that the increase in gold recovery attained at prolonged contact time is due to both gold penetration and oleophilic attachment.
基金supported by the Natural Science Foundation of Jiangsu Province (BK20220416)University Science Research Project of Jiangsu Province (22KJB550009)the National Key Research and Development Program of China (2023YFD2201300).
文摘Pre-formed V7-type short amylose(SA)could interact with curcumin to form inclusion complex(IC)thereby to improve the stability of curcumin.However,the complexation mechanism of V7-type SA and curcumin is not clear,which limit the improvement of inclusion efficiency.To obtain a starch nanocarrier with high loading capacity,the encapsulation process and interaction parameters of V7-type SA-curcumin IC was studied.The analysis results demonstrated that stoichiometric ratio value of the SA-curcumin complex was around 1.V7-type SA performed excellently in the delivery of curcumin attributing to their high loading capacity(over 20%).It was found that curcumin could enter into the pre-formed helical cavity of SA to form an IC.The conformation change of SA caused the reduction in the interaction ratio in the last 20 ns of simulation.However,SA and curcumin always remained complexation status during the simulation.Hydrogen bonds(H-bonds)and hydrophobic interaction were the most critical acting forces involved in the formation and stability of V7-type SA-curcumin complex.Molecular docking presented that H-bonds interaction between curcumin ligand and V7-type SA chain(O3 at the 25th glucose unit,and O6 at the 17th and 20th glucose units)were found.Furthermore,the hydrophobic interactions were discovered between curcumin ligand and SA chain(18th,19th,21st,22nd and 23rd glucose units).
基金by the German Research Foundation(DFG,FA 658/3-1).
文摘Parkinson's disease(PD)is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity,and when these symptoms respond to dopaminergic medications.Yet in the last years there was a greater recognition of additional aspects of the disease including non-motor symptoms and prodromal states with associated pathology in various regions of the nervous system.In this review we discuss current concepts of two major alterations found during the course of the disease:cytoplasmic aggregates of the protein a-synuclein and the degeneration of dopaminergic neurons.We provide an overview of new approaches in this field based on current concepts and latest literature.In many areas,translational research on PD has advanced the understanding of the disease but there is still a need for more effective therapeutic options based on the insights into the basic biological phenomena.
