The evolution of coronary intervention techniques and equipment has led to more sophisticated procedures for the treatment of highly complex lesions.However,as a result,the risk of complications has increased,which ar...The evolution of coronary intervention techniques and equipment has led to more sophisticated procedures for the treatment of highly complex lesions.However,as a result,the risk of complications has increased,which are mostly iatrogenic and often include equipment failure.Stent dislodgement warrants vigilance for the early diagnosis and a stepwise management approach is required to either expand or retrieve the lost stent.In the era of bioresorbable scaffolds that are not radiopaque,increased caution is required.Intravascular imaging may assist in detecting the lost scaffold in cases of no visibility fluoroscopically.Adequate lesion preparation is the key to minimizing the possibility of equipment loss;however,in the case that it occurs,commercially available and improvised devices and techniques may be applied.展开更多
Contrast-induced acute kidney injury(CI-AKI)is a major concern in clinical practice,particularly among high-risk patients with preexisting renal and cardiovascular conditions.Although periprocedural hydration has long...Contrast-induced acute kidney injury(CI-AKI)is a major concern in clinical practice,particularly among high-risk patients with preexisting renal and cardiovascular conditions.Although periprocedural hydration has long been the primary approach for CI-AKI prevention,recent advancements have led to the development of novel approaches such as RenalGuard and contrast removal systems.This editorial explores these emerging approaches and highlights their potential for enhancing CI-AKI prevention.By incorporating the latest evidence into clinical practice,health-care professionals can more effectively maintain renal function and improve outcomes for patients undergoing contrast-enhanced procedures.展开更多
Objective:Surgical procedures manifest immense risks to patients.One of the adverse events that healthcare professionals see as a threat to the patient’s health is the development of complications known as surgical s...Objective:Surgical procedures manifest immense risks to patients.One of the adverse events that healthcare professionals see as a threat to the patient’s health is the development of complications known as surgical site infection(SSI).Although several effor ts are being under taken to determine the proper means to reduce such complications,there is still a high incidence of SSI worldwide.Surgery requires knowledge in infection control and high precision in maintaining a clean surgical site.This study tested the effectiveness of an operating room(OR)bundle of care in preventing SSI in patients undergoing elective exploratory laparotomy cholecystectomy surgery.Methods:A quasi-experimental pretest and posttest design was utilized to determine its effectiveness.The study was composed of 60 par ticipants divided into two groups:30 subjects were selected to receive the OR bundle of care,while the other 30 subjects received the usual care.The groupings were determined through a systematic random sampling technique.The OR bundle of care had three interventions,namely:(1)maintaining perioperative normothermia,(2)no pre-operative surgical site hair removal,and(3)changing gloves before abdominal wall closure.These patients were evaluated using the standard instrument,Bates–Jensen Wound Assessment Tool(BWAT)in the post-intervention phases of the wound healing process,which are as follows:hemostasis,inflammatory,and proliferative phases.To describe the difference in the patients’wound status after implementation of the OR bundle of care in each post-intervention phase,Friedman’s test was used.To describe the difference in the patients’wound status in both groups after implementation of the OR bundle of care,the Mann–Whitney U test was used.Results:The patient’s wound status was lower,indicating a more healing process.Differences between the wound status of the control and the experimental group were observed on the third postoperative day.This indicates that the experimental group’s wound status healed much faster and more effectively than the control group based on the BWAT scoring severity scoring.A significant difference in the patient’s wound status from the hemostasis phase compared with the proliferative phase was observed.Conclusions:The OR bundle of care has been shown to be effective in preventing SSI in patients who had undergone exploratory laparotomy cholecystectomy surgery in the selected hospital,if there is uniform and consistent implementation of the said intervention.展开更多
The autumn season marks the peak incidence of respiratory diseases.In order to further enhance the prevention and control of respiratory infectious diseases in China and safeguard public health,the Academic Conference...The autumn season marks the peak incidence of respiratory diseases.In order to further enhance the prevention and control of respiratory infectious diseases in China and safeguard public health,the Academic Conference on Vaccines Preventing Respiratory Infections,organized by the Chinese Preventive Medicine Association(CPMA).展开更多
Cloud computing is one of the most attractive and cost-saving models,which provides online services to end-users.Cloud computing allows the user to access data directly from any node.But nowadays,cloud security is one...Cloud computing is one of the most attractive and cost-saving models,which provides online services to end-users.Cloud computing allows the user to access data directly from any node.But nowadays,cloud security is one of the biggest issues that arise.Different types of malware are wreaking havoc on the clouds.Attacks on the cloud server are happening from both internal and external sides.This paper has developed a tool to prevent the cloud server from spamming attacks.When an attacker attempts to use different spamming techniques on a cloud server,the attacker will be intercepted through two effective techniques:Cloudflare and K-nearest neighbors(KNN)classification.Cloudflare will block those IP addresses that the attacker will use and prevent spamming attacks.However,the KNN classifiers will determine which area the spammer belongs to.At the end of the article,various prevention techniques for securing cloud servers will be discussed,a comparison will be made with different papers,a conclusion will be drawn based on different results.展开更多
This research aimed to study the preventive and relieving outcomes of kiwi berry on constipation.The administration of kiwi berries to mice resulted in a significant increase in body weight gain of 148.2%compared to m...This research aimed to study the preventive and relieving outcomes of kiwi berry on constipation.The administration of kiwi berries to mice resulted in a significant increase in body weight gain of 148.2%compared to mice that were constipated.The number of stools and the water content of stools both increased by 138.5%and 106.5%,respectively.The gastrointestinal transit rate increased by 45.3%,and the time it took for the first dark stool to form decreased by 57.5%.The levels of the excitability neurotransmitters were found to be higher in the group that had been given kiwi berries in comparison to the group that had been given loperamide.The opposite results were produced by vasoactive intestinal peptide(VIP)and aquaporin-3(AQP3).In addition,kiwi berry consumption may lessen epithelial cell apoptosis and promote colon health.All the results point to kiwi berries as an extremely promising food supplement for the prevention and relief of constipation in the future since they successfully prevent and alleviate constipation brought on by loperamide.展开更多
Potential’s fluctuation of rust preventing oil film during its degradation was studied using wirebeam electrode. Being non-destructive and simple, potential measurement is a very repetitive method. Otherelectrochemic...Potential’s fluctuation of rust preventing oil film during its degradation was studied using wirebeam electrode. Being non-destructive and simple, potential measurement is a very repetitive method. Otherelectrochemical testing method, e. g., polarization resistance, can breakdown the integrity of oil coating byDC current; EIS is time consuming. As a special electrochemical sensor, wire beam electrode contains 101wires of mild steel wires, and it is helpful to improve the reproducibility of electrochemical test evidently.Using this electrode, the electrochemical parameters and their distribution which was related to under filmcorrosion process are measured directly so as to describe potential’s fluctuation of rust preventing oil film. Itis pointed out that there is potential’s fluctuation on rust preventing oil film during its degradation, and thischaracteristic has direct effect on the self-repairing ability of rust preventing oil film. However, for the uncoated metal electrode and base oil film, there is no such behavior. It is also pointed out that inhibitors in theoil film have direct effect on its self-repairing ability.展开更多
Three different methods were applied to study the alkali content of gelpores in cement. In the closed system, the concentration of K＋, Na＋ and OH - have not reduced with the increase of age. In the open system, the ...Three different methods were applied to study the alkali content of gelpores in cement. In the closed system, the concentration of K＋, Na＋ and OH - have not reduced with the increase of age. In the open system, the diffusion and transferring of K＋ and Na＋ towards free space leads to the de-crease of total alkali content. In the micro-analysis system, the contents of K＋ and Na＋ in the first hy- drated layer of ground granulated blastfurnace slag （GBFS） are very low, while the contents of calcium and magnesium are relatively high. This phenomenon shows that the mechanism of GBFS preventing alkali aggregate reaction （AAR） is： when GBFS is dissolved by alkali medium, SiO2 and Al2O3 are dissolved into the cement matrix, then around GBFS particles form reaction rings rich in Ca2＋ and Mg^2＋, and the C-S-H gel of positive charges formed in the area repulses K＋ and Na＋, which are forced to transfer to the mortar＇s matrix, pore or mortar sample surface. The transferred K ^＋ and Na^＋ form alkali gel products with other dissolved ions, then become evenly distributed in the mortar sample and react with Ca（OH）2 in pore solutions to form （Na,K）x-2z·zCa·（SiO2）y·（OH）x gel products; and thus changes the AAR gel products＇ structure. The gel products will not expand, and so they can delay expansion destruction.展开更多
Based on the meteorological data in Fushun,Qingyuan and Xinbing from 1961 to 2008,the status quo of major agro-climatic resources in Fushun were analyzed.The abundant rainfall,sufficient sunshine and rich thermal reso...Based on the meteorological data in Fushun,Qingyuan and Xinbing from 1961 to 2008,the status quo of major agro-climatic resources in Fushun were analyzed.The abundant rainfall,sufficient sunshine and rich thermal resources were suitable for the development of modern agricultural production.The specific measures of effective use of climate resources were put forward according to geographical location and climatic characteristics of Fushun.The advantages of agro-climate resources were exerted for large edible fungi industry;effective accumulated temperature was applied for adjustment of plantation structure;three-dimensional agriculture in the mountainous area was developed vigorously.The main types of meteorological disasters constraining agricultural development in Fushun and their hazards were summarized,including droughts,floods,hail,etc.In addition,some scientific preventing measures of meteorological disaster were proposed.展开更多
This study concerns the heat transfer processes during ice accretion on wires. The steady state heat balance equation assumed to describe the thermodynamics at the surface of a current heated wire subjected to icing i...This study concerns the heat transfer processes during ice accretion on wires. The steady state heat balance equation assumed to describe the thermodynamics at the surface of a current heated wire subjected to icing is obtained by analyzing and computing each terms of heat flux. The surface temperature of wire is derived from the heat balance equation, which gives out a proposed estimation of the current intensity to prevent the wire icing展开更多
Objective: To evaluate the efficacy of Genni-anchun (GNC) in preventing primary osteoporosis. Methods: Fifty female SD rats of 10 - 12 months old were randomly divided into five groups. Except those in the sham operat...Objective: To evaluate the efficacy of Genni-anchun (GNC) in preventing primary osteoporosis. Methods: Fifty female SD rats of 10 - 12 months old were randomly divided into five groups. Except those in the sham operation group, animals were ovariectomized bilaterally. The gastric perfusion was started immediately after operation, with normal saline to the sham operation group and model group; GNC to high dose (2 ml) and low dos (1 ml) GNC groups and Nilestriol to the NE group, every day for 3 months. Animals were sacrificed at the end of experiment, their vertebra and展开更多
Antiruisi (AR)prescription (安替瑞丝方) is a compound in Chinese drug-therapy, which was used to treat 35 patients with coronary heart disease after stenting by the authors, and a satisfactory effect had been proved i...Antiruisi (AR)prescription (安替瑞丝方) is a compound in Chinese drug-therapy, which was used to treat 35 patients with coronary heart disease after stenting by the authors, and a satisfactory effect had been proved in preventing restenosis. It is reported as follows.展开更多
MicroRNA pathway is down-regulated in aged dopaminergic neurons： Parkinson＇s disease （PD） is the most frequent motor neuro- degenerative disorder and is morphologically mainly associated with progressive dopaminer...MicroRNA pathway is down-regulated in aged dopaminergic neurons： Parkinson＇s disease （PD） is the most frequent motor neuro- degenerative disorder and is morphologically mainly associated with progressive dopaminergic neuronal loss in the ventral midbrain.展开更多
Atrial fibrillation (AF) is a kind of common arrhythmia, which, besides affecting cardiac function, has another serious outcome, that is, it is easy to form atrial thrombosis and induce thrombus/embolus, especially ce...Atrial fibrillation (AF) is a kind of common arrhythmia, which, besides affecting cardiac function, has another serious outcome, that is, it is easy to form atrial thrombosis and induce thrombus/embolus, especially cerebral embolus. The incidence of left atrial thrombosis ( LAT) could reach 25% - 30%(1) , the incidence of embol-展开更多
The Problem: We have previously suggested that an alternative approach to preventing cardiovascular disease is necessary because atherosclerotic cardiovascular disease (ASCVD) has been increasing for the last 50 years...The Problem: We have previously suggested that an alternative approach to preventing cardiovascular disease is necessary because atherosclerotic cardiovascular disease (ASCVD) has been increasing for the last 50 years and has now reached epidemic status. Since the year 2000, approximately 600,000 heart attacks and ASCVD related deaths have occurred annually in the United States. It is the most common cause of death in the U.S., more than all cancers combined. The financial costs are staggering, amounting to 555 billion dollars per year in direct and indirect costs. Outlook for an improvement in these statistics is not encouraging as the U.S. population continues to become more obese and to develop diabetes. The Question: Why is ASCVD continuing to be a major challenge to healthcare providers when the pathogenesis is known and inexpensive preventative treatment is available? The reasons are multiple and complex. First, present financial reimbursement policies of healthcare organizations reward treatment of a disease and its complications instead of preventing the disease. Second, professional guidelines and treatment goals are often too complex, subject to interpretation, and time-consuming to be useful in the clinical setting. Third, no specific follow-up of patients at risk for ASCVD is recommended when the risk assessment changes. Fourth, many expensive cardiovascular diagnostic tests are utilized without meeting appropriate guidelines for their use. Fifth, treatment of individuals without first proving the presence of disease results in poor adherence to therapy. The Solution: This article describes the rationale for a new approach to the prevention of ASCVD in asymptomatic individuals. It is based upon preventing ASCVD by identifying all asymptomatic individuals with subclinical disease before an ASCVD event occurs. It recommends that all adults be screened for ASCVD on or before the age of 50 using a non-invasive atherosclerosis specific coronary artery calcium heart scan. Further recommendations include treating all calcium positive individuals to reverse their atherosclerotic coronary artery plaques with a combination of a low cholesterol diet, rosuvastatin 10 mg/day, and ezetimibe 10 mg/day. The therapeutic goal is a low-density lipoprotein cholesterol below 50 mg/dl to ensure regression of atherosclerosis. For individuals who have a zero calcium score, a repeat scan in 3 to 5 years is recommended. This new approach can easily be integrated into ongoing heart disease prevention programs to reduce the burden of ASCVD within the next five years. Conclusion: The mortality, morbidity, and cost of ASCVD have reached unacceptable levels. Reducing this disease to a rare condition will require the efforts of many individuals to organize, educate, and facilitate the goal of identifying all individuals with subclinical ASCVD. Once identified, aggressive therapy is required to reverse their atherosclerotic plaques in order to prevent heart attacks and atherosclerotic strokes. If successful, within 5 years the majority of the patients with asymptomatic ASCVD can be identified and if treated appropriately, reduce the prevalence and cost of ASCVD by 90%.展开更多
After entering 2010, as main varieties patents of the global non-peptide angiotensin II receptor antagonists （ARB） expire, strong growth of anti-hypertensive drug market will tend to slow down. In drugs acting on th...After entering 2010, as main varieties patents of the global non-peptide angiotensin II receptor antagonists （ARB） expire, strong growth of anti-hypertensive drug market will tend to slow down. In drugs acting on the cardiovascular and blood system, antithrombotie drugs will become a new attraction on the market. Antithrombotic drugs are primarily formed by the anti-platelet aggregation, coagulation system activation of plasminogen thrombolytic drugs and the like. Antiplatelet drugs have both prevention and treatment effect, are the main category of antithrombotic drugs. According to IMS Health data, in 2008, sale of anti-thrombosis drug in global market is 180 million U.S. dollars, an increase of 16 %, while in 2009 the growth rate is only 7.95%, reaching $ 19.5 billion, growth rate of antithrombotic drugs is 7.13% in the world＇ s major pharmaceutical market.展开更多
Water security in Africa has never been as starkly highlighted as the countdown to Day Zero in Cape Town. South Africa, where becauseof an unprecedented drought, the entire city of about 4 million residents could be w...Water security in Africa has never been as starkly highlighted as the countdown to Day Zero in Cape Town. South Africa, where becauseof an unprecedented drought, the entire city of about 4 million residents could be without water in July. Water restrictions for all residents are already in place and Day Zero has an activation date of July 9 （at the time of writing）. If this catastrophe happens, it would make the famous tourist city that is frequently voted the world＇s most beautiful destination, earn another more dubious title that of the first major city in the world to ever run out of water.展开更多
文摘The evolution of coronary intervention techniques and equipment has led to more sophisticated procedures for the treatment of highly complex lesions.However,as a result,the risk of complications has increased,which are mostly iatrogenic and often include equipment failure.Stent dislodgement warrants vigilance for the early diagnosis and a stepwise management approach is required to either expand or retrieve the lost stent.In the era of bioresorbable scaffolds that are not radiopaque,increased caution is required.Intravascular imaging may assist in detecting the lost scaffold in cases of no visibility fluoroscopically.Adequate lesion preparation is the key to minimizing the possibility of equipment loss;however,in the case that it occurs,commercially available and improvised devices and techniques may be applied.
文摘Contrast-induced acute kidney injury(CI-AKI)is a major concern in clinical practice,particularly among high-risk patients with preexisting renal and cardiovascular conditions.Although periprocedural hydration has long been the primary approach for CI-AKI prevention,recent advancements have led to the development of novel approaches such as RenalGuard and contrast removal systems.This editorial explores these emerging approaches and highlights their potential for enhancing CI-AKI prevention.By incorporating the latest evidence into clinical practice,health-care professionals can more effectively maintain renal function and improve outcomes for patients undergoing contrast-enhanced procedures.
文摘Objective:Surgical procedures manifest immense risks to patients.One of the adverse events that healthcare professionals see as a threat to the patient’s health is the development of complications known as surgical site infection(SSI).Although several effor ts are being under taken to determine the proper means to reduce such complications,there is still a high incidence of SSI worldwide.Surgery requires knowledge in infection control and high precision in maintaining a clean surgical site.This study tested the effectiveness of an operating room(OR)bundle of care in preventing SSI in patients undergoing elective exploratory laparotomy cholecystectomy surgery.Methods:A quasi-experimental pretest and posttest design was utilized to determine its effectiveness.The study was composed of 60 par ticipants divided into two groups:30 subjects were selected to receive the OR bundle of care,while the other 30 subjects received the usual care.The groupings were determined through a systematic random sampling technique.The OR bundle of care had three interventions,namely:(1)maintaining perioperative normothermia,(2)no pre-operative surgical site hair removal,and(3)changing gloves before abdominal wall closure.These patients were evaluated using the standard instrument,Bates–Jensen Wound Assessment Tool(BWAT)in the post-intervention phases of the wound healing process,which are as follows:hemostasis,inflammatory,and proliferative phases.To describe the difference in the patients’wound status after implementation of the OR bundle of care in each post-intervention phase,Friedman’s test was used.To describe the difference in the patients’wound status in both groups after implementation of the OR bundle of care,the Mann–Whitney U test was used.Results:The patient’s wound status was lower,indicating a more healing process.Differences between the wound status of the control and the experimental group were observed on the third postoperative day.This indicates that the experimental group’s wound status healed much faster and more effectively than the control group based on the BWAT scoring severity scoring.A significant difference in the patient’s wound status from the hemostasis phase compared with the proliferative phase was observed.Conclusions:The OR bundle of care has been shown to be effective in preventing SSI in patients who had undergone exploratory laparotomy cholecystectomy surgery in the selected hospital,if there is uniform and consistent implementation of the said intervention.
文摘The autumn season marks the peak incidence of respiratory diseases.In order to further enhance the prevention and control of respiratory infectious diseases in China and safeguard public health,the Academic Conference on Vaccines Preventing Respiratory Infections,organized by the Chinese Preventive Medicine Association(CPMA).
文摘Cloud computing is one of the most attractive and cost-saving models,which provides online services to end-users.Cloud computing allows the user to access data directly from any node.But nowadays,cloud security is one of the biggest issues that arise.Different types of malware are wreaking havoc on the clouds.Attacks on the cloud server are happening from both internal and external sides.This paper has developed a tool to prevent the cloud server from spamming attacks.When an attacker attempts to use different spamming techniques on a cloud server,the attacker will be intercepted through two effective techniques:Cloudflare and K-nearest neighbors(KNN)classification.Cloudflare will block those IP addresses that the attacker will use and prevent spamming attacks.However,the KNN classifiers will determine which area the spammer belongs to.At the end of the article,various prevention techniques for securing cloud servers will be discussed,a comparison will be made with different papers,a conclusion will be drawn based on different results.
基金The First Batch of Liaoning'Unveiling Leader'Scientific and Technological Projects(2021JH1/10400036)China Agriculture Research System of MOF and MARA(CARS-29)Liaoning Province food processing chief science and technology special commissioner(2022JH5/10400125)。
文摘This research aimed to study the preventive and relieving outcomes of kiwi berry on constipation.The administration of kiwi berries to mice resulted in a significant increase in body weight gain of 148.2%compared to mice that were constipated.The number of stools and the water content of stools both increased by 138.5%and 106.5%,respectively.The gastrointestinal transit rate increased by 45.3%,and the time it took for the first dark stool to form decreased by 57.5%.The levels of the excitability neurotransmitters were found to be higher in the group that had been given kiwi berries in comparison to the group that had been given loperamide.The opposite results were produced by vasoactive intestinal peptide(VIP)and aquaporin-3(AQP3).In addition,kiwi berry consumption may lessen epithelial cell apoptosis and promote colon health.All the results point to kiwi berries as an extremely promising food supplement for the prevention and relief of constipation in the future since they successfully prevent and alleviate constipation brought on by loperamide.
文摘Potential’s fluctuation of rust preventing oil film during its degradation was studied using wirebeam electrode. Being non-destructive and simple, potential measurement is a very repetitive method. Otherelectrochemical testing method, e. g., polarization resistance, can breakdown the integrity of oil coating byDC current; EIS is time consuming. As a special electrochemical sensor, wire beam electrode contains 101wires of mild steel wires, and it is helpful to improve the reproducibility of electrochemical test evidently.Using this electrode, the electrochemical parameters and their distribution which was related to under filmcorrosion process are measured directly so as to describe potential’s fluctuation of rust preventing oil film. Itis pointed out that there is potential’s fluctuation on rust preventing oil film during its degradation, and thischaracteristic has direct effect on the self-repairing ability of rust preventing oil film. However, for the uncoated metal electrode and base oil film, there is no such behavior. It is also pointed out that inhibitors in theoil film have direct effect on its self-repairing ability.
基金Funded by the German Academic Exchange Service (DAAD) for the Project A/09/00743the Science and Technology Project of Wuhan City(No.200860423208)
文摘Three different methods were applied to study the alkali content of gelpores in cement. In the closed system, the concentration of K＋, Na＋ and OH - have not reduced with the increase of age. In the open system, the diffusion and transferring of K＋ and Na＋ towards free space leads to the de-crease of total alkali content. In the micro-analysis system, the contents of K＋ and Na＋ in the first hy- drated layer of ground granulated blastfurnace slag （GBFS） are very low, while the contents of calcium and magnesium are relatively high. This phenomenon shows that the mechanism of GBFS preventing alkali aggregate reaction （AAR） is： when GBFS is dissolved by alkali medium, SiO2 and Al2O3 are dissolved into the cement matrix, then around GBFS particles form reaction rings rich in Ca2＋ and Mg^2＋, and the C-S-H gel of positive charges formed in the area repulses K＋ and Na＋, which are forced to transfer to the mortar＇s matrix, pore or mortar sample surface. The transferred K ^＋ and Na^＋ form alkali gel products with other dissolved ions, then become evenly distributed in the mortar sample and react with Ca（OH）2 in pore solutions to form （Na,K）x-2z·zCa·（SiO2）y·（OH）x gel products; and thus changes the AAR gel products＇ structure. The gel products will not expand, and so they can delay expansion destruction.
基金Supported by Fushun Government Substance Subject (20071209)
文摘Based on the meteorological data in Fushun,Qingyuan and Xinbing from 1961 to 2008,the status quo of major agro-climatic resources in Fushun were analyzed.The abundant rainfall,sufficient sunshine and rich thermal resources were suitable for the development of modern agricultural production.The specific measures of effective use of climate resources were put forward according to geographical location and climatic characteristics of Fushun.The advantages of agro-climate resources were exerted for large edible fungi industry;effective accumulated temperature was applied for adjustment of plantation structure;three-dimensional agriculture in the mountainous area was developed vigorously.The main types of meteorological disasters constraining agricultural development in Fushun and their hazards were summarized,including droughts,floods,hail,etc.In addition,some scientific preventing measures of meteorological disaster were proposed.
文摘This study concerns the heat transfer processes during ice accretion on wires. The steady state heat balance equation assumed to describe the thermodynamics at the surface of a current heated wire subjected to icing is obtained by analyzing and computing each terms of heat flux. The surface temperature of wire is derived from the heat balance equation, which gives out a proposed estimation of the current intensity to prevent the wire icing
文摘Objective: To evaluate the efficacy of Genni-anchun (GNC) in preventing primary osteoporosis. Methods: Fifty female SD rats of 10 - 12 months old were randomly divided into five groups. Except those in the sham operation group, animals were ovariectomized bilaterally. The gastric perfusion was started immediately after operation, with normal saline to the sham operation group and model group; GNC to high dose (2 ml) and low dos (1 ml) GNC groups and Nilestriol to the NE group, every day for 3 months. Animals were sacrificed at the end of experiment, their vertebra and
文摘Antiruisi (AR)prescription (安替瑞丝方) is a compound in Chinese drug-therapy, which was used to treat 35 patients with coronary heart disease after stenting by the authors, and a satisfactory effect had been proved in preventing restenosis. It is reported as follows.
基金supported by Shanghai Jiao Tong University non-Chinese principal investigators support program AF0800056Sheng Yushou Joint Grant to IAVthe Academy of Finland grants 293392 and 287843,and TEKES 3i Regeneration grant to AD
文摘MicroRNA pathway is down-regulated in aged dopaminergic neurons： Parkinson＇s disease （PD） is the most frequent motor neuro- degenerative disorder and is morphologically mainly associated with progressive dopaminergic neuronal loss in the ventral midbrain.
基金This project is supported by Guangdong Provincial Ad-ministration of TCM(No.99592)
文摘Atrial fibrillation (AF) is a kind of common arrhythmia, which, besides affecting cardiac function, has another serious outcome, that is, it is easy to form atrial thrombosis and induce thrombus/embolus, especially cerebral embolus. The incidence of left atrial thrombosis ( LAT) could reach 25% - 30%(1) , the incidence of embol-
文摘The Problem: We have previously suggested that an alternative approach to preventing cardiovascular disease is necessary because atherosclerotic cardiovascular disease (ASCVD) has been increasing for the last 50 years and has now reached epidemic status. Since the year 2000, approximately 600,000 heart attacks and ASCVD related deaths have occurred annually in the United States. It is the most common cause of death in the U.S., more than all cancers combined. The financial costs are staggering, amounting to 555 billion dollars per year in direct and indirect costs. Outlook for an improvement in these statistics is not encouraging as the U.S. population continues to become more obese and to develop diabetes. The Question: Why is ASCVD continuing to be a major challenge to healthcare providers when the pathogenesis is known and inexpensive preventative treatment is available? The reasons are multiple and complex. First, present financial reimbursement policies of healthcare organizations reward treatment of a disease and its complications instead of preventing the disease. Second, professional guidelines and treatment goals are often too complex, subject to interpretation, and time-consuming to be useful in the clinical setting. Third, no specific follow-up of patients at risk for ASCVD is recommended when the risk assessment changes. Fourth, many expensive cardiovascular diagnostic tests are utilized without meeting appropriate guidelines for their use. Fifth, treatment of individuals without first proving the presence of disease results in poor adherence to therapy. The Solution: This article describes the rationale for a new approach to the prevention of ASCVD in asymptomatic individuals. It is based upon preventing ASCVD by identifying all asymptomatic individuals with subclinical disease before an ASCVD event occurs. It recommends that all adults be screened for ASCVD on or before the age of 50 using a non-invasive atherosclerosis specific coronary artery calcium heart scan. Further recommendations include treating all calcium positive individuals to reverse their atherosclerotic coronary artery plaques with a combination of a low cholesterol diet, rosuvastatin 10 mg/day, and ezetimibe 10 mg/day. The therapeutic goal is a low-density lipoprotein cholesterol below 50 mg/dl to ensure regression of atherosclerosis. For individuals who have a zero calcium score, a repeat scan in 3 to 5 years is recommended. This new approach can easily be integrated into ongoing heart disease prevention programs to reduce the burden of ASCVD within the next five years. Conclusion: The mortality, morbidity, and cost of ASCVD have reached unacceptable levels. Reducing this disease to a rare condition will require the efforts of many individuals to organize, educate, and facilitate the goal of identifying all individuals with subclinical ASCVD. Once identified, aggressive therapy is required to reverse their atherosclerotic plaques in order to prevent heart attacks and atherosclerotic strokes. If successful, within 5 years the majority of the patients with asymptomatic ASCVD can be identified and if treated appropriately, reduce the prevalence and cost of ASCVD by 90%.
文摘After entering 2010, as main varieties patents of the global non-peptide angiotensin II receptor antagonists （ARB） expire, strong growth of anti-hypertensive drug market will tend to slow down. In drugs acting on the cardiovascular and blood system, antithrombotie drugs will become a new attraction on the market. Antithrombotic drugs are primarily formed by the anti-platelet aggregation, coagulation system activation of plasminogen thrombolytic drugs and the like. Antiplatelet drugs have both prevention and treatment effect, are the main category of antithrombotic drugs. According to IMS Health data, in 2008, sale of anti-thrombosis drug in global market is 180 million U.S. dollars, an increase of 16 %, while in 2009 the growth rate is only 7.95%, reaching $ 19.5 billion, growth rate of antithrombotic drugs is 7.13% in the world＇ s major pharmaceutical market.
文摘Water security in Africa has never been as starkly highlighted as the countdown to Day Zero in Cape Town. South Africa, where becauseof an unprecedented drought, the entire city of about 4 million residents could be without water in July. Water restrictions for all residents are already in place and Day Zero has an activation date of July 9 （at the time of writing）. If this catastrophe happens, it would make the famous tourist city that is frequently voted the world＇s most beautiful destination, earn another more dubious title that of the first major city in the world to ever run out of water.
