Poor bone quality is a major factor in skeletal fragility in elderly individuals.The molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily d...Poor bone quality is a major factor in skeletal fragility in elderly individuals.The molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by osteocytes.We hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material properties.We examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses PLR.The control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)bone.This relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical tests.The effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.展开更多
Organoids of the central nervous system,primarily derived from pluripotent stem cells or neural stem cells,are three-dimensional tissue cultures with self-organizing properties.When exposed to the right combinations o...Organoids of the central nervous system,primarily derived from pluripotent stem cells or neural stem cells,are three-dimensional tissue cultures with self-organizing properties.When exposed to the right combinations of signals,they differentiate into a 3D tissue consisting of complex cytoarchitecture and native cell types,including various neuron subtypes and glial cells.These features closely mimic native tissues,making them invaluable for developmental studies and disease modeling.In recent years,spinal cord organoids(SCOs)have been developed to investigate spinal cord development,injuries,and various neurological disorders.As an integral part of the central nervous system,SCOs play a vital role and serve as a site for studying both neurodevelopment and neurodegenerative diseases.展开更多
Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian clock.The hormone is primarily synthesized by the vertebrate pinea...Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian clock.The hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.展开更多
The coronavirus disease 2019(COVID-19)outbreak in late 2019 significantly impacted global health.The virus’s rapid spread,with its long incubation period and high infection level,caused substantial disruption to regu...The coronavirus disease 2019(COVID-19)outbreak in late 2019 significantly impacted global health.The virus’s rapid spread,with its long incubation period and high infection level,caused substantial disruption to regular social frameworks,production,and lifestyles^([1]).COVID-19 is primarily transmitted through close contact,long-range contaminants,and airborne routes.展开更多
Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs worldwide.Due to the aging population,it is expected that the number of peopl...Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs worldwide.Due to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more prevalent.Glaucoma primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.展开更多
Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or a...Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least asymmetrically.The disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.展开更多
GENERAL Asian Pacific Journal of Tropical Biomedicine is sponsored by Hainan Medical University Journal Publisher,and aims to set up an acdemic communicating platform for scientists all over the world on tropical biom...GENERAL Asian Pacific Journal of Tropical Biomedicine is sponsored by Hainan Medical University Journal Publisher,and aims to set up an acdemic communicating platform for scientists all over the world on tropical biomedicine and related sciences.The Journal invites concise reports of original research in all areas of tropical biomedicine and related fields,both experimental and clinical,including modern,traditional and epidemiological studies,from any part of the world.Review articles based primarily on authors'own research on internationally important topics will be accepted.展开更多
Desertification poses significant threats to the ecological security and sustainable economic and social development of countries worldwide. In China, existing desertified land primarily lies between 35°–50°...Desertification poses significant threats to the ecological security and sustainable economic and social development of countries worldwide. In China, existing desertified land primarily lies between 35°–50°N, covering arid and semi-arid regions and a total area of 1.688×106 km^(2), which represents 17.58%of the total territorial area of the country (Fig. 1).展开更多
GENERAL Asian Pacific Journal of Tropical Biomedicine is sponsored by Hainan Medical University Journal Publisher,and aims to set up an acdemic communicating platform for scientists all over the world on tropical biom...GENERAL Asian Pacific Journal of Tropical Biomedicine is sponsored by Hainan Medical University Journal Publisher,and aims to set up an acdemic communicating platform for scientists all over the world on tropical biomedicine and related sciences.The Journal invites concise reports of original research in all areas of tropical biomedicine and related fields,both experimental and clinical,including modern,traditional and epidemiological studies,from any part of the world.Review articles based primarily on authors'own research on internationally important topics will be accepted.Short communications and letters to the editor are also welcome.展开更多
Background Attention-deficit/hyperactivity disorder(ADHD)is one of the most frequently diagnosed psychiatric conditions in children and adolescents.Although the symptoms appear to be well described,no coherent concept...Background Attention-deficit/hyperactivity disorder(ADHD)is one of the most frequently diagnosed psychiatric conditions in children and adolescents.Although the symptoms appear to be well described,no coherent conceptual mechanistic framework integrates their occurrence and variance and the associated problems that people with ADHD face.Aims The current study proposes that altered event segmentation processes provide a novel mechanistic framework for understanding deficits in ADHD.Methods Adolescents with ADHD and neurotypically developing(NT)peers watched a short movie and were then asked to indicate the boundaries between meaningful segments of the movie.Concomitantly recorded electroencephalography(EEG)data were analysed for differences in frequency band activity and effective connectivity between brain areas.Results Compared with their NT peers,the ADHD group showed less dependence of their segmentation behaviour on social information,indicating that they did not consider social information to the same extent as their unaffected peers.This divergence was accompanied by differences in EEG theta band activity and a different effective connectivity network architecture at the source level.Specifically,NT adolescents primarily showed error signalling in and between the left and right fusiform gyri related to social information processing,which was not the case in the ADHD group.For the ADHD group,the inferior frontal cortex associated with attentional sampling served as a hub instead,indicating problems in the deployment of attentional control.Conclusions This study shows that adolescents with ADHD perceive events differently from their NT peers,in association with a different brain network architecture that reflects less adaptation to the situation and problems in attentional sampling of environmental information.The results call for a novel conceptual view of ADHD,based on event segmentation theory.展开更多
1.Introduction Battery technology,serving as a basis for a rechargeable society,has developed rapidly over a century[1].The progress can be roughly divided into three stages,with the initial two mainly focusing on aqu...1.Introduction Battery technology,serving as a basis for a rechargeable society,has developed rapidly over a century[1].The progress can be roughly divided into three stages,with the initial two mainly focusing on aqueous battery systems.Prior to 1859,research primarily focused on the conceptualization of batteries and the development of primary(non-rechargeable)cells[2].In the subsequent150 years,rechargeable battery technology emerged。展开更多
Introduction Seafood is a widely consumed and nutritionally rich food source,but it ranks among the top allergens,with shellfish and fish being major triggers of allergic reactions.These reactions,primarily caused by ...Introduction Seafood is a widely consumed and nutritionally rich food source,but it ranks among the top allergens,with shellfish and fish being major triggers of allergic reactions.These reactions,primarily caused by proteins such as tropomyosin(TM)in shellfish and parvalbumin(PV)in fish,can lead to life-threatening anaphylaxis in susceptible individuals.The development of hypoallergenic seafood is becoming increasingly important to provide safe alternatives for those with seafood allergies.This comment reviews recent advances in allergenicity mitigation strategies,highlighting the progress made and future potential in producing hypoallergenic seafood products.展开更多
In the past,outer space was primarily the domain of a few powerful countries and generally considered separate from broader concerns of human security and development.However,in recent times,space technology developme...In the past,outer space was primarily the domain of a few powerful countries and generally considered separate from broader concerns of human security and development.However,in recent times,space technology development has been a dynamic arena in which the majority of the world’s countries,including countries across the continent of Africa,are actively engaged to address their most pressing socio-economic challenges.Since the turn of the millennium,countries across Africa have demonstrated growing interest in developing their space capabilities to address their most pressing challenges,including but not limited to climate change,poverty,terrorism,and forced migration.展开更多
The global market for bioplastic textiles,valued at US$l,046 million in 2022,is projected to expand by15.5%CAGR,reaching$3,827 million by 2032.This substantial growth is primarily driven by the escalating demand for e...The global market for bioplastic textiles,valued at US$l,046 million in 2022,is projected to expand by15.5%CAGR,reaching$3,827 million by 2032.This substantial growth is primarily driven by the escalating demand for environmentally friendly and sustainable goods in response to growing consumer awareness and governmental regulations aimed at reducing plastic consumption and waste.展开更多
Plastic mulches have become an essential component of modern agriculture since their introduction in the 1950s.However,disposal of plastic mulches poses serious environmental challenges as plastics that are not consid...Plastic mulches have become an essential component of modern agriculture since their introduction in the 1950s.However,disposal of plastic mulches poses serious environmental challenges as plastics that are not considered biodegradable or compostable can take several hundred years to degrade.Each year in the United States,only 9%of overall plastic waste is recycled while 79%is accumulated in landfills or the natural environment.Recycling of plastic mulch is especially constrained due to the contamination that results from their use in farming.Currently,recovered mulches are reported to have 30%–80%surface contamination,primarily from soil and plant debris.Plastic mulch waste is concentrated in areas where they are used and can provide logistical opportunities to the plastic recycling industries.Plastic recycling includes mechanical,advanced(chemical and thermal),and biological methods,that may all be used for polyethylene(PE).Most plastic is recycled using the mechanical method,while advanced and biological methods are promising but face significant financial and technical challenges.For all recycling methods,strategies are needed for managing surface contamination to realize the recycling potential of plastic mulch.展开更多
The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,e...The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience.展开更多
1.Challenges and opportunities for carbon neutrality Global carbon emissions,primarily from the use of fossil fuels,have dramatically risen since the industrial revolution,leading to an increase in global temperature ...1.Challenges and opportunities for carbon neutrality Global carbon emissions,primarily from the use of fossil fuels,have dramatically risen since the industrial revolution,leading to an increase in global temperature and negatively impacting Earth’s ecosystems.While the coronavirus disease 2019(COVID-19)pandemic’s economic downturn may have temporarily reduced emissions.展开更多
The interaction between light and temperature is known to influence the seasonal growth of trees.Traditional studies on"light"primarily focus on day length,specifically short day(SD)or long day(LD)conditions...The interaction between light and temperature is known to influence the seasonal growth of trees.Traditional studies on"light"primarily focus on day length,specifically short day(SD)or long day(LD)conditions.However,little research has been conducted on the process of transitioning between SD and LD conditions.展开更多
Since Legionella pneumophila(L.pneumophila)was identified in 1976 as the causative microorganism for severe pneumonia termed Legionnaires Disease(LD),more than 65 species belonging to the genus Legionella have been is...Since Legionella pneumophila(L.pneumophila)was identified in 1976 as the causative microorganism for severe pneumonia termed Legionnaires Disease(LD),more than 65 species belonging to the genus Legionella have been isolated worldwide[1].Approximately 20 Legionella spp.have been documented to be pathogenic in humans,primarily leading to transient flu-like illness(Pontiac fever)or rapid and potentially fatal pneumonia(LD).展开更多
Acrolein in spinal cord injury:The propensity of reactive aldehydes such as acrolein to both initiate and perpetuate tissue damage after spinal cord injury (SCI) is well established.Formed primarily from lipid peroxid...Acrolein in spinal cord injury:The propensity of reactive aldehydes such as acrolein to both initiate and perpetuate tissue damage after spinal cord injury (SCI) is well established.Formed primarily from lipid peroxidation,acrolein is known to be one of the most reactive aldehydes.Acrolein will quickly overwhelm endogenous clearance mechanisms and antioxidants,and form adductswith lipids,proteins,and DNA.展开更多
文摘Poor bone quality is a major factor in skeletal fragility in elderly individuals.The molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by osteocytes.We hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material properties.We examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses PLR.The control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)bone.This relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical tests.The effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.
基金supported by A*STAR Career Development Fund (C210112011)National Medical Research Council (MOH-001248-00)(to WHC)+2 种基金Singapore International Graduate Award (to YW)National Research Foundation (NRFNRFF-2018-003)Biomedical Research Council,A*STAR Research Entities (to SYN)
文摘Organoids of the central nervous system,primarily derived from pluripotent stem cells or neural stem cells,are three-dimensional tissue cultures with self-organizing properties.When exposed to the right combinations of signals,they differentiate into a 3D tissue consisting of complex cytoarchitecture and native cell types,including various neuron subtypes and glial cells.These features closely mimic native tissues,making them invaluable for developmental studies and disease modeling.In recent years,spinal cord organoids(SCOs)have been developed to investigate spinal cord development,injuries,and various neurological disorders.As an integral part of the central nervous system,SCOs play a vital role and serve as a site for studying both neurodevelopment and neurodegenerative diseases.
基金supported by JSPS KAKENHI Grant Number JP22K11823 to AH and JP22J01508 to KW。
文摘Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian clock.The hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.
基金supported by grants from the National Natural Science Foundation of China(Grant Nos.42375177,41975141)the Natural Science Foundation of Gansu(Grant No.23JRRA1079)。
文摘The coronavirus disease 2019(COVID-19)outbreak in late 2019 significantly impacted global health.The virus’s rapid spread,with its long incubation period and high infection level,caused substantial disruption to regular social frameworks,production,and lifestyles^([1]).COVID-19 is primarily transmitted through close contact,long-range contaminants,and airborne routes.
基金supported by the National Institutes of Health grants EY034116 (to WKJ, KYK, and SHC) and AG081037 (to YIM and WKJ)。
文摘Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs worldwide.Due to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more prevalent.Glaucoma primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.
基金partially supported by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research(KAKENHI,Grant numbers 23H02865[to KK],23K14927[to CA])the Brain/MINDS Beyond program of the Japan Agency for Medical Research and Development(Grant Number JP19dm0307101[to KK])。
文摘Parkinson's disease(PD)is a progressive neurodegenerative disorder characterized primarily by classical motor signs of bradykinesia,rigidity,tremors,and postural instability usually manifesti ng unilate rally or at least asymmetrically.The disease involves a loss of dopaminergic neurons projecting from the substantia nigra pars compacta to the dorsal striatum.
文摘GENERAL Asian Pacific Journal of Tropical Biomedicine is sponsored by Hainan Medical University Journal Publisher,and aims to set up an acdemic communicating platform for scientists all over the world on tropical biomedicine and related sciences.The Journal invites concise reports of original research in all areas of tropical biomedicine and related fields,both experimental and clinical,including modern,traditional and epidemiological studies,from any part of the world.Review articles based primarily on authors'own research on internationally important topics will be accepted.
文摘Desertification poses significant threats to the ecological security and sustainable economic and social development of countries worldwide. In China, existing desertified land primarily lies between 35°–50°N, covering arid and semi-arid regions and a total area of 1.688×106 km^(2), which represents 17.58%of the total territorial area of the country (Fig. 1).
文摘GENERAL Asian Pacific Journal of Tropical Biomedicine is sponsored by Hainan Medical University Journal Publisher,and aims to set up an acdemic communicating platform for scientists all over the world on tropical biomedicine and related sciences.The Journal invites concise reports of original research in all areas of tropical biomedicine and related fields,both experimental and clinical,including modern,traditional and epidemiological studies,from any part of the world.Review articles based primarily on authors'own research on internationally important topics will be accepted.Short communications and letters to the editor are also welcome.
基金supported by a grant from the Else Kröner-FreseniusStiftung(2020_EKSE.105)the Bundesministerium für Bildung und Forschung(BMBF)01GL2405H.
文摘Background Attention-deficit/hyperactivity disorder(ADHD)is one of the most frequently diagnosed psychiatric conditions in children and adolescents.Although the symptoms appear to be well described,no coherent conceptual mechanistic framework integrates their occurrence and variance and the associated problems that people with ADHD face.Aims The current study proposes that altered event segmentation processes provide a novel mechanistic framework for understanding deficits in ADHD.Methods Adolescents with ADHD and neurotypically developing(NT)peers watched a short movie and were then asked to indicate the boundaries between meaningful segments of the movie.Concomitantly recorded electroencephalography(EEG)data were analysed for differences in frequency band activity and effective connectivity between brain areas.Results Compared with their NT peers,the ADHD group showed less dependence of their segmentation behaviour on social information,indicating that they did not consider social information to the same extent as their unaffected peers.This divergence was accompanied by differences in EEG theta band activity and a different effective connectivity network architecture at the source level.Specifically,NT adolescents primarily showed error signalling in and between the left and right fusiform gyri related to social information processing,which was not the case in the ADHD group.For the ADHD group,the inferior frontal cortex associated with attentional sampling served as a hub instead,indicating problems in the deployment of attentional control.Conclusions This study shows that adolescents with ADHD perceive events differently from their NT peers,in association with a different brain network architecture that reflects less adaptation to the situation and problems in attentional sampling of environmental information.The results call for a novel conceptual view of ADHD,based on event segmentation theory.
基金financially supported by the Shenzhen Science and Technology Program(KCXST20221021111201003)the National Natural Science Foundation of China(52261160384 and 52072208)+6 种基金the Fundamental Research Project of Shenzhen(JCYJ20220818101004009)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01N111)the Shenzhen Science and Technology Program(KCXFZ20211020163810015)the Guangdong Basic and Applied Basic Research Foundation(2022A1515110531)the China Postdoctoral Science Foundation(2022M721800)the support of the Testing Technology Center of Materials and Devices of Tsinghua Shenzhen International Graduate School(SIGS)the Major Science and Technology Infrastructure Project of Material Genome Big-science Facilities Platform supported by Municipal Development and Reform Commission of Shenzhen。
文摘1.Introduction Battery technology,serving as a basis for a rechargeable society,has developed rapidly over a century[1].The progress can be roughly divided into three stages,with the initial two mainly focusing on aqueous battery systems.Prior to 1859,research primarily focused on the conceptualization of batteries and the development of primary(non-rechargeable)cells[2].In the subsequent150 years,rechargeable battery technology emerged。
文摘Introduction Seafood is a widely consumed and nutritionally rich food source,but it ranks among the top allergens,with shellfish and fish being major triggers of allergic reactions.These reactions,primarily caused by proteins such as tropomyosin(TM)in shellfish and parvalbumin(PV)in fish,can lead to life-threatening anaphylaxis in susceptible individuals.The development of hypoallergenic seafood is becoming increasingly important to provide safe alternatives for those with seafood allergies.This comment reviews recent advances in allergenicity mitigation strategies,highlighting the progress made and future potential in producing hypoallergenic seafood products.
文摘In the past,outer space was primarily the domain of a few powerful countries and generally considered separate from broader concerns of human security and development.However,in recent times,space technology development has been a dynamic arena in which the majority of the world’s countries,including countries across the continent of Africa,are actively engaged to address their most pressing socio-economic challenges.Since the turn of the millennium,countries across Africa have demonstrated growing interest in developing their space capabilities to address their most pressing challenges,including but not limited to climate change,poverty,terrorism,and forced migration.
文摘The global market for bioplastic textiles,valued at US$l,046 million in 2022,is projected to expand by15.5%CAGR,reaching$3,827 million by 2032.This substantial growth is primarily driven by the escalating demand for environmentally friendly and sustainable goods in response to growing consumer awareness and governmental regulations aimed at reducing plastic consumption and waste.
基金supported by Specialty Crops Research Initiative Award 2022-51181-38325 from the USDA National Institute of Food and Agriculture and Hatch Projects 1008680 and 1017286.
文摘Plastic mulches have become an essential component of modern agriculture since their introduction in the 1950s.However,disposal of plastic mulches poses serious environmental challenges as plastics that are not considered biodegradable or compostable can take several hundred years to degrade.Each year in the United States,only 9%of overall plastic waste is recycled while 79%is accumulated in landfills or the natural environment.Recycling of plastic mulch is especially constrained due to the contamination that results from their use in farming.Currently,recovered mulches are reported to have 30%–80%surface contamination,primarily from soil and plant debris.Plastic mulch waste is concentrated in areas where they are used and can provide logistical opportunities to the plastic recycling industries.Plastic recycling includes mechanical,advanced(chemical and thermal),and biological methods,that may all be used for polyethylene(PE).Most plastic is recycled using the mechanical method,while advanced and biological methods are promising but face significant financial and technical challenges.For all recycling methods,strategies are needed for managing surface contamination to realize the recycling potential of plastic mulch.
文摘The dental operative microscope has been widely employed in the field of dentistry,particularly in endodontics and operative dentistry,resulting in significant advancements in the effectiveness of root canal therapy,endodontic surgery,and dental restoration.However,the improper use of this microscope continues to be common in clinical settings,primarily due to operators’insufficient understanding and proficiency in both the features and established operating procedures of this equipment.In October 2019,Professor Jingping Liang,Vice Chairman of the Society of Cariology and Endodontology,Chinese Stomatological Association,organized a consensus meeting with Chinese experts in endodontics and operative dentistry.The objective of this meeting was to establish a standard operation procedure for the dental operative microscope.Subsequently,a consensus was reached and officially issued.Over the span of about four years,the content of this consensus has been further developed and improved through practical experience.
文摘1.Challenges and opportunities for carbon neutrality Global carbon emissions,primarily from the use of fossil fuels,have dramatically risen since the industrial revolution,leading to an increase in global temperature and negatively impacting Earth’s ecosystems.While the coronavirus disease 2019(COVID-19)pandemic’s economic downturn may have temporarily reduced emissions.
基金supported by the Outstanding Action Plan of Chinese Sci-tech Journals(Grant No.OAP–C–077)。
文摘The interaction between light and temperature is known to influence the seasonal growth of trees.Traditional studies on"light"primarily focus on day length,specifically short day(SD)or long day(LD)conditions.However,little research has been conducted on the process of transitioning between SD and LD conditions.
基金supported by the Research Project of Chongqing Municipal Education Commission[KJZD-K202002802]the Joint Medical Research Project of Chongqing[2021MSXM254]Internal Grants of Chongqing Medical and Pharmaceutical College[YGZ2020303 and YGZ2021107].
文摘Since Legionella pneumophila(L.pneumophila)was identified in 1976 as the causative microorganism for severe pneumonia termed Legionnaires Disease(LD),more than 65 species belonging to the genus Legionella have been isolated worldwide[1].Approximately 20 Legionella spp.have been documented to be pathogenic in humans,primarily leading to transient flu-like illness(Pontiac fever)or rapid and potentially fatal pneumonia(LD).
文摘Acrolein in spinal cord injury:The propensity of reactive aldehydes such as acrolein to both initiate and perpetuate tissue damage after spinal cord injury (SCI) is well established.Formed primarily from lipid peroxidation,acrolein is known to be one of the most reactive aldehydes.Acrolein will quickly overwhelm endogenous clearance mechanisms and antioxidants,and form adductswith lipids,proteins,and DNA.
