The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,...The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.展开更多
Damage smear method(DSM)is adopted to study trans-scale progressive rock failure process,based on statistical meso-damage model and finite element solver.The statistical approach is utilized to reflect the mesoscopic ...Damage smear method(DSM)is adopted to study trans-scale progressive rock failure process,based on statistical meso-damage model and finite element solver.The statistical approach is utilized to reflect the mesoscopic rock heterogeneity.The constitutive law of representative volume element(RVE)is established according to continuum damage mechanics in which double-damage criterion is considered.The damage evolution and accumulation of RVEs are used to reveal the macroscopic rock failure characteristics.Each single RVE will be represented by one unique element.The initiation,propagation and coalescence of meso-to macro-cracks are captured by smearing failed elements.The above ideas are formulated into the framework of the DSM and programed into self-developed rock failure process analysis(RFPA)software.Two laboratory-scale examples are conducted and the well-known engineering-scale tests,i.e.Atomic Energy of Canada Limited’s(AECL’s)Underground Research Laboratory(URL)tests,are used for verification.It shows that the simulation results match with other experimental results and field observations.展开更多
The process analysis is performed for August and December, 2002 using the process analysis tool embedded in the Community Multiscale Air Quality (CMAQ) modeling system at a fine horizontal grid resolution of 4-km over...The process analysis is performed for August and December, 2002 using the process analysis tool embedded in the Community Multiscale Air Quality (CMAQ) modeling system at a fine horizontal grid resolution of 4-km over an area in the southeastern U.S. that is centered at North Carolina. The objectives are to qunatify the contributions of major atmospheric processes to the formation of major air pollutants and provide the insights into photochemistry that governs the fate of these pollutants at a fine grid scale. The results show that emissions provide a dominant source for gases including ammonia (NH3), nitric oxide (NO), nitrogen dioxide (NO2), and sulfur dioxide (SO2) and Particulate Matter (PM) species including fine PM (PM2.5) and its composition such as sulfate, elemental carbon, primary organic aerosol, and other inorganic fine PM in both months. While transport acts as a major sink for NH3, NO, and SO2 at most sites and PM2.5 and most of PM2.5 composition at urban sites, it provides a major source for nitric acid (HNO3) and ozone (O3) at most sites in both months, and secondary PM species in August and most PM species in December at rural and remote sites. Gas-phase chemistry serves as a source for NO2 and HNO3 but a sink for O3 at urban and suburban sites and for NO and SO2 at all sites. PM processes contribute to the formation of PM2.5 and nitrate () at the urban and suburban sites and secondary organic aerosol (SOA) at most sites in December and ammonium () in both months. They reduce formation at most sites in August and at rural and remote sites in December and the formation of PM2.5 and SOA at most sites in August. Dry deposition is an important sink for all these species in both months. The total odd oxygen (Ox) production and the total hydroxyl radical (OH) reacted are much higher at urban and suburban sites than at rural sites. Significant amounts of OH are consumed by biogenic volatile organic compounds (BVOCs) in the rural and remote areas and a combination of anthropogenic VOCs (AVOCs) and BVOCs in urban and subareas areas in August and mainly by AVOCs in December. The amount of NO2 produced by the reactions of hydroperoxy radical (HO2) is similar to that of organic peroxy radical (RO2) at all sites in August but higher than that by the reactions of RO2 inDecember. The production rate of HNO3 due to the reaction of OH with NO2 dominates in both months. The ratio of the production rates of hydrogen peroxide (H2O2) and HNO3 (PH2O2/PHNO3) is a more robust photochemical indicator than the ratios of their mixing ratios (H2O2/HNO3) and the afternoon mixing ratios of NOy in both months, and it is highly sensitive to the horizontal grid resolution in August. The use of PH2O2/PHNO3 simulated at 4-km indicates a VOC-limited O3 chemistry in urban and suburban areas in August that was not captured in previous model simulations at a coarser grid resolution.展开更多
The Niumiangou landslide was the largest landslide triggered by the 2008 Wenchuan earthquake,which was significantly affected by the amplification effect of seismic acceleration.The ringshear experiments indicated tha...The Niumiangou landslide was the largest landslide triggered by the 2008 Wenchuan earthquake,which was significantly affected by the amplification effect of seismic acceleration.The ringshear experiments indicated that the materials in the source area of the Niumiangou landslide were subjected to friction degradation under a big shear displacement,which may result in rapid movement of the landslide.In order to better understand the landslide movement and study the effect of the friction degradation on movement mechanisms,the dynamic process of Niumiangou landslide was simulated with a new numerical method,which combines the finite difference method(FDM)and the discontinuous deformation analysis(DDA).First,the FDM was used to study the initiation time,amplification effect and velocity of the landslide.Afterwards,these initiation velocities were applied to the blocks in the DDA model by corresponding coordination in the FDM model.A displacementdependent friction model of the sliding surface was incorporated into DDA code to further understand the kinetic behavior of the landslide.The results show that the displacement-dependent friction strongly decreases the friction coefficient of sliding surface under a big displacement,which can obviously promote the run-out and velocity of landslide.The model output well matches the topographic map formed by the landslide.This implies that the proposed model can be applied to the simulation of earthquake-induced landslides with amplification effect,and the friction degradation model is important to clarify the movement mechanism of high-speed and long-distance landslides.展开更多
In this paper we present the main phases of the BP-M* methodology and its application to a care pathway for patients in the Oncology Division of a large hospital, to evaluate pros and cons of different drug administra...In this paper we present the main phases of the BP-M* methodology and its application to a care pathway for patients in the Oncology Division of a large hospital, to evaluate pros and cons of different drug administration modalities and the impact of these modalities to the organizational process. BP-M* has been developed for the manufacturing sector but the relevance of business modeling, analysis and reorganization is not restricted to a specific sector. The aim of this work is to show its application to a real life study of a complex process in the health sector.展开更多
During the pipeline plugging process,both the pipeline and the pipe isolation tool(PIT)will be greatly damaged,due to the violent vibration of the flow field.In this study,it was proposed for the first time to reduce ...During the pipeline plugging process,both the pipeline and the pipe isolation tool(PIT)will be greatly damaged,due to the violent vibration of the flow field.In this study,it was proposed for the first time to reduce the vibration of the flow field during the plugging process by optimizing the surface structure of the PIT.Firstly,the central composite design(CCD)was used to obtain the optimization schemes,and the drag coefficient and pressure coefficient were proposed to evaluate the degree of flow field changes.Secondly,a series of computational fluid dynamics(CFD)simulations were performed to obtain the drag coefficient and pressure coefficient during dynamic plugging.And the mathematical model of drag coefficient and pressure coefficient with the surface structure of the PIT were established respectively.Then,a modified particle swarm optimization(PSO)was applied to predict the optimal value of the surface structure of the PIT.Finally,an experimental rig was built to verify the effectiveness of the optimization.The results showed that the improved method could reduce the flow field vibration by 49.56%.This study provides a reference for the design of the PIT surface structure for flow field vibration technology.展开更多
This article proposes a framework, called BP-M* which includes: 1) a methodology to analyze, engineer, restructure and implement business processes, and 2) a process model that extends the process diagram with the spe...This article proposes a framework, called BP-M* which includes: 1) a methodology to analyze, engineer, restructure and implement business processes, and 2) a process model that extends the process diagram with the specification of resources that execute the process activities, allocation policies, schedules, times of activities, management of queues in input to the activities and workloads so that the same model can be simulated by a discrete event simulator. The BP-M* framework has been applied to a real case study, a public Contact Center which provides different typologies of answers to users’ requests. The simulation allows to study different system operating scenarios (“What-If” analysis) providing useful information for analysts to evaluate restructuring actions.展开更多
The aluminum alloy parts used in airbag of car were studied with flow control forming(FCF) method, which was a good way to low forming force and better mechanical properties. The key technology of FCF was the design o...The aluminum alloy parts used in airbag of car were studied with flow control forming(FCF) method, which was a good way to low forming force and better mechanical properties. The key technology of FCF was the design of control chamber to divide metal flow. So, the design method of FCF was analyzed and two type of control chamber were put forward. According to divisional principle, calculation model of forming force and approximate formula were given. Then forming process of aluminum alloy multi-layer cylinder parts was simulated. The effect of friction factor, die radius and punch velocity on metal flow and forming force was obtained. Finally, the experiment was preformed under the direction of theory and finite element(FE) simulation results. And the qualified parts were manufactured. The simulation data and experimental results show that the forming sequence of inner wall and outer wall, and then the force step, can be controlled by adjusting the process parameters. And the FCF technology proposed has very important application value in precision forging.展开更多
A multiple-pollutant version of CMAQ v4.6 (i.e., CMAQ-MP) has been applied by the US EPA over continental US in 2002 to demonstrate the model’s capability in reproducing the long-term trends of ambient criteria and h...A multiple-pollutant version of CMAQ v4.6 (i.e., CMAQ-MP) has been applied by the US EPA over continental US in 2002 to demonstrate the model’s capability in reproducing the long-term trends of ambient criteria and hazardous air pollutants (CAPs and HAPs, respectively) in support of regulatory analysis for air quality management. In this study, a comprehensive model performance evaluation for the full year of 2002 is performed for the first time for CMAQ-MP using the surface networks and satellite measurements. CMAQ-MP shows a comparable and improved performance for most CAPs species as compared to an older version of CMAQ that did not treat HAPs and used older versions of national emission inventories. CMAQ-MP generally gives better performance for CAPs than for HAPs. Max 8-h ozone (O3) mixing ratios are well reproduced in the O3season. The seasonal-mean performance is fairly good for fine particulate matter (PM2.5), sulfate (SO42-), and mercury (Hg) wet deposition and worse for other CAPs and HAPs species. The reasons for the model biases may be attributed to uncertainties in emissions for some species (e.g., ammonia (NH3), elemental carbon (EC), primary organic aerosol (POA), HAPs), gas/aerosol chemistry treatments (e.g., secondary or- ganic aerosol formation, meteorology (e.g., overestimate in summer precipitation), measurements (e.g., NO3-), and the use of a coarse grid resolution. CMAQ cannot well reproduce spatial and seasonal variations of column variables except for nitrogen dioxide (NO2) and the ratio of column mass of HCHO/NO2. Possible reasons include inaccurate seasonal allocation or underestimation of emissions, inaccurate BCONs at higher altitudes, lack of model treatments such as mineral dust or plume-in-grid process, and limitations and errors in satellite data retrievals. The process analysis results show that in addition to transport, gas chemistry or aerosol/emissions play the most important roles for O3 or PM2.5, respectively. For most HAPs, emissions are important sources and cloud processes are a major sink. Simulated P H2 H O2/P HNO3 and HCHO/NO2 indicate VOC-limited chemistry in major urban areas throughout the year and in other non-urban areas in winter, but NOx-limited chemistry in most areas in summer.展开更多
A geometry model of field evaporation process is set up;with this model the field evaporation process can be described as Markov process.Its application to the earliest stage of phase transition is studied.For compari...A geometry model of field evaporation process is set up;with this model the field evaporation process can be described as Markov process.Its application to the earliest stage of phase transition is studied.For comparison,Camus’system Fe-Cr 45 at.%is calculated again,and the same result is extracted from our method and intimated in our experimental data.展开更多
Business process improvement is a systematic approach used by several organizations to continuously improve their quality of service.Integral to that is analyzing the current performance of each task of the process an...Business process improvement is a systematic approach used by several organizations to continuously improve their quality of service.Integral to that is analyzing the current performance of each task of the process and assigning the most appropriate resources to each task.In continuation of our previous work,we categorize resources into human and non-human resources.For instance,in the healthcare domain,human resources include doctors,nurses,and other associated staff responsible for the execution of healthcare activities;whereas the non-human resources include surgical and other equipment needed for execution.In this study,we contend that the two types of resources(human and non-human)have a different impact on the process performance,so their suitability should be measured differently.However,no work has been done to evaluate the suitability of non-human resources for the tasks of a process.Consequently,it becomes difficult to identify and subsequently overcome the inefficiencies caused by the non-human resources to the task.To address this problem,we present a three-step method to compute a suitability score of non-human resources for the task.As an evaluation of the proposed method,a healthcare case study is used to illustrate the applicability of the proposed method.Furthermore,we performed a controlled experiment to evaluate the usability of the proposed method.The encouraging response shows the usefulness of the proposed method.展开更多
The successful fabrication of layered hybrid beads by DLM process is limited by dissimilar melting ranges of different powders.For the application of DLM process into manufacturing industries,target mechanical propert...The successful fabrication of layered hybrid beads by DLM process is limited by dissimilar melting ranges of different powders.For the application of DLM process into manufacturing industries,target mechanical properties of final product must be achieved.Process analysis was performed for the DLM fabrication of layered hybrid beads by using stainless steel (SS 316L) and titanium powders.For the analysis of fabrication characteristics,single hybrid bead was formed using SS316L powder onto the base plate and then Ti powder was melted onto the previous melted layer.In addition,multi-layer hybrid beads were fabricated for the analysis of the layering effects between them.From these studies,the effects of the processing parameters,such as laser power,scan rate and scan line spacing on surface morphology were characterized and optimum processing conditions for the DLM fabrication of layered hybrid beads were developed.展开更多
RFPA is a numerical testing tool for realistic failure process analysis(RFPA)of rock,concrete,compostites,and engineering structures.The RFPA solution offers perfect simulation tools for robust modelling of brittle ma...RFPA is a numerical testing tool for realistic failure process analysis(RFPA)of rock,concrete,compostites,and engineering structures.The RFPA solution offers perfect simulation tools for robust modelling of brittle material failure and engineering structural damage.The RFPA family of 2D and3D core products offers the full depth of analysis tools-from a conceptual simulation to advanced analysis,and has wider breadth of展开更多
Pharmaceutical production is changing from batch production to continuous production,during which granulation is one of the most important unit operations.The quality of mass-produced products is traditionally guarant...Pharmaceutical production is changing from batch production to continuous production,during which granulation is one of the most important unit operations.The quality of mass-produced products is traditionally guaranteed by conducting off-line testing,which cannot meet the demand of continuous production for real-time monitoring of critical process parameters and critical quality attributes(CQAs)of the pharmaceutical granulation technology.Since the U.S.Food and Drug Administration proposed process analytical technology(PAT)in 2004,many PAT tools have been developed to monitor the granulation process and provide information regarding the granulation operation conditions and endpoint determination.In this article,we review the recent research and application of two PAT modes in the granulation process,namely,single CQA and multi-CQA PAT,with the aim to provide references for comprehensively improving the technological level of the pharmaceutical granulation process.Furthermore,the potential applications in traditional Chinese Medicine are discussed.展开更多
Base on industrial research and experience, the process of methanol distillation is analyzed,and above all, a new concept of high pressure flowsheet and low pressure flowsheet is defined. The new configuration helps t...Base on industrial research and experience, the process of methanol distillation is analyzed,and above all, a new concept of high pressure flowsheet and low pressure flowsheet is defined. The new configuration helps to handle problems encountered in many factories in China. The inter influence between process and column internal pattern is also pointed out. Recommendation of new column internal designs is given. Finally, industrial examples tell the how the new concept works and the possibility of combining process to give more opens to solve engineering problems.展开更多
In order to study the failure process of an anchorage structure and the evolution law of the body’s deformation field,anchor push-out tests were carried out based on digital speckle correlation methods(DSCM).The stre...In order to study the failure process of an anchorage structure and the evolution law of the body’s deformation field,anchor push-out tests were carried out based on digital speckle correlation methods(DSCM).The stress distribution of the anchorage interface was investigated using the particle flow numerical simulation method.The results indicate that there are three stages in the deformation and failure process of an anchorage structure:elastic bonding stage,a de-bonding stage and a failure stage.The stress distribution in the interface controls the stability of the structure.In the elastic bonding stage,the shear stress peak point of the interface is close to the loading end,and the displacement field gradually develops into a‘‘V’’shape.In the de-bonding stage,there is a shear stress plateau in the center of the anchorage section,and shear strain localization begins to form in the deformation field.In the failure stage,the bonding of the interface fails rapidly and the shear stress peak point moves to the anchorage free end.The anchorage structure moves integrally along the macro-crack.The de-bonding stage is a research focus in the deformation and failure process of an anchorage structure,and plays an important guiding role in roadway support design and prediction of the stability of the surrounding rock.展开更多
Brittle failure of rocks is a classical rock mechanical problem.Rock failure not only involves initiation and propagation of single crack,but also is associated with initiation,propagation and coalescence of many crac...Brittle failure of rocks is a classical rock mechanical problem.Rock failure not only involves initiation and propagation of single crack,but also is associated with initiation,propagation and coalescence of many cracks.The rock failure process analysis(RFPA)tool has been proposed since 1995.The heterogeneity of rocks at a mesoscopic level is considered by assuming that the material properties follow the Weibull distribution.Elastic damage mechanics is used for describing the constitutive law of the meso-level element.The finite element method(FEM)is employed as the basic stress analysis tool.The maximum tensile strain criterion and the Mohr-Coulomb criterion are utilized as the damage threshold.In order to solve the stability problem related to rock engineering structures,fundamental principles of strength reduction method(SRM)and gravity increase method(GIM)are integrated into the RFPA.And the acoustic emission(AE)event rate is employed as the criterion for rock engineering failure.The prominent feature of the RFPA-SRM and RFPA-GIM for stability analysis of rock engineering is that the factor of safety can be obtained without any presumption for the shape and location of the failure surface.In this paper,several geotechnical engineering applications that use the RFPA method to analyze their stability are presented to provide some references for relevant researches.The principles of the RFPA method in engineering are introduced firstly,and then the stability analysis of tunnel,slope and dam is focused on.The results indicate that the RFPA method is capable of capturing the mechanism of rock engineering stability and has the potential for application in a larger range of geo-engineering.展开更多
A big debris flow which was arosed by landslide occurrence at night on July 11, 2003 in Qiongshan Ravine, Danba, Sichuan Province. According to the research, debris flow in Qiongshan Ravine is arosed by the fluidizati...A big debris flow which was arosed by landslide occurrence at night on July 11, 2003 in Qiongshan Ravine, Danba, Sichuan Province. According to the research, debris flow in Qiongshan Ravine is arosed by the fluidization of landslide. It had been rained about 70 days before debris flow occurred. That made the sediments in the gully to near to saturated or saturated in water. Being affect by the steep geography, the sediments occurrence peristalsis to transform, parts of soil bodies start disintegrate. All the sediments become transforming with water inleakaging to sediments, and than foreside slope flow to gully quickly after becoming fluidization. And the sediments come into being the debris flow with the water of the gully joining.展开更多
Web service(WS) is an emerging software technology,especially acting an important role in cloud computing.The WS choreography description language(WS-CDL) is the standard for modeling the observable behavior of WS com...Web service(WS) is an emerging software technology,especially acting an important role in cloud computing.The WS choreography description language(WS-CDL) is the standard for modeling the observable behavior of WS composition across multiple participants from a global point of view.However,it lacks of a formal semantics and could easily lead to misunderstanding and different implementations.In this paper,the WS-CDL based specifications are formally extracted in a communicating sequential process supporting a formal approach to checking WS models.In addition,formalisms and model checking are explicitly illustrated through a simple but non-trivial example with the help of model checker process analysis toolkit(PAT).展开更多
In order to obtain better quality cookies, food 3D printing technology was employed to prepare cookies. The texture, color, deformation, moisture content, and temperature of the cookie as evaluation indicators, the in...In order to obtain better quality cookies, food 3D printing technology was employed to prepare cookies. The texture, color, deformation, moisture content, and temperature of the cookie as evaluation indicators, the influences of baking process parameters, such as baking time, surface heating temperature and bottom heating temperature, on the quality of the cookie were studied to optimize the baking process parameters. The results showed that the baking process parameters had obvious effects on the texture, color, deformation, moisture content, and temperature of the cookie. All of the roasting surface heating temperature, bottom heating temperature and baking time had positive influences on the hardness, crunchiness, crispiness, and the total color difference(ΔE) of the cookie. When the heating temperatures of the surfac and bottom increased, the diameter and thickness deformation rate of the cookie increased. However,with the extension of baking time, the diameter and thickness deformation rate of the cookie first increased and then decreased. With the surface heating temperature of 180 ℃, the bottom heating temperature of 150 ℃, and baking time of 15 min, the cookie was crisp and moderate with moderate deformation and uniform color. There was no burnt phenomenon with the desired quality. Research results provided a theoretical basis for cookie manufactory based on food 3D printing technology.展开更多
基金supported by Ministry of Science and Technology of the People's Republic of China(Grant No.:2022YFC3502300)Beijing Natural Science Foundation(Grant No.:L222150)+2 种基金the National Natural Science Foundation of China(Grant No.:82072247)the second batch of“Ten thousand plan”National High Level Talents Special Support Plan(Grant No.:W02020052)Beijing University of Chinese Medicine(Grant Nos.:XJYS21005,JY21024,MSGZF-202001,2022-syjs-05,and 2022-syjs-10).
文摘The automation of traditional Chinese medicine(TCM)pharmaceuticals has driven the development of process analysis from offline to online.Most of common online process analytical technologies are based on spectroscopy,making the identification and quantification of specific ingredients still a challenge.Herein,we developed a quality control(QC)system for monitoring TCM pharmaceuticals based on paper spray ionization miniature mass spectrometry(mini-MS).It enabled real-time online qualitative and quantitative detection of target ingredients in herbal extracts using mini-MS without chromatographic separation for the first time.Dynamic changes of alkaloids in Aconiti Lateralis Radix Praeparata(Fuzi)during decoction were used as examples,and the scientific principle of Fuzi compatibility was also investigated.Finally,the system was verified to work stably at the hourly level for pilot-scale extraction.This mini-MS based online analytical system is expected to be further developed for QC applications in a wider range of pharmaceutical processes.
基金supported in part by the National Natural Science Foundation of China (Grant Nos.51679028 and 51879034)Key Laboratory for Geomechanics and Deep Underground Engineering, China University of Mining and Technology (Grant No. SKLGDUEK1804)the Fundamental Research Funds for the Central Universities (Grant No.DUT18JC10)
文摘Damage smear method(DSM)is adopted to study trans-scale progressive rock failure process,based on statistical meso-damage model and finite element solver.The statistical approach is utilized to reflect the mesoscopic rock heterogeneity.The constitutive law of representative volume element(RVE)is established according to continuum damage mechanics in which double-damage criterion is considered.The damage evolution and accumulation of RVEs are used to reveal the macroscopic rock failure characteristics.Each single RVE will be represented by one unique element.The initiation,propagation and coalescence of meso-to macro-cracks are captured by smearing failed elements.The above ideas are formulated into the framework of the DSM and programed into self-developed rock failure process analysis(RFPA)software.Two laboratory-scale examples are conducted and the well-known engineering-scale tests,i.e.Atomic Energy of Canada Limited’s(AECL’s)Underground Research Laboratory(URL)tests,are used for verification.It shows that the simulation results match with other experimental results and field observations.
文摘The process analysis is performed for August and December, 2002 using the process analysis tool embedded in the Community Multiscale Air Quality (CMAQ) modeling system at a fine horizontal grid resolution of 4-km over an area in the southeastern U.S. that is centered at North Carolina. The objectives are to qunatify the contributions of major atmospheric processes to the formation of major air pollutants and provide the insights into photochemistry that governs the fate of these pollutants at a fine grid scale. The results show that emissions provide a dominant source for gases including ammonia (NH3), nitric oxide (NO), nitrogen dioxide (NO2), and sulfur dioxide (SO2) and Particulate Matter (PM) species including fine PM (PM2.5) and its composition such as sulfate, elemental carbon, primary organic aerosol, and other inorganic fine PM in both months. While transport acts as a major sink for NH3, NO, and SO2 at most sites and PM2.5 and most of PM2.5 composition at urban sites, it provides a major source for nitric acid (HNO3) and ozone (O3) at most sites in both months, and secondary PM species in August and most PM species in December at rural and remote sites. Gas-phase chemistry serves as a source for NO2 and HNO3 but a sink for O3 at urban and suburban sites and for NO and SO2 at all sites. PM processes contribute to the formation of PM2.5 and nitrate () at the urban and suburban sites and secondary organic aerosol (SOA) at most sites in December and ammonium () in both months. They reduce formation at most sites in August and at rural and remote sites in December and the formation of PM2.5 and SOA at most sites in August. Dry deposition is an important sink for all these species in both months. The total odd oxygen (Ox) production and the total hydroxyl radical (OH) reacted are much higher at urban and suburban sites than at rural sites. Significant amounts of OH are consumed by biogenic volatile organic compounds (BVOCs) in the rural and remote areas and a combination of anthropogenic VOCs (AVOCs) and BVOCs in urban and subareas areas in August and mainly by AVOCs in December. The amount of NO2 produced by the reactions of hydroperoxy radical (HO2) is similar to that of organic peroxy radical (RO2) at all sites in August but higher than that by the reactions of RO2 inDecember. The production rate of HNO3 due to the reaction of OH with NO2 dominates in both months. The ratio of the production rates of hydrogen peroxide (H2O2) and HNO3 (PH2O2/PHNO3) is a more robust photochemical indicator than the ratios of their mixing ratios (H2O2/HNO3) and the afternoon mixing ratios of NOy in both months, and it is highly sensitive to the horizontal grid resolution in August. The use of PH2O2/PHNO3 simulated at 4-km indicates a VOC-limited O3 chemistry in urban and suburban areas in August that was not captured in previous model simulations at a coarser grid resolution.
基金supported by the National Natural Science Foundation of China(Nos.4167230041902290)Opening fund of State Key Laboratory of Geohazard Prevention and Geoenvironment Protection(Chengdu University of Technology)(No.SKLGP2017K015)。
文摘The Niumiangou landslide was the largest landslide triggered by the 2008 Wenchuan earthquake,which was significantly affected by the amplification effect of seismic acceleration.The ringshear experiments indicated that the materials in the source area of the Niumiangou landslide were subjected to friction degradation under a big shear displacement,which may result in rapid movement of the landslide.In order to better understand the landslide movement and study the effect of the friction degradation on movement mechanisms,the dynamic process of Niumiangou landslide was simulated with a new numerical method,which combines the finite difference method(FDM)and the discontinuous deformation analysis(DDA).First,the FDM was used to study the initiation time,amplification effect and velocity of the landslide.Afterwards,these initiation velocities were applied to the blocks in the DDA model by corresponding coordination in the FDM model.A displacementdependent friction model of the sliding surface was incorporated into DDA code to further understand the kinetic behavior of the landslide.The results show that the displacement-dependent friction strongly decreases the friction coefficient of sliding surface under a big displacement,which can obviously promote the run-out and velocity of landslide.The model output well matches the topographic map formed by the landslide.This implies that the proposed model can be applied to the simulation of earthquake-induced landslides with amplification effect,and the friction degradation model is important to clarify the movement mechanism of high-speed and long-distance landslides.
文摘In this paper we present the main phases of the BP-M* methodology and its application to a care pathway for patients in the Oncology Division of a large hospital, to evaluate pros and cons of different drug administration modalities and the impact of these modalities to the organizational process. BP-M* has been developed for the manufacturing sector but the relevance of business modeling, analysis and reorganization is not restricted to a specific sector. The aim of this work is to show its application to a real life study of a complex process in the health sector.
基金financially supported by the National Natural Science Foundation of China(Grant No.51575528)。
文摘During the pipeline plugging process,both the pipeline and the pipe isolation tool(PIT)will be greatly damaged,due to the violent vibration of the flow field.In this study,it was proposed for the first time to reduce the vibration of the flow field during the plugging process by optimizing the surface structure of the PIT.Firstly,the central composite design(CCD)was used to obtain the optimization schemes,and the drag coefficient and pressure coefficient were proposed to evaluate the degree of flow field changes.Secondly,a series of computational fluid dynamics(CFD)simulations were performed to obtain the drag coefficient and pressure coefficient during dynamic plugging.And the mathematical model of drag coefficient and pressure coefficient with the surface structure of the PIT were established respectively.Then,a modified particle swarm optimization(PSO)was applied to predict the optimal value of the surface structure of the PIT.Finally,an experimental rig was built to verify the effectiveness of the optimization.The results showed that the improved method could reduce the flow field vibration by 49.56%.This study provides a reference for the design of the PIT surface structure for flow field vibration technology.
文摘This article proposes a framework, called BP-M* which includes: 1) a methodology to analyze, engineer, restructure and implement business processes, and 2) a process model that extends the process diagram with the specification of resources that execute the process activities, allocation policies, schedules, times of activities, management of queues in input to the activities and workloads so that the same model can be simulated by a discrete event simulator. The BP-M* framework has been applied to a real case study, a public Contact Center which provides different typologies of answers to users’ requests. The simulation allows to study different system operating scenarios (“What-If” analysis) providing useful information for analysts to evaluate restructuring actions.
文摘The aluminum alloy parts used in airbag of car were studied with flow control forming(FCF) method, which was a good way to low forming force and better mechanical properties. The key technology of FCF was the design of control chamber to divide metal flow. So, the design method of FCF was analyzed and two type of control chamber were put forward. According to divisional principle, calculation model of forming force and approximate formula were given. Then forming process of aluminum alloy multi-layer cylinder parts was simulated. The effect of friction factor, die radius and punch velocity on metal flow and forming force was obtained. Finally, the experiment was preformed under the direction of theory and finite element(FE) simulation results. And the qualified parts were manufactured. The simulation data and experimental results show that the forming sequence of inner wall and outer wall, and then the force step, can be controlled by adjusting the process parameters. And the FCF technology proposed has very important application value in precision forging.
文摘A multiple-pollutant version of CMAQ v4.6 (i.e., CMAQ-MP) has been applied by the US EPA over continental US in 2002 to demonstrate the model’s capability in reproducing the long-term trends of ambient criteria and hazardous air pollutants (CAPs and HAPs, respectively) in support of regulatory analysis for air quality management. In this study, a comprehensive model performance evaluation for the full year of 2002 is performed for the first time for CMAQ-MP using the surface networks and satellite measurements. CMAQ-MP shows a comparable and improved performance for most CAPs species as compared to an older version of CMAQ that did not treat HAPs and used older versions of national emission inventories. CMAQ-MP generally gives better performance for CAPs than for HAPs. Max 8-h ozone (O3) mixing ratios are well reproduced in the O3season. The seasonal-mean performance is fairly good for fine particulate matter (PM2.5), sulfate (SO42-), and mercury (Hg) wet deposition and worse for other CAPs and HAPs species. The reasons for the model biases may be attributed to uncertainties in emissions for some species (e.g., ammonia (NH3), elemental carbon (EC), primary organic aerosol (POA), HAPs), gas/aerosol chemistry treatments (e.g., secondary or- ganic aerosol formation, meteorology (e.g., overestimate in summer precipitation), measurements (e.g., NO3-), and the use of a coarse grid resolution. CMAQ cannot well reproduce spatial and seasonal variations of column variables except for nitrogen dioxide (NO2) and the ratio of column mass of HCHO/NO2. Possible reasons include inaccurate seasonal allocation or underestimation of emissions, inaccurate BCONs at higher altitudes, lack of model treatments such as mineral dust or plume-in-grid process, and limitations and errors in satellite data retrievals. The process analysis results show that in addition to transport, gas chemistry or aerosol/emissions play the most important roles for O3 or PM2.5, respectively. For most HAPs, emissions are important sources and cloud processes are a major sink. Simulated P H2 H O2/P HNO3 and HCHO/NO2 indicate VOC-limited chemistry in major urban areas throughout the year and in other non-urban areas in winter, but NOx-limited chemistry in most areas in summer.
文摘A geometry model of field evaporation process is set up;with this model the field evaporation process can be described as Markov process.Its application to the earliest stage of phase transition is studied.For comparison,Camus’system Fe-Cr 45 at.%is calculated again,and the same result is extracted from our method and intimated in our experimental data.
文摘Business process improvement is a systematic approach used by several organizations to continuously improve their quality of service.Integral to that is analyzing the current performance of each task of the process and assigning the most appropriate resources to each task.In continuation of our previous work,we categorize resources into human and non-human resources.For instance,in the healthcare domain,human resources include doctors,nurses,and other associated staff responsible for the execution of healthcare activities;whereas the non-human resources include surgical and other equipment needed for execution.In this study,we contend that the two types of resources(human and non-human)have a different impact on the process performance,so their suitability should be measured differently.However,no work has been done to evaluate the suitability of non-human resources for the tasks of a process.Consequently,it becomes difficult to identify and subsequently overcome the inefficiencies caused by the non-human resources to the task.To address this problem,we present a three-step method to compute a suitability score of non-human resources for the task.As an evaluation of the proposed method,a healthcare case study is used to illustrate the applicability of the proposed method.Furthermore,we performed a controlled experiment to evaluate the usability of the proposed method.The encouraging response shows the usefulness of the proposed method.
基金Project(2012-0000-965)supported by the National Core Research Center Program through the National Research Foundation of Korea Funded by the Ministry of Education,Science and Technology
文摘The successful fabrication of layered hybrid beads by DLM process is limited by dissimilar melting ranges of different powders.For the application of DLM process into manufacturing industries,target mechanical properties of final product must be achieved.Process analysis was performed for the DLM fabrication of layered hybrid beads by using stainless steel (SS 316L) and titanium powders.For the analysis of fabrication characteristics,single hybrid bead was formed using SS316L powder onto the base plate and then Ti powder was melted onto the previous melted layer.In addition,multi-layer hybrid beads were fabricated for the analysis of the layering effects between them.From these studies,the effects of the processing parameters,such as laser power,scan rate and scan line spacing on surface morphology were characterized and optimum processing conditions for the DLM fabrication of layered hybrid beads were developed.
文摘RFPA is a numerical testing tool for realistic failure process analysis(RFPA)of rock,concrete,compostites,and engineering structures.The RFPA solution offers perfect simulation tools for robust modelling of brittle material failure and engineering structural damage.The RFPA family of 2D and3D core products offers the full depth of analysis tools-from a conceptual simulation to advanced analysis,and has wider breadth of
基金the National Natural Sciences Foundation of China(No.82074276)Tianjin Science and Technology project(No.20ZYJDJC00090).
文摘Pharmaceutical production is changing from batch production to continuous production,during which granulation is one of the most important unit operations.The quality of mass-produced products is traditionally guaranteed by conducting off-line testing,which cannot meet the demand of continuous production for real-time monitoring of critical process parameters and critical quality attributes(CQAs)of the pharmaceutical granulation technology.Since the U.S.Food and Drug Administration proposed process analytical technology(PAT)in 2004,many PAT tools have been developed to monitor the granulation process and provide information regarding the granulation operation conditions and endpoint determination.In this article,we review the recent research and application of two PAT modes in the granulation process,namely,single CQA and multi-CQA PAT,with the aim to provide references for comprehensively improving the technological level of the pharmaceutical granulation process.Furthermore,the potential applications in traditional Chinese Medicine are discussed.
文摘Base on industrial research and experience, the process of methanol distillation is analyzed,and above all, a new concept of high pressure flowsheet and low pressure flowsheet is defined. The new configuration helps to handle problems encountered in many factories in China. The inter influence between process and column internal pattern is also pointed out. Recommendation of new column internal designs is given. Finally, industrial examples tell the how the new concept works and the possibility of combining process to give more opens to solve engineering problems.
基金financially supported by the National Key Basic Research Program of China (No.2010CB226805)the National Natural Science Foundation of China (Nos.51474136 and 51474013)+1 种基金the Opening Project Fund of State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology (No.MDPC2013KF06)the Research Award Fund for the Excellent Youth of Shandong University of Science and Technology (No.2011KYJQ106)
文摘In order to study the failure process of an anchorage structure and the evolution law of the body’s deformation field,anchor push-out tests were carried out based on digital speckle correlation methods(DSCM).The stress distribution of the anchorage interface was investigated using the particle flow numerical simulation method.The results indicate that there are three stages in the deformation and failure process of an anchorage structure:elastic bonding stage,a de-bonding stage and a failure stage.The stress distribution in the interface controls the stability of the structure.In the elastic bonding stage,the shear stress peak point of the interface is close to the loading end,and the displacement field gradually develops into a‘‘V’’shape.In the de-bonding stage,there is a shear stress plateau in the center of the anchorage section,and shear strain localization begins to form in the deformation field.In the failure stage,the bonding of the interface fails rapidly and the shear stress peak point moves to the anchorage free end.The anchorage structure moves integrally along the macro-crack.The de-bonding stage is a research focus in the deformation and failure process of an anchorage structure,and plays an important guiding role in roadway support design and prediction of the stability of the surrounding rock.
基金Supported by the State Key Development Program for Basic Research of China(2007CB209400)Projects of International Cooperation and Exchanges NSFC(50820125405)the National Natural Science Foundation of China(51004020)
文摘Brittle failure of rocks is a classical rock mechanical problem.Rock failure not only involves initiation and propagation of single crack,but also is associated with initiation,propagation and coalescence of many cracks.The rock failure process analysis(RFPA)tool has been proposed since 1995.The heterogeneity of rocks at a mesoscopic level is considered by assuming that the material properties follow the Weibull distribution.Elastic damage mechanics is used for describing the constitutive law of the meso-level element.The finite element method(FEM)is employed as the basic stress analysis tool.The maximum tensile strain criterion and the Mohr-Coulomb criterion are utilized as the damage threshold.In order to solve the stability problem related to rock engineering structures,fundamental principles of strength reduction method(SRM)and gravity increase method(GIM)are integrated into the RFPA.And the acoustic emission(AE)event rate is employed as the criterion for rock engineering failure.The prominent feature of the RFPA-SRM and RFPA-GIM for stability analysis of rock engineering is that the factor of safety can be obtained without any presumption for the shape and location of the failure surface.In this paper,several geotechnical engineering applications that use the RFPA method to analyze their stability are presented to provide some references for relevant researches.The principles of the RFPA method in engineering are introduced firstly,and then the stability analysis of tunnel,slope and dam is focused on.The results indicate that the RFPA method is capable of capturing the mechanism of rock engineering stability and has the potential for application in a larger range of geo-engineering.
文摘A big debris flow which was arosed by landslide occurrence at night on July 11, 2003 in Qiongshan Ravine, Danba, Sichuan Province. According to the research, debris flow in Qiongshan Ravine is arosed by the fluidization of landslide. It had been rained about 70 days before debris flow occurred. That made the sediments in the gully to near to saturated or saturated in water. Being affect by the steep geography, the sediments occurrence peristalsis to transform, parts of soil bodies start disintegrate. All the sediments become transforming with water inleakaging to sediments, and than foreside slope flow to gully quickly after becoming fluidization. And the sediments come into being the debris flow with the water of the gully joining.
基金supported by the Shanghai Leading Academic Discipline Project (Grant No.J50103)
文摘Web service(WS) is an emerging software technology,especially acting an important role in cloud computing.The WS choreography description language(WS-CDL) is the standard for modeling the observable behavior of WS composition across multiple participants from a global point of view.However,it lacks of a formal semantics and could easily lead to misunderstanding and different implementations.In this paper,the WS-CDL based specifications are formally extracted in a communicating sequential process supporting a formal approach to checking WS models.In addition,formalisms and model checking are explicitly illustrated through a simple but non-trivial example with the help of model checker process analysis toolkit(PAT).
基金Supported by Heilongjiang Provincial Fruit Tree Modernization Agro-industrial Technology Collaborative Innovation and Promotion System Project(2019-13)。
文摘In order to obtain better quality cookies, food 3D printing technology was employed to prepare cookies. The texture, color, deformation, moisture content, and temperature of the cookie as evaluation indicators, the influences of baking process parameters, such as baking time, surface heating temperature and bottom heating temperature, on the quality of the cookie were studied to optimize the baking process parameters. The results showed that the baking process parameters had obvious effects on the texture, color, deformation, moisture content, and temperature of the cookie. All of the roasting surface heating temperature, bottom heating temperature and baking time had positive influences on the hardness, crunchiness, crispiness, and the total color difference(ΔE) of the cookie. When the heating temperatures of the surfac and bottom increased, the diameter and thickness deformation rate of the cookie increased. However,with the extension of baking time, the diameter and thickness deformation rate of the cookie first increased and then decreased. With the surface heating temperature of 180 ℃, the bottom heating temperature of 150 ℃, and baking time of 15 min, the cookie was crisp and moderate with moderate deformation and uniform color. There was no burnt phenomenon with the desired quality. Research results provided a theoretical basis for cookie manufactory based on food 3D printing technology.
