Background:The development and prognosis of breast cancer are intricately linked to psychological stress.In addition,depression is the most common psychological comorbidity among breast cancer survivors,and reportedly...Background:The development and prognosis of breast cancer are intricately linked to psychological stress.In addition,depression is the most common psychological comorbidity among breast cancer survivors,and reportedly,Fang-Xia-Dihuang decoction(FXDH)can effectively manage depression in such patients.However,its pharmacological and molecular mechanisms remain obscure.Methods:Public databases were used for obtaining active components and related targets.Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry(UPLC-HRMS).Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways.Molecule docking was used to understand the interactions between main compounds and hub targets.In addition,an animal model of breast cancer combined with depression was established to evaluate the intervention effect of FXDH and verify the pathways screened by network pharmacology.Results:174 active components of FXDH and 163 intersection targets of FXDH,breast cancer,and depression were identified.Quercetin,methyl ferulate,luteolin,ferulaldehyde,wogonin,and diincarvilone were identified as the principal active components of FXDH.Protein–protein interaction and KEGG enrichment analyses revealed that the phosphoinositide-3-kinase–protein kinase B(PI3K/AKT)and Janus kinase/signal transducer and activator of transcription(JAK2/STAT3)signaling pathways played a crucial role in mediating the efficacy of FXDH for inhibiting breast cancer progression induced by depression.In addition,in vivo experiments revealed that FXDH ameliorated depression-like behavior in mice and inhibited excessive tumor growth in mice with breast cancer and depression.FXDH treatment downregulated the expression of epinephrine,PI3K,AKT,STAT3,and JAK2 compared with the control treatment(p<0.05).Molecular docking verified the relationship between the six primary components of FXDH and the three most important targets,including phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),AKT,and STAT3.Conclusion:This study provides a scientific basis to support the clinical application of FXDH for improving depression-like behavior and inhibiting breast cancer progression promoted by chronic stress.The therapeutic effects FXDH may be closely related to the PI3K/AKT and JAK2/STAT3 pathways.This finding helps better understand the regulatory mechanisms underlying the efficacy of FXDH.展开更多
BACKGROUND The degree of psychological stress and the difficulty and efficacy of laparoscopic surgery differ in patients with pelvic abscesses after different durations of antiinfection treatment.AIM To compare and an...BACKGROUND The degree of psychological stress and the difficulty and efficacy of laparoscopic surgery differ in patients with pelvic abscesses after different durations of antiinfection treatment.AIM To compare and analyse the effects of different durations of anti-infective therapy on patients’preoperative psychological stress level and the clinical efficacy of laparoscopic surgery in patients with pelvic abscesses to offer a reference for the selection of therapy plans.METHODS A total of 100 patients with pelvic abscesses who were admitted to the Department of Gynecology of Suzhou Ninth Hospital affiliated to Soochow University(Suzhou Ninth People's Hospital)from January 2018 to December 2022 were retrospectively enrolled.According to the different durations of antiinfective therapy,they were divided into Group S(50 patients,received antiinfective therapy for 24-48 h)and Group L(50 patients,received anti-infective therapy for 48-96 h).Baseline data,state-trait anxiety score at admission and before surgery,self-rating anxiety scale(SAS)+self-rating depression scale(SDS)score,surgery time,adhesion grading score,intraoperative blood loss,presence or absence of intraoperative intestinal injury,ureteral injury or bladder injury,postoperative body temperature,length of hospital stay,and presence or absence of recurrence within 3 mo after surgery,chronic pelvic pain,incision infection,dysmenorrhea,menstrual disorder or intestinal obstruction were compared between the S group and the L group.RESULTS There was no significant difference in the background data between the S group and the L group(P<0.05).There was no significant difference in the state-trait anxiety score or SAS+SDS score between the S group and the L group on admission(P<0.05).The state-trait anxiety score and SAS+SDS score of the S group were lower than those of Group L after receiving different durations of anti-infective therapy(P<0.05).There was no significant difference in the incidence of intestinal,ureteral or bladder injury between the S group and the L group(P<0.05).The surgery time of Group S was shorter than that of Group L,and the adhesion score and intraoperative blood loss volume were lower than those of Group L(P<0.05).There was no significant difference in the incidence of incision infection,dysmenorrhea,menstrual disorder or intestinal obstruction between the S group and the L group(P<0.05).The postoperative body temperature of Group S was lower than that of Group L(P<0.05),and the hospital stay was shorter than that of Group L(P<0.05).The incidences of recurrence and chronic pelvic pain within 3 mo after surgery were lower than that of Group L(P<0.05).CONCLUSION Twenty-four to forty-eight hours of anti-infective therapy is better than 48-96 h of anti-infective therapy for patients with pelvic abscesses because the degree of psychological stress is lower,which is more conducive to achieving better outcomes after laparoscopic surgery.展开更多
Previous studies suggest that serotonin(5-HT) might interact with brain-derived neurotrophic factor(BDNF) during the stress response.However,the relationship between 5-HT and BDNF expression under purely psychological...Previous studies suggest that serotonin(5-HT) might interact with brain-derived neurotrophic factor(BDNF) during the stress response.However,the relationship between 5-HT and BDNF expression under purely psychological stress is unclear.In this study,one hour before psychological stress exposure,the 5-HT1 A receptor agonist 8-OH-DPAT or antagonist MDL73005,or the 5-HT2 A receptor agonist DOI or antagonist ketanserin were administered to rats exposed to psychological stress.Immunohistochemistry and in situ hybridization revealed that after psychological stress,with the exception of the ventral tegmental area,BDNF protein and m RNA expression levels were higher in the 5-HT1 A and the 5-HT2 A receptor agonist groups compared with the solvent control no-stress or psychological stress group in the CA1 and CA3 of the hippocampus,prefrontal cortex,central amygdaloid nucleus,dorsomedial hypothalamic nucleus,dentate gyrus,shell of the nucleus accumbens and the midbrain periaqueductal gray.There was no significant difference between the two agonist groups.In contrast,after stress exposure,BDNF protein and m RNA expression levels were lower in the 5-HT1 A and 5-HT2 A receptor antagonist groups than in the solvent control non-stress group,with the exception of the ventral tegmental area.Our findings suggest that 5-HT regulates BDNF expression in a rat model of acute psychological stress.展开更多
BACKGROUND Acute stress might increase short-term heart rate variability and blood pressure variability(BPV);however,chronic stress would not alter short-term BPV in animal models.AIM To examine the association of psy...BACKGROUND Acute stress might increase short-term heart rate variability and blood pressure variability(BPV);however,chronic stress would not alter short-term BPV in animal models.AIM To examine the association of psychological stress with long-term BPV in young male humans.METHODS We prospectively examined the association of chronic psychological stress with long-term BPV in 1112 healthy military males,averaged 32.2 years from the cardiorespiratory fitness and hospitalization events in armed forces study in Taiwan.Psychological stress was quantitatively evaluated with the Brief Symptom Rating Scale(BSRS-5),from the least symptom of 0 to the most severe of 20,and the five components of anxiety,insomnia,depression,interpersonal sensitivity,and hostility(the severity score in each component from 0 to 4).Longterm BPV was assessed by standard deviation(SD)for systolic and diastolic blood pressure(SBP and DBP),and average real variability(ARV),defined as the average absolute difference between successive measurements of SBP or DBP,across four visits in the study period from 2012 to 2018(2012-14,2014-15,2015-16,and 2016-18).RESULTS The results of multivariable linear regressions showed that there were no correlations of the BSRS-5 score with SDSBP,SDDBP,ARVSBP,and ARVDBP after adjusting for all the covariates[β(SE):-0.022(0.024),-0.023(0.026),-0.001(0.018),and 0.001(0.020),respectively;P>0.05 for all].In addition,there were also no correlations between each component of the BSRS score and the long-term BPV indexes.CONCLUSION Our findings suggest that chronic psychological stress might not be associated with long-term BPV in military young male humans.展开更多
Objective:This study aimed to evaluate sleep behaviors among college students,to assess salivary alpha-amylase(sAA)and heart rate variability(HRV)in association with stress,and to investigate sleep-related factors inc...Objective:This study aimed to evaluate sleep behaviors among college students,to assess salivary alpha-amylase(sAA)and heart rate variability(HRV)in association with stress,and to investigate sleep-related factors including sAA,HRV,and stress among them.Methods:Saliva samples for sAA assessment and HRV measurements in the supine position were taken between 3 PM and 6 PM.The level of prolonged psychological stress for the previous week was evaluated using the Korean version of the Global Assessment of Recent Stress(GARS-K),and sleep behaviors were assessed using an actigraphy device.Results:A total of 86 healthy college students participated in this study.Sleep behaviors of the college students were not good,with 84%sleep efficiency(SE)and 62.7 min wake after sleep onset(WASO).The average sAA level was 65.8 U/mL in the participants.Although neither the sAA level nor HRV indices were significantly correlated with prolonged psychological stress,decreased normalized high frequency(nHF)on HRV was independently associated with a higher level of stress when adjusted for age and sex.Higher stress(r=-0.276,P=0.011)and lower sAA(r=0.266,P=0.030)had significant correlations with shorter time in bed;however,it was sAA that was independently associated with time in bed(β=0.244,p=0.044).Decreased nHF(β=0.245,P=0.027)and higher body mass index(BMI)(β=-0.224,P=0.043)were independently related to and poorer SE.Conclusions:Poor sleep behaviors were associated with decreased parasympathetic activity,a physiological change to psychological stress,rather than with psychological stress itself among college students.Thus,sAA and HRV should be considered as significant factors for impaired sleep behaviors in relation to psychological stress.展开更多
Holistic nursing is guided by modern nursing concept and framed by nursing procedures, providing high quality nursing according to patients’ psychological, physiological, social and cultural needs. To develop holisti...Holistic nursing is guided by modern nursing concept and framed by nursing procedures, providing high quality nursing according to patients’ psychological, physiological, social and cultural needs. To develop holistic nursing in pediatrics is to develop nursing services for the purpose of satisfying the various clinical needs and psychological nursing of children. It is of great significance to establish holistic nursing concept, provide high quality nursing service for hospitalized children, and take targeted psychological intervention to alleviate their adverse psychological stress, which can improve treatment compliance and clinical efficacy, and shorten the length of hospital stay. In this paper, scientific and effective psychological nursing stress intervention means are used to improve the psychological anti-stress level of hospitalized children, and nursing intervention means are put forward, contribute to the maintenance of children’s mental health and the development of children’s mental health work and also to provide a theoretical basis for the intervention and treatment of children with psychological stress.展开更多
This study was aimed to compare the effects of acute and chronic psychological stress on metabolic factors. Forty-two male Wistar rats were divided into control and stressed groups. Stress was applied by a communicati...This study was aimed to compare the effects of acute and chronic psychological stress on metabolic factors. Forty-two male Wistar rats were divided into control and stressed groups. Stress was applied by a communication box acutely (1 d) and chronically (15 and 30 d). Blood sampling was carried out by retro-orbital-puncture method. The plasma levels of glucose, cholesterol, triglyceride, insulin, and corticosterone were measured. In addition, feed and water intake, latency to eat and drink, adrenal and body weights were determined. Acute and chronic psychological stress did not significantly change basal plasma corticosterone levels. However, immediately (1 min) after acute exposure to stress, plasma corticosterone level increased compared to that before stress exposure. Acute stress increased plasma insulin levels significantly. Fifteen days of stress exposure resulted in plasma glucose increase. Chronic stress significantly increased feed intake, latency to eat, and adrenal weight compared to acute stress. The body weights of both control and stressed groups increased markedly during the experiment. Homeostasis model assessment of insulin resistance (HOMA-IR) index did not change significantly in the stressed group. In conclusion, application of acute and chronic psychological stress leads to different metabolic and/or behavioral changes but the metabolic changes resulting from acute exposure to stress seem to be more pronounced.展开更多
The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies;however, the underlying mechanism remains underexplored. In this study, we discovered that impai...The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies;however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stressevoked tumor susceptibility, and the stress hormone glucocorticoid(GC) was identified as a principal detrimental factor. Mechanistically, GC disturbed the balance of the "eat me" signal receptor(low-density lipoprotein receptor-related protein-1, LRP1) and the "don’t eat me" signal receptor(signal regulatory protein alpha, SIRPa). Further analysis revealed that GC led to a direct, glucocorticoid receptor(GR)-dependent trans-repression of LRP1 expression, and the repressed LRP1, in turn, resulted in the elevatedgene level of SIRPa by down-regulating mi RNA-4695-3 p. These data collectively demonstrate that stress induces the imbalance of the LRP1/SIRPa axis and entails the disturbance of tumor cell clearance by macrophages. Our findings provide the mechanistic insight into psychological stress-evoked tumor susceptibility and indicate that the balance of LRP1/SIRPa axis may serve as a potential therapeutic strategy for tumor treatment.展开更多
Objectives Worldwide,the COVID-19 pandemic has significantly impacted mental health challenges for adolescent populations.The current study aims to examine the levels of perceived stress of COVID-19 and self-compassio...Objectives Worldwide,the COVID-19 pandemic has significantly impacted mental health challenges for adolescent populations.The current study aims to examine the levels of perceived stress of COVID-19 and self-compassion and their relationship among adolescents in Saudi Arabia.Methods This study employed a cross-sectional online survey of adolescents from secondary schools in Asir,Saudi Arabia.Instruments that we distributed online included the modified Perceived Stress Scale(PSS-10)and the Self-Compassion Scale(SCS),in addition to demographic and health-related questions.A total of 500 adolescents completed the survey.Results Adolescents in the study reported an average moderate perceived stress level of 18.6(SD=6.67)and an average moderate self-compassion level of 3.22(SD=0.53).A significant correlation is also found between the two variables(r=−0.460,P<0.001).This negative correlation indicates that lower levels of perceived stress are significantly correlated with higher levels of self-compassion.Conclusion The study results show that the perceived stress of COVID-19 is inversely correlated with self-compassion in Saudi adolescents.Further research is needed to explore how to enhance adolescents’self-compassion.School nurses’role should be given full play in this area.展开更多
Objective To investigate the change of plasma ghrelin level and explore the related factors of ghrelin alteration in elderly hypertensive patients with psychological distress.Methods A total of 300 elders,who were scr...Objective To investigate the change of plasma ghrelin level and explore the related factors of ghrelin alteration in elderly hypertensive patients with psychological distress.Methods A total of 300 elders,who were screened with Hamilton Anxiety Scale(HAMA),Hamilton Rating Scale for Depression(HAMD),and the Symptom Checklist-90(SCL-90)for psychological stress and somato-psychological manifestations respectively,were divided into hypertension group(n=148)and non-hypertension group(n=152).Their blood samples were collected to measure the plasma level of ghrelin and total cortisol on the same day.Results The incidences of anxiety and depression were 27.7% and 11.7%,respectively,in all the enrolled elders.However,the rates of psychological distress,particularly anxiety,were significantly higher in the hypertensive elders than in the non-hypertensive ones(43.2% vs.12.5%).Anxiety was positively related to the cortisol level but negatively related to the plasma ghrelin level,and the latter two were negatively correlated with each other.Conclusion Chronic increase of plasma cortisol induced by long-term anxiety can lead to the reduction of ghrelin level,which then adversely affects blood pressure in elders with psychological distress.Therefore,ghrelin might be a selective antihypertensive medicine for hypertensive elders with anxiety.展开更多
It is commonly known that psychological stress affects immunity through the nervous system,but the specific stress networks between brain and peripheral leukocytes,or their relationship with disease initiation or prog...It is commonly known that psychological stress affects immunity through the nervous system,but the specific stress networks between brain and peripheral leukocytes,or their relationship with disease initiation or progression have yet to been delineated.A recent study by Poller and his colleagues1 propose an innovative perspective that distinct brain circuits rapidly manipulate a large-scale whole-body re-distribution of leukocytes(neutrophils,monocytes,lymphocytes)during psychological stress.展开更多
Background:The occurrence of mental health symptoms is higher in individuals aged between 18 and 24 years than in other age groups.Mental health literacy is derived from health literacy,and focuses on the knowledge,at...Background:The occurrence of mental health symptoms is higher in individuals aged between 18 and 24 years than in other age groups.Mental health literacy is derived from health literacy,and focuses on the knowledge,attitudes,and competencies that individuals need to acquire to manage their own health effectively.Low mental health literacy is associated with poorer mental health.Grit is also a known protective factor against mental disorders.Despite a heightened focus on mental health literacy and grit as important factors for decreasing mental health symptoms,knowledge of the effect of mental health literacy and grit on mental health symptoms is very limited.This study aimed to evaluate the relationship between mental health literacy and psychological symptoms and the mediating effect of grit on these relationships.Methods:This cross-sectional descriptive study used survey data from 178 university students in Korea.Data were collected between March and May 2022.The SPSS PROCESS macro(Model 4)was used to analyze the data.Results:Mental health literacy was not directly associated with psychological symptoms.However,an indirect pathway was observed between mental health literacy,depression,and anxiety,through grit.Conclusion:Mental health literacy affects psychological symptoms through grit.Therefore,to improve the mental health of university students,it is necessary to develop programs that increase mental health literacy and grit.展开更多
Atopic dermatitis(AD)is a chronic,relapsing,multifactorial inflammatory disease with genetic,environmental,and immunological characteristics.The quality of life and sleep of patients and their families are affected by...Atopic dermatitis(AD)is a chronic,relapsing,multifactorial inflammatory disease with genetic,environmental,and immunological characteristics.The quality of life and sleep of patients and their families are affected by AD,which triggers stress,described as one of the factors that worsens AD.Salivary biomarkers such as cortisol,alpha-amylase,chromogranin A,and melatonin have been associated with stress and sleep disturbances.Therefore,the evaluation of stress and sleep disorders using salivary biomarkers in AD patients is important.This review aims to describe the possible relationship between atopic dermatitis and stress,sleep disorders,and salivary biomarkers,seeking to contribute to better understanding and clinical management of AD.This descriptive study is characterized as a narrative literature review.A literature search was conducted of studies published in English and Portuguese between January 2012 and October 2022 that are available in electronic media from various databases,such as Scientific Electronic Library Online,Latin American and Caribbean Literature on Health Sciences,and PubMed.AD is associated with different degrees of impact on the lives of individuals who present with the disease.Psychological stress may induce changes in saliva composition and worsen AD;at the same time,the severity of the disease may be associated with emotional impact.Further studies are needed to assess and correlate AD severity,stress,and sleep disturbances with salivary biomarkers in order to better understand this association.展开更多
Exploring whether medical staff perceive stress on the assigned medical tasks,what are the specific sources of stress,what are the tangible sources of support they expected to be helpful,and individual coping with str...Exploring whether medical staff perceive stress on the assigned medical tasks,what are the specific sources of stress,what are the tangible sources of support they expected to be helpful,and individual coping with stress to provide more accurate,personal support for psychological crisis.This study uses a cross-sectional descriptive survey adopting convenience sampling among the medical staff who worked for over seven days in the infected areas of one Grade 2A and three Grade 3A hospitals during the COVID-19 pandemic.The assessment includes attitude when receiving tasks,major stressors,factors relieving stress,and personal management of stress.A total of 104(76.8%)valid questionnaires are received.A majority(94.3%)of the medical staff held a positive attitude taking duty for granted but feeling nervous and afraid(81.1%).Contacting the infected(90.6%)and compensation(92.5%)are the main concerns.The major pressure sources are regarding safety for oneself(98.1%),colleagues(92.5%),and family(94.3%),as well as lack of effective treatment(92.5%),inadequate protective equipment(94.3%)and incomplete disinfection(94.3%).The main positive pressure adjustments include strict infection controlling measures(98.4%),maintaining a positive attitude(95.2%),actively attain more information 95.2%,and engage in recreational activities(93.6%),but more than 40%takes negative adjustments to vent their emotions and relieve anxiety,suggesting the importance of early psychological intervention.During the COVID-19 pandemic,the main stressors among medical staff are safety,uncertainty and shortage of resources.Positive coping includes taking effective protective measures and achieving thorough understanding of the virus.展开更多
The aim of this paper is to describe the direction of the link between stress,depression,increased inflammation and brain-derived neurotrophic factor(BDNF)reduction.We hypothesize that severe stress or prolonged stres...The aim of this paper is to describe the direction of the link between stress,depression,increased inflammation and brain-derived neurotrophic factor(BDNF)reduction.We hypothesize that severe stress or prolonged stress can be the driving factor that promote the onset of depression.Both stress and depression,if not resolved over time,activate the production of transcription factors that will switch on pro-inflammatory genes and translate them into cytokines.This cascade fosters systemic chronic inflammation and reduced plasma BDNF levels.Since people with depression have a 60%increased risk of developing type 2diabetes(T2D)and show high levels of inflammation and low levels of BDNF,we hypothesize possible reasons that might explain why T2D,depression and dementia are often associated in the same patient.展开更多
Immigration-related stress is the result of an environment that imposes demands surpassing the psychological resources of those suffering from it with a destabilizing effect on their physical and psychological health....Immigration-related stress is the result of an environment that imposes demands surpassing the psychological resources of those suffering from it with a destabilizing effect on their physical and psychological health. The purpose of this study is to determine what the chronic stress levels are and their association with psychophysiological symptoms and gender in Mexican immigrants living in Edmonton, Canada. A representative random sample was made of 237 immigrants in 2012. The stress symptoms inventory was used and a multiple regression and multivariate analysis was made. Results indicated that chronic stress levels were: 14% high, 46% medium and 40% low and psychophysiological predictor symptoms were: fatigue, constipation, frequent colds, cold hands and feet and insomnia, and the female gender. Therefore one may conclude that a precise identification of the predictor symptoms of chronic stress may help promote and implement programs aimed at timely prevention of stress before they affect the health and occupational safety of Mexican immigrants living in Edmonton, Canada.展开更多
Pathogenic microbial biological epidemics can cause negative emotions such as fear,anxiety,loneliness and depression,as well as somatization symptoms such as insomnia,headache,chest tightness and degenerative behavior...Pathogenic microbial biological epidemics can cause negative emotions such as fear,anxiety,loneliness and depression,as well as somatization symptoms such as insomnia,headache,chest tightness and degenerative behavior.As a secondary disaster of major epidemic situation,this kind of adverse psychological stress needs to be adjusted quickly.The author reviews the rapid psychological regulation methods of novel coronavirus pneumonia(coronavirus disease 2019,Covid-19),aiming to provide a useful enlightenment for the prevention of psychological stress in microorganism epidemic situation.展开更多
Objective:This study aimed to explore the effects of the different dimensions of psychological stress on the phobia and anxiety experienced by college students during the COVID-19 pandemic.Methods:Convenience sampling...Objective:This study aimed to explore the effects of the different dimensions of psychological stress on the phobia and anxiety experienced by college students during the COVID-19 pandemic.Methods:Convenience sampling was employed to distribute a total of 169 questionnaires to college students from high incidence(Hubei Province)and low incidence(Anhui Province)areas.The study was conducted from May 17,2020 to May 28,2020.In this study,only Chinese non pregnant local college students who lived in Wuhan,Hubei province or Hefei,Anhui Province from December 2019 to may 2020(i.e.during the pandemic)and could give informed consent were recruited.Results:The correlation coefficients between the variables were significant,and the path analysis model registered satisfactory fitness.The results revealed that panic(β=0.40,P<0.001)and defensiveness(β=−0.27,P<0.01)had direct effects on anxiety.Defensiveness could also mediate anxiety through SCL-90 phobia(β=0.15,P<0.01),by contrast,the direct and indirect effects of defense reaction are not consistent.The direct effect has a negative impact on anxiety,while the indirect effect of terror has a positive impact on anxiety.Besides,cognition(β=−0.08,P<0.05)could only affect anxiety through the complete mediating effect of SCL-90.Conclusion:In college students,the defensive psychology and behavior in epidemic psychological stress will have different effects on anxiety.The direct effect is that the higher the defensive psychology and behavior,the lower the anxiety.The indirect effect is that the higher the defensive psychology and behavior,the higher the terror,and the higher the anxiety.展开更多
To investigate the correlation between anxiety and related factors among international students in Wenzhou during the COVID-19 epidemic,international students from Wenzhou were selected as subjects for our research.We...To investigate the correlation between anxiety and related factors among international students in Wenzhou during the COVID-19 epidemic,international students from Wenzhou were selected as subjects for our research.We administered a self-developed questionnaire on anxiety among our subjects in question during the specific time of the COVID-19 epidemic,in which a self-assessment scale was included.Overall,an anxiety questionnaire for international students studying in Wenzhou during the outbreak of COVID–19,a self-rating anxiety scale,and statistical methods were utilized to conduct our research.During the COVID-19 epidemic,international students in Wenzhou experienced varying degrees of anxiety,which were related to concerns about contracting the virus,exam-related stress,and differences in living standards.Therefore,intervention is crucial.展开更多
Background: Multivitamins are a popular supplement taken to promote physical and mental health.During periods of stress, they may have a protective role for health and wellbeing, although the current evidence of their...Background: Multivitamins are a popular supplement taken to promote physical and mental health.During periods of stress, they may have a protective role for health and wellbeing, although the current evidence of their efficacy is mixed.Objective: To determine whether multivitamin supplementation impacts psychological and inflammatory markers of women who are experiencing psychological distress.Design, setting, participants and interventions: An 8-week randomized controlled trial was conducted to assess changes in both psychological state and pro-inflammatory markers of patients receiving multivitamins or placebo. The sample comprised women who reported elevated psychological distress in the previous 4 weeks.Main outcome measures: Psychological state was assessed using Spielberger's State-Trait Personality Inventory to assess anxiety, curiosity, depression and anger. Pro-inflammatory markers comprised interleukin(IL)-1β,IL-5, IL-6, tumour necrosis factor(TNF)-α and TNF-p.Results: Improvements across time were observed for all psychological measures and cytokines, except IL-5, but were independent of the active intervention. Only TNF-β demonstrated a significant differential change between groups over the course of the intervention, in favour of multivitamin supplementation(active group mean rank decreased from 11.1 to 7.1; placebo group mean rank decreased from 8.9 to 7.8).Conclusion: The results suggest that administration of multivitamins was not effective in improving psychological state. However, some evidence supported the positive impact of multivitamin supplementation on pro-inflammatory cytokine profiles of women currently experiencing stress.展开更多
基金supported by the Xiamen High-Level Health Talents Introduction and Training Project(Xiaweidang 2021-124)the National Natural Science Foundation of China(No.81774319).
文摘Background:The development and prognosis of breast cancer are intricately linked to psychological stress.In addition,depression is the most common psychological comorbidity among breast cancer survivors,and reportedly,Fang-Xia-Dihuang decoction(FXDH)can effectively manage depression in such patients.However,its pharmacological and molecular mechanisms remain obscure.Methods:Public databases were used for obtaining active components and related targets.Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry(UPLC-HRMS).Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways.Molecule docking was used to understand the interactions between main compounds and hub targets.In addition,an animal model of breast cancer combined with depression was established to evaluate the intervention effect of FXDH and verify the pathways screened by network pharmacology.Results:174 active components of FXDH and 163 intersection targets of FXDH,breast cancer,and depression were identified.Quercetin,methyl ferulate,luteolin,ferulaldehyde,wogonin,and diincarvilone were identified as the principal active components of FXDH.Protein–protein interaction and KEGG enrichment analyses revealed that the phosphoinositide-3-kinase–protein kinase B(PI3K/AKT)and Janus kinase/signal transducer and activator of transcription(JAK2/STAT3)signaling pathways played a crucial role in mediating the efficacy of FXDH for inhibiting breast cancer progression induced by depression.In addition,in vivo experiments revealed that FXDH ameliorated depression-like behavior in mice and inhibited excessive tumor growth in mice with breast cancer and depression.FXDH treatment downregulated the expression of epinephrine,PI3K,AKT,STAT3,and JAK2 compared with the control treatment(p<0.05).Molecular docking verified the relationship between the six primary components of FXDH and the three most important targets,including phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha(PIK3CA),AKT,and STAT3.Conclusion:This study provides a scientific basis to support the clinical application of FXDH for improving depression-like behavior and inhibiting breast cancer progression promoted by chronic stress.The therapeutic effects FXDH may be closely related to the PI3K/AKT and JAK2/STAT3 pathways.This finding helps better understand the regulatory mechanisms underlying the efficacy of FXDH.
文摘BACKGROUND The degree of psychological stress and the difficulty and efficacy of laparoscopic surgery differ in patients with pelvic abscesses after different durations of antiinfection treatment.AIM To compare and analyse the effects of different durations of anti-infective therapy on patients’preoperative psychological stress level and the clinical efficacy of laparoscopic surgery in patients with pelvic abscesses to offer a reference for the selection of therapy plans.METHODS A total of 100 patients with pelvic abscesses who were admitted to the Department of Gynecology of Suzhou Ninth Hospital affiliated to Soochow University(Suzhou Ninth People's Hospital)from January 2018 to December 2022 were retrospectively enrolled.According to the different durations of antiinfective therapy,they were divided into Group S(50 patients,received antiinfective therapy for 24-48 h)and Group L(50 patients,received anti-infective therapy for 48-96 h).Baseline data,state-trait anxiety score at admission and before surgery,self-rating anxiety scale(SAS)+self-rating depression scale(SDS)score,surgery time,adhesion grading score,intraoperative blood loss,presence or absence of intraoperative intestinal injury,ureteral injury or bladder injury,postoperative body temperature,length of hospital stay,and presence or absence of recurrence within 3 mo after surgery,chronic pelvic pain,incision infection,dysmenorrhea,menstrual disorder or intestinal obstruction were compared between the S group and the L group.RESULTS There was no significant difference in the background data between the S group and the L group(P<0.05).There was no significant difference in the state-trait anxiety score or SAS+SDS score between the S group and the L group on admission(P<0.05).The state-trait anxiety score and SAS+SDS score of the S group were lower than those of Group L after receiving different durations of anti-infective therapy(P<0.05).There was no significant difference in the incidence of intestinal,ureteral or bladder injury between the S group and the L group(P<0.05).The surgery time of Group S was shorter than that of Group L,and the adhesion score and intraoperative blood loss volume were lower than those of Group L(P<0.05).There was no significant difference in the incidence of incision infection,dysmenorrhea,menstrual disorder or intestinal obstruction between the S group and the L group(P<0.05).The postoperative body temperature of Group S was lower than that of Group L(P<0.05),and the hospital stay was shorter than that of Group L(P<0.05).The incidences of recurrence and chronic pelvic pain within 3 mo after surgery were lower than that of Group L(P<0.05).CONCLUSION Twenty-four to forty-eight hours of anti-infective therapy is better than 48-96 h of anti-infective therapy for patients with pelvic abscesses because the degree of psychological stress is lower,which is more conducive to achieving better outcomes after laparoscopic surgery.
基金supported by grants from the Natural Science Foundation of Shandong Province of China(ZR2011HM023 to GYL)the “11th Five-Year Plan”,National Supporting Program(2007BAI17B02 to GYL)+5 种基金the Science and Technology Project of Higher Education of Shandong Province of China(J10LF01 to GYL)a grant from Medical Science and Technology Development Project of Shandong Province of China(2011HZ011 to GYL)the China Postdoctoral Science Foundation of China(2012M 520585 to CJZ)the Fund of Tianjin Health Bureau of China(2014KR02 to CJZ)the Foundation of Hainan Li Ou Pharmaceutical Co.,Ltd.the Foundation of Xuzhou Enhua Pharmaceutical Co.,Ltd. of China
文摘Previous studies suggest that serotonin(5-HT) might interact with brain-derived neurotrophic factor(BDNF) during the stress response.However,the relationship between 5-HT and BDNF expression under purely psychological stress is unclear.In this study,one hour before psychological stress exposure,the 5-HT1 A receptor agonist 8-OH-DPAT or antagonist MDL73005,or the 5-HT2 A receptor agonist DOI or antagonist ketanserin were administered to rats exposed to psychological stress.Immunohistochemistry and in situ hybridization revealed that after psychological stress,with the exception of the ventral tegmental area,BDNF protein and m RNA expression levels were higher in the 5-HT1 A and the 5-HT2 A receptor agonist groups compared with the solvent control no-stress or psychological stress group in the CA1 and CA3 of the hippocampus,prefrontal cortex,central amygdaloid nucleus,dorsomedial hypothalamic nucleus,dentate gyrus,shell of the nucleus accumbens and the midbrain periaqueductal gray.There was no significant difference between the two agonist groups.In contrast,after stress exposure,BDNF protein and m RNA expression levels were lower in the 5-HT1 A and 5-HT2 A receptor antagonist groups than in the solvent control non-stress group,with the exception of the ventral tegmental area.Our findings suggest that 5-HT regulates BDNF expression in a rat model of acute psychological stress.
基金the Hualien Armed Forces General Hospital Grant,No.HAFGH-D-109007.
文摘BACKGROUND Acute stress might increase short-term heart rate variability and blood pressure variability(BPV);however,chronic stress would not alter short-term BPV in animal models.AIM To examine the association of psychological stress with long-term BPV in young male humans.METHODS We prospectively examined the association of chronic psychological stress with long-term BPV in 1112 healthy military males,averaged 32.2 years from the cardiorespiratory fitness and hospitalization events in armed forces study in Taiwan.Psychological stress was quantitatively evaluated with the Brief Symptom Rating Scale(BSRS-5),from the least symptom of 0 to the most severe of 20,and the five components of anxiety,insomnia,depression,interpersonal sensitivity,and hostility(the severity score in each component from 0 to 4).Longterm BPV was assessed by standard deviation(SD)for systolic and diastolic blood pressure(SBP and DBP),and average real variability(ARV),defined as the average absolute difference between successive measurements of SBP or DBP,across four visits in the study period from 2012 to 2018(2012-14,2014-15,2015-16,and 2016-18).RESULTS The results of multivariable linear regressions showed that there were no correlations of the BSRS-5 score with SDSBP,SDDBP,ARVSBP,and ARVDBP after adjusting for all the covariates[β(SE):-0.022(0.024),-0.023(0.026),-0.001(0.018),and 0.001(0.020),respectively;P>0.05 for all].In addition,there were also no correlations between each component of the BSRS score and the long-term BPV indexes.CONCLUSION Our findings suggest that chronic psychological stress might not be associated with long-term BPV in military young male humans.
文摘Objective:This study aimed to evaluate sleep behaviors among college students,to assess salivary alpha-amylase(sAA)and heart rate variability(HRV)in association with stress,and to investigate sleep-related factors including sAA,HRV,and stress among them.Methods:Saliva samples for sAA assessment and HRV measurements in the supine position were taken between 3 PM and 6 PM.The level of prolonged psychological stress for the previous week was evaluated using the Korean version of the Global Assessment of Recent Stress(GARS-K),and sleep behaviors were assessed using an actigraphy device.Results:A total of 86 healthy college students participated in this study.Sleep behaviors of the college students were not good,with 84%sleep efficiency(SE)and 62.7 min wake after sleep onset(WASO).The average sAA level was 65.8 U/mL in the participants.Although neither the sAA level nor HRV indices were significantly correlated with prolonged psychological stress,decreased normalized high frequency(nHF)on HRV was independently associated with a higher level of stress when adjusted for age and sex.Higher stress(r=-0.276,P=0.011)and lower sAA(r=0.266,P=0.030)had significant correlations with shorter time in bed;however,it was sAA that was independently associated with time in bed(β=0.244,p=0.044).Decreased nHF(β=0.245,P=0.027)and higher body mass index(BMI)(β=-0.224,P=0.043)were independently related to and poorer SE.Conclusions:Poor sleep behaviors were associated with decreased parasympathetic activity,a physiological change to psychological stress,rather than with psychological stress itself among college students.Thus,sAA and HRV should be considered as significant factors for impaired sleep behaviors in relation to psychological stress.
文摘Holistic nursing is guided by modern nursing concept and framed by nursing procedures, providing high quality nursing according to patients’ psychological, physiological, social and cultural needs. To develop holistic nursing in pediatrics is to develop nursing services for the purpose of satisfying the various clinical needs and psychological nursing of children. It is of great significance to establish holistic nursing concept, provide high quality nursing service for hospitalized children, and take targeted psychological intervention to alleviate their adverse psychological stress, which can improve treatment compliance and clinical efficacy, and shorten the length of hospital stay. In this paper, scientific and effective psychological nursing stress intervention means are used to improve the psychological anti-stress level of hospitalized children, and nursing intervention means are put forward, contribute to the maintenance of children’s mental health and the development of children’s mental health work and also to provide a theoretical basis for the intervention and treatment of children with psychological stress.
基金Project (No. 919) supported by the Neuroscience Research Center,Shahid Beheshti University of Medical Sciences, Tehran, Iran
文摘This study was aimed to compare the effects of acute and chronic psychological stress on metabolic factors. Forty-two male Wistar rats were divided into control and stressed groups. Stress was applied by a communication box acutely (1 d) and chronically (15 and 30 d). Blood sampling was carried out by retro-orbital-puncture method. The plasma levels of glucose, cholesterol, triglyceride, insulin, and corticosterone were measured. In addition, feed and water intake, latency to eat and drink, adrenal and body weights were determined. Acute and chronic psychological stress did not significantly change basal plasma corticosterone levels. However, immediately (1 min) after acute exposure to stress, plasma corticosterone level increased compared to that before stress exposure. Acute stress increased plasma insulin levels significantly. Fifteen days of stress exposure resulted in plasma glucose increase. Chronic stress significantly increased feed intake, latency to eat, and adrenal weight compared to acute stress. The body weights of both control and stressed groups increased markedly during the experiment. Homeostasis model assessment of insulin resistance (HOMA-IR) index did not change significantly in the stressed group. In conclusion, application of acute and chronic psychological stress leads to different metabolic and/or behavioral changes but the metabolic changes resulting from acute exposure to stress seem to be more pronounced.
基金supported,in part,by National Natural Science Foundation of China(grant numbers 81673709,82004231,U1801284 and 81873209)Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(grant number 2017BT01Y036,China)and GDUPS(2019,China)+5 种基金Guangdong Science and Technology Foundation for Distinguished Young Scholars(grant number 2017A030306004,China)Science and Technology Program of Guangzhou(grant numbers 201903010062 and 202102010116,China)Fellowship of China Postdoctoral Science Foundation(grant number 2020M683204,China)Guangdong Basic and Applied Basic Research Fund(grant number 2020A1515110388,China)Fundamental Research Funds for the Central Universities(grant number 21620448,China)support of K.C.Wong Education Foundation。
文摘The relationship between chronic psychological stress and tumorigenesis has been well defined in epidemiological studies;however, the underlying mechanism remains underexplored. In this study, we discovered that impaired macrophage phagocytosis contributed to the psychological stressevoked tumor susceptibility, and the stress hormone glucocorticoid(GC) was identified as a principal detrimental factor. Mechanistically, GC disturbed the balance of the "eat me" signal receptor(low-density lipoprotein receptor-related protein-1, LRP1) and the "don’t eat me" signal receptor(signal regulatory protein alpha, SIRPa). Further analysis revealed that GC led to a direct, glucocorticoid receptor(GR)-dependent trans-repression of LRP1 expression, and the repressed LRP1, in turn, resulted in the elevatedgene level of SIRPa by down-regulating mi RNA-4695-3 p. These data collectively demonstrate that stress induces the imbalance of the LRP1/SIRPa axis and entails the disturbance of tumor cell clearance by macrophages. Our findings provide the mechanistic insight into psychological stress-evoked tumor susceptibility and indicate that the balance of LRP1/SIRPa axis may serve as a potential therapeutic strategy for tumor treatment.
文摘Objectives Worldwide,the COVID-19 pandemic has significantly impacted mental health challenges for adolescent populations.The current study aims to examine the levels of perceived stress of COVID-19 and self-compassion and their relationship among adolescents in Saudi Arabia.Methods This study employed a cross-sectional online survey of adolescents from secondary schools in Asir,Saudi Arabia.Instruments that we distributed online included the modified Perceived Stress Scale(PSS-10)and the Self-Compassion Scale(SCS),in addition to demographic and health-related questions.A total of 500 adolescents completed the survey.Results Adolescents in the study reported an average moderate perceived stress level of 18.6(SD=6.67)and an average moderate self-compassion level of 3.22(SD=0.53).A significant correlation is also found between the two variables(r=−0.460,P<0.001).This negative correlation indicates that lower levels of perceived stress are significantly correlated with higher levels of self-compassion.Conclusion The study results show that the perceived stress of COVID-19 is inversely correlated with self-compassion in Saudi adolescents.Further research is needed to explore how to enhance adolescents’self-compassion.School nurses’role should be given full play in this area.
文摘Objective To investigate the change of plasma ghrelin level and explore the related factors of ghrelin alteration in elderly hypertensive patients with psychological distress.Methods A total of 300 elders,who were screened with Hamilton Anxiety Scale(HAMA),Hamilton Rating Scale for Depression(HAMD),and the Symptom Checklist-90(SCL-90)for psychological stress and somato-psychological manifestations respectively,were divided into hypertension group(n=148)and non-hypertension group(n=152).Their blood samples were collected to measure the plasma level of ghrelin and total cortisol on the same day.Results The incidences of anxiety and depression were 27.7% and 11.7%,respectively,in all the enrolled elders.However,the rates of psychological distress,particularly anxiety,were significantly higher in the hypertensive elders than in the non-hypertensive ones(43.2% vs.12.5%).Anxiety was positively related to the cortisol level but negatively related to the plasma ghrelin level,and the latter two were negatively correlated with each other.Conclusion Chronic increase of plasma cortisol induced by long-term anxiety can lead to the reduction of ghrelin level,which then adversely affects blood pressure in elders with psychological distress.Therefore,ghrelin might be a selective antihypertensive medicine for hypertensive elders with anxiety.
基金This work was supported by the National Natural Science Foundation of China(No.82125038,82004231)Guangdong Basic and Applied Basic Research Fund(No.2020A1515110388,China)GDUPS(2019,China).
文摘It is commonly known that psychological stress affects immunity through the nervous system,but the specific stress networks between brain and peripheral leukocytes,or their relationship with disease initiation or progression have yet to been delineated.A recent study by Poller and his colleagues1 propose an innovative perspective that distinct brain circuits rapidly manipulate a large-scale whole-body re-distribution of leukocytes(neutrophils,monocytes,lymphocytes)during psychological stress.
基金supported by the Dongguk University Research Fund of 2021.
文摘Background:The occurrence of mental health symptoms is higher in individuals aged between 18 and 24 years than in other age groups.Mental health literacy is derived from health literacy,and focuses on the knowledge,attitudes,and competencies that individuals need to acquire to manage their own health effectively.Low mental health literacy is associated with poorer mental health.Grit is also a known protective factor against mental disorders.Despite a heightened focus on mental health literacy and grit as important factors for decreasing mental health symptoms,knowledge of the effect of mental health literacy and grit on mental health symptoms is very limited.This study aimed to evaluate the relationship between mental health literacy and psychological symptoms and the mediating effect of grit on these relationships.Methods:This cross-sectional descriptive study used survey data from 178 university students in Korea.Data were collected between March and May 2022.The SPSS PROCESS macro(Model 4)was used to analyze the data.Results:Mental health literacy was not directly associated with psychological symptoms.However,an indirect pathway was observed between mental health literacy,depression,and anxiety,through grit.Conclusion:Mental health literacy affects psychological symptoms through grit.Therefore,to improve the mental health of university students,it is necessary to develop programs that increase mental health literacy and grit.
文摘Atopic dermatitis(AD)is a chronic,relapsing,multifactorial inflammatory disease with genetic,environmental,and immunological characteristics.The quality of life and sleep of patients and their families are affected by AD,which triggers stress,described as one of the factors that worsens AD.Salivary biomarkers such as cortisol,alpha-amylase,chromogranin A,and melatonin have been associated with stress and sleep disturbances.Therefore,the evaluation of stress and sleep disorders using salivary biomarkers in AD patients is important.This review aims to describe the possible relationship between atopic dermatitis and stress,sleep disorders,and salivary biomarkers,seeking to contribute to better understanding and clinical management of AD.This descriptive study is characterized as a narrative literature review.A literature search was conducted of studies published in English and Portuguese between January 2012 and October 2022 that are available in electronic media from various databases,such as Scientific Electronic Library Online,Latin American and Caribbean Literature on Health Sciences,and PubMed.AD is associated with different degrees of impact on the lives of individuals who present with the disease.Psychological stress may induce changes in saliva composition and worsen AD;at the same time,the severity of the disease may be associated with emotional impact.Further studies are needed to assess and correlate AD severity,stress,and sleep disturbances with salivary biomarkers in order to better understand this association.
文摘Exploring whether medical staff perceive stress on the assigned medical tasks,what are the specific sources of stress,what are the tangible sources of support they expected to be helpful,and individual coping with stress to provide more accurate,personal support for psychological crisis.This study uses a cross-sectional descriptive survey adopting convenience sampling among the medical staff who worked for over seven days in the infected areas of one Grade 2A and three Grade 3A hospitals during the COVID-19 pandemic.The assessment includes attitude when receiving tasks,major stressors,factors relieving stress,and personal management of stress.A total of 104(76.8%)valid questionnaires are received.A majority(94.3%)of the medical staff held a positive attitude taking duty for granted but feeling nervous and afraid(81.1%).Contacting the infected(90.6%)and compensation(92.5%)are the main concerns.The major pressure sources are regarding safety for oneself(98.1%),colleagues(92.5%),and family(94.3%),as well as lack of effective treatment(92.5%),inadequate protective equipment(94.3%)and incomplete disinfection(94.3%).The main positive pressure adjustments include strict infection controlling measures(98.4%),maintaining a positive attitude(95.2%),actively attain more information 95.2%,and engage in recreational activities(93.6%),but more than 40%takes negative adjustments to vent their emotions and relieve anxiety,suggesting the importance of early psychological intervention.During the COVID-19 pandemic,the main stressors among medical staff are safety,uncertainty and shortage of resources.Positive coping includes taking effective protective measures and achieving thorough understanding of the virus.
文摘The aim of this paper is to describe the direction of the link between stress,depression,increased inflammation and brain-derived neurotrophic factor(BDNF)reduction.We hypothesize that severe stress or prolonged stress can be the driving factor that promote the onset of depression.Both stress and depression,if not resolved over time,activate the production of transcription factors that will switch on pro-inflammatory genes and translate them into cytokines.This cascade fosters systemic chronic inflammation and reduced plasma BDNF levels.Since people with depression have a 60%increased risk of developing type 2diabetes(T2D)and show high levels of inflammation and low levels of BDNF,we hypothesize possible reasons that might explain why T2D,depression and dementia are often associated in the same patient.
文摘Immigration-related stress is the result of an environment that imposes demands surpassing the psychological resources of those suffering from it with a destabilizing effect on their physical and psychological health. The purpose of this study is to determine what the chronic stress levels are and their association with psychophysiological symptoms and gender in Mexican immigrants living in Edmonton, Canada. A representative random sample was made of 237 immigrants in 2012. The stress symptoms inventory was used and a multiple regression and multivariate analysis was made. Results indicated that chronic stress levels were: 14% high, 46% medium and 40% low and psychophysiological predictor symptoms were: fatigue, constipation, frequent colds, cold hands and feet and insomnia, and the female gender. Therefore one may conclude that a precise identification of the predictor symptoms of chronic stress may help promote and implement programs aimed at timely prevention of stress before they affect the health and occupational safety of Mexican immigrants living in Edmonton, Canada.
基金the grants from Medical Research Funding of PLA(15QNP063,2016XZH12)Natural Science Foundation of China(81372105).
文摘Pathogenic microbial biological epidemics can cause negative emotions such as fear,anxiety,loneliness and depression,as well as somatization symptoms such as insomnia,headache,chest tightness and degenerative behavior.As a secondary disaster of major epidemic situation,this kind of adverse psychological stress needs to be adjusted quickly.The author reviews the rapid psychological regulation methods of novel coronavirus pneumonia(coronavirus disease 2019,Covid-19),aiming to provide a useful enlightenment for the prevention of psychological stress in microorganism epidemic situation.
文摘Objective:This study aimed to explore the effects of the different dimensions of psychological stress on the phobia and anxiety experienced by college students during the COVID-19 pandemic.Methods:Convenience sampling was employed to distribute a total of 169 questionnaires to college students from high incidence(Hubei Province)and low incidence(Anhui Province)areas.The study was conducted from May 17,2020 to May 28,2020.In this study,only Chinese non pregnant local college students who lived in Wuhan,Hubei province or Hefei,Anhui Province from December 2019 to may 2020(i.e.during the pandemic)and could give informed consent were recruited.Results:The correlation coefficients between the variables were significant,and the path analysis model registered satisfactory fitness.The results revealed that panic(β=0.40,P<0.001)and defensiveness(β=−0.27,P<0.01)had direct effects on anxiety.Defensiveness could also mediate anxiety through SCL-90 phobia(β=0.15,P<0.01),by contrast,the direct and indirect effects of defense reaction are not consistent.The direct effect has a negative impact on anxiety,while the indirect effect of terror has a positive impact on anxiety.Besides,cognition(β=−0.08,P<0.05)could only affect anxiety through the complete mediating effect of SCL-90.Conclusion:In college students,the defensive psychology and behavior in epidemic psychological stress will have different effects on anxiety.The direct effect is that the higher the defensive psychology and behavior,the lower the anxiety.The indirect effect is that the higher the defensive psychology and behavior,the higher the terror,and the higher the anxiety.
基金2022 annual curriculum ideological and political teaching reform research project of Wenzhou Medical University and 2022“big ideological and political”teaching reform project of The First Affiliated Hospital of Wenzhou Medical University.(jglx202210)。
文摘To investigate the correlation between anxiety and related factors among international students in Wenzhou during the COVID-19 epidemic,international students from Wenzhou were selected as subjects for our research.We administered a self-developed questionnaire on anxiety among our subjects in question during the specific time of the COVID-19 epidemic,in which a self-assessment scale was included.Overall,an anxiety questionnaire for international students studying in Wenzhou during the outbreak of COVID–19,a self-rating anxiety scale,and statistical methods were utilized to conduct our research.During the COVID-19 epidemic,international students in Wenzhou experienced varying degrees of anxiety,which were related to concerns about contracting the virus,exam-related stress,and differences in living standards.Therefore,intervention is crucial.
基金supported by partial funding from Blackmores^(■)?
文摘Background: Multivitamins are a popular supplement taken to promote physical and mental health.During periods of stress, they may have a protective role for health and wellbeing, although the current evidence of their efficacy is mixed.Objective: To determine whether multivitamin supplementation impacts psychological and inflammatory markers of women who are experiencing psychological distress.Design, setting, participants and interventions: An 8-week randomized controlled trial was conducted to assess changes in both psychological state and pro-inflammatory markers of patients receiving multivitamins or placebo. The sample comprised women who reported elevated psychological distress in the previous 4 weeks.Main outcome measures: Psychological state was assessed using Spielberger's State-Trait Personality Inventory to assess anxiety, curiosity, depression and anger. Pro-inflammatory markers comprised interleukin(IL)-1β,IL-5, IL-6, tumour necrosis factor(TNF)-α and TNF-p.Results: Improvements across time were observed for all psychological measures and cytokines, except IL-5, but were independent of the active intervention. Only TNF-β demonstrated a significant differential change between groups over the course of the intervention, in favour of multivitamin supplementation(active group mean rank decreased from 11.1 to 7.1; placebo group mean rank decreased from 8.9 to 7.8).Conclusion: The results suggest that administration of multivitamins was not effective in improving psychological state. However, some evidence supported the positive impact of multivitamin supplementation on pro-inflammatory cytokine profiles of women currently experiencing stress.
