BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferati...BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferating potential in kidney injury in mice.METHODS Human umbilical cord blood(UCB)-derived CD34+cells were incubated for one week in vasculogenic conditioning medium.Vasculogenic culture significantly increased the number of CD34+cells and their ability to form endothelial progenitor cell colony-forming units.Adenineinduced tubulointerstitial injury of the kidney was induced in immunodeficient non-obese diabetic/severe combined immunodeficiency mice,and cultured human UCB-CD34+cells were administered at a dose of 1×106/mouse on days 7,14,and 21 after the start of adenine diet.RESULTS Repetitive administration of cultured UCB-CD34+cells significantly improved the time-course of kidney dysfunction in the cell therapy group compared with that in the control group.Both interstitial fibrosis and tubular damage were significantly reduced in the cell therapy group compared with those in the control group(P<0.01).Microvasculature integrity was significantly preserved(P<0.01)and macrophage infiltration into kidney tissue was dramatically decreased in the cell therapy group compared with those in the control group(P<0.001).CONCLUSION Early intervention using human cultured CD34+cells significantly improved the progression of tubulointerstitial kidney injury.Repetitive administration of cultured human UCB-CD34+cells significantly improved tubulointerstitial damage in adenine-induced kidney injury in mice via vasculoprotective and anti-inflammatory effects.展开更多
Managing quality has become a serious endeavor for many Hong Kong companies. Many forward looking chief executives recognize that effective quality management is of strategic importance to competing, winning and ret...Managing quality has become a serious endeavor for many Hong Kong companies. Many forward looking chief executives recognize that effective quality management is of strategic importance to competing, winning and retaining markets. In this respect, they have established their quality culture in order to unify the workforce and the management for better quality performance. This paper is to study the styles of quality culture in some best companies in Hong Kong.展开更多
Hong Kong′s current quality management philosophy can best be described as imported and experimental. This is because Hong Kong is at the interface of Eastern and Western culture, and modern quality management philo...Hong Kong′s current quality management philosophy can best be described as imported and experimental. This is because Hong Kong is at the interface of Eastern and Western culture, and modern quality management philosophies are at first imported from the West and implanted into the Hong Kong Subsidiaries of American and European controlled companies. Local experience in quality management is usually obtained via trial and error, and through progressive modifications. The influence of Chinese culture on quality management in Hong Kong has formed the main subject of this study. This study is to initiate the interest to develop modern quality management concepts based on Chinese culture. Some initial results suggest that Hong Kong managers have great interest in applying Chinese working principle to quality management.展开更多
Until now, the issue of quality of the products of SMEs （small and medium enterprises） remains the main issues as the cause of low ability to compete. This study focused into the issue of what happened with regard t...Until now, the issue of quality of the products of SMEs （small and medium enterprises） remains the main issues as the cause of low ability to compete. This study focused into the issue of what happened with regard to the quality of products in the supply chain SME products. This study aims to describe how the culture of quality in the supply chain of SMEs and their role in contributing to the lack of SME products. The study involved 128 SMEs in the food processing industry cluster and garment industry. The research uses qualitative method with case study approach. The results showed an average internal quality culture reached 3.62661 supply included in the category enough. Of the five industry cluster, a culture of quality in the internal supply chain is the best T-shirt industry （4.3385） in both categories, while other four clusters exist in enough categories, with grades： hoods （3.661）, soy crisps （3.6635）, cassava chips （3.64）, and the last chips fish balls （2.829）. The low average internal quality culture supply mainly is in industrial processing of cassava chips and chips fish balls. One reason is the low awareness of quality. There is no technology and equipment adequate to safeguard the stability of quality. The upper most excellent quality culture occurred in the supply chain, where the product is controlled by big industry, is the industry shirts （4.018）, soy crisps （3.613）, and hoods （3.473）, while when in the upstream industry controlled by small or SMEs, there is deterioration in the cultural values of quality： cassava chips （2.917） and chips fish balls （2.781）. For downstream, 100% controlled by SMEs, there is an average value of quality culture 3.5662.展开更多
The Whole-Process People’s Democracy has become an important proposition of the socialist modernization democratic theory with Chinese characteristics,and has important value for the development of the new form of hu...The Whole-Process People’s Democracy has become an important proposition of the socialist modernization democratic theory with Chinese characteristics,and has important value for the development of the new form of human civilization.The Whole-Process People’s Democracy is not only a“democracy”system,its focus is to achieve“people’s democracy”,its unique feature is to surpass“non process”democracy with the“Whole-Process”,and create a new governance path of a new form of human civilization.Of course,the emphasis of people’s democracy on the consciousness of people’s subjective participation in the whole process also puts forward corresponding requirements for the cultural quality construction of Chinese social citizens in the new era,so it is also of great significance to pay attention to the cultivation of citizens’public spirit.展开更多
文摘BACKGROUND There is no established treatment to impede the progression or restore kidney function in human chronic kidney disease(CKD).AIM To examine the efficacy of cultured human CD34+cells with enhanced proliferating potential in kidney injury in mice.METHODS Human umbilical cord blood(UCB)-derived CD34+cells were incubated for one week in vasculogenic conditioning medium.Vasculogenic culture significantly increased the number of CD34+cells and their ability to form endothelial progenitor cell colony-forming units.Adenineinduced tubulointerstitial injury of the kidney was induced in immunodeficient non-obese diabetic/severe combined immunodeficiency mice,and cultured human UCB-CD34+cells were administered at a dose of 1×106/mouse on days 7,14,and 21 after the start of adenine diet.RESULTS Repetitive administration of cultured UCB-CD34+cells significantly improved the time-course of kidney dysfunction in the cell therapy group compared with that in the control group.Both interstitial fibrosis and tubular damage were significantly reduced in the cell therapy group compared with those in the control group(P<0.01).Microvasculature integrity was significantly preserved(P<0.01)and macrophage infiltration into kidney tissue was dramatically decreased in the cell therapy group compared with those in the control group(P<0.001).CONCLUSION Early intervention using human cultured CD34+cells significantly improved the progression of tubulointerstitial kidney injury.Repetitive administration of cultured human UCB-CD34+cells significantly improved tubulointerstitial damage in adenine-induced kidney injury in mice via vasculoprotective and anti-inflammatory effects.
文摘Managing quality has become a serious endeavor for many Hong Kong companies. Many forward looking chief executives recognize that effective quality management is of strategic importance to competing, winning and retaining markets. In this respect, they have established their quality culture in order to unify the workforce and the management for better quality performance. This paper is to study the styles of quality culture in some best companies in Hong Kong.
文摘Hong Kong′s current quality management philosophy can best be described as imported and experimental. This is because Hong Kong is at the interface of Eastern and Western culture, and modern quality management philosophies are at first imported from the West and implanted into the Hong Kong Subsidiaries of American and European controlled companies. Local experience in quality management is usually obtained via trial and error, and through progressive modifications. The influence of Chinese culture on quality management in Hong Kong has formed the main subject of this study. This study is to initiate the interest to develop modern quality management concepts based on Chinese culture. Some initial results suggest that Hong Kong managers have great interest in applying Chinese working principle to quality management.
文摘Until now, the issue of quality of the products of SMEs （small and medium enterprises） remains the main issues as the cause of low ability to compete. This study focused into the issue of what happened with regard to the quality of products in the supply chain SME products. This study aims to describe how the culture of quality in the supply chain of SMEs and their role in contributing to the lack of SME products. The study involved 128 SMEs in the food processing industry cluster and garment industry. The research uses qualitative method with case study approach. The results showed an average internal quality culture reached 3.62661 supply included in the category enough. Of the five industry cluster, a culture of quality in the internal supply chain is the best T-shirt industry （4.3385） in both categories, while other four clusters exist in enough categories, with grades： hoods （3.661）, soy crisps （3.6635）, cassava chips （3.64）, and the last chips fish balls （2.829）. The low average internal quality culture supply mainly is in industrial processing of cassava chips and chips fish balls. One reason is the low awareness of quality. There is no technology and equipment adequate to safeguard the stability of quality. The upper most excellent quality culture occurred in the supply chain, where the product is controlled by big industry, is the industry shirts （4.018）, soy crisps （3.613）, and hoods （3.473）, while when in the upstream industry controlled by small or SMEs, there is deterioration in the cultural values of quality： cassava chips （2.917） and chips fish balls （2.781）. For downstream, 100% controlled by SMEs, there is an average value of quality culture 3.5662.
基金This paper is the phased research result of the project“The Centennial Exploration Process and Innovative Development of the Communist Party of China on the Marxist Concept of Problems”(Project No.:nkxj21110104)of the Tianjin Collaborative Innovation Center of Basic Principles of Marxism in 2021The phased research results of the topic“Research on Common Prosperity and the Promotion of Democratic Process in the New Era”(Project No.:2022xs-0068)of the Independent Innovation Fund(social influence project)of Tianjin University in 2022.
文摘The Whole-Process People’s Democracy has become an important proposition of the socialist modernization democratic theory with Chinese characteristics,and has important value for the development of the new form of human civilization.The Whole-Process People’s Democracy is not only a“democracy”system,its focus is to achieve“people’s democracy”,its unique feature is to surpass“non process”democracy with the“Whole-Process”,and create a new governance path of a new form of human civilization.Of course,the emphasis of people’s democracy on the consciousness of people’s subjective participation in the whole process also puts forward corresponding requirements for the cultural quality construction of Chinese social citizens in the new era,so it is also of great significance to pay attention to the cultivation of citizens’public spirit.
