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Optimization of Preparative Separation and Purification of Total Flavonoids from Radix Puerariae by Macroporous Resin Method 被引量:11
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作者 刘火安 王伯初 +3 位作者 戴传云 邵志勇 何从林 贾云 《Journal of Chinese Pharmaceutical Sciences》 CAS 2006年第2期121-126,共6页
Aim To screen the optimum macroporous resin and conditions for the isolation and purification of flavonoids from Radix Puerariae. Methods The static and dynamic adsorption/desorption methods were used, and the separat... Aim To screen the optimum macroporous resin and conditions for the isolation and purification of flavonoids from Radix Puerariae. Methods The static and dynamic adsorption/desorption methods were used, and the separation and purification process was evaluated by measuring the concentration of total flavonoid in the fractions with UV spectrophotometer. Results The SP70 macroporous resin was the most effective compared with other macroporous resins. The optimum conditions were screened, which were 0.5 g· mL^- 1 corresponding to crude drug for concentration of extract, pH 5 - 6, and appended 60 times the volume of the resin bed (BV) with the adsorption speed 2 BV·h^-1, and the volume of aq. 70% (V/V) ethanol as eluant was 5 BV with desorption speed 2 BV·h^-1. By this method, the final contents of total flavonoids exceeded 80%. Conclusion The SP70 macroporous resin is the most effective one for large-scale isolation and purification of flavonoids from Radix Pueraria, which meets industrial needs. 展开更多
关键词 radix puerariae total flavonoids macroporous resin SEPARATION PURIFICATION
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Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation
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作者 Yu Ga Yuanyuan Wei +9 位作者 Qingyu Zhao Yimeng Fan Yannan Zhang Zhifang Zhang Sijia Hao Lixia Wang Zhifen Wang Jinlong Han Shuang Wu Zhihui Hao 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第4期2266-2276,共11页
Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal tract.Traditional Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrhea... Ulcerative colitis(UC)is a common inflammatory disease of the gastrointestinal tract.Traditional Chinese medicine(TCM)has long been used in Asia as a treatment for UC and Puerariae Radix(PR)is a reliable anti-diarrheal therapy.The aims of this study were to investigate the protective effect of PR using the dextran sulfate sodium salt(DSS)-induced UC model in mice and identify molecular mechanisms of PR action.The chemical constituents of PR via ultra-performance liquid chromatography/tandem mass spectrometry and identified potential PR and UC targets using a network pharmacology(NP)approach were obtained to guide mouse experiments.A total of 180 peaks were identified from PR including 48 flavonoids,46 organic acids,14 amino acids,8 phenols,8 carbohydrates,7 alkaloids,6 coumarins and 43 other constituents.NP results showed that caspase-1 was the most dysregulated of the core genes associated with UC.A PR dose of 0.136 mg/g administered to DSS treated mice reversed weight loss and decreased colon lengths found in UC mice.PR also alleviated intestinal mucosal shedding,inflammatory cell infiltration and mucin loss.PR treatment suppressed upregulation of NOD-like receptor protein 3(NLRP3),cysteinyl aspartate-specific proteases-1(caspase-1),apoptosis-associated speck-like(ASC)and gasdermin D(GSDMD)at both the protein and m RNA expression levels.The addition of a small molecule dual-specificity phosphatase inhibitor NSC 95397 inhibited the positive effects of PR.These results indicated that PR exerts a protective effect on DSS-induced colitis by inhibiting NLRP3 inflammasome activation in mice. 展开更多
关键词 puerariae radix Ulcerative colitis Molecular mechanisms PYROPTOSIS NOD-like receptor protein 3 inflammasome
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Effects of Radix Puerariae, Radix Rehmanniae and Their Compatibility on Blood Glucose and Blood Lipids in Mice
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作者 Yumei ZHANG Yulin ZHAO +3 位作者 Yanmei QIN Jialing WEI Xiang QIN Suoyi HUANG 《Medicinal Plant》 2024年第1期45-47,共3页
[Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fa... [Objectives]To explore the effects of the compatibility of Radix Puerariae and Radix Rehmanniae on blood glucose and blood lipids in diabetic mouses.[Methods]Diabetic mouse model was established.The body weight and fasting blood glucose of mice were measured after 7 and 14 d of administration,and the biochemical indicators of blood lipids(TC,HDL-C,and LDL-C)were detected after 14 d of administration.[Results]Compared with the Radix Puerariae group and Radix Rehmanniae group,the compatibility group(1:2)had the best hypoglycemic effect(P<0.05),and TC and LDL-C in the compatibility group(2:1)significantly decreased(P<0.05),while HDL-C in the compatibility group(1:1)significantly increased(P<0.05).[Conclusions]Radix Puerariae,Radix Rehmanniae and their combination can reduce the blood glucose of diabetic mice.The compatibility group(1:2)had a significant hypoglycemic effect(P<0.05),and LDL-C in the compatibility group(2:1)significantly declined,while HDL-C in the compatibility group(1:1)rose significantly. 展开更多
关键词 radix puerariae radix Rehmanniae Compatibility Hypoglycemic effect Blood lipids
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Effects of Ethanol Condensation Reflux Extraction and Ultrasound-assisted Extraction on the Content of Total Flavonoids of Pueraria edulis
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作者 Jun TANG Jianguang ZENG +1 位作者 Hao LI Chenzhong JIN 《Agricultural Biotechnology》 CAS 2023年第2期91-95,104,共6页
With Pueraria edulis from different habitats in Yunnan Province,Guangdong Province and Guangxi Zhuang autonomous region as materials,the medicinal materials of P.edulis were extracted by ethanol condensation reflux ex... With Pueraria edulis from different habitats in Yunnan Province,Guangdong Province and Guangxi Zhuang autonomous region as materials,the medicinal materials of P.edulis were extracted by ethanol condensation reflux extraction and ultrasound-assisted extraction,and the effects of different extraction methods the contents of total flavonoids in P.edulis from different areas were compared.The results showed that the best extraction time for P.edulis in Yunnan Province was 20 min,and that for Guangdong and Guangxi Zhuang Autonomous Region was 30 min.The yield of total flavonoids from P.edulis extracted by the condensation reflux extraction method was relatively better.The content of total flavonoids in P.edulis in Yunnan was the highest with an average content of 0.2557%,while the average content of total flavonoids in P.edulis in Guangdong was the lowest with an average content of 0.2108%. 展开更多
关键词 pueraria edulis Total flavonoids Condensation reflux extraction method Ultrasound-assisted extraction
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Kinetics of Leaching Flavonoids from Pueraria Lobata with Ethanol 被引量:5
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作者 池汝安 田君 +4 位作者 高洪 周芳 刘敏 王存文 吴元欣 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2006年第3期402-406,共5页
The kinetics of leaching flavonoids from Pueraria Lobata with ethanol was investigated. The effects of leaching temperature, mechanical agitation rate, concentration of ethanol and feed particle size on leaching kinet... The kinetics of leaching flavonoids from Pueraria Lobata with ethanol was investigated. The effects of leaching temperature, mechanical agitation rate, concentration of ethanol and feed particle size on leaching kinetics were examined. It is found that the smaller the feed particle size or the higher the leaching temperature, the higher the leaching rate. The leaching process can be described by the shrinking-core model. The apparent activation energy is 10.8kJ·mol^-1, suggesting that the leaching process is controlled by the inner diffusion. An empirical equation relating the flavonoids leaching rate constant to the feed particle size and leaching temperature was expected. 展开更多
关键词 KINETICS LEACHING flavonoids pueraria Lobata
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Kinetics of Leaching Flavonoids from Pueraria Lobata with Ethanol 被引量:2
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作者 池汝安 田君 +4 位作者 高洪 周芳 刘敏 王存文 吴元欣 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2006年第3X期402-406,共5页
The kinetics of leaching flavonoids from Pueraria Lobata with ethanol was investigated. The effects of leaching temperature, mechanical agitation rate,concentration of ethanol and feed particle size on leaching kineti... The kinetics of leaching flavonoids from Pueraria Lobata with ethanol was investigated. The effects of leaching temperature, mechanical agitation rate,concentration of ethanol and feed particle size on leaching kinetics were examined.It is found that the smaller the feed particle size or the higher the leaching temperature,the higher the leaching rate. The leaching process can be described by the shrinking-core model. The apparent activation en- ergy is 10.8kJ·mol-1, suggesting that the leaching process is controlled by the inner diffusion. An empirical equa- tion relating the flavonoids leaching rate constant to the feed particle size and leaching temperature was expected. 展开更多
关键词 KINETICS LEACHING flavonoids pueraria Lobata
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Radix Ilicis Pubescentis total flavonoids combined with mobilization of bone marrow stem cells to protect against cerebral ischemia/reperfusion injury 被引量:3
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作者 Ming-san Miao Lin Guo +1 位作者 Rui-qi Li Xiao Ma 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第2期278-284,共7页
Previous studies have shown that Radix Ilicis Pubescentis total flavonoids have a neuroprotective effect, but it remains unclear whether Radix Ilicis Pubescentis total flavonoids have a synergistic effect with the rec... Previous studies have shown that Radix Ilicis Pubescentis total flavonoids have a neuroprotective effect, but it remains unclear whether Radix Ilicis Pubescentis total flavonoids have a synergistic effect with the recombinant human granulocyte colony stimulating factor-mobilized bone marrow stem cell transplantation on cerebral ischemia/reperfusion injury. Rat ischemia models were administered 0.3, 0.15 and 0.075 g/kg Radix Ilicis Pubescentis total flavonoids from 3 days before modeling to 2 days after injury. Results showed that Radix Ilicis Pubescentis total flavonoids could reduce pathological injury in rats with cerebral ischemia/reperfusion injury. The number of Nissl bodies increased, Bax protein expression decreased, Bcl-2 protein expression increased and the number of CD34-positive cells increased. Therefore, Radix Ilicis Pubescentis total flavonoids can improve the bone marrow stem cell mobilization effect, enhance the anti-apoptotic ability of nerve cells, and have a neuroprotective effect on cerebral ischemia/reperfusion injury in rats. 展开更多
关键词 nerve regeneration radix Ilicis Pubescentis total flavonoids bone marrow stem cells MOBILIZATION cerebral ischemia/reperfusion Nissl bodies Bax Bcl-2 CD34 neurons neural regeneration
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Extraction and separation of total flavonoids from Flos Puerariae and its antioxidant activity 被引量:1
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作者 ZHANG Rui-xue1,OUYANG Chang-han2,WU Ji-liang1(1.Department of Pharmacology,Xianning College,Xianning 437100,China 2.Department of Pharmacology,School of Medicine,Wuhan University,Wuhan 430071,China) 《沈阳药科大学学报》 CAS CSCD 北大核心 2008年第S1期116-116,共1页
Objective To study the optimum extraction and separation process of total flavonoids in the flowers of Flos Puerariae and its antioxidative activity.Methods The total flavonoids were extracted with assistance of ultra... Objective To study the optimum extraction and separation process of total flavonoids in the flowers of Flos Puerariae and its antioxidative activity.Methods The total flavonoids were extracted with assistance of ultrasonic wave and the content was determined at 265 nm wavelength by Spectrophotometric method.Orthogonal experiment L9(34)was carried out to investigate the effects of concentration of solvent,the ratio of material to liquid,time length of extraction,and frequency of extraction on extraction results of total flavonoids from Flos Puerariae.The extracted solution was purified by petroleum ether and ethanol sequently.Under these conditions,the total flavonoids was eluted gradiently with mixed mobile phase of methanol-chloroform solution in the silica gel column system,and then determined by UV scanning and HPLC.Fenton reaction was used to produce and detect hydroxyl radicals(·OH),and pyrogallol system was used to produce and detect the superoxide radical anion(O2-·).Results The optimum conditions were as follows;using 40%(V/V)methanol as extractor with the ratio of material to liquid at 1∶30,and extracting for 2.5 h a time for 3 times.The extraction yield of total flavonoids was 13.6%.Six isoflavone compounds were isolated from the flowers of Flos Puerariae by the method of silica gel column chromatography.Antioxidative test results showed good performance of flavonoid scavenging capacity in both hydroxyl radical system and superoxide radical system and its IC50 was 7.65 μg·mL-1 and 0.18 mg·mL-1,respectively.Conclusions This study provided scientific basis for further development and utilization of Flos Puerariae and make preparation for later pharmacological research. 展开更多
关键词 flos puerariae TOTAL flavonoids EXTRACTION SEPARATION ANTIOXIDATION
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Content Determination of Flavonoids in Radix Millettiae Speciosae from Different Areas of Guangxi 被引量:1
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作者 Jingwen GU Liuping WANG +1 位作者 Dongping TU Xiajun ZHONG 《Medicinal Plant》 CAS 2019年第1期31-33,共3页
[Objectives] This study aimed to investigate the quality of Radix Millettiae Speciosae at different planting sites in Guangxi. [Methods] The content of flavonoids in Radix Millettiae Speciosae was determined by HPLC. ... [Objectives] This study aimed to investigate the quality of Radix Millettiae Speciosae at different planting sites in Guangxi. [Methods] The content of flavonoids in Radix Millettiae Speciosae was determined by HPLC. The chromatographic conditions were as follows: column, ZORBAX SB-C_(18); mobile phase, acetonitrile-0.1% glacial acetic acid(42∶58); detection wavelength, 250(formononetin) and 310(maackiain) nm; flow rate, 1.0 mL/min; and column temperature, 30℃. [Results] Under the chromatographic conditions above, formononetin and maackiain could be completely separated from impurities. The standard curve had a good linear relationship(R^2>0.999 9). The precision and stability met analysis requirements. The average recovery rates were 97.53% and 98.54%, respectively, and the RSD values were 2.03% and 1.88%, respectively, indicating that the established method has good reproducibility, durability and accuracy. The content of formononetin was highest in the Radix Millettiae Speciosae from Yongning District, Nanning City, and the content of maackiain was highest in the Radix Millettiae Speciosae from Xichang Town, Hepu County. [Conclusions] The HPLC method established in this study is simple, accurate and stable. It can be used as a quality control method for Radix Millettiae Speciosae. The contents of flavonoids in Radix Millettiae Speciosae from Yongning District, Nanning City and Xichang Town, Hepu County were higher than those from other planting bases. 展开更多
关键词 radix Millettiae Speciosae flavonoids FORMONONETIN Maackiain HPLC
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Molecular mechanism study of Radix Pueraria for the treatment of glioma based on network pharmacology
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作者 Li Ye Jiaoyang Hou Guodong Yao 《Asian Journal of Traditional Medicines》 CAS 2023年第1期1-14,共14页
Radix Pueraria(RP)has a long history of dual-use in medicine and food,and is well known as“Asian ginseng”.Recently,some studies about the effect of RP against glioma have been reported.However,little is elucidated a... Radix Pueraria(RP)has a long history of dual-use in medicine and food,and is well known as“Asian ginseng”.Recently,some studies about the effect of RP against glioma have been reported.However,little is elucidated about the molecular mechanism of interaction.This study used network pharmacology and molecular docking techniques to clarify the molecular mechanism of RP in the treatment of glioma.Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)was applied to screen potential active ingredients of RP and their targets.Targets for glioma were obtained from Genecards,OMIM,and Therapeutic Target Database(TTD).The topological analysis of cross-target and core target interaction was conducted using protein-protein interaction analysis(PPI).With the application of bioinformatics,GO and KEGG enrichment analyses were further carried out.Molecular docking was used then to validate the binding affinity between active components and key targets.This study successfully identified 6 potential active ingredients,namely beta-sitosterol,daidzein,formononetin,genistein,ononin,and puerarin.The hub targets were AKT1,TP53,VEGRA,EGFR,and MAPK3.These targets were mainly involved in biological processes,such as RNA polymerase II-specific DNA-binding transcription factor binding,and positive regulation of cell migration in the membrane raft,and were regulated by PI3K-Akt pathway.Further study showed that almost all the compounds had good binding abilities with above-mentioned targets.In short,this study systematically revealed the anti-glioma mechanism of RP to provide reference for the treatment of glioma. 展开更多
关键词 radix pueraria GLIOMA network pharmacology molecular docking blood-brain barrier
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Radix Ilicis Pubescentis total flavonoids ameliorates neuronal damage and reduces lesion extent in a mouse model of transient ischemic attack 被引量:2
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作者 Ming-san Miao Lin Guo +1 位作者 Rui-qi Li Xiao-lei Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第3期441-446,共6页
Flavonoids are a major component in the traditional Chinese medicine Radix Ilicis Pubescentis.Previous studies have shown that the administration of Radix Ilicis Pubescentis total flavonoids is protective in cerebral ... Flavonoids are a major component in the traditional Chinese medicine Radix Ilicis Pubescentis.Previous studies have shown that the administration of Radix Ilicis Pubescentis total flavonoids is protective in cerebral ischemia.However,to our knowledge,no studies have examined whether the total flavonoids extracted from Radix Ilicis Pubescentis prevent or ameliorate neuronal damage following transient ischemic attacks.Therefore,Radix Ilicis Pubescentis total flavonoids question and the potential underlying mechanisms.Thus,beginning 3 days before the induction of a mouse model of transient ischemic attack using tert-butyl hydroperoxide injections,mice were intragastrically administered 0.3,0.15,or 0.075 g/kg of Radix Ilicis Pubescentis total flavonoids daily for 10 days.The results of spectrophotometric analyses demonstrated that Radix Ilicis Pubescentis total flavonoids enhanced oxygen free radical scavenging and reduced pathological alterations in the brain.Hematoxylin-eosin staining results showed that Radix Ilicis Pubescentis total flavonoids reduced hippocampal neuronal damage and cerebral vascular injury in this mouse model of transient ischemic attack.These results suggest that the antioxidant effects of Radix Ilicis Pubescentis total flavonoids alleviate the damage to brain tissue caused by transient ischemic attack. 展开更多
关键词 nerve regeneration transient ischemic attack radix Ilicis Pubescentis total flavonoids tert-butyl hydroperoxide malondialdehyde nitric oxide nitric oxide synthetase superoxide dismutase neural regeneration
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Extraction Technology of Total Flavonoids from Pueraria lobata (Willd.) Ohwi and Content Determination of Pueraria lobata (Willd.) Ohwi at Different Altitudes 被引量:2
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作者 Chunlin LIU Yingchen LI +1 位作者 Bochao LI Yuan LIU 《Medicinal Plant》 2017年第2期12-14,18,共4页
[Objectives]To optimize the extraction technology of total flavonoids from Pueraria lobata( Willd.) Ohwi. [Methods]The ultraviolet-visible spectrophotometry was used to determine the content of total flavonoids in Pue... [Objectives]To optimize the extraction technology of total flavonoids from Pueraria lobata( Willd.) Ohwi. [Methods]The ultraviolet-visible spectrophotometry was used to determine the content of total flavonoids in Pueraria lobata( Willd.) Ohwi. With the puerarin as index,the reflux extraction and single factor test were employed to investigate the effects of temperature,time,ethanol concentration and solid-liquid ratio on the content of total flavonoids in Pueraria lobata( Willd.) Ohwi,respectively. Under the optimal extraction technology,the content of total flavonoids in Pueraria lobata( Willd.) Ohwi at different altitudes was determined.[Results] The optimum extraction process was as follows: 70%ethanol; solid-liquid ratio of 1∶ 30; 1 h reflux extraction. Under these conditions,the extraction rate of flavonoids in Pueraria lobata( Willd.) Ohwi was 11. 48%,the total flavonoids content of different kudzu parts was in the order of roots > stems > leaves,and the total flavonoids content of the sample at about an altitude of 1000 m was significantly higher than at the altitudes of 1400 m and 1700 m.[Conclusions]It was suggested that the Pueraria lobata( Willd.) Ohwi should not be cultivated as medicinal plant in too high mountains,and the stems and leaves of Pueraria lobata( Willd.) Ohwi could be used as raw materials for extracting total flavonoids. 展开更多
关键词 pueraria lobata(Willd.) Ohwi TOTAL flavonoids EXTRACTION technology Different ALTITUDES CONTENT determination
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Optimization of Extraction Process and Content Determination of Total Flavonoids from Sanguisorbae Radix and Carbonized Sanguisorba Root by Orthogonal Experimental Design 被引量:1
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作者 Fenglin WANG Yunzhang XU +1 位作者 Jingxia WANG Yuan LIU 《Medicinal Plant》 2017年第6期5-9,共5页
[Objectives] To optimize the extraction process of total flavonoids from Sanguisorbae Radix and carbonized Sanguisorba root,compare quality of different batches of Sanguisorbae Radix,study the effects of processing on... [Objectives] To optimize the extraction process of total flavonoids from Sanguisorbae Radix and carbonized Sanguisorba root,compare quality of different batches of Sanguisorbae Radix,study the effects of processing on the content of flavonoids,and provide scientific basis for reasonable utilization of Sanguisorbae Radix. [Methods] Test samples were prepared by heating,refluxing,and extraction,the extraction process was optimized by orthogonal experiment design,color was developed by NaNO_2-Al( NO_3)3-NaOH,and total flavonoids were measured by UV method at the wavelength of 510 nm. [Results] The linear relationship of rutin was excellent in the concentration range of 0. 1248 mg/mL-0. 5712 mg/mL,R^2= 0. 9997; the average recovery was 99. 67% and the RSD was 0. 70%. The optimum extraction conditions were as follows: the volume fraction of ethanol was 50%,the extraction temperature was 90℃,the extraction time was 90 min,and the solid-to-liquid ratio was 1∶ 20( g/mL). [Conclusions] After optimization of the extraction process,the extraction rate of total flavonoids in samples of Sanguisorbae Radix was significantly increased; there was certain difference in the content of total flavonoids between different batches of Sanguisorbae Radix and processed products; the total flavonoids significantly declines in carbonized sanguisorba root,and the influence of processing on its curative effect was to be further studied. 展开更多
关键词 Sanguisorbae radix Carbonized sanguisorba ROOT TOTAL flavonoids EXTRACTION process CONTENT determination
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Response surface optimization of microwave-assisted extraction for HPLC-fluorescence determination of puerarin and daidzein in Radix Puerariae thomsonii 被引量:8
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作者 Ying-Kun Liu E Yan +1 位作者 Han-Ying Zhan Zhi-Qi Zhang 《Journal of Pharmaceutical Analysis》 SCIE CAS 2011年第1期13-19,共7页
Microwave-assisted extraction was optimized with response surface methodology for HPLC-fluorescence determination of puerarin and daidzein in Radix Puerariae thomsonii.The optimized extraction procedure was achieved b... Microwave-assisted extraction was optimized with response surface methodology for HPLC-fluorescence determination of puerarin and daidzein in Radix Puerariae thomsonii.The optimized extraction procedure was achieved by soaking the sample with 70% methanol(1∶15,v/v)for 30 min,and then microwave irradiation for 11 min at a power of 600 W.Coupling the extraction process with HPLC-fluorescence presented good recovery,satisfactory precision,and good linear relation.Compared with a method from the Chinese Pharmacopoeia,the proposed method enables higher extraction efficiency and more accurate analytical results.It can be of potential value in quality assessment of Radix Puerariae thomsonii medicinal materials. 展开更多
关键词 microwave-assisted extraction(MAE) response surface methodology(RSM) PUERARIN DAIDZEIN HPLC-fluorescence detection radix puerariae thomsonii
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Determination and Analysis of Flavonoid Contents in Different Batches of Dried Radix Rehmannia and Prepared Radix Rehmanniae
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作者 Fengyan SONG 《Agricultural Biotechnology》 CAS 2019年第6期90-91,共2页
[Objectives] This study was conducted to understand Radix Rehmannia quality and provide reference for selection in application. [Methods] The contents of flavonoids in five batches of commercially available samples we... [Objectives] This study was conducted to understand Radix Rehmannia quality and provide reference for selection in application. [Methods] The contents of flavonoids in five batches of commercially available samples were determined by ultraviolet spectrophotometry, and the precision and reproducibility of the determination method were analyzed. [Results] The contents of flavonoids in different batches of Radix Rehmannia samples were not completely the same, but the differences were not large overall. The experiment results have good reliability. As a medicinal plant, the climate and soil conditions of the producing areas would have an impact on the quality of Radix Rehmannia. [Conclusions] The contents of flavonoids determined in Radix Rehmannia were relatively stable, the quality was basically the same, and the overall quality was good. 展开更多
关键词 radix Rehmannia flavonoids UV spectrophotometry DETERMINATION
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Effects of Carbon Ion Beam Radiation on the Accumulation of Flavonoids in Astragalus membranaceus
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作者 Wang Yuanmeng Zhou LibinJin Ling +4 位作者 Ge Linghui Liu Xiao Du Yan Jin Wenjie Xin Zhijun 《IMP & HIRFL Annual Report》 2022年第1期155-155,共1页
Astragali Radix from the dried root of Astragalus membranaceus(A.membranaceus),as a medicinal and edible traditional Chinese medicine,has crucial application value in the prevention and treatment of COVID-19 in China.... Astragali Radix from the dried root of Astragalus membranaceus(A.membranaceus),as a medicinal and edible traditional Chinese medicine,has crucial application value in the prevention and treatment of COVID-19 in China.Among them^([1]),avonoids are one of the main compounds of astragali radix to exert pharmacological activity and therapeutic effects^([2]).However,the meager germplasm and uneven quality of A. 展开更多
关键词 PREVENTION radix flavonoids
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葛斛调脂方干预代谢综合征患者的随机对照研究
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作者 郑蓉 刘志栋 +3 位作者 王淼 张笑 陈俊岚 周时高 《中国全科医学》 北大核心 2024年第3期343-347,共5页
背景 全球约有1/4的人患有代谢综合征(Met S)。近年来我国Met S患病率也呈逐年上升趋势,对生命健康造成严重威胁。中医药治疗Met S有着多靶点、多环节的优势,但目前临床上缺乏高质量的随机对照研究和真实世界研究。目的 观察葛斛调脂方... 背景 全球约有1/4的人患有代谢综合征(Met S)。近年来我国Met S患病率也呈逐年上升趋势,对生命健康造成严重威胁。中医药治疗Met S有着多靶点、多环节的优势,但目前临床上缺乏高质量的随机对照研究和真实世界研究。目的 观察葛斛调脂方对Met S患者腰围(WC)、体质量、体脂率(BFP)及糖脂代谢的影响。方法2021年6月—2022年11月前瞻性选取上海中医药大学附属龙华医院门诊就诊及住院的84例Met S患者为研究对象。应用SPSS 25.0统计软件给定随机种子数,将受试者随机分为葛斛组(42例)和对照组(42例)。葛斛组应用葛斛调脂方颗粒治疗(葛根6 g,铁皮石斛6 g),患者空腹早晚各1次,1包/次,冲服,连续服用8周。对照组应用安慰剂颗粒干预,患者空腹早晚各1次,1包/次,冲服,连续服用8周。干预期间对两组患者进行相同的健康宣教(包括膳食方案和运动处方的指导)。干预8周后对比分析两组患者的WC、体质量、BMI、BFP、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)。结果 最终葛斛组41例、对照组41例完成8周的干预研究。治疗前两组患者WC、体质量、BMI、BFP比较,差异均无统计学意义(P>0.05)。两组治疗前后WC、体质量、BMI、BFP差值比较,差异均有统计学意义(P<0.05)。治疗前两组患者的TG、TC、HDL-C、LDL-C、FBG比较,差异均无统计学意义(P>0.05)。两组治疗前后TG、TC、FBG差值比较,差异均有统计学意义(P<0.05)。在治疗期间和随访结束后两组均未发生严重不良反应事件。结论 葛斛调脂方能较好地改善MetS患者的WC、体质量、BMI、BFP、TG、TC及FBG,且安全性较好。 展开更多
关键词 代谢综合征 葛根 铁皮石斛 中医药学 临床研究 治疗结果
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超声波法提取恒山黄芪叶茶黄酮最佳工艺研究
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作者 张永芳 杨文华 +3 位作者 张东旭 李侠 郭浩然 王碧玉 《山西大同大学学报(自然科学版)》 2024年第4期85-90,共6页
目的探索超声波法提取黄芪叶茶中黄酮的最优方法。方法利用超声波辅助提取法结合单因素试验和正交试验,确定提取恒山黄芪叶茶中黄酮的最佳提取工艺。结果因素影响力排序:料液比>乙醇浓度>超声波功率>提取温度>提取时间。得... 目的探索超声波法提取黄芪叶茶中黄酮的最优方法。方法利用超声波辅助提取法结合单因素试验和正交试验,确定提取恒山黄芪叶茶中黄酮的最佳提取工艺。结果因素影响力排序:料液比>乙醇浓度>超声波功率>提取温度>提取时间。得到最佳提取工艺为:料液比为1∶35 g/mL,乙醇浓度为60%,超声波功率为280 W,提取温度为60℃,提取时间为45 min。结论在此最佳条件下,恒山黄芪叶茶中总黄酮的提取率为14.302%。 展开更多
关键词 超声波辅助提取 恒山黄芪 叶茶 黄酮
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黄芪黄酮类成分及其药理作用研究 被引量:22
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作者 何嘉郡 秦晨 +5 位作者 贺廉清 王盼盼 曹惠妍 刘维丽 刘秀波 马伟 《辽宁中医药大学学报》 CAS 2024年第1期112-119,共8页
黄芪是豆科黄芪属多年生草本植物。中药黄芪历史悠久,作为中国传统中药之一,具有应用范围广、药用价值高等特点。黄芪的化学成分主要包含黄芪甲苷、黄芪多糖、黄芪黄酮、氨基酸等。近年来药理研究表明黄芪中黄酮类成分具有抗肿瘤、抗炎... 黄芪是豆科黄芪属多年生草本植物。中药黄芪历史悠久,作为中国传统中药之一,具有应用范围广、药用价值高等特点。黄芪的化学成分主要包含黄芪甲苷、黄芪多糖、黄芪黄酮、氨基酸等。近年来药理研究表明黄芪中黄酮类成分具有抗肿瘤、抗炎、抗氧化、抗病毒、免疫调节、降血糖等多种药理作用,其抗肿瘤作用效果显著,成为近年来学者们广泛研究的热点。文章对黄芪黄酮的化学成分及其药理作用相关文献进行搜集、检索、查阅、归纳与整理,并进行系统概括与总结,以期为黄芪黄酮类成分进一步开发与利用提供理论依据。 展开更多
关键词 黄芪 黄酮 化学成分 药理作用
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吴伟基于“瘀毒致悸”辨治房颤思路探讨
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作者 翟惠奇 黎燚华 +7 位作者 康亮 余润佳 李荣 吴辉 周小雄 都治伊 褚庆民 吴伟(指导) 《广州中医药大学学报》 CAS 2024年第5期1316-1322,共7页
吴伟教授在辨治房颤过程中,创新性地提出“心-血-脉三位一体论”与“瘀毒致悸”论。认为房颤由瘀毒所致,其病位在心-血-脉,核心病机为“气滞血瘀毒成”。治法当紧扣病机,提倡“从瘀论治,兼以解毒,缓消其毒”,且认为理气活血化瘀便是解... 吴伟教授在辨治房颤过程中,创新性地提出“心-血-脉三位一体论”与“瘀毒致悸”论。认为房颤由瘀毒所致,其病位在心-血-脉,核心病机为“气滞血瘀毒成”。治法当紧扣病机,提倡“从瘀论治,兼以解毒,缓消其毒”,且认为理气活血化瘀便是解毒。方拟桃仁红花煎加减,主要组成药物有桃仁、红花、川芎、延胡索、生地黄、赤芍、丹参、大枣、葛根、甘松、牡蛎、茯苓、玉竹等,并根据岭南之气候与房颤多影响情志之特点,去方中辛烈之品,而加特色解毒药对葛根-甘松以辨病而治。吴伟教授治疗房颤还常配合沐足、针灸、导引等中医外治法和保健法,全面调理,缓消其毒,以复其元。吴伟教授治疗房颤采用中医药精准干预,综合调理,可达到促进症状消失及恢复窦性心律、改善体质等目的,其辨治思路可为房颤的中医药治疗提供参考。 展开更多
关键词 房颤 心-血-脉三位一体 瘀毒致悸 活血化瘀 桃仁红花煎 葛根 甘松 吴伟
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