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Random walk modeling of wake dispersion for the exhaust tower of an underground tunnel in urban area 被引量:2
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作者 JIANG Wei\|mei\+1, YU Hong\|bin\+1, LI Xin\+2 (1.Department of Atmospheric Sciences, Nanjing University, Nanjing 210093, China 2.LAPC, Institute of Atmospheric Physics,Chinese Academy of Sciences, Beijing 100029, China) 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 1999年第4期474-479,共6页
In this paper, some experimental studies on the impact of effluent from an exhaust tower of an underground tunnel with special construction are reported. By measuring the flow field downstream of the tower in NJU mete... In this paper, some experimental studies on the impact of effluent from an exhaust tower of an underground tunnel with special construction are reported. By measuring the flow field downstream of the tower in NJU meteorological wind tunnel, some flow characteristics in the make area were established. Based on these, an advanced random\|walk dispersion model was set up and applied successfully to the simulation of dispersion in the wake area. The modelling results were in accordance with wind tunnel measurements. The computed maximum of ground surface concentration in the building case was a factor of 3-4 higher than that in the flat case and appeared much closer to the source. The simulation indicated that random walk modelling is an effective and practical tool for the wake stream impact assessment. 展开更多
关键词 exhaust tower air pollution in urban area atmospheric dispersion random walk modelling
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Application of random walk model to fit temperature in 46 gamma world cities from 1901 to 1998 被引量:3
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作者 Shaomin Yan Guang Wu 《Natural Science》 2010年第12期1425-1431,共7页
Very recently, we have applied the random walk model to fit the global temperature anomaly, CRUTEM3. With encouraging results, we apply the random walk model to fit the temperature walk that is the conversion of recor... Very recently, we have applied the random walk model to fit the global temperature anomaly, CRUTEM3. With encouraging results, we apply the random walk model to fit the temperature walk that is the conversion of recorded tem-perature and real recorded temperature in 46 gamma world cities from 1901 to 1998 in this study. The results show that the random walk model can fit both temperature walk and real recorded temperature although the fitted results from other climate models are unavailable for comparison in these 46 cities. Therefore, the random walk model can fit not only the global temperature anomaly, but also the real recorded temperatures in various cities around the world. 展开更多
关键词 GAMMA World CITIES Global WARMING modeling random walk TEMPERATURE Change
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Development and application of a new random walk model to simulate the transport of degradable pollutants
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作者 Lin Zhang Li-na Chen +3 位作者 Jian-yin Zhou Jia-sheng Wang Qi-hong Yang Long-xi Han 《Journal of Hydrodynamics》 SCIE EI CSCD 2020年第4期784-789,共6页
To simulate the pollutant transport with seif-purification in inland waters,the widely used random walk model(RWM)is modified to include a source term for the degradation and to consider the impact of land boundaries.... To simulate the pollutant transport with seif-purification in inland waters,the widely used random walk model(RWM)is modified to include a source term for the degradation and to consider the impact of land boundaries.The source term for the degradation is derived from the assumption of the first-order reaction kinetics.Parameters for the new model are determined by a comparison to the analytical results.The proposed model is then applied to simulate and analyze the transport of a test pollutant and its spatial distribution in a large reservoir in northeast China.Reasonable results are obtained,and the effects of the runoff,the flow structure,and the wind on the pollutant transport are analyzed.The results may help the risk assessment and the management of the water pollution in inland waters. 展开更多
关键词 Degradable pollutants inland water Lagrangian method random walk model
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Modelling of the behavior of marine oil spills: applications based on random walk techniques 被引量:2
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作者 Li, Zhi-Wei Mead, Christopher T. Zhang, Shu-Shen 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2000年第1期3-8,共6页
A numerical model has been developed to simulate the transport and fate of oil spilled at sea. The model combines the transport and fate processes of spilled oil with the random walk technique. Oil movement under th... A numerical model has been developed to simulate the transport and fate of oil spilled at sea. The model combines the transport and fate processes of spilled oil with the random walk technique. Oil movement under the influence of tidal currents, wind driven currents, and turbulent eddies is simulated by the PLUME RW dispersion model developed by HR Wallingford. The weathering processes in the model represent physical and chemical changes of soil slicks with time, and comprise mechanical spreading, dispersion, evaporation and emulsification. Shoreline stranding is determined approximately using a capacity method for different shoreline types. This paper presents details of the model, and describe the results of various sensitivity tests. The model is suitable for oil spill contingency planning. 展开更多
关键词 oil spill modelLING random walk technique CLC number: TQ021 4 Document code: A
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Scheduling trains on railway network using random walk method
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作者 李克平 《Chinese Physics B》 SCIE EI CAS CSCD 2010年第3期227-232,共6页
According to random walk, in this paper, we propose a new traffic model for scheduling trains on a railway network. In the proposed method, using some iteration rules for walkers, the departure and the arrival times o... According to random walk, in this paper, we propose a new traffic model for scheduling trains on a railway network. In the proposed method, using some iteration rules for walkers, the departure and the arrival times of trains at each station are determined. We test the proposed method on an assumed railway network. The numerical simulations and the analytical results demonstrate that the proposed method provides an effective tool for scheduling trains. Some characteristic behaviours of train movement can be reproduced, such as train delay. 展开更多
关键词 train schedule random walk model passenger transportation plan
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Random walk immunization strategy on scale-free networks
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作者 Weidong PEI Zengqiang CHEN Zhuzhi YUAN 《控制理论与应用(英文版)》 EI 2009年第2期151-156,共6页
A novel immunization strategy called the random walk immunization strategy on scale-free networks is proposed. Different from other known immunization strategies, this strategy works as follows: a node is randomly ch... A novel immunization strategy called the random walk immunization strategy on scale-free networks is proposed. Different from other known immunization strategies, this strategy works as follows: a node is randomly chosen from the network. Starting from this node, randomly walk to one of its neighbor node; if the present node is not immunized, then immunize it and continue the random walk; otherwise go back to the previous node and randomly walk again. This process is repeated until a certain fraction of nodes is immunized. By theoretical analysis and numerical simulations, we found that this strategy is very effective in comparison with the other known immunization strategies. 展开更多
关键词 Scale-free networks Immunization strategy random walk SIS model Epidemic spreading control
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Imperfect Trapping in a Random Walk with Both Species Mobile
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作者 Natalia C. Bustos Miguel A. Ré 《Advances in Pure Mathematics》 2018年第1期141-153,共13页
It is presented here a continuous time random walk model for diffusion mediated reactions with both species mobile. The random walk is carried out over an infinite homogeneouos lattice. They are calculated the probabi... It is presented here a continuous time random walk model for diffusion mediated reactions with both species mobile. The random walk is carried out over an infinite homogeneouos lattice. They are calculated the probability density for the time of reaction of a pair, the reaction rate and the time evolution of the concentration of the majority species. Analytical results are obtained in the Fourier-Laplace transform representation. Known results for a fixed trap are reobtained with appropriate marginal probabilities. It is thus justified Smoluchowski’s original approximation considering the trap at a fixed position and the majority species diffusing with a coefficient sum of the individual coefficients. The results obtained are illustrated by a one dimensional model with bias. 展开更多
关键词 MOBILE TRAP Diffusion Mediated REACTIONS Continuouos Time random walk TRAPPING models
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基于环境中移动运输代理的传感器网络建模
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作者 赵海军 陈华月 崔梦天 《电子测量与仪器学报》 CSCD 北大核心 2024年第2期199-210,共12页
针对大型稀疏传感器网络中的数据获取,本文提出了一种利用环境中普遍存在的移动代理来连接稀疏传感器的网络体系结构和一种2-维网格随机游走分析模型;提出的传感器网络模型由3个抽象层构成,即由无线传感器构成的底层、由各种运输代理构... 针对大型稀疏传感器网络中的数据获取,本文提出了一种利用环境中普遍存在的移动代理来连接稀疏传感器的网络体系结构和一种2-维网格随机游走分析模型;提出的传感器网络模型由3个抽象层构成,即由无线传感器构成的底层、由各种运输代理构成的中间层和由接入点/中央存储库构成的顶层。具体实现原理是位于中间层的移动运输代理从底层分布的无线传感器收集数据并缓冲数据,然后经过游走运输,最后将从底层的无线传感器收集的数据交付到顶层必要的接入点进行必要的存储和处理,从而实现整个传感器网络的数据获取;理论分析和仿真实验结果表明,提出的基于移动运输代理的传感器网络模型不仅具有较好的鲁棒性和可扩展性,而且相比于基站网络模型和Ad-hoc网络模型,在传感器功率消耗、数据成功率和基础设施投入成本方面有明显的优势。 展开更多
关键词 传感器网络 移动代理 网格模型 随机游走 马尔科夫链 缓冲容量 数据成功率 功率消耗
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基于随机行走模型的人致振动舒适度研究 被引量:1
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作者 吴刚杰 陈得意 +1 位作者 黄仕平 李智海 《振动与冲击》 EI CSCD 北大核心 2024年第9期226-233,共8页
为研究人群密度对人行桥结构的振动影响,首先,建立了双向随机行走模型,推导了随机荷载作用下结构振动响应解析解;然后,对比分析了人群密度对结构振动响应的影响规律;最后,通过研究行人实感时程与总时程之间的相关关系,定义了舒适度放大... 为研究人群密度对人行桥结构的振动影响,首先,建立了双向随机行走模型,推导了随机荷载作用下结构振动响应解析解;然后,对比分析了人群密度对结构振动响应的影响规律;最后,通过研究行人实感时程与总时程之间的相关关系,定义了舒适度放大系数,以荆州市某人行天桥为例,进行振动舒适度评价,验证了双向随机行走模型及舒适度放大系数的适用性。结果表明:人行桥结构加速度响应随人群密度增大呈现出先增大后减小的规律;行人实感时程与总时程具有显著的相关性,根据舒适度放大系数可建立对应关系;舒适度放大系数随着振动响应峰值的增大而减小,随着人群密度的增大而增大;该类结果对人行桥振动舒适度定量计算具有参考借鉴意义。 展开更多
关键词 随机行走模型 振动响应 人行桥 舒适度放大系数
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基于随机游走麻雀搜索算法的多特征结构尺寸熔融沉积成型工艺参数优化
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作者 郭润兰 薛凯 +2 位作者 邓文强 范雅琼 王虎林 《兰州理工大学学报》 CAS 北大核心 2024年第1期41-47,共7页
在熔融沉积成型过程中,打印参数对成型样件精度有着重要影响.为了提高整体尺寸精度,采用随机游走的麻雀算法获得最优实验方案.首先,以熔融沉积成型的分层厚度、喷头温度、打印速度和填充率为实验变量设计4因素4水平的正交试验;然后,以... 在熔融沉积成型过程中,打印参数对成型样件精度有着重要影响.为了提高整体尺寸精度,采用随机游走的麻雀算法获得最优实验方案.首先,以熔融沉积成型的分层厚度、喷头温度、打印速度和填充率为实验变量设计4因素4水平的正交试验;然后,以样件不同特征结构尺寸的相对误差为优化对象,使用田口-灰色关联法对实验数据进行处理;最后,通过随机游走的麻雀算法计算最优参数方案.结果表明,相比常用的田口-灰色关联法,采用优化后工艺参数成型样件的综合尺寸精度提高了20%,灰色关联度提高了27%. 展开更多
关键词 熔融沉积成型 田口法 灰色关联法 随机游走的麻雀搜索算法
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隐蔽线索对基于时间前瞻记忆的影响
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作者 王胤雅 于洪娜 +1 位作者 任智 王丽娟 《心理研究》 CSSCI 2024年第1期15-25,53,共12页
本研究通过三个实验,从不同角度考察隐蔽线索对基于时间前瞻记忆的影响,以期进一步了解基于时间前瞻记忆的加工特点。实验1A旨在考察不同进行中任务线索条件下基于时间前瞻记忆的表现差异;实验1B旨在考察不同干扰任务条件下的线索对基... 本研究通过三个实验,从不同角度考察隐蔽线索对基于时间前瞻记忆的影响,以期进一步了解基于时间前瞻记忆的加工特点。实验1A旨在考察不同进行中任务线索条件下基于时间前瞻记忆的表现差异;实验1B旨在考察不同干扰任务条件下的线索对基于时间前瞻记忆的影响;实验2旨在考察嵌入不同的前瞻记忆任务线索和进行中任务线索对基于时间前瞻记忆的影响。结果表明:(1)适当的隐蔽线索对个体的基于时间前瞻表现具有促进作用。对于提示回溯成分的隐蔽线索,时间线索无论隐藏在进行中任务中还是干扰任务中都显著提高被试基于时间前瞻记忆的表现。(2)与出现在干扰任务阶段中的线索相比,出现在进行中任务阶段中的线索更能提高个体基于时间前瞻记忆的表现,说明线索越临近目标时间,促进效应越大。(3)基于时间范式的线索能够促进基于时间前瞻记忆表现,基于事件的线索则不能。本研究结果支持随机游动模型。 展开更多
关键词 基于时间前瞻记忆 隐蔽线索 随机游动模型 任务范式 时间监控
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富血小板纤维蛋白对拔牙术后角化龈宽度以及牙龈软组织增量的影响 被引量:1
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作者 汤琼 龙鑫燚 《中国美容医学》 CAS 2024年第5期113-118,共6页
目的:探究拔牙术后应用富血小板纤维蛋白(Platelet-rich fibrin,PRF)对患者角化龈宽度及牙龈软组织增量的影响。方法:选择2020年12月-2021年12月于笔者医院行拔牙术的90例患者为研究对象,采用随机数字表法分为对照组(45例)和观察组(45例... 目的:探究拔牙术后应用富血小板纤维蛋白(Platelet-rich fibrin,PRF)对患者角化龈宽度及牙龈软组织增量的影响。方法:选择2020年12月-2021年12月于笔者医院行拔牙术的90例患者为研究对象,采用随机数字表法分为对照组(45例)和观察组(45例)。拔牙后,对照组采用新鲜血凝块填充拔牙窝,观察组采用PRF凝胶填充。比较两组患者拔牙创术区黏膜愈合时间、术后3 d和7 d的愈合率、黏膜颜色分级、肿胀程度分级、视觉模拟评分(Visual analogue score,VAS);比较两组患者术前及术后6个月的角化龈宽度、牙龈软组织增量。随机行走模型评价PRF的应用对患者上述指标的影响。比较两组患者术后并发症发生情况。结果:术后,观察组黏膜愈合时间明显短于对照组(P<0.05);术后3 d和7 d,观察组的黏膜愈合率明显高于对照组,黏膜颜色分级、肿胀程度分级、VAS评分明显低于对照组(P<0.05);术后6个月,两组患者的角化龈宽度明显高于术前,牙龈软组织增量明显低于术前,且观察组角化龈宽度、牙龈软组织增量明显低于观察组(P<0.05)。随机行走模型结果显示,观察组术后VAS评分、角化龈宽度改善显著,观察组能够维持患者牙龈软组织增量的相对稳定。观察组术后并发症发生率明显低于对照组(P<0.05)。结论:拔牙术后应用PRF能够促进拔牙创术区黏膜的愈合,减轻患者术后疼痛,保持角化龈宽度及牙龈软组织增量。 展开更多
关键词 拔牙术 富血小板纤维蛋白 角化龈宽度 牙龈软组织增量 随机行走模型
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A time fractional model to represent rainfall process 被引量:1
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作者 Jacques GOLDER Maminirina JOELSON +1 位作者 Marie-Christine NEEL Liliana DI PIETRO 《Water Science and Engineering》 EI CAS CSCD 2014年第1期32-40,共9页
This paper deals with a stochastic representation of the rainfall process. The analysis of a rainfall time series shows that cumulative representation of a rainfall time series can be modeled as a non-Gaussian random ... This paper deals with a stochastic representation of the rainfall process. The analysis of a rainfall time series shows that cumulative representation of a rainfall time series can be modeled as a non-Gaussian random walk with a log-normal jump distribution and a time-waiting distribution following a tempered a-stable probability law. Based on the random walk model, a fractional Fokker-Planck equation (FFPE) with tempered a-stable waiting times was obtained. Through the comparison of observed data and simulated results from the random walk model and FFPE model with tempered a-stable waiting times, it can be concluded that the behavior of the rainfall process is globally reproduced, and the FFPE model with tempered a-stable waiting times is more efficient in reproducing the observed behavior. 展开更多
关键词 rainfall process heavy-tailed probability distribution tempered a-stable probability law log-normal law Hurst exponent continuous time random walk model fractional Fokker-Planck equation
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基于随机游走的图扩散模型
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作者 周安众 谢丁峰 《软件工程》 2024年第8期74-78,共5页
图注意力网络(Graph Attention Networks,GAT)通过汇聚相邻节点计算中心节点特征时,缺少图的结构信息且没有利用高阶邻域节点。针对此问题,提出一种采用随机游走策略的图扩散模型。该模型通过随机游走访问邻域内的节点以提取结构信息,... 图注意力网络(Graph Attention Networks,GAT)通过汇聚相邻节点计算中心节点特征时,缺少图的结构信息且没有利用高阶邻域节点。针对此问题,提出一种采用随机游走策略的图扩散模型。该模型通过随机游走访问邻域内的节点以提取结构信息,并通过设置游走时的重启参数和迭代次数,控制邻域范围以提取局部和全局节点信息,再通过图注意力的加权求和机制对特征进行转换。该模型在3个引文图数据集上进行实验比较,比传统GAT模型的准确率平均提升了1.1%,证明了随机游走策略在捕获节点结构信息方面发挥了重要作用。 展开更多
关键词 随机游走 图模型 注意力机制 图扩散
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基于高斯过程回归模型对一回路泄漏率的预测
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作者 魏淋东 赵新文 朱康 《舰船科学技术》 北大核心 2024年第13期102-106,共5页
工况的剧烈变化可能导致一回路系统中法兰连接部位、泵的密封面等处发生泄漏。针对准确的泄漏物理模型很难建立的实际情况,在对不可测的温度应力参数进行正态随机游走的基础上,以高斯过程回归模型为替代模型对一回路泄露率进行预测,并... 工况的剧烈变化可能导致一回路系统中法兰连接部位、泵的密封面等处发生泄漏。针对准确的泄漏物理模型很难建立的实际情况,在对不可测的温度应力参数进行正态随机游走的基础上,以高斯过程回归模型为替代模型对一回路泄露率进行预测,并对替代模型的不确定性进行定量分析。结果表明,高斯过程回归模型能够方便地实现对替代模型的不确定性评估,并且在小样本容量的情况下,能够实现对一回路泄漏率较准确的预测。 展开更多
关键词 高斯过程回归模型 替代模型的不确定性 正态随机游走 一回路泄漏率
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On Mixed Model for Improvement in Stock Price Forecasting
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作者 Qunhui Zhang Mengzhe Lu Liang Dai 《Computer Systems Science & Engineering》 SCIE EI 2022年第5期795-809,共15页
Stock market trading is an activity in which investors need fast and accurate information to make effective decisions.But the fact is that forecasting stock prices by using various models has been suffering from low a... Stock market trading is an activity in which investors need fast and accurate information to make effective decisions.But the fact is that forecasting stock prices by using various models has been suffering from low accuracy,slow convergence,and complex parameters.This study aims to employ a mixed model to improve the accuracy of stock price prediction.We present how to use a random walk based on jump-diffusion,to obtain stock predictions with a good-fitting degree by adjusting different parameters.Aimed at getting better parameters and then using the time series model to predict the data,we employed the time series model to smooth the sequence utilizing logarithm and difference,which successfully resulted in drawing the auto-correlation figure and partial the auto-correlation figure.According to the comparative analysis,which focuses on checking the mean absolute error,including root mean square error and R square evaluation index,we have drawn a clear conclusion that our mixed model prediction effect is relatively good.In the context of Chinese stocks,the hybrid random walk model is very suitable for predicting stocks.It can“interpret”the randomness of stocks very well,and it also has an unparalleled prediction effect compared with other models.Based on the time series model’s application in this paper,the abovementioned series is more suitable for predicting trends. 展开更多
关键词 random walk model time series model stock forecasting
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利用Transformer的组合聚类算法在蛋白质数据分析中的应用
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作者 陈祥龙 李海军 +1 位作者 赵福军 袁媛 《无线互联科技》 2024年第14期74-81,共8页
该研究将Transformer模型适配于蛋白质特征降维场景,通过其特有的自注意力机制,赋予模型对长程依赖关系的较好建模性能,同时,多头注意力设计使得模型能够从不同角度捕获特征间的相互作用,进一步提升降维结果的表达力和鲁棒性。文章提出... 该研究将Transformer模型适配于蛋白质特征降维场景,通过其特有的自注意力机制,赋予模型对长程依赖关系的较好建模性能,同时,多头注意力设计使得模型能够从不同角度捕获特征间的相互作用,进一步提升降维结果的表达力和鲁棒性。文章提出了一种新型的GRKM组合聚类算法,在原始K-means算法中引入了灰狼优化算法(Grey Wolf Optimization Algorithm)确定聚类的K值,以随机游走算法(Random Walk)确定初始聚类中心,以马氏距离(Markov Distance)来衡量样本间的相似性。研究中,对5种具有代表性的蛋白质数据集进行了实验验证,得到了改进后算法在轮廓系数以及DB指数等方面相较于改进前都有较大提升的结论。最终的结果分析选取APP蛋白质数据,将蛋白质聚为8类,探讨了各类别的生物功能,在解释性方面也取得了较为明显的效果。所提算法为深入理解蛋白质功能、发现潜在生物标志物以及指导药物设计等实际应用提供了参考工具。 展开更多
关键词 蛋白质序列 Transformer模型 聚类算法 马氏距离 随机游走 灰狼优化算法
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GNSS对流层湿延迟随机游走过程噪声时空变化特征分析
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作者 裴雪艳 张兴刚 荆文芳 《时间频率学报》 CSCD 2024年第2期139-152,共14页
全球导航卫星系统GNSS对流层天顶湿延迟(zenith wet delay,ZWD)随机噪声不仅影响ZWD估计值大小,还会影响ZWD的趋势项变化。为揭示ZWD随机游走过程噪声(random walk process noise,RWPN)的时空变化特征,本文选取全球20个IGS(Internationa... 全球导航卫星系统GNSS对流层天顶湿延迟(zenith wet delay,ZWD)随机噪声不仅影响ZWD估计值大小,还会影响ZWD的趋势项变化。为揭示ZWD随机游走过程噪声(random walk process noise,RWPN)的时空变化特征,本文选取全球20个IGS(International GNSS Service)测站,基于JPL(Jet Propulsion Laboratory)、GFZ(Helmholtz-Centre Potsdam-German Research Centre for Geosciences)和CODE(Center for Orbit Determination in Europe)分析中心2010至2020年对流层产品,从不同地理位置和不同时间序列分析GNSS ZWD随机游走过程噪声的变化范围和特征;并且在扣除ZWD的趋势项和主要周期项后,进一步揭示了ZWD残差信号分量构成。结果表明:不同地理位置湿延迟RWPN具有显著差异,年均值范围在0.01~0.146 mm/√s之间,且在大气集中的中低纬地区湿延迟RWPN值较大,在大气相对稀薄的极地地区其值较小;同一测站的湿延迟RWPN具有明显的周年、半周年和季节性特征,极差值高达0.12 mm/√s以上;通过对ZWD残差值分析,发现ZWD残差信号除包含白噪声外,还具有4.8 h至2.43 d的高频信号分量。 展开更多
关键词 对流层 全球导航卫星系统 湿延迟 随机游走过程噪声 时空变化 数值天气模型
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Construction of Clonal Growth Models in Trifolium repens
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作者 HUBaozhong LI Fenglan HU Xiaomei HU Guofu YUAN Qiang 《Journal of Northeast Agricultural University(English Edition)》 CAS 2009年第4期14-18,共5页
The suitability of models for describing the clonal growth of Trifolium repens population was discussed. The results showed that deterministic models were inadequate for describing its clonal growth, but the diffusion... The suitability of models for describing the clonal growth of Trifolium repens population was discussed. The results showed that deterministic models were inadequate for describing its clonal growth, but the diffusion models and the randomwalk models suited for the clonal growth characteristics of the population. And it was found that random-walk models were better than diffusion models for describing a population in an environment with rich natural resources, and the latter was better in a poor environment. 展开更多
关键词 Trifolium repens clonal growth model diffusion model random-walk model
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Exploration of the oxidative-inflammatory potential targets of Coicis Semen in osteoarthritis:Data mining and systematic pharmacology 被引量:1
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作者 QIAO ZHOU JIAN LIU +4 位作者 LING XIN YANYAN FANG LEI WAN DAN HUANG JIANTING WEN 《BIOCELL》 SCIE 2023年第7期1623-1643,共21页
On the basis of data mining,systematic pharmacology,molecular docking,and experiment validation,the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis(OA)were explored.Methods:Th... On the basis of data mining,systematic pharmacology,molecular docking,and experiment validation,the oxidative-inflammatory molecular targets of Coicis Semen in the therapy of osteoarthritis(OA)were explored.Methods:The association rule analysis was effectively applied to highlight the correlation between Coicis Semen and oxidative inflammation indices.The random walk model was subsequently used to evaluate the clinical efficacy of Coicis Semen.Network pharmacology was used to predict network targets.The binding affinity of the active ingredient in Coicis Semen to the key target of OA was also successfully predicted.Results:Coicis Semen showed a significant reduction in oxidative-inflammatory indicators of OA.A total of 108 promising targets were predicted for the 24 bioactive compounds in Coicis Semen.Eight target genes were considered core target genes.The enrichment analysis predicts that Coicis Semen may activate the interleukin(IL)-17,mitogen-activated protein kinase(MAPK),and nuclear factor kappa B(NF-kappa B)signaling pathways.Molecular docking demonstrated that stigmasterol,2-monoolein,sitosterol,and sitosterol alpha1 had free binding energies to oxidative and inflammatory targets(MAPK1,Estrogen Receptor 1[ESR1],and Peroxisome Proliferator-Activated Receptor Alpha[PPARA]).Both clinical trials and in vitro cell experiments revealed that Coicis Semen could increase ESR1 and PPAR-αlevels while decreasing MAPK1 levels.Conclusions:Coicis Semen has a remarkable anti-OA effect.Precisely,the major components of Coicis Semen,including stigmasterol,sitosterol alpha1,sitosterol,and 2-monoolein,specifically inhibit MAPK1,ESR1,and PPARA to reduce the inflammatory response and oxidative damage in OA. 展开更多
关键词 Pharmacologic actions Chinese herbal medicine OSTEOARTHRITIS random walk model Molecular docking
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