Seismological Bureau of Sichuan Province, Chengdu 610041, China2) Center for Analysis and Prediction, State Seismological Bureau, Beijing 100036, China3) Observation Center for Prediction of Earthquakes and Volcanic E...Seismological Bureau of Sichuan Province, Chengdu 610041, China2) Center for Analysis and Prediction, State Seismological Bureau, Beijing 100036, China3) Observation Center for Prediction of Earthquakes and Volcanic Eruptions, Faculty of Sciences, Tohoku University, Sendai 98077, Japan展开更多
A simple way of interpolation for real time processing is pres -ented. For passive localization, the time delay between two signals can be determined by the peak of their cross-correlation. It is more efficient to est...A simple way of interpolation for real time processing is pres -ented. For passive localization, the time delay between two signals can be determined by the peak of their cross-correlation. It is more efficient to estimate a cross-correlation function by the inverse FFT of the cross-spectral density. The original smapling rate is usually very low to reduce computation. The sampling rate of the cross-correlation so computed is too low to estimate satisfactorily and an interpolation procedure is therefore needed. The interpolation by zero augmented spectrum is concise, fast and accurate. The results of the computer simulation and real nuderwater signal processing are given in the paper.展开更多
In our previous work, a novel algorithm to perform robust pose estimation was presented. The pose was estimated using points on the object to regions on image correspondence. The laboratory experiments conducted in th...In our previous work, a novel algorithm to perform robust pose estimation was presented. The pose was estimated using points on the object to regions on image correspondence. The laboratory experiments conducted in the previous work showed that the accuracy of the estimated pose was over 99% for position and 84% for orientation estimations respectively. However, for larger objects, the algorithm requires a high number of points to achieve the same accuracy. The requirement of higher number of points makes the algorithm, computationally intensive resulting in the algorithm infeasible for real-time computer vision applications. In this paper, the algorithm is parallelized to run on NVIDIA GPUs. The results indicate that even for objects having more than 2000 points, the algorithm can estimate the pose in real time for each frame of high-resolution videos.展开更多
A real time algorithm is presented here to recognize and analyze 8 channel simultaneous electro cardiograph(ECG). The algorithm transforms 8 channel simultaneous ECG into three orthogonal vectors and spatial veloc...A real time algorithm is presented here to recognize and analyze 8 channel simultaneous electro cardiograph(ECG). The algorithm transforms 8 channel simultaneous ECG into three orthogonal vectors and spatial velocity first, then forms the spatial velocity sample, and uses this spatial velocity sample to recognize each beat. The algorithm computes the averaged parameters by using averaged spatial velocity and the averaged ECG and the current parameters by using the current beat period and current width of QRS. The algorithm can recognize P, QRS and T onsets and ends of simultaneous 12 lead ECG precisely, and some arrhythmias such as premature ventricular beat, ventricular escape beat, R on T, bigeminy, trigeminy. The algorithm software works well on a real 8 channel ECG system and meets the demands of designing.展开更多
Simple GNSS navigation receivers, developed for the mass market, can be used for positioning with sub centimeter accuracy in a wireless sensor network if the read-out of the carrier phase data is possible and all data...Simple GNSS navigation receivers, developed for the mass market, can be used for positioning with sub centimeter accuracy in a wireless sensor network if the read-out of the carrier phase data is possible and all data is permanently broadcast to a central computer for near real time processing of the respective base lines. Experiences gained in two research projects related to landslide monitoring are depicted in terms of quality and reliability of the results by the developed approach. As far as possible a modular system set up with commercial off-the-shelf components, e.g., standard WLAN fur commtmication, solar batteries with solar panels for autarkic power supply and in cooperation of existing proofed program tools is chosen. The challenge of the still ongoing development is to have a flexible and robust GNSS based sensor network available - concerned not only for landslide monitoring in future.展开更多
Compared to small molecule process analytical technology （PAT） applications, biotechnology product PAT applications have certain unique challenges and opportunities. Understanding process dynamics of bioreactor cell...Compared to small molecule process analytical technology （PAT） applications, biotechnology product PAT applications have certain unique challenges and opportunities. Understanding process dynamics of bioreactor cell culture process is essential to establish an appropriate process control strategy for biotechnology product PAT applications. Inline spectroscopic techniques for real time monitoring of bioreactor cell culture process have the distinct potential to develop PAT approaches in manufac- turing biotechnology drug products. However, the use of inline Fourier transform infrared （FTIR） spectroscopic techniques for bioreactor cell culture process monitoring has not been reported. In this work, real time inline FTIR Spectroscopy was applied to a lab scale bioreactor mAb IgG3 cell culture fluid biomolecular dynamic model. The technical feasibility of using FTIR Spectroscopy for real time tracking and monitoring four key cell culture metabolites （including glucose, glutamine, lactate, and ammonia） and protein yield at increasing levels of complexity （simple binary system, fully formulated media, actual bioreactor cell culture process） was evaluated via a stepwise approach. The FTIR fingerprints of the key metabolites were identified. The multivariate partial least squares （PLS） calibration models were established to correlate the process FTIR spectra with the concentrations of key metabolites and protein yield of in-process samples, either individually for each metabolite and protein or globally for all four metabolites simultaneously. Applying the 2＇ld derivative pre-processing algorithm to the FTIR spectra helps to reduce the number of PLS latent variables needed significantly and thus simplify the interpretation of the PLS models. The validated PLS models show promise in predicting the concentration profiles of glucose, glutamine, lactate, and ammonia and protein yield over the course of the bioreactor cell culture process. Therefore, this work demonstrated the technical feasibility of real time monitoring of the bioreactor cell culture process via FTIR spectroscopy. Its implications for enabling cell culture PAT were discussed.展开更多
文摘Seismological Bureau of Sichuan Province, Chengdu 610041, China2) Center for Analysis and Prediction, State Seismological Bureau, Beijing 100036, China3) Observation Center for Prediction of Earthquakes and Volcanic Eruptions, Faculty of Sciences, Tohoku University, Sendai 98077, Japan
文摘A simple way of interpolation for real time processing is pres -ented. For passive localization, the time delay between two signals can be determined by the peak of their cross-correlation. It is more efficient to estimate a cross-correlation function by the inverse FFT of the cross-spectral density. The original smapling rate is usually very low to reduce computation. The sampling rate of the cross-correlation so computed is too low to estimate satisfactorily and an interpolation procedure is therefore needed. The interpolation by zero augmented spectrum is concise, fast and accurate. The results of the computer simulation and real nuderwater signal processing are given in the paper.
文摘In our previous work, a novel algorithm to perform robust pose estimation was presented. The pose was estimated using points on the object to regions on image correspondence. The laboratory experiments conducted in the previous work showed that the accuracy of the estimated pose was over 99% for position and 84% for orientation estimations respectively. However, for larger objects, the algorithm requires a high number of points to achieve the same accuracy. The requirement of higher number of points makes the algorithm, computationally intensive resulting in the algorithm infeasible for real-time computer vision applications. In this paper, the algorithm is parallelized to run on NVIDIA GPUs. The results indicate that even for objects having more than 2000 points, the algorithm can estimate the pose in real time for each frame of high-resolution videos.
文摘A real time algorithm is presented here to recognize and analyze 8 channel simultaneous electro cardiograph(ECG). The algorithm transforms 8 channel simultaneous ECG into three orthogonal vectors and spatial velocity first, then forms the spatial velocity sample, and uses this spatial velocity sample to recognize each beat. The algorithm computes the averaged parameters by using averaged spatial velocity and the averaged ECG and the current parameters by using the current beat period and current width of QRS. The algorithm can recognize P, QRS and T onsets and ends of simultaneous 12 lead ECG precisely, and some arrhythmias such as premature ventricular beat, ventricular escape beat, R on T, bigeminy, trigeminy. The algorithm software works well on a real 8 channel ECG system and meets the demands of designing.
文摘Simple GNSS navigation receivers, developed for the mass market, can be used for positioning with sub centimeter accuracy in a wireless sensor network if the read-out of the carrier phase data is possible and all data is permanently broadcast to a central computer for near real time processing of the respective base lines. Experiences gained in two research projects related to landslide monitoring are depicted in terms of quality and reliability of the results by the developed approach. As far as possible a modular system set up with commercial off-the-shelf components, e.g., standard WLAN fur commtmication, solar batteries with solar panels for autarkic power supply and in cooperation of existing proofed program tools is chosen. The challenge of the still ongoing development is to have a flexible and robust GNSS based sensor network available - concerned not only for landslide monitoring in future.
文摘Compared to small molecule process analytical technology （PAT） applications, biotechnology product PAT applications have certain unique challenges and opportunities. Understanding process dynamics of bioreactor cell culture process is essential to establish an appropriate process control strategy for biotechnology product PAT applications. Inline spectroscopic techniques for real time monitoring of bioreactor cell culture process have the distinct potential to develop PAT approaches in manufac- turing biotechnology drug products. However, the use of inline Fourier transform infrared （FTIR） spectroscopic techniques for bioreactor cell culture process monitoring has not been reported. In this work, real time inline FTIR Spectroscopy was applied to a lab scale bioreactor mAb IgG3 cell culture fluid biomolecular dynamic model. The technical feasibility of using FTIR Spectroscopy for real time tracking and monitoring four key cell culture metabolites （including glucose, glutamine, lactate, and ammonia） and protein yield at increasing levels of complexity （simple binary system, fully formulated media, actual bioreactor cell culture process） was evaluated via a stepwise approach. The FTIR fingerprints of the key metabolites were identified. The multivariate partial least squares （PLS） calibration models were established to correlate the process FTIR spectra with the concentrations of key metabolites and protein yield of in-process samples, either individually for each metabolite and protein or globally for all four metabolites simultaneously. Applying the 2＇ld derivative pre-processing algorithm to the FTIR spectra helps to reduce the number of PLS latent variables needed significantly and thus simplify the interpretation of the PLS models. The validated PLS models show promise in predicting the concentration profiles of glucose, glutamine, lactate, and ammonia and protein yield over the course of the bioreactor cell culture process. Therefore, this work demonstrated the technical feasibility of real time monitoring of the bioreactor cell culture process via FTIR spectroscopy. Its implications for enabling cell culture PAT were discussed.
