目的镜像神经元疗法对中风后复杂性区域疼痛综合征(CRPS)Ⅰ期的临床疗效及作用机制的探讨。方法选择康复科收治的40例CRPSⅠ期患者为研究对象。在研究中采用随机法,将选择的40例患者分为对照组与镜像组,每组20例。均采取基础以及常规康...目的镜像神经元疗法对中风后复杂性区域疼痛综合征(CRPS)Ⅰ期的临床疗效及作用机制的探讨。方法选择康复科收治的40例CRPSⅠ期患者为研究对象。在研究中采用随机法,将选择的40例患者分为对照组与镜像组,每组20例。均采取基础以及常规康复治疗,镜像组额外追加镜像治疗,两组每天上下午各治疗1次,5次/周,共治疗3周。采用休息状态视觉模拟评分(resting state visual analogue scale,R-VAS)与被动运动视觉模拟评分(passive movement state visual analogue scale,P-VAS)来评估上肢肩关节疼痛状况,选择运用排水法来评估手部肿胀状况,并且选择运用Fugl-Meyer量表,评估上肢运动功能,采用ELISA检测技术进行测定血清降钙素基因相关肽(CGRP)、P物质(SP)含量。结果镜像组患者治疗3周后的肩关节R-VAS、P-VAS评分及肿胀程度均低于对照组(P<0.05),Fugl-Meyer评分高于对照组(P<0.05),SP含量低于对照组(P<0.05),CGRP含量高于对照组(P<0.05)。结论镜像组能更有效地改善CRPSⅠ期患者肩关节疼痛、手部肿胀及上肢功能障碍,调节血清CGRP及SP细胞水平。展开更多
目的探讨体素镜像同伦连接(voxel-mirrored homotopic connectivity,VMHC)与局部一致性(regional homogeneity,ReHo)在评价经颅直流电刺激(transcranial direct current stimulation,tDCS)改善脑卒中后认知障碍中的应用价值。材料与方...目的探讨体素镜像同伦连接(voxel-mirrored homotopic connectivity,VMHC)与局部一致性(regional homogeneity,ReHo)在评价经颅直流电刺激(transcranial direct current stimulation,tDCS)改善脑卒中后认知障碍中的应用价值。材料与方法前瞻性纳入47名脑卒中后认知障碍(post-stroke cognitive impairment,PSCI)患者,随机分配到tDCS组与假刺激组,其中tDCS组23人,假刺激组24人,应用Mann-Whitney U检验比较两组患者在基线期与15天tDCS或假刺激治疗后认知量表评分变化值的差异,应用配对t检验比较两组患者在基线期与15天tDCS或假刺激治疗后VMHC与ReHo指标的差异,并提取差异脑区的VMHC与ReHo值与治疗前后认知量表评分的变化值进行相关性分析。结果tDCS组与假刺激组在治疗后的简易智能精神状态量表(Mini-Mental State Examination,MMSE)与蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评分均优于治疗前,但tDCS组具有更好的治疗效果,治疗后相较于治疗前MMSE与MoCA量表评分改善值更大,差异具有统计学意义(P<0.05);VMHC指标结果:tDCS组患者在治疗后,双侧岛叶、楔前叶的VMHC值升高(P<0.05,FDR校正),假刺激组患者在治疗后,在双侧枕上回的VMHC值升高(P<0.05,FDR校正);ReHo指标结果:tDCS组患者在治疗后,前扣带回和顶下缘角回的ReHo值升高(P<0.05,FDR校正),假刺激组患者在治疗后相较于治疗前,未见明显差异脑区;相关性分析:tDCS组患者在治疗后,双侧楔前叶VMHC增加的值与MMSE、MoCA量表评分的变化值呈现正相关,MMSE(r=0.47,P=0.02);MoCA(r=0.43,P=0.04);其他差异脑区与MMSE与MoCA量表评分变化值无明显相关性。结论tDCS联合常规康复治疗对PSCI患者的认知康复效果优于仅进行常规康复治疗手段,应用VMHC与ReHo发现tDCS的治疗机制可能与改善默认模式网络(default mode network,DMN)与突显网络(salience network,SN)中部分脑区在双侧大脑半球之间的功能连接与自发活动有关。展开更多
Using temporal and spectral methods,the effects of dispersion and filtering induced by Mo/Si multilayer mirrors reflection on incident attosecond pulses were studied.First,two temporal parameters,the pulse broadening ...Using temporal and spectral methods,the effects of dispersion and filtering induced by Mo/Si multilayer mirrors reflection on incident attosecond pulses were studied.First,two temporal parameters,the pulse broadening factor,and the energy loss factor,were defined to evaluate the effects of dispersion and filtering.Then,by analyzing these temporal parameters,we investigated and compared the dispersion and filtering effects on attosecond pulses.In addition,we explored the origins of pulse broadening and energy loss by analyzing the spectral and temporal characteristics of periodic Mo/Si multilayer mirrors.The results indicate that the filtering effect induced by Mo/Si multilayer mirrors reflection is the dominant reason for pulse broadening and energy loss.展开更多
文摘目的镜像神经元疗法对中风后复杂性区域疼痛综合征(CRPS)Ⅰ期的临床疗效及作用机制的探讨。方法选择康复科收治的40例CRPSⅠ期患者为研究对象。在研究中采用随机法,将选择的40例患者分为对照组与镜像组,每组20例。均采取基础以及常规康复治疗,镜像组额外追加镜像治疗,两组每天上下午各治疗1次,5次/周,共治疗3周。采用休息状态视觉模拟评分(resting state visual analogue scale,R-VAS)与被动运动视觉模拟评分(passive movement state visual analogue scale,P-VAS)来评估上肢肩关节疼痛状况,选择运用排水法来评估手部肿胀状况,并且选择运用Fugl-Meyer量表,评估上肢运动功能,采用ELISA检测技术进行测定血清降钙素基因相关肽(CGRP)、P物质(SP)含量。结果镜像组患者治疗3周后的肩关节R-VAS、P-VAS评分及肿胀程度均低于对照组(P<0.05),Fugl-Meyer评分高于对照组(P<0.05),SP含量低于对照组(P<0.05),CGRP含量高于对照组(P<0.05)。结论镜像组能更有效地改善CRPSⅠ期患者肩关节疼痛、手部肿胀及上肢功能障碍,调节血清CGRP及SP细胞水平。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11547183 and 11547241)the Fundamental Research Funds for Central Universities,China(Grant Nos.JD1517 and 2652014012)
文摘Using temporal and spectral methods,the effects of dispersion and filtering induced by Mo/Si multilayer mirrors reflection on incident attosecond pulses were studied.First,two temporal parameters,the pulse broadening factor,and the energy loss factor,were defined to evaluate the effects of dispersion and filtering.Then,by analyzing these temporal parameters,we investigated and compared the dispersion and filtering effects on attosecond pulses.In addition,we explored the origins of pulse broadening and energy loss by analyzing the spectral and temporal characteristics of periodic Mo/Si multilayer mirrors.The results indicate that the filtering effect induced by Mo/Si multilayer mirrors reflection is the dominant reason for pulse broadening and energy loss.
