This paper is concerned with the relation between the parameters of nonwoven filter and removing of white cells. Melt-blown polypropylene nonwovens are used as filtration materials of white cells filter. According to ...This paper is concerned with the relation between the parameters of nonwoven filter and removing of white cells. Melt-blown polypropylene nonwovens are used as filtration materials of white cells filter. According to the combination of different fiber diameter, different product density and different weight, optimized combination of parameters of nonwoven filter with more effective removing of white cells is obtained. The result is that removing of white cells is 96.90 percent; recovery of red cells is 92.27 percent.展开更多
In this study,a patch removing based Isogeometric analysis(PR-IGA)method is proposed to conduct the holed structural analysis with only one parametric domain,in which there are also no trimmed elements.The theoretical...In this study,a patch removing based Isogeometric analysis(PR-IGA)method is proposed to conduct the holed structural analysis with only one parametric domain,in which there are also no trimmed elements.The theoretical foundation of this novel patch removing approach is that any holed structure can be obtained by removing sub-patches(i.e.,the holes)from an intact base patch.Since the parametric domains of these patches are all meshed by rectangular grids,the elements in the resulted holed structural parametric domain could all be untrimmed rectangles under certain mapping conditions.To achieve the special condition,a systematic technique consisting of T-spline local refinement and control points substitution/adjustment is provided.Due to the intactness of parametric elements,the analysis procedure of holed structures based on the proposed PRIGA is quite simplified and efficient compared to traditional multi-patch and trimming schemes.Moreover,after the deduction of analytical sensitivities related to structural mass and mechanical responses,the PR-IGA is directly employed in the holed structural shape optimization to successfully eliminate the need for model transformation during modeling,analysis and optimization processes.Numerical examples involving analysis and shape optimization of complex holed structures are presented to demonstrate the effectiveness of the proposed method.展开更多
The non-operative treatment of ectopicpregnancy with traditional Chinese medicine(TCM)combined with western medicine hasbeen widely used clinically.The therapeuticresults are satisfactory.Although there areminor varia...The non-operative treatment of ectopicpregnancy with traditional Chinese medicine(TCM)combined with western medicine hasbeen widely used clinically.The therapeuticresults are satisfactory.Although there areminor variations among different medical institutions,the general principles of thetherapy are the same,i.e.promoting bloodcirculation and removing blood stasis.展开更多
The black cubic boron nitride(cBN)single crystal is synthesized by using hBN-LiH and hBN-Li_(3)N-B as the raw materials at high temperature and high pressure(HTHP).The colors of the cBN crystal synthesized in an hBN-L...The black cubic boron nitride(cBN)single crystal is synthesized by using hBN-LiH and hBN-Li_(3)N-B as the raw materials at high temperature and high pressure(HTHP).The colors of the cBN crystal synthesized in an hBN-Li_(3)N-B system vary from transparent yellow,half-transparent and then opaque black with the increasing B content in the raw materials.It is worth noting that a trigonal shadow is presented at the center of the cBN crystal synthesized in the hBN-Li_(3)N-B system but can not be found in the hBN-LiH system.Analyzing the Raman spectrum,we find that the darkening and the trigonal shadow in the cBN crystal may be due to the presence of excess B atoms.The above-mentioned phenomenon can be determined by removing impurity capacity and growth environment of the cBN crystal.展开更多
On December 28,2020 the project on R&D of guard catalyst for removing carbonyl iron/carbonyl nickel undertaken by the SINOPEC Nanjing Chemical Research Institute(NCRI)has passed the research achievements appraisal...On December 28,2020 the project on R&D of guard catalyst for removing carbonyl iron/carbonyl nickel undertaken by the SINOPEC Nanjing Chemical Research Institute(NCRI)has passed the research achievements appraisal organized by the Sinopec Science and Technology Division.The experts attending the appraisal meeting have suggested speeding up the commercial application tests as soon as possible.展开更多
It is important to identify and remove the wastes not only from manufacturing process, but also from nonmanufacturing process. In the last several decades, significant research achievements and practice benefits have ...It is important to identify and remove the wastes not only from manufacturing process, but also from nonmanufacturing process. In the last several decades, significant research achievements and practice benefits have been achieved about removing wastes from manufacturing process. Since the1990 s, some researchers and lean practitioners have paid more attention to removing waste from non-manufacturing process.Based on the authors' research work and industrial practice, the paper introduces a kind of lean approach for removing waste from non-manufacturing process. In its case study, the order handling process in a value chain is described with respect to a factory and its downstream distribution centers(DCs). The paper proposes a lean approach solution for creating the improved order handling process, and analyze how great improvements in performance can be achieved. As a result, the significant achievement has created a win-win scenario for both the nonmanufacturing process in a factory and non-manufacturing facilities(like DCs) across the value chain. It demonstrates that improvements have been made by removing waste from the non-manufacturing process that takes place within a factory as well as with external participants through the whole value chain. Likewise, the proposed lean approach has helped the case companies to achieve greater levels of efficiency and more benefits. Finally, some conclusions are drawn.展开更多
Chronic kidney disease is a general term for various types of renal diseases characterized by a long course of disease and difficulty in early detection.It is one of the social diseases that need to be solved urgently...Chronic kidney disease is a general term for various types of renal diseases characterized by a long course of disease and difficulty in early detection.It is one of the social diseases that need to be solved urgently and its pathogenesis and treatment have always been a hotspot for researchers.Studies have shown that traditional Chinese medicine(TCM)can effectively delay the progress of chronic kidney disease.According to the clinical experience of national famous TCM physicians,based on its pathogenesis of"kidney deficiency as the foundation and poison as the target",chronic kidney disease can be treated by invigorating the kidney and removing toxic.Based on the above background,this paper summarizes the research progress of invigorating the kidney and removing toxic in delaying chronic kidney disease from multiple mechanisms and pathways in modern research.展开更多
Developing autonomous mobile robot system has been a hot topic in AI area. With recent advances in technology, autonomous robots are attracting more and more attention worldwide, and there are a lot of ongoing researc...Developing autonomous mobile robot system has been a hot topic in AI area. With recent advances in technology, autonomous robots are attracting more and more attention worldwide, and there are a lot of ongoing research and development activities in both industry and academia. In complex ground environment, obstacles positions are uncertain. Path finding for robots in such environment is very hot issues currently. In this paper, we present the design and implementation of a multi-sensor based object detecting and moving autonomous robot exploration system, 4RE, with the VEX robotics design system. With the goals of object detecting and removing in complex ground environment with different obstacles, a novel object detecting and removing algorithms is proposed and implemented. Experimental results indicate that our robot system with our object detecting and removing algorithm can effectively detect the obstacles on the path and remove them in complex ground environment and avoid collision with the obstacles.展开更多
Hepatic sinusoidal endothelial cells(HSEC)are the most important cells that constitute the microcirculation barrier of liver.Clinically,W-P bodies have been detected in the HSEC cells of most patients with liver fibro...Hepatic sinusoidal endothelial cells(HSEC)are the most important cells that constitute the microcirculation barrier of liver.Clinically,W-P bodies have been detected in the HSEC cells of most patients with liver fibrosis,and these bodies have become the synthesis and storage sites of vW factor,ET-1 and other factors of liver fibrosis;during pathological stimulation,W-P bodies will excrete the above factors into the cytoplasm,which can make the structure and function of HSEC maladjusted,cause the disturbance of liver microcirculation,and aggravate the process of liver fibrosis.However,previous studies have found that Plumbagin,the active ingredient of Guangxi specialty ethnic medicine,has the definite function of promoting blood circulation and removing blood stasis and anti-liver fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived from it as follows:the role of Plumbagin in promoting blood circulation and removing blood stasis and anti-liver fibrosis is produced by affecting the formation quantity of W-P bodies,affecting the synthesis and storage of the contents of W-P bodies,and interfering with their exocytosis ability.展开更多
Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Data...Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Database(TCMSP),and the drug targets were searched in the Swiss Target Prediction database;in the Disease-Gene Database(DisGeNET))Search for angiogenesis-promoting and inhibiting angiogenesis targets;use the protein interaction database(STRING)database and Cytoscape software to analyze the network core targets;use the DAVID database to enrich the drug-disease target intersection for GO and KEGG;RT-qPCR experiments verified the effect of luteolin on MMP9 gene expression;in vitro tube formation experiments analyzed the effect of luteolin on endothelial cell neovascularization.Results:After analysis,it is concluded that Danshen has 10 active ingredients and 50 angiogenesis targets;Chuanxiong has 2 active ingredients and 4 angiogenesis targets.The intersection of drug-taking targets yielded 9 targets,including AR,PARP1,MMP9,MMP2,MMP12,AKR1B10,ABCC1,CDK6,and STAT3.After analyzing the active ingredient-target network graph of Danshen/Chuanxiong,it was concluded that luteolin is the key chemical ingredient.After protein interaction(PPI)analysis,the results showed that MMP9 is the core target.The KEGG pathway is mainly enriched in 5 signaling pathways,the most important pathway is cancer-related pathways.There are 22 main biological processes of GO,which mainly involve collagen catabolism,protein extracellular matrix,metal endopeptidase activity,etc.The preliminary analysis of tubule formation experiment shows that luteolin inhibits angiogenesis and down-regulates the expression of MMP9 gene.Conclusion:Luteolin,the key chemical component of the Danshen-Ligusticum chuanxiong drug pair,inhibits angiogenesis by regulating the MMP9 target,and develops the reverse regulation of angiogenesis for the traditional Chinese medicine for promoting blood circulation and removing blood stasis on the basis of the known treatment of ischemic diseases.Provide a new perspective and theoretical basis for the use of Danshen and Chuanxiong medicine in clinical cancer patients.Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.展开更多
Hepatic fibrosis is a reversible pathological phenomenon in the early and middle stages,but but no satisfactory intervention drugs have been available so far.Recent studies have suggested that microcirculation disturb...Hepatic fibrosis is a reversible pathological phenomenon in the early and middle stages,but but no satisfactory intervention drugs have been available so far.Recent studies have suggested that microcirculation disturbance of liver is one of the important pathogenesis of chronic liver disease,the improvement of microcirculation is beneficial to the recovery of liver function and the delay of liver fibrosis.Hepatic stellate cells are the core cells of hepatic fibrosis,and also the most critical cells that affect the microcirculation of the liver.While TLR4/MyD88/NF-κB and TLR4/MyD88/MAPKs which are based on the action of hepatic stellate cells are two pathways that have very important influence on the inflammatory response of liver,the proliferation and apoptosis of hepatic stellate cells,and the secretion of fibrogenic cytokines.It was found that Plumbapin,the active ingredient of Guangxi specialty ethnic medicine,has the definite effect of promoting blood circulation and removing blood stasis and anti-hepatic fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived as follows:the pharmacological effect of Plumbapin on anti-hepatic fibrosis,promoting blood circulation and removing stasis was based on the influence of TLR4/MyD88/NF-κB and MAPKs signal pathway.展开更多
:This article first analyzes the problems existing in the teaching about diagnosing and removing automobile’s failure,and then discusses some specific teaching strategies on diagnosing and removing automobile’s fail...:This article first analyzes the problems existing in the teaching about diagnosing and removing automobile’s failure,and then discusses some specific teaching strategies on diagnosing and removing automobile’s failure to provide some effective reference for the related staff.展开更多
To compare the efficacy of various irrigants(citric acid, ethylenediaminetetraacetic acid(EDTA) and Na OCl) and techniques in removing Ca(OH)_2 in two types of curved root canal systems, simulated root canals with spe...To compare the efficacy of various irrigants(citric acid, ethylenediaminetetraacetic acid(EDTA) and Na OCl) and techniques in removing Ca(OH)_2 in two types of curved root canal systems, simulated root canals with specific curvatures were used to investigate the effects of different irrigants and instruments on Ca(OH)_2 removal. The optimal methods were verified on extracted human teeth. Simulated root canals were assigned to one of two groups based on the irrigation solution: 10% citric acid or2.5% Na OCl. Each group was divided into four subgroups according to the technique used to remove Ca(OH)_2 . The percentage of Ca(OH)_2 removal in different sections of root canals was calculated. On the basis of the results obtained for the simulated canals, 10% citric acid and 17% EDTA were applied to remove Ca(OH)_2 from the extracted human teeth with curved root canal systems. The teeth were scanned by micro computed tomography to calculate the percentage of Ca(OH)_2 removal in the canals.In simulated root canals, we found that 10% citric acid removed more Ca(OH)_2 than 2.5% NaOCl in the 0–1 mm group from the apex level(Po0.05). Ultrasonic and Endo Activator activation significantly removed more Ca(OH)_2 than a size 30 K file in the apical third(Po0.05). However, there were no significant differences in any sections of the canals for 10% citric acid or 17%EDTA in removing Ca(OH)_2 in extracted human teeth. We concluded that it was effective to remove residual Ca(OH)_2 using the decalcifying solution with Endo Activator or Passive Ultrasonic Irrigation in a curved root canal system. A protocol for Ca(OH)_2 removal was provided based on the conclusions of this study and the methods recommended in previous studies.展开更多
The removal of Cr,sulfates and Chemical Oxygen Demand(COD)from industrial tannery wastewater by chemical precipitation was carried out using Calcium oxide(CaO)and Calcium hydroxide(Ca(OH)2).Different doses of alkalis,...The removal of Cr,sulfates and Chemical Oxygen Demand(COD)from industrial tannery wastewater by chemical precipitation was carried out using Calcium oxide(CaO)and Calcium hydroxide(Ca(OH)2).Different doses of alkalis,ranging from deficiency to excess hydroxyl species over the stoichiometric necessary,were used to remove theoretically the 100%of Cr[0.3-3.2 g alkali·(g Cr^3+)^-1].The precipitation was carried out at room temperature,10 min of vigorous stirring,200 r·min^-1 and a settling time of 24 h,followed by separation and characterization of liquid product.As result of addition of alkalis,pH underwent increase as did the alkali concentration.The removal of Cr,and sulfates also increased as alkali concentration did,although for first species the changes at higher alkali contents were less evident.COD removal on the other hand,did not follow a unique trend,instead exhibited a maximum.Based on our results,selection of a specific dose of alkali was carried out taking as reference the efficiency on total chromium removal,keeping the pH in the range 7 to 9 to ensure Cr precipitation as chromium hydroxide.With those conditions,jar test was used to produce enough liquid product in order to determine the removal percent of several other species.The removal percent of the species was as follows:Cr,SO4^2-,ZnSO4,FeSO4,CN^-1,NiSO4,Fe2[Fe(CN)6]at 99.8%,66.9%,99.6%,21.4%,70.9%,52.8%and 76.4%with CaO,and 99.8%,61.6%,99.9%,7.1%,84.0%,54.4%and 90.5%with Ca(OH)2,respectively.展开更多
Based on the effects of skim components on ammonium removal as well as the current processing technology, a new process-intensified technology of removing ammonia from skim by air stripping on rotating packed bed was ...Based on the effects of skim components on ammonium removal as well as the current processing technology, a new process-intensified technology of removing ammonia from skim by air stripping on rotating packed bed was proposed. The experiments were conducted on a wave-thread packed Rotating Packed Bed(RPB) under atmospheric pressure, suggesting that, in terms of order of importance, the ammonium concentration of feed-stock(x_w), the average ultra-gravity factor(β), feed-stock flux(L), and gas flux(G) had significant impact on ammonium removal rate(η) and the ammonium concentration of products(x_D). In the experiment, mass-transfer coefficient in gas phase(k_ya_e) increases with the increase of β, G/L, and L. The ammonium concentration of products decreases with the increase of β, G/L and the increase of L. The ammonium concentration of products would be as low as ~0.10% and the ammonia removal rate would be 63.21% when skim temperature was 25 °C, x_w0.28%, β 133.2, and G/L 15.0 m^3·L^(-1). Experiment results indicated that the proposed technology for removing ammonium from skim on a rotating packed bed would be a new process-intensified technique compared with traditional aeration process and centrifugal atomization method.展开更多
In the process of nickel production by diaphragm electrolysis, the quality of the product has been tremendously affec ted by the content of zinc in the nickel electrolyte. Removing zinc from nickel electrolyte by ion ...In the process of nickel production by diaphragm electrolysis, the quality of the product has been tremendously affec ted by the content of zinc in the nickel electrolyte. Removing zinc from nickel electrolyte by ion exchange is studied in the paper. Resin D201 is selected as the resin for zinc removing. Effects of the operative parameters, such as temperature, pH value and the contact time on zinc adsorption are observed and the desorption feature of the zinc loaded resin is inspected. The results show that macroporous anion exchange resin D201 has excellent adsorption and desorption properties. Its breakthrough capacity and saturation capacity in zinc adsorption reach 0.81 g/L of zinc and 1.16 g/L of zinc respectively, when the operative temperature is 60 ℃ and the contact time is only 5 min. In addition, compared with gel type IER 201×7 used industrially nowadays, this resin has better wearability and greater intensity.展开更多
Dry laser cleaning(DLC)and laser shockwave cleaning(LSC)are used to remove the particulate contamination from SiO_(2) sol−gel optical films.The results show that the LSC with a shockwave initiated by plasma formation ...Dry laser cleaning(DLC)and laser shockwave cleaning(LSC)are used to remove the particulate contamination from SiO_(2) sol−gel optical films.The results show that the LSC with a shockwave initiated by plasma formation under a focused laser beam pulse offers much better efficiency than DLC.Silica particles up to 10µm on SiO_(2 )films can be removed without substrate damage at a gap distance of 0.5 mm,and a more uniform surface microstructure can be obtained after LSC.Furthermore,it is demonstrated that the transmittance of contaminated SiO2 films can be restored to the as-deposited value after the LSC on dispersed-particle zones.LSC has potential applications in engineering-oriented large components.展开更多
Hospital wastewater represents an infectious and toxic risk to human health and the environment due to its contents. Most hospitals in developing countries, including Benin, do not have a wastewater treatment plant. I...Hospital wastewater represents an infectious and toxic risk to human health and the environment due to its contents. Most hospitals in developing countries, including Benin, do not have a wastewater treatment plant. In this study, the wastewater from two hospitals in northern Benin was characterized and then treated with Azadirachta indica leaves, Moringa oleifera and Luffa cylindrica seeds by coagulation/flocculation process. The wastewater characteristics showed that the collected samples are greatly polluted by organic matter and fecal bacteria such as Escherichia coli, Enterococcus fecal and Total coliforms. Jar-test results revealed that 95.74%, 78%, 49.19% of turbidity, 51.35%, 38.32%, 22.19% of COD, 93.16%, 85.26%, 83.30% against Escherichia coli, 92.11%, 90.93%, 94.60% against total Coliforms and 99.37%, 91%, 99%, 55.07% against Enterococcus were removed from hospital wastewater using Moringa oleifera, Luffa cylindrica seed and Azadirachta indica leaves respectively at dose of 100 mg/L. The results highlighted that the natural coagulants could be successfully used for the removal of turbidity and fecal bacteria from hospital wastewater.展开更多
文摘This paper is concerned with the relation between the parameters of nonwoven filter and removing of white cells. Melt-blown polypropylene nonwovens are used as filtration materials of white cells filter. According to the combination of different fiber diameter, different product density and different weight, optimized combination of parameters of nonwoven filter with more effective removing of white cells is obtained. The result is that removing of white cells is 96.90 percent; recovery of red cells is 92.27 percent.
基金This work is supported by National Natural Science Foundation of China(Project No.11702254,SC,www.nsfc.gov.cn)Postdoctoral Science Foundation of China(Project No.2016M592306,SC,www.chinapostdoctor.org.cn)Key Scientific Research Project in Higher Education Institutions of Henan Province(Project No.17A130001,SC,www.haedu.gov.cn).
文摘In this study,a patch removing based Isogeometric analysis(PR-IGA)method is proposed to conduct the holed structural analysis with only one parametric domain,in which there are also no trimmed elements.The theoretical foundation of this novel patch removing approach is that any holed structure can be obtained by removing sub-patches(i.e.,the holes)from an intact base patch.Since the parametric domains of these patches are all meshed by rectangular grids,the elements in the resulted holed structural parametric domain could all be untrimmed rectangles under certain mapping conditions.To achieve the special condition,a systematic technique consisting of T-spline local refinement and control points substitution/adjustment is provided.Due to the intactness of parametric elements,the analysis procedure of holed structures based on the proposed PRIGA is quite simplified and efficient compared to traditional multi-patch and trimming schemes.Moreover,after the deduction of analytical sensitivities related to structural mass and mechanical responses,the PR-IGA is directly employed in the holed structural shape optimization to successfully eliminate the need for model transformation during modeling,analysis and optimization processes.Numerical examples involving analysis and shape optimization of complex holed structures are presented to demonstrate the effectiveness of the proposed method.
文摘The non-operative treatment of ectopicpregnancy with traditional Chinese medicine(TCM)combined with western medicine hasbeen widely used clinically.The therapeuticresults are satisfactory.Although there areminor variations among different medical institutions,the general principles of thetherapy are the same,i.e.promoting bloodcirculation and removing blood stasis.
文摘The black cubic boron nitride(cBN)single crystal is synthesized by using hBN-LiH and hBN-Li_(3)N-B as the raw materials at high temperature and high pressure(HTHP).The colors of the cBN crystal synthesized in an hBN-Li_(3)N-B system vary from transparent yellow,half-transparent and then opaque black with the increasing B content in the raw materials.It is worth noting that a trigonal shadow is presented at the center of the cBN crystal synthesized in the hBN-Li_(3)N-B system but can not be found in the hBN-LiH system.Analyzing the Raman spectrum,we find that the darkening and the trigonal shadow in the cBN crystal may be due to the presence of excess B atoms.The above-mentioned phenomenon can be determined by removing impurity capacity and growth environment of the cBN crystal.
文摘On December 28,2020 the project on R&D of guard catalyst for removing carbonyl iron/carbonyl nickel undertaken by the SINOPEC Nanjing Chemical Research Institute(NCRI)has passed the research achievements appraisal organized by the Sinopec Science and Technology Division.The experts attending the appraisal meeting have suggested speeding up the commercial application tests as soon as possible.
基金supported in part by the National Natural Science Foundation of China (61773381,61773382,61533019,91520301)Finnish TEKES’s Project "SoMa2020:Social Manufacturing" (211560)+1 种基金Chinese Guangdong’s S&T Project (2015B010103001,2016B090910001,2017B090912001)Dongguan’s Innovation Talents Project (Gang Xiong)
文摘It is important to identify and remove the wastes not only from manufacturing process, but also from nonmanufacturing process. In the last several decades, significant research achievements and practice benefits have been achieved about removing wastes from manufacturing process. Since the1990 s, some researchers and lean practitioners have paid more attention to removing waste from non-manufacturing process.Based on the authors' research work and industrial practice, the paper introduces a kind of lean approach for removing waste from non-manufacturing process. In its case study, the order handling process in a value chain is described with respect to a factory and its downstream distribution centers(DCs). The paper proposes a lean approach solution for creating the improved order handling process, and analyze how great improvements in performance can be achieved. As a result, the significant achievement has created a win-win scenario for both the nonmanufacturing process in a factory and non-manufacturing facilities(like DCs) across the value chain. It demonstrates that improvements have been made by removing waste from the non-manufacturing process that takes place within a factory as well as with external participants through the whole value chain. Likewise, the proposed lean approach has helped the case companies to achieve greater levels of efficiency and more benefits. Finally, some conclusions are drawn.
基金National Natural Science Foundation of China(No.81873270)"Six Talent Peaks"High-level Talent Project of Jiangsu Province(No.WSN-012)+2 种基金International Joint Research and Development Project of Nanjing Science and Technology Bureau for Medical and Health Care(No.202002051)PhaseⅢProject of TCM Advantaged Discipline in Nanjing University of Traditional Chinese Medicine(No.ZYX03KF076)"Peak Academic"Talent Project of Jiangsu Hospital of Traditional Chinese Medicine(No.Y2018RC17)。
文摘Chronic kidney disease is a general term for various types of renal diseases characterized by a long course of disease and difficulty in early detection.It is one of the social diseases that need to be solved urgently and its pathogenesis and treatment have always been a hotspot for researchers.Studies have shown that traditional Chinese medicine(TCM)can effectively delay the progress of chronic kidney disease.According to the clinical experience of national famous TCM physicians,based on its pathogenesis of"kidney deficiency as the foundation and poison as the target",chronic kidney disease can be treated by invigorating the kidney and removing toxic.Based on the above background,this paper summarizes the research progress of invigorating the kidney and removing toxic in delaying chronic kidney disease from multiple mechanisms and pathways in modern research.
文摘Developing autonomous mobile robot system has been a hot topic in AI area. With recent advances in technology, autonomous robots are attracting more and more attention worldwide, and there are a lot of ongoing research and development activities in both industry and academia. In complex ground environment, obstacles positions are uncertain. Path finding for robots in such environment is very hot issues currently. In this paper, we present the design and implementation of a multi-sensor based object detecting and moving autonomous robot exploration system, 4RE, with the VEX robotics design system. With the goals of object detecting and removing in complex ground environment with different obstacles, a novel object detecting and removing algorithms is proposed and implemented. Experimental results indicate that our robot system with our object detecting and removing algorithm can effectively detect the obstacles on the path and remove them in complex ground environment and avoid collision with the obstacles.
基金Supported by the Research Project of National Natural Science Foundation of China(No.81960761,81960751,81680705)Basic Ability Improvement Project for Young and Middle-aged Teachers in Colleges and Universities of Guangxi(No.2018KY1149)。
文摘Hepatic sinusoidal endothelial cells(HSEC)are the most important cells that constitute the microcirculation barrier of liver.Clinically,W-P bodies have been detected in the HSEC cells of most patients with liver fibrosis,and these bodies have become the synthesis and storage sites of vW factor,ET-1 and other factors of liver fibrosis;during pathological stimulation,W-P bodies will excrete the above factors into the cytoplasm,which can make the structure and function of HSEC maladjusted,cause the disturbance of liver microcirculation,and aggravate the process of liver fibrosis.However,previous studies have found that Plumbagin,the active ingredient of Guangxi specialty ethnic medicine,has the definite function of promoting blood circulation and removing blood stasis and anti-liver fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived from it as follows:the role of Plumbagin in promoting blood circulation and removing blood stasis and anti-liver fibrosis is produced by affecting the formation quantity of W-P bodies,affecting the synthesis and storage of the contents of W-P bodies,and interfering with their exocytosis ability.
基金Fund Project:Outstanding Doctoral Graduates of Shanxi University of Traditional Chinese Medicine Come to Shanxi to Work,Reward Funds,Scientific Research Start-Up Fund Project(No.2020BKS06)。
文摘Objective:Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.Methods:The effective components of Danshen and chuanxiong were searched in the TCM System Pharmacology Database(TCMSP),and the drug targets were searched in the Swiss Target Prediction database;in the Disease-Gene Database(DisGeNET))Search for angiogenesis-promoting and inhibiting angiogenesis targets;use the protein interaction database(STRING)database and Cytoscape software to analyze the network core targets;use the DAVID database to enrich the drug-disease target intersection for GO and KEGG;RT-qPCR experiments verified the effect of luteolin on MMP9 gene expression;in vitro tube formation experiments analyzed the effect of luteolin on endothelial cell neovascularization.Results:After analysis,it is concluded that Danshen has 10 active ingredients and 50 angiogenesis targets;Chuanxiong has 2 active ingredients and 4 angiogenesis targets.The intersection of drug-taking targets yielded 9 targets,including AR,PARP1,MMP9,MMP2,MMP12,AKR1B10,ABCC1,CDK6,and STAT3.After analyzing the active ingredient-target network graph of Danshen/Chuanxiong,it was concluded that luteolin is the key chemical ingredient.After protein interaction(PPI)analysis,the results showed that MMP9 is the core target.The KEGG pathway is mainly enriched in 5 signaling pathways,the most important pathway is cancer-related pathways.There are 22 main biological processes of GO,which mainly involve collagen catabolism,protein extracellular matrix,metal endopeptidase activity,etc.The preliminary analysis of tubule formation experiment shows that luteolin inhibits angiogenesis and down-regulates the expression of MMP9 gene.Conclusion:Luteolin,the key chemical component of the Danshen-Ligusticum chuanxiong drug pair,inhibits angiogenesis by regulating the MMP9 target,and develops the reverse regulation of angiogenesis for the traditional Chinese medicine for promoting blood circulation and removing blood stasis on the basis of the known treatment of ischemic diseases.Provide a new perspective and theoretical basis for the use of Danshen and Chuanxiong medicine in clinical cancer patients.Reveal the material basis and mechanism of angiogenesis effect of Danshen-chuanxiong herb-partners.
基金the Research Project of National Natural Science Foundation of China(81960761,81960751,81680705)Basic Ability Improvement Project for Young and Middle-aged Teachers in Colleges and Universities of Guangxi(2018KY1149)Natural Science Foundation of Guangxi Province(2020JJA140257).
文摘Hepatic fibrosis is a reversible pathological phenomenon in the early and middle stages,but but no satisfactory intervention drugs have been available so far.Recent studies have suggested that microcirculation disturbance of liver is one of the important pathogenesis of chronic liver disease,the improvement of microcirculation is beneficial to the recovery of liver function and the delay of liver fibrosis.Hepatic stellate cells are the core cells of hepatic fibrosis,and also the most critical cells that affect the microcirculation of the liver.While TLR4/MyD88/NF-κB and TLR4/MyD88/MAPKs which are based on the action of hepatic stellate cells are two pathways that have very important influence on the inflammatory response of liver,the proliferation and apoptosis of hepatic stellate cells,and the secretion of fibrogenic cytokines.It was found that Plumbapin,the active ingredient of Guangxi specialty ethnic medicine,has the definite effect of promoting blood circulation and removing blood stasis and anti-hepatic fibrosis,but its mechanism is not clear.In this study,the research progress of the above problems was reviewed,and further research ideas were derived as follows:the pharmacological effect of Plumbapin on anti-hepatic fibrosis,promoting blood circulation and removing stasis was based on the influence of TLR4/MyD88/NF-κB and MAPKs signal pathway.
文摘:This article first analyzes the problems existing in the teaching about diagnosing and removing automobile’s failure,and then discusses some specific teaching strategies on diagnosing and removing automobile’s failure to provide some effective reference for the related staff.
基金supported by projects from the Sichuan Science and Technology Department(Grant No.2013JY0164)the National Nature Science Foundation of China(Grant No.81670980)
文摘To compare the efficacy of various irrigants(citric acid, ethylenediaminetetraacetic acid(EDTA) and Na OCl) and techniques in removing Ca(OH)_2 in two types of curved root canal systems, simulated root canals with specific curvatures were used to investigate the effects of different irrigants and instruments on Ca(OH)_2 removal. The optimal methods were verified on extracted human teeth. Simulated root canals were assigned to one of two groups based on the irrigation solution: 10% citric acid or2.5% Na OCl. Each group was divided into four subgroups according to the technique used to remove Ca(OH)_2 . The percentage of Ca(OH)_2 removal in different sections of root canals was calculated. On the basis of the results obtained for the simulated canals, 10% citric acid and 17% EDTA were applied to remove Ca(OH)_2 from the extracted human teeth with curved root canal systems. The teeth were scanned by micro computed tomography to calculate the percentage of Ca(OH)_2 removal in the canals.In simulated root canals, we found that 10% citric acid removed more Ca(OH)_2 than 2.5% NaOCl in the 0–1 mm group from the apex level(Po0.05). Ultrasonic and Endo Activator activation significantly removed more Ca(OH)_2 than a size 30 K file in the apical third(Po0.05). However, there were no significant differences in any sections of the canals for 10% citric acid or 17%EDTA in removing Ca(OH)_2 in extracted human teeth. We concluded that it was effective to remove residual Ca(OH)_2 using the decalcifying solution with Endo Activator or Passive Ultrasonic Irrigation in a curved root canal system. A protocol for Ca(OH)_2 removal was provided based on the conclusions of this study and the methods recommended in previous studies.
基金financial support from IPN-México through grants 20170292,20180385,and 20195583financial support from CONACyT-México through grant 246176。
文摘The removal of Cr,sulfates and Chemical Oxygen Demand(COD)from industrial tannery wastewater by chemical precipitation was carried out using Calcium oxide(CaO)and Calcium hydroxide(Ca(OH)2).Different doses of alkalis,ranging from deficiency to excess hydroxyl species over the stoichiometric necessary,were used to remove theoretically the 100%of Cr[0.3-3.2 g alkali·(g Cr^3+)^-1].The precipitation was carried out at room temperature,10 min of vigorous stirring,200 r·min^-1 and a settling time of 24 h,followed by separation and characterization of liquid product.As result of addition of alkalis,pH underwent increase as did the alkali concentration.The removal of Cr,and sulfates also increased as alkali concentration did,although for first species the changes at higher alkali contents were less evident.COD removal on the other hand,did not follow a unique trend,instead exhibited a maximum.Based on our results,selection of a specific dose of alkali was carried out taking as reference the efficiency on total chromium removal,keeping the pH in the range 7 to 9 to ensure Cr precipitation as chromium hydroxide.With those conditions,jar test was used to produce enough liquid product in order to determine the removal percent of several other species.The removal percent of the species was as follows:Cr,SO4^2-,ZnSO4,FeSO4,CN^-1,NiSO4,Fe2[Fe(CN)6]at 99.8%,66.9%,99.6%,21.4%,70.9%,52.8%and 76.4%with CaO,and 99.8%,61.6%,99.9%,7.1%,84.0%,54.4%and 90.5%with Ca(OH)2,respectively.
基金Supported by the Opening Project Fund of Key Laboratory of Danzhou Investigation&Experiment Station of Tropical Crops,Ministry of Agriculture(RRI-KLOF201701)
文摘Based on the effects of skim components on ammonium removal as well as the current processing technology, a new process-intensified technology of removing ammonia from skim by air stripping on rotating packed bed was proposed. The experiments were conducted on a wave-thread packed Rotating Packed Bed(RPB) under atmospheric pressure, suggesting that, in terms of order of importance, the ammonium concentration of feed-stock(x_w), the average ultra-gravity factor(β), feed-stock flux(L), and gas flux(G) had significant impact on ammonium removal rate(η) and the ammonium concentration of products(x_D). In the experiment, mass-transfer coefficient in gas phase(k_ya_e) increases with the increase of β, G/L, and L. The ammonium concentration of products decreases with the increase of β, G/L and the increase of L. The ammonium concentration of products would be as low as ~0.10% and the ammonia removal rate would be 63.21% when skim temperature was 25 °C, x_w0.28%, β 133.2, and G/L 15.0 m^3·L^(-1). Experiment results indicated that the proposed technology for removing ammonium from skim on a rotating packed bed would be a new process-intensified technique compared with traditional aeration process and centrifugal atomization method.
文摘In the process of nickel production by diaphragm electrolysis, the quality of the product has been tremendously affec ted by the content of zinc in the nickel electrolyte. Removing zinc from nickel electrolyte by ion exchange is studied in the paper. Resin D201 is selected as the resin for zinc removing. Effects of the operative parameters, such as temperature, pH value and the contact time on zinc adsorption are observed and the desorption feature of the zinc loaded resin is inspected. The results show that macroporous anion exchange resin D201 has excellent adsorption and desorption properties. Its breakthrough capacity and saturation capacity in zinc adsorption reach 0.81 g/L of zinc and 1.16 g/L of zinc respectively, when the operative temperature is 60 ℃ and the contact time is only 5 min. In addition, compared with gel type IER 201×7 used industrially nowadays, this resin has better wearability and greater intensity.
基金by the National High-Technology Research and Development Program of China(2008AA8040508)the Funda-mental Research Funds for the Central Universities(ZYGX2009X007).
文摘Dry laser cleaning(DLC)and laser shockwave cleaning(LSC)are used to remove the particulate contamination from SiO_(2) sol−gel optical films.The results show that the LSC with a shockwave initiated by plasma formation under a focused laser beam pulse offers much better efficiency than DLC.Silica particles up to 10µm on SiO_(2 )films can be removed without substrate damage at a gap distance of 0.5 mm,and a more uniform surface microstructure can be obtained after LSC.Furthermore,it is demonstrated that the transmittance of contaminated SiO2 films can be restored to the as-deposited value after the LSC on dispersed-particle zones.LSC has potential applications in engineering-oriented large components.
文摘Hospital wastewater represents an infectious and toxic risk to human health and the environment due to its contents. Most hospitals in developing countries, including Benin, do not have a wastewater treatment plant. In this study, the wastewater from two hospitals in northern Benin was characterized and then treated with Azadirachta indica leaves, Moringa oleifera and Luffa cylindrica seeds by coagulation/flocculation process. The wastewater characteristics showed that the collected samples are greatly polluted by organic matter and fecal bacteria such as Escherichia coli, Enterococcus fecal and Total coliforms. Jar-test results revealed that 95.74%, 78%, 49.19% of turbidity, 51.35%, 38.32%, 22.19% of COD, 93.16%, 85.26%, 83.30% against Escherichia coli, 92.11%, 90.93%, 94.60% against total Coliforms and 99.37%, 91%, 99%, 55.07% against Enterococcus were removed from hospital wastewater using Moringa oleifera, Luffa cylindrica seed and Azadirachta indica leaves respectively at dose of 100 mg/L. The results highlighted that the natural coagulants could be successfully used for the removal of turbidity and fecal bacteria from hospital wastewater.
