In this article , the present state of cotton production in Xinjiang is introduced. The strong points and problems in cotton production are discussed in detail. In addition, cotton research advances are reviewed in a ...In this article , the present state of cotton production in Xinjiang is introduced. The strong points and problems in cotton production are discussed in detail. In addition, cotton research advances are reviewed in a comprehensive manner. In consideration of all this, the authors expound some monographic topics and disciplinary projects regarding Xinjiang cotton research which are to be implemented in the years to come.展开更多
Purpose: Formal concept analysis(FCA) and concept lattice theory(CLT) are introduced for constructing a network of IDR topics and for evaluating their effectiveness for knowledge structure exploration.Design/methodolo...Purpose: Formal concept analysis(FCA) and concept lattice theory(CLT) are introduced for constructing a network of IDR topics and for evaluating their effectiveness for knowledge structure exploration.Design/methodology/approach: We introduced the theory and applications of FCA and CLT, and then proposed a method for interdisciplinary knowledge discovery based on CLT. As an example of empirical analysis, interdisciplinary research(IDR) topics in Information & Library Science(LIS) and Medical Informatics, and in LIS and Geography-Physical, were utilized as empirical fields. Subsequently, we carried out a comparative analysis with two other IDR topic recognition methods.Findings: The CLT approach is suitable for IDR topic identification and predictions.Research limitations: IDR topic recognition based on the CLT is not sensitive to the interdisciplinarity of topic terms, since the data can only reflect whether there is a relationship between the discipline and the topic terms. Moreover, the CLT cannot clearly represent a large amounts of concepts.Practical implications: A deeper understanding of the IDR topics was obtained as the structural and hierarchical relationships between them were identified, which can help to get more precise identification and prediction to IDR topics.Originality/value: IDR topics identification based on CLT have performed well and this theory has several advantages for identifying and predicting IDR topics. First, in a concept lattice, there is a partial order relation between interconnected nodes, and consequently, a complete concept lattice can present hierarchical properties. Second, clustering analysis of IDR topics based on concept lattices can yield clusters that highlight the essential knowledge features and help display the semantic relationship between different IDR topics. Furthermore, the Hasse diagram automatically displays all the IDR topics associated with the different disciplines, thus forming clusters of specific concepts and visually retaining and presenting the associations of IDR topics through multiple inheritance relationships between the concepts.展开更多
Purpose:This paper introduces an analysis framework for tracking the evolution of research topics at the selected topics level,covering a research topic's evolution trend,evolution path and its content changes ove...Purpose:This paper introduces an analysis framework for tracking the evolution of research topics at the selected topics level,covering a research topic's evolution trend,evolution path and its content changes over time.Design/methodology/approach:After the topics were recovered by the author-topic model,we first built the keyword-topic co-occurrence network to track the dynamics of topic trends.Then a single-mode network was constructed with each node representing a topic and edge indicating the relationship between topics.It was used to illustrate the evolution path and content changes of research topics.A case study was conducted on the digital library research in China to verify the effectiveness of the analysis framework.Findings:The experimental results show that this analysis framework can be used to track evolution of research topics at a micro level and using social network analysis method can help understand research topics'evolution paths and content changes with the passage of time.Research limitations:Using the analysis framework will produce limited results when examining unstructured data such as social media data.In addition,the effectiveness of the framework introduced in this paper needs to be verified with more research topics in information science and in more scientific fields.Practical implications:This analysis framework can help scholars and researchers map research topics'evolution process and gain insights into how a field's topics have evolved over time.Originality/value:Tbe analysis framework used in this study can help reveal more micro evolution details.The index to measure topic association strength defined in this paper reflects both similarity and dissimilarity between topics,which belps better understand research topics'evolution paths and content changes.展开更多
Over the past two decades,the convergences of translation studies and international business studies have attracted a growing amount of attention from stakeholders in the respective research field.This is particularly...Over the past two decades,the convergences of translation studies and international business studies have attracted a growing amount of attention from stakeholders in the respective research field.This is particularly because professionals and scholars in international business and management realize the importance of the role of language and translation in international trade and multilingual communication.The research results in this interdisciplinary field could provide basis for making critical decisions,such as the staff recruitment,company language policy and company development strategy.However,few reviews have been available that provide a comprehensive overview of relevant practice and research in this cross-disciplinary efforts.The present article therefore aims to offer a state-of-the-art review and investigate the existing literature to map the main research topics and discover future agenda.This article first provides an overview of the perception of“translation”,the role of translator,and translational activities in international business studies.Second,the review focuses on the translation and knowledge transfer in multinational corporations.Lastly,it identifies future directions towards the cross-fertility of the interdisciplinary collaboration.展开更多
In order to support scientific evaluation and decision-making,this paper characterizes and identifies core researchers and their research topics by modeling the portrait of core researchers in technical fields.In this...In order to support scientific evaluation and decision-making,this paper characterizes and identifies core researchers and their research topics by modeling the portrait of core researchers in technical fields.In this paper,we constructed a portrait model of core researchers,explained the information attributes and their label data in each dimension of the portrait.Selected six identification indicators that can be measured,used the CRITIC method and gray correlation method to determine the weight coefficient and comprehensive score of the index,and designed quantitative identification methods for core researchers using Price's calculation formula and golden section coefficient.Took the field of artificial intelligence as an example for empirical analysis and result verification,selected representative core researchers to track the changes of research topics at the two levels of their teams and individuals,and characterize them based on the portrait model.展开更多
In the speech delivered at the centenary celebration of the Communist Party of China(CPC),Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,made important remarks on the“Chinese path ...In the speech delivered at the centenary celebration of the Communist Party of China(CPC),Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,made important remarks on the“Chinese path to modernization.”This term represents the latest achievement China has scored in adapting Marxism to the Chinese context and the needs of the times.It has set the course as China embarks on a new journey of building a strong socialist country with Chinese characteristics and achieving national rejuvenation.Drawing on CiteSpace,we conducted a visualized bibliometric analysis of literature on the Chinese path to modernization by searching the CNKI database using subject terms such as“Chinese modernization,Chinese path to modernization,and Chinese-style modernization.”The findings reveal that:(a)Research on the Chinese path to modernization has gone through three stages:initial establishment,pioneering exploration,and comprehensive in-depth development.(b)Existing literature has covered the four key topics associated with the Chinese path to modernization,namely its essence,goal,methodology,and pioneering achievements.(c)Future research may focus on building up China’s strength in agriculture,developing the digital economy,modernizing China’s system and capacity for governance,and establishing a unique socialist discourse system for Chinese modernization.展开更多
Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epid...Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epidemiology of these conditions has not been well characterized. In this study, we collected information on diabetic eye disease-related research grants from seven representative countries––the United States, China, Japan, the United Kingdom, Spain, Germany, and France––by searching for all global diabetic eye disease journal articles in the Web of Science and Pub Med databases, all global registered clinical trials in the Clinical Trials database, and new drugs approved by the United States, China, Japan, and EU agencies from 2012 to 2021. During this time period, diabetic retinopathy accounted for the vast majority(89.53%) of the 2288 government research grants that were funded to investigate diabetic eye disease, followed by diabetic macular edema(9.27%). The United States granted the most research funding for diabetic eye disease out of the seven countries assessed. The research objectives of grants focusing on diabetic retinopathy and diabetic macular edema differed by country. Additionally, the United States was dominant in terms of research output, publishing 17.53% of global papers about diabetic eye disease and receiving 22.58% of total citations. The United States and the United Kingdom led international collaborations in research into diabetic eye disease. Of the 415 clinical trials that we identified, diabetic macular edema was the major disease that was targeted for drug development(58.19%). Approximately half of the trials(49.13%) pertained to angiogenesis. However, few drugs were approved for ophthalmic(40 out of 1830;2.19%) and diabetic eye disease(3 out of 1830;0.02%) applications. Our findings show that basic and translational research related to diabetic eye disease in the past decade has not been highly active, and has yielded few new treatment methods and newly approved drugs.展开更多
Objectives: In this study, bibliometric approach was used to explore the literature in the field of research related to Diabetic Myasthenia Gravis in order to identify the current research progress in Diabetic Myasthe...Objectives: In this study, bibliometric approach was used to explore the literature in the field of research related to Diabetic Myasthenia Gravis in order to identify the current research progress in Diabetic Myasthenia Gravis related research and to help the researchers to predict the future hotspots in the field of research and to provide reference for the research. Methods: Literature related to diabetic sarcopenia published from 1993 to 2023 since the inception of the repository was extracted from the Web of Science Core Collection (WoSCC) and bibliometric analyses were performed. We have analysed the published literature of the last approximately almost 30 years, as well as publication and citation analyses from different countries, institutions, journals and authors. For keywords, we performed co-occurrence, clustering, timeline view and citation burst analysis. Results: On the basis of 1564 publications, we found a continuous increase in the number of publications and citations, especially in the last six years. The United States is the most representative country, and Seoul National University (SNU) is the most representative institution. The most popular journal in the field is Diabetes Care;Fukui, Michiaki is the most prolific author, leading many studies related to diabetic sarcopenia. The most frequently cited reference was a revised European consensus on the definition and diagnosis of sarcopenia;the most cited keywords were related to physiological factors of diabetes, sarcopenia and related conditions, such as “insulin resistance”, “skeletal muscle”, “body composition”, “risk” and “prevalence”. Conclusion: With more and more studies on the relationship between diabetic sarcopenia, this study presents the current status and trend of research related to diabetic sarcopenia over the past nearly 30 years through the visualization software CiteSpace. It can help researchers identify potential collaborators and partner institutions, hotspots and research frontiers in the field of diabetic sarcopenia. However, our work is only based on the English language literature in the WoSCC database, and for future studies, we recommend that researchers explore the literature from multiple databases to enhance the scope of their research.展开更多
The Sun et al's training program for clinical research nurses(CRNs)in the World Journal of Clinical Cases is a comprehensive and scientific approach.It includes structured frameworks for CRN training,aiming to imp...The Sun et al's training program for clinical research nurses(CRNs)in the World Journal of Clinical Cases is a comprehensive and scientific approach.It includes structured frameworks for CRN training,aiming to improve CRN competency.This program emphasizes practical abilities,updates training content,and improves evaluation methods.The cultivation of CRN talents focuses on enhancing the training system,establishing a multifaceted evaluation framework,and continuously refining the training programs.Regular feedback and evalua-tion are essential to improve CRNs'competency in practical settings.展开更多
Introduction: Near-infrared fluorescence imaging is a technique that will establish itself in the short term at the international level because it is recognized for its potential to improve the performance of surgical...Introduction: Near-infrared fluorescence imaging is a technique that will establish itself in the short term at the international level because it is recognized for its potential to improve the performance of surgical interventions, its moderate investment and operating costs and its portability. Although the technology is now mature, there is currently the problem of the availability of contrast agents to be injected IV. The aim of this methodology article is to propose an alternative solution to the need for contrast agents for clinical research, particularly in oncology. Methodology: They consist of coupling a fluorescent marker in the form of an NHS derivative, such as IR DYE manufactured in compliance with GMP, with therapeutic monoclonal antibodies having marketing authorization for molecular imaging. For a given antibody, the marking procedure must be the subject of a validation file on the final preparation filtered on a sterilizing membrane at 0.22 μm. Once the procedure has been validated, it would be unnecessary to repeat the tests before each clinical research examination. A check of the marking by thin-layer chromatography (TLC) and place it in a sample bank at +4˚C for 1 month of each injected formulation would be sufficient for additional tests if necessary. Conclusion: Molecular near-infrared fluorescence imaging is experiencing development, the process of which could be accelerated by greater availability of clinical contrast agents. Alternative solutions are therefore necessary to promote clinical research in this area. These methods must be shared to make it easier for researchers.展开更多
This paper introduced the content, compilation process, reliability and validity, scoring method of the evaluation tool for patients’ medication compliance at home and abroad, and reviewed the research progress of th...This paper introduced the content, compilation process, reliability and validity, scoring method of the evaluation tool for patients’ medication compliance at home and abroad, and reviewed the research progress of the tool. The evaluation method, dimension, scoring method, evaluation content and application scope of the tool were compared, so as to provide reference for nurses to comprehensively and accurately evaluate patients’ medication status.展开更多
Microplastics are plastic particles or fibers with a diameter of less than 5 mm,and they widely exist in the environment and pose potential risks to the ecosystem and human health.Microplastics detection can provide b...Microplastics are plastic particles or fibers with a diameter of less than 5 mm,and they widely exist in the environment and pose potential risks to the ecosystem and human health.Microplastics detection can provide basic data for formulating effective environmental protection strategies.In this paper,the physical,chemical and biological detection methods of microplastics are reviewed,and the advantages and disadvantages of different methods are analyzed.The problems and challenges encountered in microplastics detection are analyzed,and the future research is discussed.展开更多
The coexistence of venous thromboembolism(VTE)within patients with cancer,known as cancer-associated thrombosis(CAT),stands as a prominent cause of mortality in this population.Over recent years,the incidence of VTE h...The coexistence of venous thromboembolism(VTE)within patients with cancer,known as cancer-associated thrombosis(CAT),stands as a prominent cause of mortality in this population.Over recent years,the incidence of VTE has demonstrated a steady increase across diverse tumor types,influenced by several factors such as patient management,tumor-specific risks,and treatment-related aspects.Furthermore,mutations in specific genes have been identified as potential contributors to increased CAT occurrence in particular cancer subtypes.We conducted an extensive review encompassing pivotal historical and ongoing studies on CAT.This review elucidates the risks,mechanisms,reliable markers,and risk assessment methodologies that can significantly guide effective interventions in clinical practice.展开更多
Mitochondrial autophagy is widely found in mammals,and plays an important role in maintaining mitochondrial balance and mitochondrial quality control in cells.In this review,we reviewed the research progress of BNIP3-...Mitochondrial autophagy is widely found in mammals,and plays an important role in maintaining mitochondrial balance and mitochondrial quality control in cells.In this review,we reviewed the research progress of BNIP3-mediated mitochondrial autophagy and diseases in recent 5 years,providing new ideas for clinical diagnosis and treatment.展开更多
Dictyophora rubrovalvata is an edible fungus with rich nutritional value.It contains various nutrients and bioactive components,and has immunomodulation,anti-tumor,anti-oxidation,anti-fatigue,anti-aging,anti-inflammat...Dictyophora rubrovalvata is an edible fungus with rich nutritional value.It contains various nutrients and bioactive components,and has immunomodulation,anti-tumor,anti-oxidation,anti-fatigue,anti-aging,anti-inflammation and alcoholic hepatitis-protection effects.With the continuous expansion of planting area of Dictyophora,the disease problem has become a major problem affecting the development of Dictyophora industry.In this paper,the pathogens,harmful symptoms and causes of main diseases in Dictyophora were summarized,so as to provide reference for comprehensive control of Dictyophora diseases and promote the high-quality development of Dictyophora industry.展开更多
Objective:This paper aims to evaluate the implementation effect of the diversified course assessment method reform.Methods:A diversified assessment method was implemented for 196 undergraduate nursing students.Student...Objective:This paper aims to evaluate the implementation effect of the diversified course assessment method reform.Methods:A diversified assessment method was implemented for 196 undergraduate nursing students.Students’mastery of key knowledge in“Nursing Research”was assessed through group reports on topic selection and literature retrieval,as well as the proposition level of the final examination.Results:81.6%of the students agreed with the course assessment method,and 97.9%believed studying“Nursing Research”would be helpful for future scientific research applications.Conclusion:Diversified assessment methods can help improve undergraduate nursing students’scientific research skills and comprehensive quality.展开更多
In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for t...In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for the future research and development of new anti-cancer drugs of Aconiti Radix.展开更多
In order to better carry out research on education and teaching,the author consulted relevant literature on blended teaching mode from 2011-2021 through CNKI,Web of Science and other websites,summarized and analyzed t...In order to better carry out research on education and teaching,the author consulted relevant literature on blended teaching mode from 2011-2021 through CNKI,Web of Science and other websites,summarized and analyzed the research status of blended teaching mode,in order to lay a good foundation for studying blended teaching mode in course teaching.展开更多
Owing to significantly prolonged survival,targeted therapy has become standardized recommendation for advanced non-small cell lung cancer patients with mutated driver genes.However,the genetic status of lung cancer pa...Owing to significantly prolonged survival,targeted therapy has become standardized recommendation for advanced non-small cell lung cancer patients with mutated driver genes.However,the genetic status of lung cancer patients is dynamic.By dynamically monitoring the evolution of genes status,differential genes and concomitant genes related to progressive disease could be confirmed early,so as to achieve a more accurate and comprehensive insight of the whole process management of targeted therapy for lung cancer patients.Under the guidance of accurate genetic testing results,it is helpful to provide patients with more effective,long-term,and stable individualized targeted therapy.展开更多
As a subversive manufacturing technology, additive manufacturing technology has many technical advantages such as high freedom of design and not limited by complex structure of parts. The application of additive manuf...As a subversive manufacturing technology, additive manufacturing technology has many technical advantages such as high freedom of design and not limited by complex structure of parts. The application of additive manufacturing technology to the charge molding of energetic materials will subvert the traditional manufacturing concept of energetic materials, realize the advanced charge design concept, shorten the research and development time of weapons and equipment, and improve the comprehensive performance of weapons and equipment, which is of great significance for the rapid development of high-tech weapons and equipment. This paper analyzes the research progress of additive manufacturing technology in the field of energetic materials at home and abroad and puts forward some suggestions for future research of this technology. .展开更多
基金The project is supported by the Research Project "95-001-04-04-02".
文摘In this article , the present state of cotton production in Xinjiang is introduced. The strong points and problems in cotton production are discussed in detail. In addition, cotton research advances are reviewed in a comprehensive manner. In consideration of all this, the authors expound some monographic topics and disciplinary projects regarding Xinjiang cotton research which are to be implemented in the years to come.
基金an outcome of the project "Study on the Recognition Method of Innovative Evolving Trajectory based on Topic Correlation Analysis of Science and Technology" (No. 71704170) supported by National Natural Science Foundation of Chinathe project "Study on Regularity and Dynamics of Knowledge Diffusion among Scientific Disciplines" (No. 71704063) supported by National Natura Science Foundation of Chinathe Youth Innovation Promotion Association, CAS (Grant No. 2016159)
文摘Purpose: Formal concept analysis(FCA) and concept lattice theory(CLT) are introduced for constructing a network of IDR topics and for evaluating their effectiveness for knowledge structure exploration.Design/methodology/approach: We introduced the theory and applications of FCA and CLT, and then proposed a method for interdisciplinary knowledge discovery based on CLT. As an example of empirical analysis, interdisciplinary research(IDR) topics in Information & Library Science(LIS) and Medical Informatics, and in LIS and Geography-Physical, were utilized as empirical fields. Subsequently, we carried out a comparative analysis with two other IDR topic recognition methods.Findings: The CLT approach is suitable for IDR topic identification and predictions.Research limitations: IDR topic recognition based on the CLT is not sensitive to the interdisciplinarity of topic terms, since the data can only reflect whether there is a relationship between the discipline and the topic terms. Moreover, the CLT cannot clearly represent a large amounts of concepts.Practical implications: A deeper understanding of the IDR topics was obtained as the structural and hierarchical relationships between them were identified, which can help to get more precise identification and prediction to IDR topics.Originality/value: IDR topics identification based on CLT have performed well and this theory has several advantages for identifying and predicting IDR topics. First, in a concept lattice, there is a partial order relation between interconnected nodes, and consequently, a complete concept lattice can present hierarchical properties. Second, clustering analysis of IDR topics based on concept lattices can yield clusters that highlight the essential knowledge features and help display the semantic relationship between different IDR topics. Furthermore, the Hasse diagram automatically displays all the IDR topics associated with the different disciplines, thus forming clusters of specific concepts and visually retaining and presenting the associations of IDR topics through multiple inheritance relationships between the concepts.
文摘Purpose:This paper introduces an analysis framework for tracking the evolution of research topics at the selected topics level,covering a research topic's evolution trend,evolution path and its content changes over time.Design/methodology/approach:After the topics were recovered by the author-topic model,we first built the keyword-topic co-occurrence network to track the dynamics of topic trends.Then a single-mode network was constructed with each node representing a topic and edge indicating the relationship between topics.It was used to illustrate the evolution path and content changes of research topics.A case study was conducted on the digital library research in China to verify the effectiveness of the analysis framework.Findings:The experimental results show that this analysis framework can be used to track evolution of research topics at a micro level and using social network analysis method can help understand research topics'evolution paths and content changes with the passage of time.Research limitations:Using the analysis framework will produce limited results when examining unstructured data such as social media data.In addition,the effectiveness of the framework introduced in this paper needs to be verified with more research topics in information science and in more scientific fields.Practical implications:This analysis framework can help scholars and researchers map research topics'evolution process and gain insights into how a field's topics have evolved over time.Originality/value:Tbe analysis framework used in this study can help reveal more micro evolution details.The index to measure topic association strength defined in this paper reflects both similarity and dissimilarity between topics,which belps better understand research topics'evolution paths and content changes.
文摘Over the past two decades,the convergences of translation studies and international business studies have attracted a growing amount of attention from stakeholders in the respective research field.This is particularly because professionals and scholars in international business and management realize the importance of the role of language and translation in international trade and multilingual communication.The research results in this interdisciplinary field could provide basis for making critical decisions,such as the staff recruitment,company language policy and company development strategy.However,few reviews have been available that provide a comprehensive overview of relevant practice and research in this cross-disciplinary efforts.The present article therefore aims to offer a state-of-the-art review and investigate the existing literature to map the main research topics and discover future agenda.This article first provides an overview of the perception of“translation”,the role of translator,and translational activities in international business studies.Second,the review focuses on the translation and knowledge transfer in multinational corporations.Lastly,it identifies future directions towards the cross-fertility of the interdisciplinary collaboration.
基金support from the National Social Science Fund of China(16ZDA224)。
文摘In order to support scientific evaluation and decision-making,this paper characterizes and identifies core researchers and their research topics by modeling the portrait of core researchers in technical fields.In this paper,we constructed a portrait model of core researchers,explained the information attributes and their label data in each dimension of the portrait.Selected six identification indicators that can be measured,used the CRITIC method and gray correlation method to determine the weight coefficient and comprehensive score of the index,and designed quantitative identification methods for core researchers using Price's calculation formula and golden section coefficient.Took the field of artificial intelligence as an example for empirical analysis and result verification,selected representative core researchers to track the changes of research topics at the two levels of their teams and individuals,and characterize them based on the portrait model.
基金the phased outcome of the National Social Science Fund of China(NSSFC)Project,A Case Study on Urbanization in Xizang with Local Features from the Perspective of Stabilizing Border Areas and Boosting Local Economies(22CMZ013)。
文摘In the speech delivered at the centenary celebration of the Communist Party of China(CPC),Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,made important remarks on the“Chinese path to modernization.”This term represents the latest achievement China has scored in adapting Marxism to the Chinese context and the needs of the times.It has set the course as China embarks on a new journey of building a strong socialist country with Chinese characteristics and achieving national rejuvenation.Drawing on CiteSpace,we conducted a visualized bibliometric analysis of literature on the Chinese path to modernization by searching the CNKI database using subject terms such as“Chinese modernization,Chinese path to modernization,and Chinese-style modernization.”The findings reveal that:(a)Research on the Chinese path to modernization has gone through three stages:initial establishment,pioneering exploration,and comprehensive in-depth development.(b)Existing literature has covered the four key topics associated with the Chinese path to modernization,namely its essence,goal,methodology,and pioneering achievements.(c)Future research may focus on building up China’s strength in agriculture,developing the digital economy,modernizing China’s system and capacity for governance,and establishing a unique socialist discourse system for Chinese modernization.
基金supported by the National Natural Science Foundation of China,No.82122009 (to JX)Science Research Foundation ofAier Eye Hospital Group,No.AM2001D1 (to JX)the Natural Science Foundation of Hunan Province,No.2020JJ5002 (to SJ)。
文摘Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epidemiology of these conditions has not been well characterized. In this study, we collected information on diabetic eye disease-related research grants from seven representative countries––the United States, China, Japan, the United Kingdom, Spain, Germany, and France––by searching for all global diabetic eye disease journal articles in the Web of Science and Pub Med databases, all global registered clinical trials in the Clinical Trials database, and new drugs approved by the United States, China, Japan, and EU agencies from 2012 to 2021. During this time period, diabetic retinopathy accounted for the vast majority(89.53%) of the 2288 government research grants that were funded to investigate diabetic eye disease, followed by diabetic macular edema(9.27%). The United States granted the most research funding for diabetic eye disease out of the seven countries assessed. The research objectives of grants focusing on diabetic retinopathy and diabetic macular edema differed by country. Additionally, the United States was dominant in terms of research output, publishing 17.53% of global papers about diabetic eye disease and receiving 22.58% of total citations. The United States and the United Kingdom led international collaborations in research into diabetic eye disease. Of the 415 clinical trials that we identified, diabetic macular edema was the major disease that was targeted for drug development(58.19%). Approximately half of the trials(49.13%) pertained to angiogenesis. However, few drugs were approved for ophthalmic(40 out of 1830;2.19%) and diabetic eye disease(3 out of 1830;0.02%) applications. Our findings show that basic and translational research related to diabetic eye disease in the past decade has not been highly active, and has yielded few new treatment methods and newly approved drugs.
文摘Objectives: In this study, bibliometric approach was used to explore the literature in the field of research related to Diabetic Myasthenia Gravis in order to identify the current research progress in Diabetic Myasthenia Gravis related research and to help the researchers to predict the future hotspots in the field of research and to provide reference for the research. Methods: Literature related to diabetic sarcopenia published from 1993 to 2023 since the inception of the repository was extracted from the Web of Science Core Collection (WoSCC) and bibliometric analyses were performed. We have analysed the published literature of the last approximately almost 30 years, as well as publication and citation analyses from different countries, institutions, journals and authors. For keywords, we performed co-occurrence, clustering, timeline view and citation burst analysis. Results: On the basis of 1564 publications, we found a continuous increase in the number of publications and citations, especially in the last six years. The United States is the most representative country, and Seoul National University (SNU) is the most representative institution. The most popular journal in the field is Diabetes Care;Fukui, Michiaki is the most prolific author, leading many studies related to diabetic sarcopenia. The most frequently cited reference was a revised European consensus on the definition and diagnosis of sarcopenia;the most cited keywords were related to physiological factors of diabetes, sarcopenia and related conditions, such as “insulin resistance”, “skeletal muscle”, “body composition”, “risk” and “prevalence”. Conclusion: With more and more studies on the relationship between diabetic sarcopenia, this study presents the current status and trend of research related to diabetic sarcopenia over the past nearly 30 years through the visualization software CiteSpace. It can help researchers identify potential collaborators and partner institutions, hotspots and research frontiers in the field of diabetic sarcopenia. However, our work is only based on the English language literature in the WoSCC database, and for future studies, we recommend that researchers explore the literature from multiple databases to enhance the scope of their research.
文摘The Sun et al's training program for clinical research nurses(CRNs)in the World Journal of Clinical Cases is a comprehensive and scientific approach.It includes structured frameworks for CRN training,aiming to improve CRN competency.This program emphasizes practical abilities,updates training content,and improves evaluation methods.The cultivation of CRN talents focuses on enhancing the training system,establishing a multifaceted evaluation framework,and continuously refining the training programs.Regular feedback and evalua-tion are essential to improve CRNs'competency in practical settings.
文摘Introduction: Near-infrared fluorescence imaging is a technique that will establish itself in the short term at the international level because it is recognized for its potential to improve the performance of surgical interventions, its moderate investment and operating costs and its portability. Although the technology is now mature, there is currently the problem of the availability of contrast agents to be injected IV. The aim of this methodology article is to propose an alternative solution to the need for contrast agents for clinical research, particularly in oncology. Methodology: They consist of coupling a fluorescent marker in the form of an NHS derivative, such as IR DYE manufactured in compliance with GMP, with therapeutic monoclonal antibodies having marketing authorization for molecular imaging. For a given antibody, the marking procedure must be the subject of a validation file on the final preparation filtered on a sterilizing membrane at 0.22 μm. Once the procedure has been validated, it would be unnecessary to repeat the tests before each clinical research examination. A check of the marking by thin-layer chromatography (TLC) and place it in a sample bank at +4˚C for 1 month of each injected formulation would be sufficient for additional tests if necessary. Conclusion: Molecular near-infrared fluorescence imaging is experiencing development, the process of which could be accelerated by greater availability of clinical contrast agents. Alternative solutions are therefore necessary to promote clinical research in this area. These methods must be shared to make it easier for researchers.
文摘This paper introduced the content, compilation process, reliability and validity, scoring method of the evaluation tool for patients’ medication compliance at home and abroad, and reviewed the research progress of the tool. The evaluation method, dimension, scoring method, evaluation content and application scope of the tool were compared, so as to provide reference for nurses to comprehensively and accurately evaluate patients’ medication status.
文摘Microplastics are plastic particles or fibers with a diameter of less than 5 mm,and they widely exist in the environment and pose potential risks to the ecosystem and human health.Microplastics detection can provide basic data for formulating effective environmental protection strategies.In this paper,the physical,chemical and biological detection methods of microplastics are reviewed,and the advantages and disadvantages of different methods are analyzed.The problems and challenges encountered in microplastics detection are analyzed,and the future research is discussed.
基金Guizhou Provincial Basic Research Program,No.ZK2023376Guizhou Provincial Health Commission Science and Technology Fund Project,No.GZWKJ2023164 and No.SYXK2018-0001Guizhou Medical University Hospital National Natural Science Foundation Cultivation Project,No.GYFYnsfc-2021-36.
文摘The coexistence of venous thromboembolism(VTE)within patients with cancer,known as cancer-associated thrombosis(CAT),stands as a prominent cause of mortality in this population.Over recent years,the incidence of VTE has demonstrated a steady increase across diverse tumor types,influenced by several factors such as patient management,tumor-specific risks,and treatment-related aspects.Furthermore,mutations in specific genes have been identified as potential contributors to increased CAT occurrence in particular cancer subtypes.We conducted an extensive review encompassing pivotal historical and ongoing studies on CAT.This review elucidates the risks,mechanisms,reliable markers,and risk assessment methodologies that can significantly guide effective interventions in clinical practice.
基金National Natural Science Foundation of China(No.81860654)Guangxi Health Commission Key Laboratory Construction Project(No.ZZH2020006)。
文摘Mitochondrial autophagy is widely found in mammals,and plays an important role in maintaining mitochondrial balance and mitochondrial quality control in cells.In this review,we reviewed the research progress of BNIP3-mediated mitochondrial autophagy and diseases in recent 5 years,providing new ideas for clinical diagnosis and treatment.
基金Supported by Guiyang Science and Technology Planning Project (ZKHT[2020]3-13).
文摘Dictyophora rubrovalvata is an edible fungus with rich nutritional value.It contains various nutrients and bioactive components,and has immunomodulation,anti-tumor,anti-oxidation,anti-fatigue,anti-aging,anti-inflammation and alcoholic hepatitis-protection effects.With the continuous expansion of planting area of Dictyophora,the disease problem has become a major problem affecting the development of Dictyophora industry.In this paper,the pathogens,harmful symptoms and causes of main diseases in Dictyophora were summarized,so as to provide reference for comprehensive control of Dictyophora diseases and promote the high-quality development of Dictyophora industry.
基金Nursing Research Outcome of the Pilot Project for Course Assessment Reform in Sanya University(Project number:SYJGKH2022138)。
文摘Objective:This paper aims to evaluate the implementation effect of the diversified course assessment method reform.Methods:A diversified assessment method was implemented for 196 undergraduate nursing students.Students’mastery of key knowledge in“Nursing Research”was assessed through group reports on topic selection and literature retrieval,as well as the proposition level of the final examination.Results:81.6%of the students agreed with the course assessment method,and 97.9%believed studying“Nursing Research”would be helpful for future scientific research applications.Conclusion:Diversified assessment methods can help improve undergraduate nursing students’scientific research skills and comprehensive quality.
基金Supported by Science and Technology Innovation Plan for Medical Workers in Shandong Province(SDYWZGKCJH2023095)Clinical Pharmacy Research Project of Shandong Provincial Medical Association(YXH2022ZX010)+1 种基金Traditional Chinese Medicine Science and Technology Development Project of Shandong Province(2019-0400&2021Q097)Traditional Chinese Medicine Research Program of Qingdao City(2020-zyy031)Medical Research Guidance Plan of Qingdao City(2020-WJZD087).
文摘In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for the future research and development of new anti-cancer drugs of Aconiti Radix.
文摘In order to better carry out research on education and teaching,the author consulted relevant literature on blended teaching mode from 2011-2021 through CNKI,Web of Science and other websites,summarized and analyzed the research status of blended teaching mode,in order to lay a good foundation for studying blended teaching mode in course teaching.
基金National Natural Science Foundation of China(No.81873396)Capital Health Development Research Project(No.2018-2-4065)Project of China-Japan Friendship Hospital(No.2018-HX-26)。
文摘Owing to significantly prolonged survival,targeted therapy has become standardized recommendation for advanced non-small cell lung cancer patients with mutated driver genes.However,the genetic status of lung cancer patients is dynamic.By dynamically monitoring the evolution of genes status,differential genes and concomitant genes related to progressive disease could be confirmed early,so as to achieve a more accurate and comprehensive insight of the whole process management of targeted therapy for lung cancer patients.Under the guidance of accurate genetic testing results,it is helpful to provide patients with more effective,long-term,and stable individualized targeted therapy.
文摘As a subversive manufacturing technology, additive manufacturing technology has many technical advantages such as high freedom of design and not limited by complex structure of parts. The application of additive manufacturing technology to the charge molding of energetic materials will subvert the traditional manufacturing concept of energetic materials, realize the advanced charge design concept, shorten the research and development time of weapons and equipment, and improve the comprehensive performance of weapons and equipment, which is of great significance for the rapid development of high-tech weapons and equipment. This paper analyzes the research progress of additive manufacturing technology in the field of energetic materials at home and abroad and puts forward some suggestions for future research of this technology. .
