Solasodine rhamnosides produced in plants as secondary metabolites, are safe and effective when treating a variety of cancers, including non-melanoma skin cancers. They are cytotoxic against multi-drug resistant tumor...Solasodine rhamnosides produced in plants as secondary metabolites, are safe and effective when treating a variety of cancers, including non-melanoma skin cancers. They are cytotoxic against multi-drug resistant tumor cells, stimulate lasting immunity against cancer, are not mutagenic and display anti-mutagenic properties. These antineoplastics, through cellular specific receptor-mediated actions, directly induce apoptosis by triggering extrinsic and intrinsic apoptotic pathways in cancer cells but not normal cells. CuradermBEC5 contains solasodine rhamnosides and is a topical formulation for the treatment of keratoses and non-melanoma skin cancers. The mode of action, together with the selectivity towards cancer cells, with CuradermBEC5 therapy, results in outstanding beneficial outcomes. This study shows graphically and pictorially that CuradermBEC5 seeks and destroys basal cell carcinoma whilst normal skin cells replace the dead cancer cells during therapy, emanating into impressive cosmetic end results. The clinical observations with CuradermBEC5 therapy reveal that initially the lesion size increases over four-fold due to the interaction of CuradermBEC5 with deeper and more lateral tumor cells, followed by a decrease in size, ultimately, resulting in complete elimination of the basal cell carcinoma.展开更多
从骨碎补(Drynaria fortunei)的乙酸乙酯萃取物中分离得到了2个黄酮苷类化合物,结合其理化性质,并通过ESI-MS,IR,1 H NMR,13 C NMR,1 H-1 H COSY,HSQC,HMBC等多种波谱学方法进行结构鉴定,鉴定化合物1和2分别为山奈酚-3-O-β-D-6″′-乙...从骨碎补(Drynaria fortunei)的乙酸乙酯萃取物中分离得到了2个黄酮苷类化合物,结合其理化性质,并通过ESI-MS,IR,1 H NMR,13 C NMR,1 H-1 H COSY,HSQC,HMBC等多种波谱学方法进行结构鉴定,鉴定化合物1和2分别为山奈酚-3-O-β-D-6″′-乙酰基-吡喃葡萄糖-(1→4)-α-L-吡喃鼠李糖苷及山奈酚-3-O-β-D-吡喃葡萄糖-(1→4)-α-L-吡喃鼠李糖苷,并对二者的1 H NMR化学位移信号进行了全归属,纠正了文献中C-5和C-9的归属错误.展开更多
文摘Solasodine rhamnosides produced in plants as secondary metabolites, are safe and effective when treating a variety of cancers, including non-melanoma skin cancers. They are cytotoxic against multi-drug resistant tumor cells, stimulate lasting immunity against cancer, are not mutagenic and display anti-mutagenic properties. These antineoplastics, through cellular specific receptor-mediated actions, directly induce apoptosis by triggering extrinsic and intrinsic apoptotic pathways in cancer cells but not normal cells. CuradermBEC5 contains solasodine rhamnosides and is a topical formulation for the treatment of keratoses and non-melanoma skin cancers. The mode of action, together with the selectivity towards cancer cells, with CuradermBEC5 therapy, results in outstanding beneficial outcomes. This study shows graphically and pictorially that CuradermBEC5 seeks and destroys basal cell carcinoma whilst normal skin cells replace the dead cancer cells during therapy, emanating into impressive cosmetic end results. The clinical observations with CuradermBEC5 therapy reveal that initially the lesion size increases over four-fold due to the interaction of CuradermBEC5 with deeper and more lateral tumor cells, followed by a decrease in size, ultimately, resulting in complete elimination of the basal cell carcinoma.
文摘从骨碎补(Drynaria fortunei)的乙酸乙酯萃取物中分离得到了2个黄酮苷类化合物,结合其理化性质,并通过ESI-MS,IR,1 H NMR,13 C NMR,1 H-1 H COSY,HSQC,HMBC等多种波谱学方法进行结构鉴定,鉴定化合物1和2分别为山奈酚-3-O-β-D-6″′-乙酰基-吡喃葡萄糖-(1→4)-α-L-吡喃鼠李糖苷及山奈酚-3-O-β-D-吡喃葡萄糖-(1→4)-α-L-吡喃鼠李糖苷,并对二者的1 H NMR化学位移信号进行了全归属,纠正了文献中C-5和C-9的归属错误.
