Micrometric-thin cells(MCs)with alkali vapor atoms have been valuable for research and applications of hyperfine Zeeman splitting and atomic magnetometers under strong magnetic fields.We theoretically and experimental...Micrometric-thin cells(MCs)with alkali vapor atoms have been valuable for research and applications of hyperfine Zeeman splitting and atomic magnetometers under strong magnetic fields.We theoretically and experimentally study the saturated absorption spectra using a 100-μm cesium MC,where the pump and probe beams are linearly polarized with mutually perpendicular polarizations,and the magnetic field is along the pump beam.Because of the distinctive thin chamber of the MC,crossover spectral lines in saturated absorption spectra are largely suppressed leading to clear splittings of hyperfine Zeeman transitions in experiments,and the effect of spatial magnetic field gradient is expected to be reduced.A calculation method is proposed to achieve good agreements between theoretical calculations and experimental results.This method successfully explains the suppression of crossover lines in MCs,as well as the effects of magnetic field direction,propagation and polarization directions of the pump/probe beam on saturated absorption spectrum.The saturated absorption spectrum with suppressed crossover lines is used for laser frequency stabilization,which may provide the potential value of MCs for high spatial resolution strong-field magnetometry with high sensitivity.展开更多
Three high-temperature resistant polymeric additives for water-based drilling fluids are designed and developed:weakly cross-linked zwitterionic polymer fluid loss reducer(WCZ),flexible polymer microsphere nano-pluggi...Three high-temperature resistant polymeric additives for water-based drilling fluids are designed and developed:weakly cross-linked zwitterionic polymer fluid loss reducer(WCZ),flexible polymer microsphere nano-plugging agent(FPM)and comb-structure polymeric lubricant(CSP).A high-temperature resistant and high-density polymeric saturated brine-based drilling fluid was developed for deep drilling.The WCZ has a good anti-polyelectrolyte effect and exhibits the API fluid loss less than 8 mL after aging in saturated salt environment at 200°C.The FPM can reduce the fluid loss by improving the quality of the mud cake and has a good plugging effect on nano-scale pores/fractures.The CSP,with a weight average molecular weight of 4804,has multiple polar adsorption sites and exhibits excellent lubricating performance under high temperature and high salt conditions.The developed drilling fluid system with a density of 2.0 g/cm^(3)has good rheological properties.It shows a fluid loss less than 15 mL at 200°C and high pressure,a sedimentation factor(SF)smaller than 0.52 after standing at high temperature for 5 d,and a rolling recovery of hydratable drill cuttings similar to oil-based drilling fluid.Besides,it has good plugging and lubricating performance.展开更多
Frost heave in seasonally frozen regions is a one-dimensional process that could severely damage infrastructure subgrades.Stress state,temperature and water migration are important factors for frost heave.This work in...Frost heave in seasonally frozen regions is a one-dimensional process that could severely damage infrastructure subgrades.Stress state,temperature and water migration are important factors for frost heave.This work investigated the effects of soil temperature and volumetric water content on the transient frost heave ratio during the freezing of saturated silty clay in an open system and analyzed the relationships between the transient frost heave ratio and freezing rate and between temperature gradient and frost heave rate.The results show that the frost heave ratio,frost heave rate,and freezing rate are positively correlated with the temperature gradient since the temperature gradient drives the water migration during freezing,indicating the transient temperature gradient could be used to evaluate the frost heave of saturated silty clay.The transient freezing rate and transient frost heave ratio are logarithmically related to the transient frost heave ratio and transient temperature gradient,respectively.The effects of transient temperature gradient on frost heave are the principal mechanism responsible for different frost heave characteristics and uneven frost heave along a subgrade of the same soil type.展开更多
Mathematical modelling has been extensively used to measure intervention strategies for the control of contagious conditions.Alignment between different models is pivotal for furnishing strong substantiation for polic...Mathematical modelling has been extensively used to measure intervention strategies for the control of contagious conditions.Alignment between different models is pivotal for furnishing strong substantiation for policymakers because the differences in model features can impact their prognostications.Mathematical modelling has been widely used in order to better understand the transmission,treatment,and prevention of infectious diseases.Herein,we study the dynamics of a human immunodeficiency virus(HIV)infection model with four variables:S(t),I(t),C(t),and A(t)the susceptible individuals;HIV infected individuals(with no clinical symptoms of AIDS);HIV infected individuals(under ART with a viral load remaining low),and HIV infected individuals with two different incidence functions(bilinear and saturated incidence functions).A novel numerical scheme called the continuous Galerkin-Petrov method is implemented for the solution of themodel.The influence of different clinical parameters on the dynamical behavior of S(t),I(t),C(t)and A(t)is described and analyzed.All the results are depicted graphically.On the other hand,we explore the time-dependent movement of nanofluid in porous media on an extending sheet under the influence of thermal radiation,heat flux,hall impact,variable heat source,and nanomaterial.The flow is considered to be 2D,boundary layer,viscous,incompressible,laminar,and unsteady.Sufficient transformations turn governing connected PDEs intoODEs,which are solved using the proposed scheme.To justify the envisaged problem,a comparison of the current work with previous literature is presented.展开更多
Hydraulic conductivity is the ability of a porous media to transfer water through its pore matrix. That is a key parameter for the design and analysis of soil fluid associated structures and issues. This paper present...Hydraulic conductivity is the ability of a porous media to transfer water through its pore matrix. That is a key parameter for the design and analysis of soil fluid associated structures and issues. This paper presents the test results of the vertical hydraulic conductivity k<sub>v</sub><sub> </sub>carried out on one poorly graded sand and three gap graded gravely sand. It was found that the vertical hydraulic conductivity of saturated soil depends on the grain size distribution curve, on the initial relative density of the soil. Compilation of these current test results and other test results published, shows that the common approaches predict well to some extent the vertical hydraulic conductivity k<sub>v</sub> for the poorly graded sand materials and underestimate the k<sub>v</sub> values for gap graded gravely sand materials. Therefore, new approaches are developed for the prediction of the vertical hydraulic conductivity in saturated poorly graded sand and gap graded gravely sand. The derived results from the new approaches lie in the range of the recommended values by (EAU 2012) and (NAVFAC DM 7 1974).展开更多
Shale porosity measurements have crucial scientific and economical applications in unconventionalpetroleum systems. As a standard technique, liquid saturation methods, including water saturation (WS)and oil saturation...Shale porosity measurements have crucial scientific and economical applications in unconventionalpetroleum systems. As a standard technique, liquid saturation methods, including water saturation (WS)and oil saturation (OS), have been widely used to measure the porosity of many rock types. For clay-richshale reservoirs with high organic matter content, it is well known that the WS method may cause clayswelling and induce structural changes in the pore system. The OS method affects the accuracy ofporosity measurements because of some of the oil being dissolved by kerogen within the shale;however,this has not received sufficient research attention. In this study, we compare the previously reported andnewly tested OS porosities with helium (He) expansion porosity. Results show that OS porosity generallyexceeds the He porosity. Furthermore, the higher the total organic carbon (TOC) content and lower thematurity of shale, the greater the difference between the OS and helium porosities. When using the OSmethod, the effect of kerogen-dissolved oil causes an overestimation of the shale porosity by ~30%. To thebest of our knowledge, this is the first time to note the kerogen-dissolve oil effects on OS porosity. Herein,we propose a new, simple, and effective correction method for estimating OS porosity that involvessubtracting the kerogen-dissolved oil content from raw OS porosity. In addition, the quantification modelof kerogen-dissolved oil capacity is established, taking into account the abundance and maturity oforganic matter. Taking the He porosity as the benchmark, the absolute error of the corrected OS porositydoes not exceed 1% and the average relative error is only ~10%. The obtained results can help improve theaccuracy of shale porosity evaluation methods.展开更多
AIM: To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis. METHODS: Primary pancreatic acinar cells were treated with low and high conc...AIM: To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis. METHODS: Primary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca2+ signal and the expression of protein kinase C(PKC) were measured after treatment. RESULTS: Unsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca2+ concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca2+ concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression.CONCLUSION: At sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.展开更多
Based on the three-dimensional Gurtin-type variational principle of the incompressible saturated porous media, a one-dimensional mathematical model for dynamics of the saturated poroelastic Timoshenko cantilever beam ...Based on the three-dimensional Gurtin-type variational principle of the incompressible saturated porous media, a one-dimensional mathematical model for dynamics of the saturated poroelastic Timoshenko cantilever beam is established with two assumptions, i.e., the deformation satisfies the classical single phase Timoshenko beam and the movement of the pore fluid is only in the axial direction of the saturated poroelastic beam. Under some special cases, this mathematical model can be degenerated into the Euler-Bernoulli model, the Rayleigh model, and the shear model of the saturated poroelastic beam, respectively. The dynamic and quasi-static behaviors of a saturated poroelastic Timoshenko cantilever beam with an impermeable fixed end and a permeable free end subjected to a step load at its free end are analyzed by the Laplace transform. The variations of the deflections at the beam free end against time are shown in figures. The influences of the interaction coefficient between the pore fluid and the solid skeleton as well as the slenderness ratio of the beam on the dynamic/quasi-static performances of the beam are examined. It is shown that the quasi-static deflections of the saturated poroelastic beam possess a creep behavior similar to that of viscoelastic beams. In dynamic responses, with the increase of the slenderness ratio, the vibration periods and amplitudes of the deflections at the free end increase, and the time needed for deflections approaching to their stationary values also increases. Moreover, with the increase of the interaction coefficient, the vibrations of the beam deflections decay more strongly, and, eventually, the deflections of the saturated poroelastic beam converge to the static deflections of the classic single phase Timoshenko beam.展开更多
AIM: To investigate the effect of different dietary fatty acids on hepatic inflammasome activation.METHODS: Wild-type C57BL/6 mice were fed either a high-fat diet or polyunsaturated fatty acid(PUFA)-enriched diet. Pri...AIM: To investigate the effect of different dietary fatty acids on hepatic inflammasome activation.METHODS: Wild-type C57BL/6 mice were fed either a high-fat diet or polyunsaturated fatty acid(PUFA)-enriched diet. Primary hepatocytes were treated with either saturated fatty acids(SFAs) or PUFAs as well as combined with lipopolysaccharide(LPS). The expression of NOD-like receptor protein 3(NLRP3) inflammasome, peroxisome proliferator-activated receptor-γ and nuclear factor-kappa B(NF-κB) was determined by real-time PCR and Western blot. The activity of Caspase-1 and interleukine-1β production were measured.RESULTS: high-fat diet-induced hepatic steatosis was sufficient to induce and activate hepatic NLRP3 inflammasome. SFA palmitic acid(PA) directly activated NLRP3 inflammasome and increased sensitization to LPS-induced inflammasome activation in hepatocytes. In contrast, PUFA docosahexaenoic acid(Dh A) had thepotential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation. Furthermore, a highfat diet increased but PUFA-enriched diet decreased sensitization to LPS-induced hepatic NLRP3 inflammasome activation in vivo. Moreover, PA increased but Dh A decreased phosphorylated NF-κB p65 protein expression in hepatocytes.CONCLUSION:Hepatic NLRP 3 inflammasome activation played an important role in the development of non-alcoholic fatty liver disease. Dietary SFAs and PUFAs oppositely regulated the activity of NLRP3 inflammasome through direct activation or inhibition of NF-κB.展开更多
The Biot' s wave equations of transversely isotropic saturated poroelastic media excited by non- axisymmetrical harmonic source were solved by means of Fourier expansion and Hankel transform. Then the components o...The Biot' s wave equations of transversely isotropic saturated poroelastic media excited by non- axisymmetrical harmonic source were solved by means of Fourier expansion and Hankel transform. Then the components of total stress in porous media are expressed with the solutions of Biot's wave equations. The method of research on non-axisymmetrical dynamic response of saturated porous media is discussed, and a numerical result is presented.展开更多
Based on the theory of porous media,a general Gurtin variational principle for theinitial boundary value problem of dynamical response of fluid-saturated elastic porous media isdeveloped by assuming infinitesimal defo...Based on the theory of porous media,a general Gurtin variational principle for theinitial boundary value problem of dynamical response of fluid-saturated elastic porous media isdeveloped by assuming infinitesimal deformation and incompressible constituents of the solid andfluid phase.The finite element formulation based on this variational principle is also derived.Asthe functional of the variational principle is a spatial integral of the convolution formulation,thegeneral finite element discretization in space results in symmetrical differential-integral equationsin the time domain.In some situations,the differential-integral equations can be reduced to sym-metrical differential equations and,as a numerical example,it is employed to analyze the reflectionof one-dimensional longitudinal wave in a fluid-saturated porous solid.The numerical results canprovide further understanding of the wave propagation in porous media.展开更多
In order to analyze the impact of stretching-segment on the saturated flow rate of signalized intersection approach, an improved cellular automation model was proposed to estimate its saturated flow rate. The NaSch mo...In order to analyze the impact of stretching-segment on the saturated flow rate of signalized intersection approach, an improved cellular automation model was proposed to estimate its saturated flow rate. The NaSch model was improved by adding different slow probabilities, turning deceleration rules and modified lane changing rules. The relationship between the saturated flow rate of stretching-segments and adjacent lanes was tested in numerical simulation. The length of stretching-segment, cycle length and green time were selected as impact factors of the cellular automation model. The simulation result indicates that the geometrics design of stretching-segment and the traffic signal timing scenario have major effects on the saturated flow rate of the intersection approach. The saturated flow rate will continually increase with increasing stretching-segment length until it reaches a threshold. After reaching the threshold, the stretching-segment can be treated as a separate lane. The green time is approximately linearly related to the threshold length of the stretching-segment. An optimum cycle length exists when the length of the stretching-segment is not long enough, and it is approximately linearly related to the length of stretching-segment.展开更多
It has been reported that when a loosely packed column of sat-urated sand in a vertical cylindrical container is shock loaded axially by droppingto the floor,large horizontal cracks initiate,grow and eventually fade a...It has been reported that when a loosely packed column of sat-urated sand in a vertical cylindrical container is shock loaded axially by droppingto the floor,large horizontal cracks initiate,grow and eventually fade away in thesand as it settles under gravity.This paper shows that a similar phenomenon canalso be observed when shock loading is replaced by forcing water to percolate upwardthrough the sand column.It is believed that our result sheds further light on thephysics of formation of these cracks.展开更多
Akebia trifoliata subsp.australis is a well-known medicinal and potential woody oil plant in China.The limited genetic information available for A.trifoliata subsp.australis has hindered its exploitation.Here,a high-q...Akebia trifoliata subsp.australis is a well-known medicinal and potential woody oil plant in China.The limited genetic information available for A.trifoliata subsp.australis has hindered its exploitation.Here,a high-quality chromosomelevel genome sequence of A.trifoliata subsp.australis is reported.The de novo genome assembly of 682.14 Mb was generated with a scaffold N50 of 43.11 Mb.The genome includes 25,598 protein-coding genes,and 71.18%(485.55 Mb)of the assembled sequences were identi fi ed as repetitive sequences.An ongoing massive burst of long terminal repeat(LTR)insertions,which occurred~1.0 million years ago,has contributed a large proportion of LTRs in the genome of A.trifoliata subsp.australis.Phylogenetic analysis shows that A.trifoliata subsp.australis is closely related to Aquilegia coerulea and forms a clade with Papaver somniferum and Nelumbo nucifera,which supports the well-established hypothesis of a close relationship between basal eudicot species.The expansion of UDP-glucoronosyl and UDP-glucosyl transferase gene families and fi-amyrin synthase-like genes and the exclusive contraction of terpene synthase gene families may be responsible for the abundant oleanane-type triterpenoids in A.trifoliata subsp.australis.Furthermore,the acyl-ACP desaturase gene family,including 12 stearoyl-acyl-carrier protein desaturase(SAD)genes,has expanded exclusively.A combined transcriptome and fatty-acid analysis of seeds at fi ve developmental stages revealed that homologs of SADs,acyl-lipid desaturase omega fatty acid desaturases(FADs),and oleosins were highly expressed,consistent with the rapid increase in the content of fatty acids,especially unsaturated fatty acids.The genomic sequences of A.trifoliata subsp.australis will be a valuable resource for comparative genomic analyses and molecular breeding.展开更多
Artificial neural networks(ANNs)are a core component of artificial intelligence and are frequently used in machine learning.In this report,we investigate the use of ANNs to recover the saturated signals acquired in hi...Artificial neural networks(ANNs)are a core component of artificial intelligence and are frequently used in machine learning.In this report,we investigate the use of ANNs to recover the saturated signals acquired in highenergy particle and nuclear physics experiments.The inherent properties of the detector and hardware imply that particles with relatively high energies probably often generate saturated signals.Usually,these saturated signals are discarded during data processing,and therefore,some useful information is lost.Thus,it is worth restoring the saturated signals to their normal form.The mapping from a saturated signal waveform to a normal signal waveform constitutes a regression problem.Given that the scintillator and collection usually do not form a linear system,typical regression methods such as multi-parameter fitting are not immediately applicable.One important advantage of ANNs is their capability to process nonlinear regression problems.To recover the saturated signal,three typical ANNs were tested including backpropagation(BP),simple recurrent(Elman),and generalized radial basis function(GRBF)neural networks(NNs).They represent a basic network structure,a network structure with feedback,and a network structure with a kernel function,respectively.The saturated waveforms were produced mainly by the environmental gamma in a liquid scintillation detector for the China Dark Matter Detection Experiment(CDEX).The training and test data sets consisted of 6000 and 3000 recordings of background radiation,respectively,in which saturation was simulated by truncating each waveform at 40%of the maximum signal.The results show that the GBRF-NN performed best as measured using a Chi-squared test to compare the original and reconstructed signals in the region in which saturation was simulated.A comparison of the original and reconstructed signals in this region shows that the GBRF neural network produced the best performance.This ANN demonstrates a powerful efficacy in terms of solving the saturation recovery problem.The proposed method outlines new ideas and possibilities for the recovery of saturated signals in high-energy particle and nuclear physics experiments.This study also illustrates an innovative application of machine learning in the analysis of experimental data in particle physics.展开更多
This paper aims at eliminating the asymmetric and saturated hysteresis nonlinearities by designing hysteresis pseudo inverse compensator and robust adaptive dynamic surface control(DSC)scheme.The"pseudo inverse&q...This paper aims at eliminating the asymmetric and saturated hysteresis nonlinearities by designing hysteresis pseudo inverse compensator and robust adaptive dynamic surface control(DSC)scheme.The"pseudo inverse"means that an on-line calculation mechanism of approximate control signal is developed by applying a searching method to the designed temporary control signal where the true control signal is included.The main contributions are summarized as:1)to our best knowledge,it is the first time to compensate the asymmetric and saturated hysteresis by using hysteresis pseudo inverse compensator because the construction of the true saturated-type hysteresis inverse model is very difficult;2)by designing the saturated-type hysteresis pseudo inverse compensator,the construction of true explicit hysteresis inverse and the identifications of its corresponding unknown parameters are not required when dealing with the saturated-type hysteresis;3)by combining DSC technique with the tracking error transformed function,the"explosion of complexity"problem in backstepping method is overcome and the prespecified tracking performance is achieved.Analysis of stability and experimental results on the hardware-inloop platform illustrate the effectiveness of the proposed adaptive pseudo inverse control scheme.展开更多
As the continuation study on amplification of in-plane seismic ground motion by underground group cavities in layered half-space, this study extends to the case of poroelastic half-space with dry poroelastic and satur...As the continuation study on amplification of in-plane seismic ground motion by underground group cavities in layered half-space, this study extends to the case of poroelastic half-space with dry poroelastic and saturated poroelastic soil layers. The influence of poroelastic layers on the amplification of seismic ground motion is studied both in frequency domain and time domain using indirect boundary element method (IBEM). It is shown that for the example of a saturated poroelastic site in Tianjin under the excitation of Taft wave and El Centro wave, the amplification of seismic ground motion in poroelastic case is slightly smaller than that in the elastic case, and the amplification of PGA (peak ground acceleration) and its PRS (peak response spectrum) can be increased up to 38.8% and 64.6%; the predominant period of response spectra in poroelastic case becomes shorter to some extent compared with that in the elastic case. It is suggested that the effect of underground group cavities in poroelastic half-space on design seismic ground motion should be considered.展开更多
Based on the principle of saturated infiltration and the Green-Ampt model,an unsaturated infiltration model for a soil slope surface was established for either constant moisture content,or depth-varying moisture conte...Based on the principle of saturated infiltration and the Green-Ampt model,an unsaturated infiltration model for a soil slope surface was established for either constant moisture content,or depth-varying moisture content and the slope.Infiltration parameters in the partially saturated slope were revealed under sustained rainfall.Through analysis of the variation of initial moisture content in the slope,the ponding time,infiltration depth,and infiltration rate were deduced for an unsaturated soil slope subject to rainfall infiltration.There is no ponded water on the surface of the slope under sustained low-intensity rainfall.The results show that the infiltration parameters of an unsaturated slope are influenced by the initial moisture content and the wetting front saturation,the soil cohesion and rainfall intensity under sustained rainfall.More short-term slope failures can occur with the decrease of cohesion of the soil of the slope.The ponding time and infiltration depth differ considering constant or different initial moisture content respectively in the soil slope.Then,best-fit curves of the infiltration rate,ponding time,and infiltration depth to the wetting front saturation were obtained with constant or different initial moisture contents.And the slope failure time is roughly uniform when subject to a rainfall intensity I>5 mm/h.展开更多
In this paper, the foundation soil of offshore structure is simulated as a two phase saturated porous medium. The dynamic equations of porous medium and finite element formulation are given. For structural analysis, t...In this paper, the foundation soil of offshore structure is simulated as a two phase saturated porous medium. The dynamic equations of porous medium and finite element formulation are given. For structural analysis, the technique of multilevel substructure is used, and the saturated soil analysis is set in the highest level substructure model. Based on these theories a dynamic finite element analysis program DIASS for the analysis of interaction between two phase ocean soil foundation and platform structures has been developed. A numerical example is given here to illustrate the influence of the pore water in soil on the structural response of an ocean platform.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61571018 and 61531003).
文摘Micrometric-thin cells(MCs)with alkali vapor atoms have been valuable for research and applications of hyperfine Zeeman splitting and atomic magnetometers under strong magnetic fields.We theoretically and experimentally study the saturated absorption spectra using a 100-μm cesium MC,where the pump and probe beams are linearly polarized with mutually perpendicular polarizations,and the magnetic field is along the pump beam.Because of the distinctive thin chamber of the MC,crossover spectral lines in saturated absorption spectra are largely suppressed leading to clear splittings of hyperfine Zeeman transitions in experiments,and the effect of spatial magnetic field gradient is expected to be reduced.A calculation method is proposed to achieve good agreements between theoretical calculations and experimental results.This method successfully explains the suppression of crossover lines in MCs,as well as the effects of magnetic field direction,propagation and polarization directions of the pump/probe beam on saturated absorption spectrum.The saturated absorption spectrum with suppressed crossover lines is used for laser frequency stabilization,which may provide the potential value of MCs for high spatial resolution strong-field magnetometry with high sensitivity.
基金Supported by the National Natural Science Foundation of China(52288101).
文摘Three high-temperature resistant polymeric additives for water-based drilling fluids are designed and developed:weakly cross-linked zwitterionic polymer fluid loss reducer(WCZ),flexible polymer microsphere nano-plugging agent(FPM)and comb-structure polymeric lubricant(CSP).A high-temperature resistant and high-density polymeric saturated brine-based drilling fluid was developed for deep drilling.The WCZ has a good anti-polyelectrolyte effect and exhibits the API fluid loss less than 8 mL after aging in saturated salt environment at 200°C.The FPM can reduce the fluid loss by improving the quality of the mud cake and has a good plugging effect on nano-scale pores/fractures.The CSP,with a weight average molecular weight of 4804,has multiple polar adsorption sites and exhibits excellent lubricating performance under high temperature and high salt conditions.The developed drilling fluid system with a density of 2.0 g/cm^(3)has good rheological properties.It shows a fluid loss less than 15 mL at 200°C and high pressure,a sedimentation factor(SF)smaller than 0.52 after standing at high temperature for 5 d,and a rolling recovery of hydratable drill cuttings similar to oil-based drilling fluid.Besides,it has good plugging and lubricating performance.
基金supported by the National Natural Science Foundation of China(No.51808128)the Natural Science Foundation of Fujian Province(No.2022J01091)。
文摘Frost heave in seasonally frozen regions is a one-dimensional process that could severely damage infrastructure subgrades.Stress state,temperature and water migration are important factors for frost heave.This work investigated the effects of soil temperature and volumetric water content on the transient frost heave ratio during the freezing of saturated silty clay in an open system and analyzed the relationships between the transient frost heave ratio and freezing rate and between temperature gradient and frost heave rate.The results show that the frost heave ratio,frost heave rate,and freezing rate are positively correlated with the temperature gradient since the temperature gradient drives the water migration during freezing,indicating the transient temperature gradient could be used to evaluate the frost heave of saturated silty clay.The transient freezing rate and transient frost heave ratio are logarithmically related to the transient frost heave ratio and transient temperature gradient,respectively.The effects of transient temperature gradient on frost heave are the principal mechanism responsible for different frost heave characteristics and uneven frost heave along a subgrade of the same soil type.
文摘Mathematical modelling has been extensively used to measure intervention strategies for the control of contagious conditions.Alignment between different models is pivotal for furnishing strong substantiation for policymakers because the differences in model features can impact their prognostications.Mathematical modelling has been widely used in order to better understand the transmission,treatment,and prevention of infectious diseases.Herein,we study the dynamics of a human immunodeficiency virus(HIV)infection model with four variables:S(t),I(t),C(t),and A(t)the susceptible individuals;HIV infected individuals(with no clinical symptoms of AIDS);HIV infected individuals(under ART with a viral load remaining low),and HIV infected individuals with two different incidence functions(bilinear and saturated incidence functions).A novel numerical scheme called the continuous Galerkin-Petrov method is implemented for the solution of themodel.The influence of different clinical parameters on the dynamical behavior of S(t),I(t),C(t)and A(t)is described and analyzed.All the results are depicted graphically.On the other hand,we explore the time-dependent movement of nanofluid in porous media on an extending sheet under the influence of thermal radiation,heat flux,hall impact,variable heat source,and nanomaterial.The flow is considered to be 2D,boundary layer,viscous,incompressible,laminar,and unsteady.Sufficient transformations turn governing connected PDEs intoODEs,which are solved using the proposed scheme.To justify the envisaged problem,a comparison of the current work with previous literature is presented.
文摘Hydraulic conductivity is the ability of a porous media to transfer water through its pore matrix. That is a key parameter for the design and analysis of soil fluid associated structures and issues. This paper presents the test results of the vertical hydraulic conductivity k<sub>v</sub><sub> </sub>carried out on one poorly graded sand and three gap graded gravely sand. It was found that the vertical hydraulic conductivity of saturated soil depends on the grain size distribution curve, on the initial relative density of the soil. Compilation of these current test results and other test results published, shows that the common approaches predict well to some extent the vertical hydraulic conductivity k<sub>v</sub> for the poorly graded sand materials and underestimate the k<sub>v</sub> values for gap graded gravely sand materials. Therefore, new approaches are developed for the prediction of the vertical hydraulic conductivity in saturated poorly graded sand and gap graded gravely sand. The derived results from the new approaches lie in the range of the recommended values by (EAU 2012) and (NAVFAC DM 7 1974).
基金funded by the National Natural Science Foundation of China(42102154,41922015,42072147)Postdoctoral Research Foundation of China(2021M690168)+4 种基金Postdoctoral Innovative Talent Support Program of Shandong Province(SDBX2021004)Open Fund of Shaanxi Key Laboratory of Petroleum Accumulation Geology(PAG-2021-02)Open Funds of the Key Laboratory of Tectonics and Petroleum Resources(China University of Geosciences)(TPR-2021-02)Fundamental Research Funds for the Central Universities(20CX06085A)Qingdao Postdoctoral(ZX20210070).
文摘Shale porosity measurements have crucial scientific and economical applications in unconventionalpetroleum systems. As a standard technique, liquid saturation methods, including water saturation (WS)and oil saturation (OS), have been widely used to measure the porosity of many rock types. For clay-richshale reservoirs with high organic matter content, it is well known that the WS method may cause clayswelling and induce structural changes in the pore system. The OS method affects the accuracy ofporosity measurements because of some of the oil being dissolved by kerogen within the shale;however,this has not received sufficient research attention. In this study, we compare the previously reported andnewly tested OS porosities with helium (He) expansion porosity. Results show that OS porosity generallyexceeds the He porosity. Furthermore, the higher the total organic carbon (TOC) content and lower thematurity of shale, the greater the difference between the OS and helium porosities. When using the OSmethod, the effect of kerogen-dissolved oil causes an overestimation of the shale porosity by ~30%. To thebest of our knowledge, this is the first time to note the kerogen-dissolve oil effects on OS porosity. Herein,we propose a new, simple, and effective correction method for estimating OS porosity that involvessubtracting the kerogen-dissolved oil content from raw OS porosity. In addition, the quantification modelof kerogen-dissolved oil capacity is established, taking into account the abundance and maturity oforganic matter. Taking the He porosity as the benchmark, the absolute error of the corrected OS porositydoes not exceed 1% and the average relative error is only ~10%. The obtained results can help improve theaccuracy of shale porosity evaluation methods.
文摘AIM: To investigate how the saturated and unsaturated fatty acid composition influences the susceptibility of developing acute pancreatitis. METHODS: Primary pancreatic acinar cells were treated with low and high concentrations of different saturated and unsaturated fatty acids, and changes in the cytosolic Ca2+ signal and the expression of protein kinase C(PKC) were measured after treatment. RESULTS: Unsaturated fatty acids at high concentrations, including oleic acid, linoleic acid, palmitoleic acid, docosahexaenoic acid, and arachidonic acid, induced a persistent rise in cytosolic Ca2+ concentrations in acinar cells. Unsaturated fatty acids at low concentrations and saturated fatty acids, including palmitic acid, stearic acid, and triglycerides, at low and high concentrations were unable to induce a rise in Ca2+ concentrations in acinar cells. Unsaturated fatty acids at high concentrations but not saturated fatty acids induced intra-acinar cell trypsin activation and cell damage and increased PKC expression.CONCLUSION: At sufficiently high concentrations, unsaturated fatty acids were able to induce acinar cells injury and promote the development of pancreatitis. Unsaturated fatty acids may play a distinctive role in the pathogenesis of pancreatitis through the activation of PKC family members.
基金Project supported by the National Natural Science Foundation of China (No. 10872124)
文摘Based on the three-dimensional Gurtin-type variational principle of the incompressible saturated porous media, a one-dimensional mathematical model for dynamics of the saturated poroelastic Timoshenko cantilever beam is established with two assumptions, i.e., the deformation satisfies the classical single phase Timoshenko beam and the movement of the pore fluid is only in the axial direction of the saturated poroelastic beam. Under some special cases, this mathematical model can be degenerated into the Euler-Bernoulli model, the Rayleigh model, and the shear model of the saturated poroelastic beam, respectively. The dynamic and quasi-static behaviors of a saturated poroelastic Timoshenko cantilever beam with an impermeable fixed end and a permeable free end subjected to a step load at its free end are analyzed by the Laplace transform. The variations of the deflections at the beam free end against time are shown in figures. The influences of the interaction coefficient between the pore fluid and the solid skeleton as well as the slenderness ratio of the beam on the dynamic/quasi-static performances of the beam are examined. It is shown that the quasi-static deflections of the saturated poroelastic beam possess a creep behavior similar to that of viscoelastic beams. In dynamic responses, with the increase of the slenderness ratio, the vibration periods and amplitudes of the deflections at the free end increase, and the time needed for deflections approaching to their stationary values also increases. Moreover, with the increase of the interaction coefficient, the vibrations of the beam deflections decay more strongly, and, eventually, the deflections of the saturated poroelastic beam converge to the static deflections of the classic single phase Timoshenko beam.
基金Supported by The National Natural Science Foundation of ChinaNO.81170374 and NO.81470842 to Hua J
文摘AIM: To investigate the effect of different dietary fatty acids on hepatic inflammasome activation.METHODS: Wild-type C57BL/6 mice were fed either a high-fat diet or polyunsaturated fatty acid(PUFA)-enriched diet. Primary hepatocytes were treated with either saturated fatty acids(SFAs) or PUFAs as well as combined with lipopolysaccharide(LPS). The expression of NOD-like receptor protein 3(NLRP3) inflammasome, peroxisome proliferator-activated receptor-γ and nuclear factor-kappa B(NF-κB) was determined by real-time PCR and Western blot. The activity of Caspase-1 and interleukine-1β production were measured.RESULTS: high-fat diet-induced hepatic steatosis was sufficient to induce and activate hepatic NLRP3 inflammasome. SFA palmitic acid(PA) directly activated NLRP3 inflammasome and increased sensitization to LPS-induced inflammasome activation in hepatocytes. In contrast, PUFA docosahexaenoic acid(Dh A) had thepotential to inhibit NLRP3 inflammasome expression in hepatocytes and partly abolished LPS-induced NLRP3 inflammasome activation. Furthermore, a highfat diet increased but PUFA-enriched diet decreased sensitization to LPS-induced hepatic NLRP3 inflammasome activation in vivo. Moreover, PA increased but Dh A decreased phosphorylated NF-κB p65 protein expression in hepatocytes.CONCLUSION:Hepatic NLRP 3 inflammasome activation played an important role in the development of non-alcoholic fatty liver disease. Dietary SFAs and PUFAs oppositely regulated the activity of NLRP3 inflammasome through direct activation or inhibition of NF-κB.
文摘The Biot' s wave equations of transversely isotropic saturated poroelastic media excited by non- axisymmetrical harmonic source were solved by means of Fourier expansion and Hankel transform. Then the components of total stress in porous media are expressed with the solutions of Biot's wave equations. The method of research on non-axisymmetrical dynamic response of saturated porous media is discussed, and a numerical result is presented.
基金Project supported by the National Nattural Science Foundation of China(No.10272070)
文摘Based on the theory of porous media,a general Gurtin variational principle for theinitial boundary value problem of dynamical response of fluid-saturated elastic porous media isdeveloped by assuming infinitesimal deformation and incompressible constituents of the solid andfluid phase.The finite element formulation based on this variational principle is also derived.Asthe functional of the variational principle is a spatial integral of the convolution formulation,thegeneral finite element discretization in space results in symmetrical differential-integral equationsin the time domain.In some situations,the differential-integral equations can be reduced to sym-metrical differential equations and,as a numerical example,it is employed to analyze the reflectionof one-dimensional longitudinal wave in a fluid-saturated porous solid.The numerical results canprovide further understanding of the wave propagation in porous media.
基金Projects(50422283,51208054) supported by the National Natural Science Foundation of China
文摘In order to analyze the impact of stretching-segment on the saturated flow rate of signalized intersection approach, an improved cellular automation model was proposed to estimate its saturated flow rate. The NaSch model was improved by adding different slow probabilities, turning deceleration rules and modified lane changing rules. The relationship between the saturated flow rate of stretching-segments and adjacent lanes was tested in numerical simulation. The length of stretching-segment, cycle length and green time were selected as impact factors of the cellular automation model. The simulation result indicates that the geometrics design of stretching-segment and the traffic signal timing scenario have major effects on the saturated flow rate of the intersection approach. The saturated flow rate will continually increase with increasing stretching-segment length until it reaches a threshold. After reaching the threshold, the stretching-segment can be treated as a separate lane. The green time is approximately linearly related to the threshold length of the stretching-segment. An optimum cycle length exists when the length of the stretching-segment is not long enough, and it is approximately linearly related to the length of stretching-segment.
基金The project supported by the National Natural Science Foundation of China(19832010)by the Chinese Academy of Sciences(KJ952-S1-202)
文摘It has been reported that when a loosely packed column of sat-urated sand in a vertical cylindrical container is shock loaded axially by droppingto the floor,large horizontal cracks initiate,grow and eventually fade away in thesand as it settles under gravity.This paper shows that a similar phenomenon canalso be observed when shock loading is replaced by forcing water to percolate upwardthrough the sand column.It is believed that our result sheds further light on thephysics of formation of these cracks.
基金the Natural Science Foundation of Hunan Province(2019JJ50475)Key Scientific Research Projects of Hunan Education Department(18A448)Foundation of Hunan Double First-rate Discipline Construction Pr ojects of Bioengineering and Key Lab oratory of Resea rch and Utilizati on of Ethnomedicinal Plant Resources of Hunan Province,and the National Science Foundation(81874334).
文摘Akebia trifoliata subsp.australis is a well-known medicinal and potential woody oil plant in China.The limited genetic information available for A.trifoliata subsp.australis has hindered its exploitation.Here,a high-quality chromosomelevel genome sequence of A.trifoliata subsp.australis is reported.The de novo genome assembly of 682.14 Mb was generated with a scaffold N50 of 43.11 Mb.The genome includes 25,598 protein-coding genes,and 71.18%(485.55 Mb)of the assembled sequences were identi fi ed as repetitive sequences.An ongoing massive burst of long terminal repeat(LTR)insertions,which occurred~1.0 million years ago,has contributed a large proportion of LTRs in the genome of A.trifoliata subsp.australis.Phylogenetic analysis shows that A.trifoliata subsp.australis is closely related to Aquilegia coerulea and forms a clade with Papaver somniferum and Nelumbo nucifera,which supports the well-established hypothesis of a close relationship between basal eudicot species.The expansion of UDP-glucoronosyl and UDP-glucosyl transferase gene families and fi-amyrin synthase-like genes and the exclusive contraction of terpene synthase gene families may be responsible for the abundant oleanane-type triterpenoids in A.trifoliata subsp.australis.Furthermore,the acyl-ACP desaturase gene family,including 12 stearoyl-acyl-carrier protein desaturase(SAD)genes,has expanded exclusively.A combined transcriptome and fatty-acid analysis of seeds at fi ve developmental stages revealed that homologs of SADs,acyl-lipid desaturase omega fatty acid desaturases(FADs),and oleosins were highly expressed,consistent with the rapid increase in the content of fatty acids,especially unsaturated fatty acids.The genomic sequences of A.trifoliata subsp.australis will be a valuable resource for comparative genomic analyses and molecular breeding.
基金supported by the ‘‘Detection of very low-flux background neutrons in China Jinping Underground Laboratory’’ project of the National Natural Science Foundation of China(No.11275134)
文摘Artificial neural networks(ANNs)are a core component of artificial intelligence and are frequently used in machine learning.In this report,we investigate the use of ANNs to recover the saturated signals acquired in highenergy particle and nuclear physics experiments.The inherent properties of the detector and hardware imply that particles with relatively high energies probably often generate saturated signals.Usually,these saturated signals are discarded during data processing,and therefore,some useful information is lost.Thus,it is worth restoring the saturated signals to their normal form.The mapping from a saturated signal waveform to a normal signal waveform constitutes a regression problem.Given that the scintillator and collection usually do not form a linear system,typical regression methods such as multi-parameter fitting are not immediately applicable.One important advantage of ANNs is their capability to process nonlinear regression problems.To recover the saturated signal,three typical ANNs were tested including backpropagation(BP),simple recurrent(Elman),and generalized radial basis function(GRBF)neural networks(NNs).They represent a basic network structure,a network structure with feedback,and a network structure with a kernel function,respectively.The saturated waveforms were produced mainly by the environmental gamma in a liquid scintillation detector for the China Dark Matter Detection Experiment(CDEX).The training and test data sets consisted of 6000 and 3000 recordings of background radiation,respectively,in which saturation was simulated by truncating each waveform at 40%of the maximum signal.The results show that the GBRF-NN performed best as measured using a Chi-squared test to compare the original and reconstructed signals in the region in which saturation was simulated.A comparison of the original and reconstructed signals in this region shows that the GBRF neural network produced the best performance.This ANN demonstrates a powerful efficacy in terms of solving the saturation recovery problem.The proposed method outlines new ideas and possibilities for the recovery of saturated signals in high-energy particle and nuclear physics experiments.This study also illustrates an innovative application of machine learning in the analysis of experimental data in particle physics.
基金supported in part by the National Natural Science Foundation of China(61673101,61973131,61733006,U1813201)the Japan Society for the Promotion of Science(C18K04212)+2 种基金the Science and Technology Project of Jilin Province(20180201009SF,20170414011GH,20180201004SF,20180101069JC)the Fundamental Research Funds for the Central Universities(N2008002)“Xing Liao Ying Cai”Program(XLYC1907073)。
文摘This paper aims at eliminating the asymmetric and saturated hysteresis nonlinearities by designing hysteresis pseudo inverse compensator and robust adaptive dynamic surface control(DSC)scheme.The"pseudo inverse"means that an on-line calculation mechanism of approximate control signal is developed by applying a searching method to the designed temporary control signal where the true control signal is included.The main contributions are summarized as:1)to our best knowledge,it is the first time to compensate the asymmetric and saturated hysteresis by using hysteresis pseudo inverse compensator because the construction of the true saturated-type hysteresis inverse model is very difficult;2)by designing the saturated-type hysteresis pseudo inverse compensator,the construction of true explicit hysteresis inverse and the identifications of its corresponding unknown parameters are not required when dealing with the saturated-type hysteresis;3)by combining DSC technique with the tracking error transformed function,the"explosion of complexity"problem in backstepping method is overcome and the prespecified tracking performance is achieved.Analysis of stability and experimental results on the hardware-inloop platform illustrate the effectiveness of the proposed adaptive pseudo inverse control scheme.
基金supported by National Natural Science Foundation of China under grant No. 50978183Key Project for Applied Basic Research of Tianjin Municipality under Grant No. 12JCZDJC29000
文摘As the continuation study on amplification of in-plane seismic ground motion by underground group cavities in layered half-space, this study extends to the case of poroelastic half-space with dry poroelastic and saturated poroelastic soil layers. The influence of poroelastic layers on the amplification of seismic ground motion is studied both in frequency domain and time domain using indirect boundary element method (IBEM). It is shown that for the example of a saturated poroelastic site in Tianjin under the excitation of Taft wave and El Centro wave, the amplification of seismic ground motion in poroelastic case is slightly smaller than that in the elastic case, and the amplification of PGA (peak ground acceleration) and its PRS (peak response spectrum) can be increased up to 38.8% and 64.6%; the predominant period of response spectra in poroelastic case becomes shorter to some extent compared with that in the elastic case. It is suggested that the effect of underground group cavities in poroelastic half-space on design seismic ground motion should be considered.
基金sponsored by the Zhejiang Provincial Natural Science Foundation of China(Grant No.LY19E080007,No.LY19E080008)the Natural Science Foundation of China(Grant No.51578356)the Science and Technology Fund of Yunnan Provincial Communication Department of China(Grant No.2010(A)06-b)。
文摘Based on the principle of saturated infiltration and the Green-Ampt model,an unsaturated infiltration model for a soil slope surface was established for either constant moisture content,or depth-varying moisture content and the slope.Infiltration parameters in the partially saturated slope were revealed under sustained rainfall.Through analysis of the variation of initial moisture content in the slope,the ponding time,infiltration depth,and infiltration rate were deduced for an unsaturated soil slope subject to rainfall infiltration.There is no ponded water on the surface of the slope under sustained low-intensity rainfall.The results show that the infiltration parameters of an unsaturated slope are influenced by the initial moisture content and the wetting front saturation,the soil cohesion and rainfall intensity under sustained rainfall.More short-term slope failures can occur with the decrease of cohesion of the soil of the slope.The ponding time and infiltration depth differ considering constant or different initial moisture content respectively in the soil slope.Then,best-fit curves of the infiltration rate,ponding time,and infiltration depth to the wetting front saturation were obtained with constant or different initial moisture contents.And the slope failure time is roughly uniform when subject to a rainfall intensity I>5 mm/h.
文摘In this paper, the foundation soil of offshore structure is simulated as a two phase saturated porous medium. The dynamic equations of porous medium and finite element formulation are given. For structural analysis, the technique of multilevel substructure is used, and the saturated soil analysis is set in the highest level substructure model. Based on these theories a dynamic finite element analysis program DIASS for the analysis of interaction between two phase ocean soil foundation and platform structures has been developed. A numerical example is given here to illustrate the influence of the pore water in soil on the structural response of an ocean platform.
