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Progress of MJO Prediction at CMA from Phase I to Phase II of the Sub-Seasonal to Seasonal Prediction Project 被引量:1
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作者 Junchen YAO Xiangwen LIU +3 位作者 Tongwen WU Jinghui YAN Qiaoping LI Weihua JIE 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第10期1799-1815,共17页
As one of the participants in the Subseasonal to Seasonal(S2S)Prediction Project,the China Meteorological Administration(CMA)has adopted several model versions to participate in the S2S Project.This study evaluates th... As one of the participants in the Subseasonal to Seasonal(S2S)Prediction Project,the China Meteorological Administration(CMA)has adopted several model versions to participate in the S2S Project.This study evaluates the models’capability to simulate and predict the Madden-Julian Oscillation(MJO).Three versions of the Beijing Climate Center Climate System Model(BCC-CSM)are used to conduct historical simulations and re-forecast experiments(referred to as EXP1,EXP1-M,and EXP2,respectively).In simulating MJO characteristics,the newly-developed high-resolution BCC-CSM outperforms its predecessors.In terms of MJO prediction,the useful prediction skill of the MJO index is enhanced from 15 days in EXP1 to 22 days in EXP1-M,and further to 24 days in EXP2.Within the first forecast week,the better initial condition in EXP2 largely contributes to the enhancement of MJO prediction skill.However,during forecast weeks 2–3,EXP2 shows little advantage compared with EXP1-M because the increased skill at MJO initial phases 6–7 is largely offset by the degraded skill at MJO initial phases 2–3.Particularly at initial phases 2–3,EXP1-M skillfully captures the wind field and Kelvin-wave response to MJO convection,leading to the highest prediction skill of the MJO.Our results reveal that,during the participation of the CMA models in the S2S Project,both the improved model initialization and updated model physics played positive roles in improving MJO prediction.Future efforts should focus on improving the model physics to better simulate MJO convection over the Maritime Continent and further improve MJO prediction at long lead times. 展开更多
关键词 Madden-Julian Oscillation(MJO) Subseasonal to seasonal(s2s) prediction skill improvement initial phase
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Implications from Subseasonal Prediction Skills of the Prolonged Heavy Snow Event over Southern China in Early 2008 被引量:2
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作者 Keyue ZHANG Juan LI +1 位作者 Zhiwei ZHU Tim LI 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2021年第11期1873-1888,共16页
An exceptionally prolonged heavy snow event(PHSE)occurred in southern China from 10 January to 3 February 2008,which caused considerable economic losses and many casualties.To what extent any dynamical model can predi... An exceptionally prolonged heavy snow event(PHSE)occurred in southern China from 10 January to 3 February 2008,which caused considerable economic losses and many casualties.To what extent any dynamical model can predict such an extreme event is crucial for disaster prevention and mitigation.Here,we found the three S2S models(ECMWF,CMA1.0 and CMA2.0)can predict the distribution and intensity of precipitation and surface air temperature(SAT)associated with the PHSE at 10-day lead and 10−15-day lead,respectively.The success is attributed to the models’capability in forecasting the evolution of two important low-frequency systems in the tropics and mid-latitudes[the persistent Siberian High and the suppressed phase of the Madden−Julian Oscillation(MJO)],especially in the ECMWF model.However,beyond the 15-day lead,the three models show almost no skill in forecasting this PHSE.The bias in capturing the two critical circulation systems is responsible for the low skill in forecasting the 2008 PHSE beyond the 15-day lead.On one hand,the models cannot reproduce the persistence of the Siberian High,which results in the underestimation of negative SAT anomalies over southern China.On the other hand,the models cannot accurately capture the suppressed convection of the MJO,leading to weak anomalous southerly and moisture transport,and therefore the underestimation of precipitation over southern China.The Singular Value Decomposition(SVD)analyses between the critical circulation systems and SAT/precipitation over southern China shows a robust historical relation,indicating the fidelity of the predictability sources for both regular events and extreme events(e.g.,the 2008 PHSE). 展开更多
关键词 prolonged heavy snow event s2s prediction models subseasonal prediction skill MJO Siberian High
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血清KLK6、CCR2、ox-LDL水平与帕金森病的相关性研究
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作者 马晓琳 胡兆婷 +3 位作者 郑伟 崔晓 张真 许谦 《国际检验医学杂志》 CAS 2024年第5期614-617,623,共5页
目的分析血清激肽释放酶6(KLK6)、CC趋化因子受体2(CCR2)、氧化修饰低密度脂蛋白(ox-LDL)与帕金森病的相关性。方法将2020年7月至2022年12月于该院诊治的帕金森病患者150例纳入研究作为患者组,按照Hoehn-Yahr(H-Y)分期进一步分为Ⅰ期27... 目的分析血清激肽释放酶6(KLK6)、CC趋化因子受体2(CCR2)、氧化修饰低密度脂蛋白(ox-LDL)与帕金森病的相关性。方法将2020年7月至2022年12月于该院诊治的帕金森病患者150例纳入研究作为患者组,按照Hoehn-Yahr(H-Y)分期进一步分为Ⅰ期27例、Ⅱ期42例、Ⅲ期47例、Ⅳ期34例。另外,选取同期健康体检者150例作为对照组。采用简易精神状态检查(MMSE)量表评估患者精神障碍情况。比较患者组与对照组及不同H-Y分期帕金森病患者血清KLK6、CCR2、ox-LDL水平。分析血清KLK6、CCR2、ox-LDL对帕金森病的诊断价值。分析血清KLK6、CCR2、ox-LDL与H-Y分期、MMSE评分的相关性。结果患者组血清KLK6、CCR2、ox-LDL水平高于对照组(P<0.05)。受试者工作特征(ROC)曲线分析显示,KLK6、CCR2、ox-LDL诊断帕金森病的曲线下面积(AUC)分别为0.813、0.847、0.826,最佳临界值对应的灵敏度、特异度:KLK6为66.7%、90.0%,CCR2为68.0、91.3%,ox-LDL为59.3%、100.0%。不同H-Y分期患者血清KLK6、CCR2、ox-LDL比较:Ⅰ期<Ⅱ期<Ⅲ期<Ⅳ期;MMSE评分比较:Ⅰ期>Ⅱ期>Ⅲ期>Ⅳ期;两两比较差异均有统计学意义(P<0.05)。血清KLK6、CCR2、ox-LDL水平与H-Y分期均呈正相关(r=0.559、0.716、0.722,P<0.05);血清KLK6、CCR2、ox-LDL水平与MMSE评分均呈负相关(r=-0.276、-0.448、-0.457,P<0.05)。结论血清KLK6、CCR2、ox-LDL对帕金森病患者具有一定的诊断价值,并且与帕金森病患者的病情严重程度和认知功能有关。 展开更多
关键词 帕金森病 激肽释放酶6 CC趋化因子受体2 氧化修饰低密度脂蛋白 相关性 预测价值
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Sub-Seasonal Predictability of the Northeast China Cold Vortex in BCC and ECMWF S2S Model Forecasts for 2006-2021
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作者 Yiqiu YU Jie WU +3 位作者 Yihe FANG Chunyu ZHAO Zongjian KE Yitong LIN 《Journal of Meteorological Research》 SCIE CSCD 2024年第3期453-468,共16页
As an important atmospheric circulation system in the mid-high latitudes of East Asia,the Northeast China cold vortex(NCCV)substantially influences weather and climate in this region.So far,systematic assessment on th... As an important atmospheric circulation system in the mid-high latitudes of East Asia,the Northeast China cold vortex(NCCV)substantially influences weather and climate in this region.So far,systematic assessment on the performance of numerical prediction of the NCCVs has not been carried out.Based on the Beijing Climate Centre(BCC)and the ECMWF model hindcast and forecast data that participated in the Sub-seasonal to Seasonal(S2S)Prediction Project,this study systematically examines the performance of both models in simulating and forecasting the NCCVs at the sub-seasonal timescale.The results demonstrate that the two models can effectively capture the seasonal variations in the intensity,active days,and spatial distribution of NCCVs;however,the duration of NCCVs is shorter and the intensity is weaker in the models than in the observations.Diagnostic analysis shows that the differences in the intensity and location of the East Asian subtropical westerly jet and the wave train pattern from North Atlantic to East Asia may be responsible for the deficient simulation of NCCV events in the S2S models.Nonetheless,in the deterministic forecasts,BCC and ECMWF provide skillful prediction on the anomalous numbers of NCCV days and intensity at a lead time of 4-5(5-6)pentads,and the skill limit of the ensemble mean is 1-2 pentads longer than that of individual members.In the probabilistic forecasts of daily NCCV activities,BCC and ECMWF exhibit a forecasting skill of approximately 7 and 11 days,respectively;both models show seasonal dependency in the simulation performance and forecast skills of NCCV events,with better performance in winter than in summer.The results from this study provide helpful references for further improvement of the S2S prediction of NCCVs. 展开更多
关键词 Northeast China cold vortex(NCCV) PREDICTABILITY sub-seasonal to seasonal(s2s)prediction deterministic forecast probabilistic forecast
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Sub-seasonal to Seasonal Hindcasts of Stratospheric Sudden Warming by BCC_CSM1.1(m):A Comparison with ECMWF 被引量:3
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作者 Jian RAO Rongcai REN +3 位作者 Haishan CHEN Xiangwen LIU Yueyue YU Yang YANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2019年第5期479-494,共16页
This study focuses on model predictive skill with respect to stratospheric sudden warming(SSW) events by comparing the hindcast results of BCC_CSM1.1(m) with those of the ECMWF's model under the sub-seasonal to se... This study focuses on model predictive skill with respect to stratospheric sudden warming(SSW) events by comparing the hindcast results of BCC_CSM1.1(m) with those of the ECMWF's model under the sub-seasonal to seasonal prediction project of the World Weather Research Program and World Climate Research Program. When the hindcasts are initiated less than two weeks before SSW onset, BCC_CSM and ECMWF show comparable predictive skill in terms of the temporal evolution of the stratospheric circumpolar westerlies and polar temperature up to 30 days after SSW onset. However, with earlier hindcast initialization, the predictive skill of BCC_CSM gradually decreases, and the reproduced maximum circulation anomalies in the hindcasts initiated four weeks before SSW onset replicate only 10% of the circulation anomaly intensities in observations. The earliest successful prediction of the breakdown of the stratospheric polar vortex accompanying SSW onset for BCC_CSM(ECMWF) is the hindcast initiated two(three) weeks earlier. The predictive skills of both models during SSW winters are always higher than that during non-SSW winters, in relation to the successfully captured tropospheric precursors and the associated upward propagation of planetary waves by the model initializations. To narrow the gap in SSW predictive skill between BCC_CSM and ECMWF, ensemble forecasts and error corrections are performed with BCC_CSM. The SSW predictive skill in the ensemble hindcasts and the error corrections are improved compared with the previous control forecasts. 展开更多
关键词 sub-seasonal to seasonal(s2s)hindcast STRATOSPHERIC sudden warming BCC_CSM ensemble forecast error correction
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A Statistical Scheme for the Seasonal Forecasting of North China's Surface Air Temperature during Winter 被引量:6
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作者 FAN Ke 《Atmospheric and Oceanic Science Letters》 2011年第2期81-85,共5页
This paper presents a statistical scheme for the seasonal forecasting of North China's surface air temperature (NCSAT) during winter. Firstly, a prediction model for an decrease or increase of winter NCSAT is esta... This paper presents a statistical scheme for the seasonal forecasting of North China's surface air temperature (NCSAT) during winter. Firstly, a prediction model for an decrease or increase of winter NCSAT is established, whose predictors are available for no later than the previous September, as this is the most favorable month for seasonal forecasting up to two months ahead.The predicted NCSAT is then derived as the sum of the predicted increment of NCSAT and the previous NCSAT. The scheme successfully predicts the interannual and the decadal variability of NCSAT. Additionally, the advantages of the prediction scheme are discussed. 展开更多
关键词 seasonal prediction scheme North China's winter surface temperature year-to year increment
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内源性H_(2)S、TAT、sPECAM-1对老年髋部骨折围术期下肢深静脉血栓形成的预测价值研究
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作者 叶欣 赵斌 刘志伟 《北京医学》 CAS 2023年第9期749-752,757,共5页
目的探讨内源性硫化氢(endogenous hydrogen sulfidem,H_(2)S)、血浆凝血酶-抗凝血酶复合物(thrombin/antithrombin complex,TAT)及可溶性血小板内皮细胞黏附分子-1(soluble platelet endothelial cell adhesion molecule 1,sPECAM-1)... 目的探讨内源性硫化氢(endogenous hydrogen sulfidem,H_(2)S)、血浆凝血酶-抗凝血酶复合物(thrombin/antithrombin complex,TAT)及可溶性血小板内皮细胞黏附分子-1(soluble platelet endothelial cell adhesion molecule 1,sPECAM-1)对老年髋部骨折围术期下肢深静脉血栓形成(deep vein thrombosis,DVT)的预测价值。方法选取2018年11月至2019年7月北京积水潭医院急诊科住院接受手术治疗的新发老年髋部骨折患者187例,随机抽取120例患者(建模集),采用多因素logistic回归方程分析建模集患者DVT的影响因素,并建立预测模型;将剩余67例患者纳入验证集,进行预测模型的内部验证。结果建模集120例患者中男39例(32.50%),女81例(67.50%);平均年龄(78.6±7.1)岁;BMI为(22.5±4.2)kg/m^(2)。多因素logisitic回归分析显示,BMI、发病至就诊的时间及TAT越高,H_(2)S及sPECAM-1越低的患者,越容易发生DVT(P<0.05)。建立的DVT风险预测模型为:logit(P)=0.130×BMI+0.010×发病至就诊的时间-0.098×H_(2)S+0.039×TAT-0.322×sPECAM-1-3.581。预测模型的ROC曲线的AUC为0.844(95%CI:0.774~0.915,P=0.000)。应用验证集数据对模型进行内部验证结果显示验证模型的ROC曲线的AUC为0.816(95%CI:0.713~0.919,P=0.000)。结论基于BMI、受伤至入院时间、TAT、H_(2)S和sPECAM-1等因素建立的模型对于预测老年髋部骨折患者围术期DVT的发生具有良好的筛查能力。 展开更多
关键词 内源性硫化氢 髋部骨折 深静脉血栓 预测模型 老年
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H2S腐蚀预测模型研究综述 被引量:2
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作者 刘祖旺 《精细石油化工进展》 CAS 2023年第3期52-58,共7页
由于腐蚀过程和腐蚀产物的复杂性,H2S的预测模型相对于CO_(2)预测模型和CO_(2)/H_(2)S共存体系预测模型起步较晚。目前,H_(2)S预测模型考虑的因素较少,建模方法以经验和半经验为主。在大量学者的努力下,H2S腐蚀的腐蚀机制逐渐清晰,对H_(... 由于腐蚀过程和腐蚀产物的复杂性,H2S的预测模型相对于CO_(2)预测模型和CO_(2)/H_(2)S共存体系预测模型起步较晚。目前,H_(2)S预测模型考虑的因素较少,建模方法以经验和半经验为主。在大量学者的努力下,H2S腐蚀的腐蚀机制逐渐清晰,对H_(2)S腐蚀预测的研究逐渐深入。一方面,H2S腐蚀机制中的“双波”行为,由于其对阴极反应的独特影响,将成为今后研究H2S腐蚀预测模型的关键;另一方面,由于现今大量机器学习方法所具备的适应性强、效果好等优势,今后的H_(2)S腐蚀预测研究工作在该技术领域也有不小的开发空间。 展开更多
关键词 H_(2)S腐蚀 腐蚀产物 腐蚀机制 预测模型 腐蚀速率预测
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X65钢多因素协同腐蚀行为和腐蚀预测模型研究
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作者 张金龙 王丹丹 +2 位作者 魏晨亮 李霞 邹庆 《材料保护》 CAS CSCD 2023年第8期97-102,132,共7页
海底管道腐蚀失效风险激增,有必要对海底管道内腐蚀行为和腐蚀速率进行研究。采用海底管道常用钢材X65钢,利用高温高压反应釜进行了六因素三水平18组正交模拟试验,研究了CO_(2)、H_(2)S、pH值、Cl^(-)、温度、流速等服役环境因素对X65... 海底管道腐蚀失效风险激增,有必要对海底管道内腐蚀行为和腐蚀速率进行研究。采用海底管道常用钢材X65钢,利用高温高压反应釜进行了六因素三水平18组正交模拟试验,研究了CO_(2)、H_(2)S、pH值、Cl^(-)、温度、流速等服役环境因素对X65钢的协同腐蚀行为,确定了腐蚀主控因素为CO_(2)分压>H_(2)S分压> Cl~-浓度>pH值>流速>温度。基于扫描电镜检测结果,明确了H_(2)S、CO_(2)与Cl^(-)的协同腐蚀行为,CO_(2)形成致密的FeCO_(3)位于腐蚀产物膜底部,表面为Fe的硫化物,Cl^(-)穿过腐蚀产物膜层,促进腐蚀的发生。最后基于正交试验数据,建立了六因素腐蚀速率预测模型,预测误差在20%以内。 展开更多
关键词 X65钢 CO_(2) H_(2)S 腐蚀预测
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Intraseasonal Variability of Summertime Surface Air Temperature over Mid-High-Latitude Eurasia and Its Prediction Skill in S2S Models
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作者 Jing CUI Shuangyan YANG Tim LI 《Journal of Meteorological Research》 SCIE CSCD 2021年第5期815-830,共16页
Features of the dominant modes of surface air temperature(SAT)on the intraseasonal timescale over the mid-highlatitude Eurasia(MHE)during boreal summer(June-September)are investigated based on the ERA5 reanalysis data... Features of the dominant modes of surface air temperature(SAT)on the intraseasonal timescale over the mid-highlatitude Eurasia(MHE)during boreal summer(June-September)are investigated based on the ERA5 reanalysis data from 1979 to 2016.The intraseasonal variability(ISV)of SAT over MHE is primarily characterized by an eastward propagation along 60°N,which is found to impact the regional weather in China,including summertime extreme hot and cool events.The forecast skill and potential predictability of the ISV of SAT over MHE are assessed for 5 dynamical models that have participated in the subseasonal-to-seasonal(S2 S)prediction project,by analyzing12 years’(1999-2010)model reforecast/hindcast data.By using the principal component(PC)index of the leading intraseasonal SAT modes as a predictand,we found that the forecast skill for ISV of SAT can reach out to 11-17 days,and the ECMWF model exhibits the best score.All the S2 S models tend to show 1)a relatively higher skill for strong intraseasonal oscillation(ISO)cases,2)a systematic underestimate of the amplitude of the SAT ISV signal,and 3)different skills during different phases of ISO cases.Analysis of potential predictability based on the perfectmodel assumption reveals a 4-6-day skill gap for most models,and the skill gap also varies among different phases of ISO events.The results imply the need for continued development of operational forecasting systems to improve the actual prediction skills for the ISV of SAT over MHE. 展开更多
关键词 surface air temperature(SAT) intraseasonal variability(ISV) mid-high-latitude Eurasia(MHE) subseasonal-to-seasonal(s2s)prediction prediction skill predictability
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新型冠状病毒S蛋白B细胞表位的预测与分析 被引量:6
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作者 朱珊丽 丁宁 +3 位作者 项丹 董海艳 薛向阳 张丽芳 《温州医科大学学报》 CAS 2020年第3期173-176,共4页
目的:分析新型冠状病毒(SARS-CoV-2)S刺突蛋白的二级结构并预测其可能的B细胞表位。方法:基于SARS-CoV-2 S蛋白氨基酸序列,分别采用SOPMA、GOR方法预测S蛋白的二级结构,并结合其跨膜区、亲水性、表面可及性和抗原性参数等综合分析,预测S... 目的:分析新型冠状病毒(SARS-CoV-2)S刺突蛋白的二级结构并预测其可能的B细胞表位。方法:基于SARS-CoV-2 S蛋白氨基酸序列,分别采用SOPMA、GOR方法预测S蛋白的二级结构,并结合其跨膜区、亲水性、表面可及性和抗原性参数等综合分析,预测SARS-CoV-2 S蛋白可能的B细胞表位。结果:对SARS-CoV-2 S蛋白二级结构的预测表明,其二级结构中柔性区域以无规卷曲为主,少见转角。多种参数综合分析推测,其可能的优势B细胞表位位于354~360、437~445、454~471、527~537、567~582、678~685、772~779和806~818位氨基酸。结论:采用多参数预测SARS-CoV-2 S蛋白的B细胞表位,为深入研究S蛋白的功能奠定基础。 展开更多
关键词 新型冠状病毒 S蛋白 B细胞表位 预测
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贵州湄潭降水量演变特征及趋势预测 被引量:5
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作者 黄鑫 陈学凯 +1 位作者 杨静 张泽中 《华北水利水电大学学报(自然科学版)》 2015年第3期13-16,共4页
贵州多为季节性干旱,且降水量年内分配极不均匀.以贵州省湄潭县1951—2012年全年及四季降水资料序列为研究对象,采用Mann-Kendall非参数秩次相关检验法、R/S分析方法对湄潭站降水量的趋势性和持续性进行分析,并将二者结合预测未来降水... 贵州多为季节性干旱,且降水量年内分配极不均匀.以贵州省湄潭县1951—2012年全年及四季降水资料序列为研究对象,采用Mann-Kendall非参数秩次相关检验法、R/S分析方法对湄潭站降水量的趋势性和持续性进行分析,并将二者结合预测未来降水量变化趋势.结果表明:1湄潭地区春季降水量未来有明显的下降趋势,且下降的趋势随时间的变化越来越显著;2夏季降水量未来有缓慢的上升趋势;3秋季、冬季和全年降水量未来均有缓慢的下降趋势. 展开更多
关键词 演变规律 R/S分析 MANN-KENDALL 四季降水量 趋势预测
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连续两个生长季大气CO2浓度升高对银杏希尔反应活力和叶绿体ATP酶活性的影响 被引量:3
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作者 赵天宏 郭丹 +2 位作者 王美玉 徐胜 何兴元 《生态学报》 CAS CSCD 北大核心 2009年第3期1391-1397,共7页
近年来,随着温室气体浓度不断上升,有关CO2浓度升高对植物影响的研究已取得一定进展,但CO2浓度升高对植物光合作用的影响需要从生理生化水平上进一步深入的研究。以沈阳城市森林树种银杏(Ginkgobiloba L.)为研究对象,利用开顶式气室研... 近年来,随着温室气体浓度不断上升,有关CO2浓度升高对植物影响的研究已取得一定进展,但CO2浓度升高对植物光合作用的影响需要从生理生化水平上进一步深入的研究。以沈阳城市森林树种银杏(Ginkgobiloba L.)为研究对象,利用开顶式气室研究连续两个生长季大气CO2浓度升高对银杏光合特性的影响。结果表明,在大气CO2浓度为700μmol.mol-1条件下,与对照相比,第1个生长季CO2处理的银杏叶片净光合速率极显著增加(P<0.01),希尔反应活力极显著增大(P<0.01)、Ca2+/Mg2+-ATP酶活性显著(P<0.05)或极显著增强(P<0.01)、光合产物淀粉的含量极显著增多(P<0.01);第2生长季CO2处理的银杏叶片净光合速率显著增加(P<0.05),希尔反应活力在通气60d时极显著(P<0.01)增大,Ca2+/Mg2+-ATP酶活性在处理30d时显著降低(P<0.05),淀粉含量增多。与第1个生长季相比,第2个生长季CO2处理的银杏叶片净光合速率降低,希尔反应活力减小,Ca2+/Mg2+-ATP酶活性减弱,叶绿素含量增多,淀粉含量减少。试验中出现了光合适应现象。 展开更多
关键词 CO2浓度升高 连续两个生长季 银杏 希尔反应活力 Ca2+/Mg2+-ATP酶活性 光合适应现象
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LRRK2基因核心启动子的预测 被引量:1
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作者 莫晓云 肖和卫 +2 位作者 李丽 杨苏萍 张国 《广西医学》 CAS 2013年第1期38-41,共4页
目的运用生物信息学方法对LRRK2基因的启动子区域进行预测,以指导LRRK2基因核心启动子的克隆,为LRRK2基因的转录调控机制的研究奠定基础。方法在数据库中查询LRRK2基因相关的序列信息,运用多种在线软件对LRRK2基因的转录起始位点、第一... 目的运用生物信息学方法对LRRK2基因的启动子区域进行预测,以指导LRRK2基因核心启动子的克隆,为LRRK2基因的转录调控机制的研究奠定基础。方法在数据库中查询LRRK2基因相关的序列信息,运用多种在线软件对LRRK2基因的转录起始位点、第一个外显子和启动子进行预测,并对预测结果进行综合分析。结果将LRRK2基因脑组织主要剪切本(ENST00000298910,相当于NM_198578)的启动子定位于-803~-1区间。结论 LRRK2基因主要剪切本(ENST00000298910)的启动子区间可能定位于-803~-1区间。 展开更多
关键词 帕金森病 LRRK2 启动子 生物信息学 预测
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苏里格气田苏147井区盒8段二维地震储层预测 被引量:2
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作者 郝骞 张志刚 +4 位作者 祁越 范萍 李武科 刘艳霞 付斌 《湖北大学学报(自然科学版)》 CAS 2015年第1期61-65,72,共6页
为提高致密低渗气田薄储层预测精度,对不同年度采集的二维地震数据从道集和提高分辨率角度进行特殊处理,选取鄂尔多斯盆地苏里格气田苏147井区主力产气层盒8段河流相储层做弹性参数敏感性分析,优选出横波阻抗、纵横波速度比、泊松比... 为提高致密低渗气田薄储层预测精度,对不同年度采集的二维地震数据从道集和提高分辨率角度进行特殊处理,选取鄂尔多斯盆地苏里格气田苏147井区主力产气层盒8段河流相储层做弹性参数敏感性分析,优选出横波阻抗、纵横波速度比、泊松比这3类储层预测敏感因子,确定横波阻抗门槛值在7000--8500 g·cm-3·m·s-1之间为砂岩,纵横波速度比小于1.6或泊松比小于0.18为含气砂岩.由此开展二维地震反演和储层含气性预测,指明研究区盒8段砂岩和含气砂岩储层的平面分布特征,为气田平稳开发提供合理依据. 展开更多
关键词 纵横波速比 泊松比 AVO分析 二维地震 含气性预测 苏里格气田
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酸性气田中CO_(2)和H_(2)S的腐蚀预测模型研究进展 被引量:6
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作者 王彦然 肖杰 +3 位作者 范永昭 张寅晖 田源 李珊 《材料保护》 CAS CSCD 2022年第3期130-135,共6页
综述了关于CO_(2)腐蚀和CO_(2)/H_(2)S共存体系的腐蚀速率预测模型,阐述了各种模型的建模思路、考虑因素、局限性等方面。CO_(2)的预测模型经过不断改进,逐渐将流态、腐蚀产物膜、材质等复杂因素都纳入了计算模型,在半经验模型、经验模... 综述了关于CO_(2)腐蚀和CO_(2)/H_(2)S共存体系的腐蚀速率预测模型,阐述了各种模型的建模思路、考虑因素、局限性等方面。CO_(2)的预测模型经过不断改进,逐渐将流态、腐蚀产物膜、材质等复杂因素都纳入了计算模型,在半经验模型、经验模型和机理模型3种类型方面都有了比较成熟的理论成果。而对于H_(2)S/CO_(2)共存体系的预测模型,目前考虑的因素较少,建模方法以经验和半经验为主,一方面未与生产现场紧密结合,另一方面有待于将腐蚀机理更深入地应用于预测模型的研究。 展开更多
关键词 预测模型 CO_(2)腐蚀 CO_(2)/H_(2)S共存体系 考虑因素
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室内舒适性指标PMV的区间Ⅱ型T-S模糊建模 被引量:1
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作者 陈朦 李柠 李少远 《智能系统学报》 2011年第3期219-224,共6页
预测平均投票值(PMV)是室内热环境的标准化指标,其涉及的数学模型复杂且存在不确定性,不能适应实时控制的需要.同时,传统的采用一个PMV值评价热环境的方法具有局限性,不能反映不同位置人体舒适感的差异.为了处理测量噪声和人体因素带来... 预测平均投票值(PMV)是室内热环境的标准化指标,其涉及的数学模型复杂且存在不确定性,不能适应实时控制的需要.同时,传统的采用一个PMV值评价热环境的方法具有局限性,不能反映不同位置人体舒适感的差异.为了处理测量噪声和人体因素带来的不确定性,通过对室内气流和传热计算流体动力学(CFD)模拟数值以准确描述PMV值,建立了PMV的区间II型T-S模糊模型.针对二阶模糊隶属度的确定问题,在G-K聚类的基础上,采用遗传算法对二阶隶属度函数的参数进行优选,再由最小二乘法辨识得到后件参数.仿真结果表明II型T-S模糊模型比I型更有效地减少了不确定性,对模型精度的影响,对动态过程和稳态数值都有很好的预测能力. 展开更多
关键词 PMV CFD Ⅱ型模糊模型 区间T-S模糊系统
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Identification of the epitopes on HCV core protein recognized by HLA-A2 restricted cytotoxic T lymphocytes 被引量:11
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作者 Hong-Chao Zhou De-Zhong Xu Xue-Ping Wang Jing-Xia Zhang Ying-Huang Yong-Ping Yan Yong Zhu Bo-Quan Jin Department of Epidemiology,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,ChinaDepartment of Immunology,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第4期583-586,共4页
AIM: To identify hepatitis C virus(HCV) core protein epitopes recognized by HLA-A2 restricted cytotoxic T lymphocyte (CTL). METHODS: Utilizing the method of computer prediction followed by a 4h(51)Cr release assay con... AIM: To identify hepatitis C virus(HCV) core protein epitopes recognized by HLA-A2 restricted cytotoxic T lymphocyte (CTL). METHODS: Utilizing the method of computer prediction followed by a 4h(51)Cr release assay confirmation. RESULTS: The results showed that peripheral blood mononuclear cells (PBMC) obtained from two HLA-A2 positive donors who were infected with HCV could lyse autologous target cells labeled with peptide &quot;ALAHGVRAL (core 150-158)&quot;. The rates of specific lysis of the cells from the two donors were 37.5% and 15.8%, respectively. Blocking of the CTL response with anti-CD4 mAb caused no significant decrease of the specific lysis. But blocking of CTL response with anti-CD8 mAb could abolish the lysis. CONCLUSION: The peptide (core 150-158) is the candidate epitope recognized by HLAA2 restricted CTL. 展开更多
关键词 Amino Acid Sequence Antibodies Viral B-LYMPHOCYTES Cell Line Epitope Mapping HLA-A2 Antigen HEPACIVIRUS Hepatitis C Humans Peptide Fragments Predictive Value of Tests Research Support Non-U.S. Gov't T-Lymphocytes Cytotoxic Viral Core Proteins
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Progress and Prospects of Research on Subseasonal to Seasonal Variability and Prediction of the East Asian Monsoon 被引量:2
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作者 Congwen ZHU Boqi LIU +3 位作者 Lun LI Shuangmei MA Ning JIANG Yuhan YAN 《Journal of Meteorological Research》 SCIE CSCD 2022年第5期677-690,共14页
Subseasonal to seasonal(S2S)variability represents the atmospheric disturbance on the 10–90-day timescale,which is an important bridge linking weather and climate.In 2015,China Meteorological Administration(CMA)liste... Subseasonal to seasonal(S2S)variability represents the atmospheric disturbance on the 10–90-day timescale,which is an important bridge linking weather and climate.In 2015,China Meteorological Administration(CMA)listed the S2S prediction project that was initiated by WMO programs three years ago as one of its key tasks.After five years of research,significant progress has been made on the mechanisms of the East Asian monsoon(EAM)S2S variability,related impact of climate change,as well as the predictability on the S2S timescale of numerical models.The S2S variability of the EAM is closely linked to extreme persistent climate events in China and is an important target for seasonal climate prediction.However,under the influence of global warming and the interactions among climate systems,the S2S variability of the EAM is so complex that its prediction remains a great challenge.This paper reviews the past achievement and summarizes the recent progress in research of the EAM S2S variability and prediction,including characteristics of the main S2S modes of the EAM,their impact on the extreme events in China,effects of external and internal forcing on the S2S variability,as well as uncertainties of climate models in predicting the S2S variability,with a focus on the progress achieved by the S2S research team of the Chinese Academy of Meteorological Sciences.The present bottlenecks,future directions,and critical research recommendations are also analyzed and presented. 展开更多
关键词 East Asian monsoon(EAM) subseasonal to seasonal(s2s)timescale change mechanism predictability of climate models
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Predictive Model for Corrosion Rate of Oil Tubes in CO_2/H_2S Coexistent Environment Part Ⅰ: Building of Model 被引量:5
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作者 李全安 白真权 +3 位作者 黄得志 张清 文九巴 李鹤林 《Journal of Southwest Jiaotong University(English Edition)》 2004年第2期141-147,共7页
Based on an analysis of the existing models of CO 2 corrosion in literatures and the autoclave simulative experiments, a predictive model of corrosion rate (r corr) in CO 2/H 2S corrosion for oil tubes has been ... Based on an analysis of the existing models of CO 2 corrosion in literatures and the autoclave simulative experiments, a predictive model of corrosion rate (r corr) in CO 2/H 2S corrosion for oil tubes has been established, in which r corr is expressed as a function of pH, temperature (T), pressure of CO 2 (P CO 2) and pressure of H 2S (P H 2S). The model has been verified by experimental data obtained on N80 steel. The improved features of the predictive model include the following aspects: (1) The influence of temperature on the protectiveness of corrosion film is taken into consideration for establishment of predictive model of the r corr in CO 2/H 2S corrosion. The Equations of scale temperature and scale factor are put forward, and they fit the experimental result very well. (2) The linear relationship still exists between ln r corr and ln P CO 2 in CO 2/H 2S corrosion (as same as that in CO 2 corrosion). Therefore, a correction factor as a function of P H 2S has been introduced into the predictive model in CO 2/H 2S corrosion. (3) The model is compatible with the main existing models. 展开更多
关键词 Predictive model CO 2/H 2S corrosion Corrosion rate Scale temperature Oil tube
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