目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以...目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以及甲胎蛋白(alpha fetoprotein,AFP)水平。结果观察组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05)。观察组AFP水平高于对照组,差异有统计学意义(P<0.05)。PHC血清患者25(OH)D3水平与中国肝癌分期(China live cancer staging,CNLC)、淋巴结转移有关,差异有统计学意义(P<0.05)。结论针对PHC患者,其血清25(OH)D3水平主要相关因素为CNLC分期、淋巴结转移,根据血清25(OH)D3水平可为疾病治疗及其预后评估提供依据。展开更多
Objective To study the effect of oral vitamin D(VD) supplementation on VD status and serum lipid in Chinese obese and healthy normal-weightmen.Methods Twenty-one obese men with their body mass index(BMI)>28 kg/m2se...Objective To study the effect of oral vitamin D(VD) supplementation on VD status and serum lipid in Chinese obese and healthy normal-weightmen.Methods Twenty-one obese men with their body mass index(BMI)>28 kg/m2served as an obese group and 22 healthy normal-weight men with their BMI<24 kg/m2served as a control group in this study.After they were given 50 000 IU of oral VD,once a week for 8 weeks,the serum25-hydroxyvitamin D [25(OH)D] concentration was measured with an enzyme-immunoassay kit.Results After oral VD supplementation,the serum 25(OH)D concentration significantly increased from46.1±9.1 nmol/L to 116.7±20.3 nmol/L in the obese subjects(P<0.01) and from 52.8±17.8 nmol/L to181.3±30.2 nmol/L in the control ones(P=0.13).The serum high-density lipoprotein cholesterol(HDL-C)level was reduced within the normal reference range in the obese group.However,no significant change was observed in the level of other serum lipids(triglycerides,total cholesterol,and low-density lipoprotein cholesterol) in either of the two groups.Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group.High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.展开更多
文摘目的观察原发性肝癌(primary hepatocellular carcinoma,PHC)与血清25(OH)维生素D水平的相关性。方法抽取2018年8月—2020年8月莆田市第一医院PHC患者50例作为观察组,抽取同时期健康体检者50例作为对照组。检测两组血清25(OH)D3水平以及甲胎蛋白(alpha fetoprotein,AFP)水平。结果观察组血清25(OH)D3水平低于对照组,差异有统计学意义(P<0.05)。观察组AFP水平高于对照组,差异有统计学意义(P<0.05)。PHC血清患者25(OH)D3水平与中国肝癌分期(China live cancer staging,CNLC)、淋巴结转移有关,差异有统计学意义(P<0.05)。结论针对PHC患者,其血清25(OH)D3水平主要相关因素为CNLC分期、淋巴结转移,根据血清25(OH)D3水平可为疾病治疗及其预后评估提供依据。
基金supported by grants from Danone Institute,China Diet Nutrition Research & Communication (DIC2010-03)National Natural Science Foundation of China (81172669)+1 种基金Medical Scientific Research Foundation of Guangdong Province (A2012581)National Key Technology Research and Development Program of China (2012BAI02B02)
文摘Objective To study the effect of oral vitamin D(VD) supplementation on VD status and serum lipid in Chinese obese and healthy normal-weightmen.Methods Twenty-one obese men with their body mass index(BMI)>28 kg/m2served as an obese group and 22 healthy normal-weight men with their BMI<24 kg/m2served as a control group in this study.After they were given 50 000 IU of oral VD,once a week for 8 weeks,the serum25-hydroxyvitamin D [25(OH)D] concentration was measured with an enzyme-immunoassay kit.Results After oral VD supplementation,the serum 25(OH)D concentration significantly increased from46.1±9.1 nmol/L to 116.7±20.3 nmol/L in the obese subjects(P<0.01) and from 52.8±17.8 nmol/L to181.3±30.2 nmol/L in the control ones(P=0.13).The serum high-density lipoprotein cholesterol(HDL-C)level was reduced within the normal reference range in the obese group.However,no significant change was observed in the level of other serum lipids(triglycerides,total cholesterol,and low-density lipoprotein cholesterol) in either of the two groups.Conclusion The effect of high-dose oral VD supplementation is weaker on VD status in the obese group than in the control group.High-dose oral VD supplementation has no side effect on serum lipid level in obese and control groups.
