β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unkno...β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.展开更多
Based on the hourly precipitation data from 4 observation stations of Xining City from June to September during 2005-2011,the temporal and spatial distribution characteristics of short-time precipitation were analyzed...Based on the hourly precipitation data from 4 observation stations of Xining City from June to September during 2005-2011,the temporal and spatial distribution characteristics of short-time precipitation were analyzed.The results show that the precipitation distribution in Xining region exhibited the less-more-less trend from southwest to northeast,while the torrential rain gradually increased from the northwest and southwest to the middle.The hourly general precipitation in Xining region had obviously seasonal characteristics,and its annual distribution showed wavy changes,but the annual variation of short-time heavy precipitation and rainstorm was very obvious.Furthermore,short-time heavy precipitation was concentrated from 18:00 to 24:00,followed by 03:00-07:00 on the following day.The occurrence time of short-time rainstorm accorded with short-time heavy precipitation.It offers a useful reference for the accurate and timely short-term forecast.展开更多
Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte ...Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte biology,but their roles and the associated mechanisms in mechanical stress-associated chondrocyte senescence and OA have not been elucidated.展开更多
In this paper,to study the mechanical responses of a solid propellant subjected to ultrahigh acceleration overload during the gun-launch process,specifically designed projectile flight tests with an onboard measuremen...In this paper,to study the mechanical responses of a solid propellant subjected to ultrahigh acceleration overload during the gun-launch process,specifically designed projectile flight tests with an onboard measurement system were performed.Two projectiles containing dummy HTPB propellant grains were successfully recovered after the flight tests with an ultrahigh acceleration overload value of 8100 g.The onboard-measured time-resolved axial displacement,contact stress and overload values were successfully obtained and analysed.Uniaxial compression tests of the dummy HTPB propellant used in the gunlaunched tests were carried out at low and intermediate strain rates to characterize the propellant's dynamic properties.A linear viscoelastic constitutive model was employed and applied in finite-element simulations of the projectile-launching process.During the launch process,the dummy propellant grain exhibited large deformation due to the high acceleration overload,possibly leading to friction between the motor case and propellant grain.The calculated contact stress showed good agreement with the experimental results,though discrepancies in the overall displacement of the dummy propellant grain were observed.The dynamic mechanical response process of the dummy propellant grain was analysed in detail.The results can be used to estimate the structural integrity of the analysed dummy propellant grain during the gun-launch process.展开更多
Objective The aim of this study was to explore the role and mechanism of ferroptosis in SiO_(2)-induced cardiac injury using a mouse model.Methods Male C57BL/6 mice were intratracheally instilled with SiO_(2) to creat...Objective The aim of this study was to explore the role and mechanism of ferroptosis in SiO_(2)-induced cardiac injury using a mouse model.Methods Male C57BL/6 mice were intratracheally instilled with SiO_(2) to create a silicosis model.Ferrostatin-1(Fer-1)and deferoxamine(DFO)were used to suppress ferroptosis.Serum biomarkers,oxidative stress markers,histopathology,iron content,and the expression of ferroptosis-related proteins were assessed.Results SiO_(2) altered serum cardiac injury biomarkers,oxidative stress,iron accumulation,and ferroptosis markers in myocardial tissue.Fer-1 and DFO reduced lipid peroxidation and iron overload,and alleviated SiO_(2)-induced mitochondrial damage and myocardial injury.SiO_(2) inhibited Nuclear factor erythroid 2-related factor 2(Nrf2)and its downstream antioxidant genes,while Fer-1 more potently reactivated Nrf2 compared to DFO.Conclusion Iron overload-induced ferroptosis contributes to SiO_(2)-induced cardiac injury.Targeting ferroptosis by reducing iron accumulation or inhibiting lipid peroxidation protects against SiO_(2) cardiotoxicity,potentially via modulation of the Nrf2 pathway.展开更多
Thalamic hemorrhage can lead to the development of central post-stroke pain.Changes in histone acetylation levels,which are regulated by histone deacetylases,affect the excitability of neurons surrounding the hemorrha...Thalamic hemorrhage can lead to the development of central post-stroke pain.Changes in histone acetylation levels,which are regulated by histone deacetylases,affect the excitability of neurons surrounding the hemorrhagic area.However,the regulato ry mechanism of histone deacetylases in central post-stroke pain remains unclea r.Here,we show that iron overload leads to an increase in histone deacetylase 2expression in damaged ventral posterolateral nucleus neurons.Inhibiting this increase restored histone H3 acetylation in the Kcna2 promoter region of the voltage-dependent potassium(Kv)channel subunit gene in a rat model of central post-stroke pain,thereby increasing Kcna2expression and relieving central pain.However,in the absence of nerve injury,increasing histone deacetylase 2 expression decreased Kcna2expression,decreased Kv current,increased the excitability of neurons in the ventral posterolateral nucleus area,and led to neuropathic pain symptoms.Moreover,treatment with the iron chelator deferiprone effectively reduced iron overload in the ventral posterolateral nucleus after intracerebral hemorrhage,reversed histone deacetylase 2 upregulation and Kv1.2 downregulation,and alleviated mechanical hypersensitivity in central post-stroke pain rats.These results suggest that histone deacetylase 2 upregulation and Kv1.2 downregulation,mediated by iron overload,are important factors in central post-stroke pain pathogenesis and co uld se rve as new to rgets for central poststroke pain treatment.展开更多
Segmentally assembled bridges are increasinglyfinding engineering applications in recent years due to their unique advantages,especially as urban viaducts.Vehicle loads are one of the most important variable loads acti...Segmentally assembled bridges are increasinglyfinding engineering applications in recent years due to their unique advantages,especially as urban viaducts.Vehicle loads are one of the most important variable loads acting on bridge structures.Accordingly,the influence of overloaded vehicles on existing assembled bridge structures is an urgent concern at present.This paper establishes thefinite element model of the segmentally assembled bridge based on ABAQUS software and analyzes the influence of vehicle overload on an assembled girder bridge struc-ture.First,afinite element model corresponding to the target bridge is established based on ABAQUS software,and the load is controlled to simulate vehicle movement in each area of the traveling zone at different times.Sec-ond,the key cross-sections of segmental girder bridges are monitored in real time based on the force character-istics of continuous girder bridges,and they are compared with the simulation results.Finally,a material damage ontology model is introduced,and the structural damage caused by different overloading rates is compared and analyzed.Results show that thefinite element modeling method is accurate by comparing with on-site measured data,and it is suitable for the numerical simulation of segmental girder bridges;Dynamic sensors installed at 1/4L,1/2L,and 3/4L of the segmental girder main beams could be used to identify the dynamic response of segmental girder bridges;The bottom plate of the segmental girder bridge is mostly damaged at the position where the length of the precast beam section changes and the midspan position.With the increase in load,damage in the direction of the bridge develops faster than that in the direction of the transverse bridge.Thefindings of this study can guide maintenance departments in the management and maintenance of bridges and vehicles.展开更多
With the rapid development of mechanical equipment, the mechanical health monitoring field has entered the era of big data. However, the method of manual feature extraction has the disadvantages of low efficiency and ...With the rapid development of mechanical equipment, the mechanical health monitoring field has entered the era of big data. However, the method of manual feature extraction has the disadvantages of low efficiency and poor accuracy, when handling big data. In this study, the research object was the asynchronous motor in the drivetrain diagnostics simulator system. The vibration signals of different fault motors were collected. The raw signal was pretreated using short time Fourier transform （STFT） to obtain the corresponding time-frequency map. Then, the feature of the time-frequency map was adap- tively extracted by using a convolutional neural network （CNN）. The effects of the pretreatment method, and the hyper parameters of network diagnostic accuracy, were investigated experimentally. The experimental results showed that the influence of the preprocessing method is small, and that the batch-size is the main factor affecting accuracy and training efficiency. By investigating feature visualization, it was shown that, in the case of big data, the extracted CNN features can represent complex mapping relationships between signal and health status, and can also overcome the prior knowledge and engineering experience requirement for feature extraction, which is used by tra- ditional diagnosis methods. This paper proposes a new method, based on STFT and CNN, which can complete motor fault diagnosis tasks more intelligently and accurately.展开更多
Abstract： Microstructural evolution in a new kind of aluminum （A1） alloy with the chemical composition of AI-8.82Zn-2.08Mg- 0.80Cu-3.31Sc-0.3Zr was investigated. It is found that the secondary phase MgZn2 is comple...Abstract： Microstructural evolution in a new kind of aluminum （A1） alloy with the chemical composition of AI-8.82Zn-2.08Mg- 0.80Cu-3.31Sc-0.3Zr was investigated. It is found that the secondary phase MgZn2 is completely dissolved into the matrix during a short homogenization treatment （470℃, 1 h）, while the primary phase A13（Sc,Zr） remains stable. This is due to Sc and Zr additions into the A1 al- loy, high Zn/Mg mass ratio, and low Cu content. The experimental findings fit well with the results calculated by the homogenization diffusion kinetics equation. The alloy shows an excellent mechanical performance after the short homogenization process followed by hot-extrusion and T6 treatment. Consequently, a good combination of low energy consumotion and favorable mechanical properties is obtained.展开更多
This study was conducted to explore the regulation mechanism for key protein expression. The Microcystis treated by short-time ultrasonic wave was select-ed to analyze the total protein based on 2-DE. The results show...This study was conducted to explore the regulation mechanism for key protein expression. The Microcystis treated by short-time ultrasonic wave was select-ed to analyze the total protein based on 2-DE. The results showed that there were 71 up-regulated protein spots, 56 down-regulated protein spots, 54 new protein spots and 21 protein spots disappeared under short-time ultrasonic stress. Eight dif-ferential proteins were chosen for further MALDI-TOFTOF/MS analysis, and the re-sults showed that 2 unknown proteins and 6 functional proteins were detected. These proteins were relevant to some physiological processes, such as antioxidation and anti-inflammatory process, phosphate synthesis and electron transfer, which is beneficial to the metabolic balance and self-protection under short-time ultrasonic stress.展开更多
Traditional short-time fractional Fourier transform(STFrFT)has a single and fixed window function,which can not be adjusted adaptively according to the characteristics of fre-quency and frequency change rate.In order ...Traditional short-time fractional Fourier transform(STFrFT)has a single and fixed window function,which can not be adjusted adaptively according to the characteristics of fre-quency and frequency change rate.In order to overcome the shortcomings,the STFrFT method with adaptive window function is proposed.In this method,the window function of STFrFT is ad-aptively adjusted by establishing a library containing multiple window functions and taking the minimum information entropy as the criterion,so as to obtain a time-frequency distribution that better matches the desired signal.This method takes into account the time-frequency resolution characteristics of STFrFT and the excellent characteristics of adaptive adjustment to window func-tion,improves the time-frequency aggregation on the basis of eliminating cross term interference,and provides a new tool for improving the time-frequency analysis ability of complex modulated sig-nals.展开更多
According to the characteristic that Hilbert-Huang transform （HHT） can detect abnormity in signals, an HHT-based method to eliminate short-time strong disturbance was proposed. The signal with short-time strong dist...According to the characteristic that Hilbert-Huang transform （HHT） can detect abnormity in signals, an HHT-based method to eliminate short-time strong disturbance was proposed. The signal with short-time strong disturbance was decomposed into a series of intrinsic mode functions （IMFs） and a residue by the empirical mode decomposition （EMD）. The instantaneous amplitudes and frequencies of each IMF were calculated. And at abnormal section, instantaneous amplitudes and frequencies were fired according to the data at normal section, replacing the fitted data for the original ones. A new set of IMFs was reconstructed by using the processed instantaneous amplitudes and frequencies. For the residue, abnormal fluctuations could be directly eliminated. And a new signal with the short-time strong disturbance eliminated was reconstructed by superposing all the new IMFs and the residue, The numerical simulation shows that there is a good correlation between the reconstructed signal and the undisturbed signal, The correlation coefficient is equal to 0.999 1. The processing results of the measured strain signal of a bridge with short-time strong disturbance verify the practicability of the method.展开更多
By using the conventional observations, radar data, NCEP/NCAR FNL 1°×1° reanalysis data and numerical simulation data and with the construction and calculation of radar echo parameters, this paper prese...By using the conventional observations, radar data, NCEP/NCAR FNL 1°×1° reanalysis data and numerical simulation data and with the construction and calculation of radar echo parameters, this paper presents the structural characteristics and physical processes of a short-time heavy precipitation supercell that occurred in the squall line process in Shanxi Province on 24 June 2020. The results show that this squall line event occurred in front of a surface cold front,combined with infiltration of low-level cold air and continuous increase of near-surface humidity in the afternoon. The surface mesoscale convergence line and mesoscale dew point front contributed to the development and systemization of the squall line by a large degree. The short-time extremely heavy precipitation in Pingshun County was caused by the development of a supercell from thunderstorm cells on the front side of the squall line. The characteristics of sharp increase in vertical integral liquid water content, persistent increase in reflectivity factor and continuous rise in the echo top height appeared about 23 min earlier than the severe precipitation, which has qualitative indicating significance for the nowcasting of short-time heavy precipitation. A quantitative analysis of the radar echo parameters suggests that the“sudden drop”of FV40was a precursor signal of cells’ coalescence and rapid development to the mature stage. The areal change of the echo core at the 6 km height was highly subject to the merging and developing of cells, the rapid change of hydrometeor particles in clouds and the precipitation intensity. Changes in the cross-sectional area of convective cells at different heights can indirectly reflect the changes of liquid particles and ice particles in clouds, which is indicatively meaningful for predicting the coalescing and developing-to-maturing of cells and heavy precipitation 30-45 min earlier.A comprehensive echo parameter prediction model constructed by the random forest principle can predict the magnitude of short-time heavy precipitation 40-50 min in advance. Numerical simulation reveals that large amounts of water vapor existed in the near-surface atmosphere, and that the cells rapidly obtained moisture from the ambient atmosphere and developed rapidly through maternal feeding. The cold cloud zone was narrow, upright and had a high stretch height. The upward motion in clouds was strong and deep, and very rich in liquid water content. The graupel particles had a large vertical distribution range, the coexistence area of graupel and snow was large, the height of raindrops was close to the surface with a wide horizontal scale, and the precipitation efficiency was high. These may be the important elements responsible for the occurrence of the short-time heavy precipitation that exceeded historical extreme values. On the basis of the above analyses, a comprehensive parameter(CP) prediction model is worked out, which can estimate the developing trend of supercells and the intensity of short-time heavy precipitation about 1 h in advance.展开更多
In order to provide a reference for the correct forecasting of short-term heavy rainfall and better disaster prevention and mitigation services in Shanxi Province, China, it is very important to carry out systematic r...In order to provide a reference for the correct forecasting of short-term heavy rainfall and better disaster prevention and mitigation services in Shanxi Province, China, it is very important to carry out systematic research on short-term heavy precipitation events in Shanxi Province. Based on hourly precipitation data during the flood season (May to September) from 109 meteorological stations in Shanxi, China in 1980-2015, the temporal and spatial variation characteristics of short-time heavy rainfall during the flood season are analyzed by using wavelet analysis and Mann-Kendall test. The results show that the short-time heavy rainfall in the flood season in Shanxi Province is mainly at the grade of 20 - 30 mm/h, with an average of 97 stations having short-time heavy rainfall each year, accounting for 89% of the total stations. The short-time heavy rainfall mainly concentrated in July and August, and the maximal rain intensity in history appeared at 23 - 24 on June 17, 1991 in Yongji, Shanxi is 91.7 mm/h. During the flood season, the short-time heavy rainfalls always occur at 16 - 18 pm, and have slightly different concentrated time in different months. The main peaks of June, July and August are at 16, 17 and 18 respectively, postponed for one hour. Short-time heavy rainfall overall has the distribution that the south is more than the north and the east less than the west in Shanxi area. In the last 36 years, short-time heavy rainfall has a slight increasing trend in Shanxi, but not significant. There is a clear 4-year period of oscillation and inter-decadal variation. It has a good correlation between the total precipitation and times of short-time heavy rainfall during the flood season.展开更多
Anti-jamming solutions based on antenna arrays enhance the anti-jamming ability and the robustness of global navigation satellite system(GNSS)receiver remarkably.However,the performance of the receiver will deteriorat...Anti-jamming solutions based on antenna arrays enhance the anti-jamming ability and the robustness of global navigation satellite system(GNSS)receiver remarkably.However,the performance of the receiver will deteriorate significantly in the overloaded interferences scenario.We define the overloaded interferences scenario as where the number of interferences is more than or equal to the number of antenna arrays elements.In this paper,the effect mechanism of interferences with different incident directions is found by studying the anti-jamming performance of the adaptive space filter.The theoretical analysis and conclusions,which are first validated through numerical examples,reveal the relationships between the optimal weight vector and the eigenvectors of the input signal autocorrelation matrix,the relationships between the interference cancellation ratio(ICR),the signal to interference and noise power ratio(SINR)of the adaptive space filter output and the number of interferences,the eigenvalues of the input signal autocorrelation matrix.In addition,two simulation experiments are utilized to further corroborate the theoretical findings through soft anti-jamming receiver.The simulation results match well with the theoretical analysis results,thus validating the effect mechanism of overloaded interferences.The simulation results show that,for a four elements circular array,the performance difference is up to 19 dB with different incident directions of interferences.Anti-jamming performance evaluation and jamming deployment optimization can obtain more accurate and efficient results by using the conclusions.展开更多
We investigate the short-time decoherence of a solid-state qubit under Ohmic noise at optimal operation points. The decoherence is analyzed by maximum norm of the deviation density operator. It is shown that at the te...We investigate the short-time decoherence of a solid-state qubit under Ohmic noise at optimal operation points. The decoherence is analyzed by maximum norm of the deviation density operator. It is shown that at the temperature T = 3 mK, the loss of the fidelity due to decoherence is much smaller than the DiVincenzo low decoherence criterion, which means that the mode/may be an optimal candidate of qubit for quantum computation.展开更多
Dynamic tensile failure is a common phenomenon in deep rock practices,and thus accurately evaluating the dynamic tensile responses of rocks under triaxial pressures is of great significance.The Brazilian disc(BD)test ...Dynamic tensile failure is a common phenomenon in deep rock practices,and thus accurately evaluating the dynamic tensile responses of rocks under triaxial pressures is of great significance.The Brazilian disc(BD)test is the suggested method by the International Society for Rock Mechanics and Rock Engineering(ISRM)for measuring both the static and dynamic tensile strengths of rock-like materials.However,due to the overload phenomenon and the complex preloading conditions,the dynamic tensile strengths of rocks measured by the BD tests tend to be overestimated.To address this issue,the dynamic BD tensile strength(BTS)of Fangshan marble(FM)under different preloading conditions were measured through a triaxial split Hopkinson pressure bar(SHPB).The fracture onset in BD specimen was captured through a strain gage around the disc center.The discrepancy between the traditional tensile strength(TTS,determined by the peak load P_(f) of the BD specimen)and the nominal tensile strength(NTS,obtained from the load P_(i) when the diametral fracture commences in the tested BD specimen)was applied to quantitatively evaluating the overload phenomenon.The Griffith criterion was used to rectify the calculation of the tensile stress at the disc center under triaxial stress states.The results demonstrate that the overload ratio(s)increases with the loading rate(σ)and decreases with the hydrostatic pressure(σ_(s)).The TTS corrected by the Griffith criterion is independent of theσ_(s)due to the overload phenomenon,while the NTS corrected by the Griffith criterion is sensitive to both the andσ.Therefore,it is essential to modify the tensile stress in dynamic confined BD tests using both the overload correction and the Griffith criterion rectification to obtain the accurate dynamic BTS of rocks.展开更多
Short-time critical behavior of the random n-vector model is studied by the theoretic renormalization-group approach.Asymptotic scaling laws are studied in a frame of the expansion in e = 4 - d for n ≠ 1 and for n = ...Short-time critical behavior of the random n-vector model is studied by the theoretic renormalization-group approach.Asymptotic scaling laws are studied in a frame of the expansion in e = 4 - d for n ≠ 1 and for n = 1respectively.In d ＜ 4,the initial slip exponents θ′ for the order parameter and θ for the response function are calculated up to the second order in e ＝ 4 - d for n ≠ 1 and for n ＝ 1 at the random fixed point respectively.Our results show that the random impurities exert a strong influence on the short-time dynamics for d ＜ 4 and n ＜ nc.展开更多
By means of conceptual model prediction, two short-time strong precipitation processes in Xiamen on June 12th and 14th, 2008 were analyzed from the aspects of real precipitation, weather situation, physical parameter ...By means of conceptual model prediction, two short-time strong precipitation processes in Xiamen on June 12th and 14th, 2008 were analyzed from the aspects of real precipitation, weather situation, physical parameter and radar echo. The results showed that two short-time strong precipitation processes had complete different weather backgrounds, so physical quantities which could reflect atmospheric thermal and dynamic characteristic were different, as well as the characteristic and evolution process of radar echo, and it revealed that two short-time strong precipitation processes in Xiamen had various formation mechanisms and evolution processes. Therefore, many data should be combined to grasp different vantage points in precipitation forecast.展开更多
The high-rise frame structure has become more and more widespread, like its damage from the complication of the environment. The traditional method of damage detection, which is only suitable for the stationary signal...The high-rise frame structure has become more and more widespread, like its damage from the complication of the environment. The traditional method of damage detection, which is only suitable for the stationary signal, does not apply to a high-rise frame structure because its damage signal is non-stationary. Thus, this paper presents an application of the short-time Fourier transform(STFT) to damage detection of high-rise frame structures. Compared with the fast Fourier transform, STFT is found to be able to express the frequency spectrum property of the time interval using the signal within this interval. Application of STFT to analyzing a Matlab model and the shaking table test with a twelve-story frame-structure model reveals that there is a positive correlation between the slope of the frequency versus time and the damage level. If the slope is equal to or greater than zero, the structure is not damaged. If the slope is smaller than zero, the structure is damaged, and the less the slope is, the more serious the damage is. The damage results from calculation based on the Matlab model are consistent with those from the shaking table test, demonstrating that STFT can be a reliable tool for the damage detection of high-rise frame structures.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82104158(to XT),31800887(to LY),31972902(to LY),82001422(to YL)China Postdoctoral Science Foundation,No.2020M683750(to LY)partially by Young Talent Fund of University Association for Science and Technology in Shaanxi Province of China,No.20200307(to LY).
文摘β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.
基金Supported by the Key Research and Development and Transformation Project of Science and Technology Department of Qinghai Province in 2021(2021-SF-141-2).
文摘Based on the hourly precipitation data from 4 observation stations of Xining City from June to September during 2005-2011,the temporal and spatial distribution characteristics of short-time precipitation were analyzed.The results show that the precipitation distribution in Xining region exhibited the less-more-less trend from southwest to northeast,while the torrential rain gradually increased from the northwest and southwest to the middle.The hourly general precipitation in Xining region had obviously seasonal characteristics,and its annual distribution showed wavy changes,but the annual variation of short-time heavy precipitation and rainstorm was very obvious.Furthermore,short-time heavy precipitation was concentrated from 18:00 to 24:00,followed by 03:00-07:00 on the following day.The occurrence time of short-time rainstorm accorded with short-time heavy precipitation.It offers a useful reference for the accurate and timely short-term forecast.
基金supported by grants from Natural Science Foundation of China grant No 82172491 (CN)National Natural Science Funds for Excellent Young Scholar No 82322044 (CN)+2 种基金National Key Research and Development Program of China (2022YFC3601902)Youth Talent Support Programme of Guangdong Provincial Association for Science and Technology (SKXRC202308)State-funded postdoctoral researcher program No GZC20231062 (CN)。
文摘Mechanical overloading and aging are two essential factors for osteoarthritis(OA)development.Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals and chondrocyte biology,but their roles and the associated mechanisms in mechanical stress-associated chondrocyte senescence and OA have not been elucidated.
文摘In this paper,to study the mechanical responses of a solid propellant subjected to ultrahigh acceleration overload during the gun-launch process,specifically designed projectile flight tests with an onboard measurement system were performed.Two projectiles containing dummy HTPB propellant grains were successfully recovered after the flight tests with an ultrahigh acceleration overload value of 8100 g.The onboard-measured time-resolved axial displacement,contact stress and overload values were successfully obtained and analysed.Uniaxial compression tests of the dummy HTPB propellant used in the gunlaunched tests were carried out at low and intermediate strain rates to characterize the propellant's dynamic properties.A linear viscoelastic constitutive model was employed and applied in finite-element simulations of the projectile-launching process.During the launch process,the dummy propellant grain exhibited large deformation due to the high acceleration overload,possibly leading to friction between the motor case and propellant grain.The calculated contact stress showed good agreement with the experimental results,though discrepancies in the overall displacement of the dummy propellant grain were observed.The dynamic mechanical response process of the dummy propellant grain was analysed in detail.The results can be used to estimate the structural integrity of the analysed dummy propellant grain during the gun-launch process.
基金supported by the National Natural Science Foundation of China[No.U21A20334,82373544]Hebei Provincial Department of Science and Technology Centrally Guided Local Development Fund Project[236Z7705G]Occupational health risk assessment and the formulation of national occupational health standards[102393220020090000020].
文摘Objective The aim of this study was to explore the role and mechanism of ferroptosis in SiO_(2)-induced cardiac injury using a mouse model.Methods Male C57BL/6 mice were intratracheally instilled with SiO_(2) to create a silicosis model.Ferrostatin-1(Fer-1)and deferoxamine(DFO)were used to suppress ferroptosis.Serum biomarkers,oxidative stress markers,histopathology,iron content,and the expression of ferroptosis-related proteins were assessed.Results SiO_(2) altered serum cardiac injury biomarkers,oxidative stress,iron accumulation,and ferroptosis markers in myocardial tissue.Fer-1 and DFO reduced lipid peroxidation and iron overload,and alleviated SiO_(2)-induced mitochondrial damage and myocardial injury.SiO_(2) inhibited Nuclear factor erythroid 2-related factor 2(Nrf2)and its downstream antioxidant genes,while Fer-1 more potently reactivated Nrf2 compared to DFO.Conclusion Iron overload-induced ferroptosis contributes to SiO_(2)-induced cardiac injury.Targeting ferroptosis by reducing iron accumulation or inhibiting lipid peroxidation protects against SiO_(2) cardiotoxicity,potentially via modulation of the Nrf2 pathway.
基金supported by the National Natural Science Foundation of China,Nos.U2004106 (to WY),81971061 (to JC)the Key Scientific Research Project of Colleges and Universities in Henan Province,No.21A320039 (to WY)。
文摘Thalamic hemorrhage can lead to the development of central post-stroke pain.Changes in histone acetylation levels,which are regulated by histone deacetylases,affect the excitability of neurons surrounding the hemorrhagic area.However,the regulato ry mechanism of histone deacetylases in central post-stroke pain remains unclea r.Here,we show that iron overload leads to an increase in histone deacetylase 2expression in damaged ventral posterolateral nucleus neurons.Inhibiting this increase restored histone H3 acetylation in the Kcna2 promoter region of the voltage-dependent potassium(Kv)channel subunit gene in a rat model of central post-stroke pain,thereby increasing Kcna2expression and relieving central pain.However,in the absence of nerve injury,increasing histone deacetylase 2 expression decreased Kcna2expression,decreased Kv current,increased the excitability of neurons in the ventral posterolateral nucleus area,and led to neuropathic pain symptoms.Moreover,treatment with the iron chelator deferiprone effectively reduced iron overload in the ventral posterolateral nucleus after intracerebral hemorrhage,reversed histone deacetylase 2 upregulation and Kv1.2 downregulation,and alleviated mechanical hypersensitivity in central post-stroke pain rats.These results suggest that histone deacetylase 2 upregulation and Kv1.2 downregulation,mediated by iron overload,are important factors in central post-stroke pain pathogenesis and co uld se rve as new to rgets for central poststroke pain treatment.
基金supported in part by the Key Research Projects of Higher Education Institutions in Henan Province(Grant No.24A560021)in part by the Henan Postdoctoral Foundation(Grant No.202102015).
文摘Segmentally assembled bridges are increasinglyfinding engineering applications in recent years due to their unique advantages,especially as urban viaducts.Vehicle loads are one of the most important variable loads acting on bridge structures.Accordingly,the influence of overloaded vehicles on existing assembled bridge structures is an urgent concern at present.This paper establishes thefinite element model of the segmentally assembled bridge based on ABAQUS software and analyzes the influence of vehicle overload on an assembled girder bridge struc-ture.First,afinite element model corresponding to the target bridge is established based on ABAQUS software,and the load is controlled to simulate vehicle movement in each area of the traveling zone at different times.Sec-ond,the key cross-sections of segmental girder bridges are monitored in real time based on the force character-istics of continuous girder bridges,and they are compared with the simulation results.Finally,a material damage ontology model is introduced,and the structural damage caused by different overloading rates is compared and analyzed.Results show that thefinite element modeling method is accurate by comparing with on-site measured data,and it is suitable for the numerical simulation of segmental girder bridges;Dynamic sensors installed at 1/4L,1/2L,and 3/4L of the segmental girder main beams could be used to identify the dynamic response of segmental girder bridges;The bottom plate of the segmental girder bridge is mostly damaged at the position where the length of the precast beam section changes and the midspan position.With the increase in load,damage in the direction of the bridge develops faster than that in the direction of the transverse bridge.Thefindings of this study can guide maintenance departments in the management and maintenance of bridges and vehicles.
基金Supported by National Natural Science Foundation of China(Grant No.51405241,51505234,51575283)
文摘With the rapid development of mechanical equipment, the mechanical health monitoring field has entered the era of big data. However, the method of manual feature extraction has the disadvantages of low efficiency and poor accuracy, when handling big data. In this study, the research object was the asynchronous motor in the drivetrain diagnostics simulator system. The vibration signals of different fault motors were collected. The raw signal was pretreated using short time Fourier transform （STFT） to obtain the corresponding time-frequency map. Then, the feature of the time-frequency map was adap- tively extracted by using a convolutional neural network （CNN）. The effects of the pretreatment method, and the hyper parameters of network diagnostic accuracy, were investigated experimentally. The experimental results showed that the influence of the preprocessing method is small, and that the batch-size is the main factor affecting accuracy and training efficiency. By investigating feature visualization, it was shown that, in the case of big data, the extracted CNN features can represent complex mapping relationships between signal and health status, and can also overcome the prior knowledge and engineering experience requirement for feature extraction, which is used by tra- ditional diagnosis methods. This paper proposes a new method, based on STFT and CNN, which can complete motor fault diagnosis tasks more intelligently and accurately.
基金financially supported by the High Technology Research and Development Program of China (No. 2013AA031002)
文摘Abstract： Microstructural evolution in a new kind of aluminum （A1） alloy with the chemical composition of AI-8.82Zn-2.08Mg- 0.80Cu-3.31Sc-0.3Zr was investigated. It is found that the secondary phase MgZn2 is completely dissolved into the matrix during a short homogenization treatment （470℃, 1 h）, while the primary phase A13（Sc,Zr） remains stable. This is due to Sc and Zr additions into the A1 al- loy, high Zn/Mg mass ratio, and low Cu content. The experimental findings fit well with the results calculated by the homogenization diffusion kinetics equation. The alloy shows an excellent mechanical performance after the short homogenization process followed by hot-extrusion and T6 treatment. Consequently, a good combination of low energy consumotion and favorable mechanical properties is obtained.
基金Supported by National Natural Science Foundation of China(513080061006239)~~
文摘This study was conducted to explore the regulation mechanism for key protein expression. The Microcystis treated by short-time ultrasonic wave was select-ed to analyze the total protein based on 2-DE. The results showed that there were 71 up-regulated protein spots, 56 down-regulated protein spots, 54 new protein spots and 21 protein spots disappeared under short-time ultrasonic stress. Eight dif-ferential proteins were chosen for further MALDI-TOFTOF/MS analysis, and the re-sults showed that 2 unknown proteins and 6 functional proteins were detected. These proteins were relevant to some physiological processes, such as antioxidation and anti-inflammatory process, phosphate synthesis and electron transfer, which is beneficial to the metabolic balance and self-protection under short-time ultrasonic stress.
基金supported by the National Natural Science Found-ation of China(No.61571454)Special Fund for Taishan Scholar Project(No.201712072)。
文摘Traditional short-time fractional Fourier transform(STFrFT)has a single and fixed window function,which can not be adjusted adaptively according to the characteristics of fre-quency and frequency change rate.In order to overcome the shortcomings,the STFrFT method with adaptive window function is proposed.In this method,the window function of STFrFT is ad-aptively adjusted by establishing a library containing multiple window functions and taking the minimum information entropy as the criterion,so as to obtain a time-frequency distribution that better matches the desired signal.This method takes into account the time-frequency resolution characteristics of STFrFT and the excellent characteristics of adaptive adjustment to window func-tion,improves the time-frequency aggregation on the basis of eliminating cross term interference,and provides a new tool for improving the time-frequency analysis ability of complex modulated sig-nals.
基金Project (50675230) supported by the National Natural Science Foundation of China
文摘According to the characteristic that Hilbert-Huang transform （HHT） can detect abnormity in signals, an HHT-based method to eliminate short-time strong disturbance was proposed. The signal with short-time strong disturbance was decomposed into a series of intrinsic mode functions （IMFs） and a residue by the empirical mode decomposition （EMD）. The instantaneous amplitudes and frequencies of each IMF were calculated. And at abnormal section, instantaneous amplitudes and frequencies were fired according to the data at normal section, replacing the fitted data for the original ones. A new set of IMFs was reconstructed by using the processed instantaneous amplitudes and frequencies. For the residue, abnormal fluctuations could be directly eliminated. And a new signal with the short-time strong disturbance eliminated was reconstructed by superposing all the new IMFs and the residue, The numerical simulation shows that there is a good correlation between the reconstructed signal and the undisturbed signal, The correlation coefficient is equal to 0.999 1. The processing results of the measured strain signal of a bridge with short-time strong disturbance verify the practicability of the method.
基金National Natural Science Foundation of China(41475050)。
文摘By using the conventional observations, radar data, NCEP/NCAR FNL 1°×1° reanalysis data and numerical simulation data and with the construction and calculation of radar echo parameters, this paper presents the structural characteristics and physical processes of a short-time heavy precipitation supercell that occurred in the squall line process in Shanxi Province on 24 June 2020. The results show that this squall line event occurred in front of a surface cold front,combined with infiltration of low-level cold air and continuous increase of near-surface humidity in the afternoon. The surface mesoscale convergence line and mesoscale dew point front contributed to the development and systemization of the squall line by a large degree. The short-time extremely heavy precipitation in Pingshun County was caused by the development of a supercell from thunderstorm cells on the front side of the squall line. The characteristics of sharp increase in vertical integral liquid water content, persistent increase in reflectivity factor and continuous rise in the echo top height appeared about 23 min earlier than the severe precipitation, which has qualitative indicating significance for the nowcasting of short-time heavy precipitation. A quantitative analysis of the radar echo parameters suggests that the“sudden drop”of FV40was a precursor signal of cells’ coalescence and rapid development to the mature stage. The areal change of the echo core at the 6 km height was highly subject to the merging and developing of cells, the rapid change of hydrometeor particles in clouds and the precipitation intensity. Changes in the cross-sectional area of convective cells at different heights can indirectly reflect the changes of liquid particles and ice particles in clouds, which is indicatively meaningful for predicting the coalescing and developing-to-maturing of cells and heavy precipitation 30-45 min earlier.A comprehensive echo parameter prediction model constructed by the random forest principle can predict the magnitude of short-time heavy precipitation 40-50 min in advance. Numerical simulation reveals that large amounts of water vapor existed in the near-surface atmosphere, and that the cells rapidly obtained moisture from the ambient atmosphere and developed rapidly through maternal feeding. The cold cloud zone was narrow, upright and had a high stretch height. The upward motion in clouds was strong and deep, and very rich in liquid water content. The graupel particles had a large vertical distribution range, the coexistence area of graupel and snow was large, the height of raindrops was close to the surface with a wide horizontal scale, and the precipitation efficiency was high. These may be the important elements responsible for the occurrence of the short-time heavy precipitation that exceeded historical extreme values. On the basis of the above analyses, a comprehensive parameter(CP) prediction model is worked out, which can estimate the developing trend of supercells and the intensity of short-time heavy precipitation about 1 h in advance.
文摘In order to provide a reference for the correct forecasting of short-term heavy rainfall and better disaster prevention and mitigation services in Shanxi Province, China, it is very important to carry out systematic research on short-term heavy precipitation events in Shanxi Province. Based on hourly precipitation data during the flood season (May to September) from 109 meteorological stations in Shanxi, China in 1980-2015, the temporal and spatial variation characteristics of short-time heavy rainfall during the flood season are analyzed by using wavelet analysis and Mann-Kendall test. The results show that the short-time heavy rainfall in the flood season in Shanxi Province is mainly at the grade of 20 - 30 mm/h, with an average of 97 stations having short-time heavy rainfall each year, accounting for 89% of the total stations. The short-time heavy rainfall mainly concentrated in July and August, and the maximal rain intensity in history appeared at 23 - 24 on June 17, 1991 in Yongji, Shanxi is 91.7 mm/h. During the flood season, the short-time heavy rainfalls always occur at 16 - 18 pm, and have slightly different concentrated time in different months. The main peaks of June, July and August are at 16, 17 and 18 respectively, postponed for one hour. Short-time heavy rainfall overall has the distribution that the south is more than the north and the east less than the west in Shanxi area. In the last 36 years, short-time heavy rainfall has a slight increasing trend in Shanxi, but not significant. There is a clear 4-year period of oscillation and inter-decadal variation. It has a good correlation between the total precipitation and times of short-time heavy rainfall during the flood season.
基金supported by the National Natural Science Foundation of China(62003354).
文摘Anti-jamming solutions based on antenna arrays enhance the anti-jamming ability and the robustness of global navigation satellite system(GNSS)receiver remarkably.However,the performance of the receiver will deteriorate significantly in the overloaded interferences scenario.We define the overloaded interferences scenario as where the number of interferences is more than or equal to the number of antenna arrays elements.In this paper,the effect mechanism of interferences with different incident directions is found by studying the anti-jamming performance of the adaptive space filter.The theoretical analysis and conclusions,which are first validated through numerical examples,reveal the relationships between the optimal weight vector and the eigenvectors of the input signal autocorrelation matrix,the relationships between the interference cancellation ratio(ICR),the signal to interference and noise power ratio(SINR)of the adaptive space filter output and the number of interferences,the eigenvalues of the input signal autocorrelation matrix.In addition,two simulation experiments are utilized to further corroborate the theoretical findings through soft anti-jamming receiver.The simulation results match well with the theoretical analysis results,thus validating the effect mechanism of overloaded interferences.The simulation results show that,for a four elements circular array,the performance difference is up to 19 dB with different incident directions of interferences.Anti-jamming performance evaluation and jamming deployment optimization can obtain more accurate and efficient results by using the conclusions.
文摘We investigate the short-time decoherence of a solid-state qubit under Ohmic noise at optimal operation points. The decoherence is analyzed by maximum norm of the deviation density operator. It is shown that at the temperature T = 3 mK, the loss of the fidelity due to decoherence is much smaller than the DiVincenzo low decoherence criterion, which means that the mode/may be an optimal candidate of qubit for quantum computation.
基金We acknowledge the funding support from the National Natural Science Foundation of China(Grant Nos.42141010,51879184 and 12172253).
文摘Dynamic tensile failure is a common phenomenon in deep rock practices,and thus accurately evaluating the dynamic tensile responses of rocks under triaxial pressures is of great significance.The Brazilian disc(BD)test is the suggested method by the International Society for Rock Mechanics and Rock Engineering(ISRM)for measuring both the static and dynamic tensile strengths of rock-like materials.However,due to the overload phenomenon and the complex preloading conditions,the dynamic tensile strengths of rocks measured by the BD tests tend to be overestimated.To address this issue,the dynamic BD tensile strength(BTS)of Fangshan marble(FM)under different preloading conditions were measured through a triaxial split Hopkinson pressure bar(SHPB).The fracture onset in BD specimen was captured through a strain gage around the disc center.The discrepancy between the traditional tensile strength(TTS,determined by the peak load P_(f) of the BD specimen)and the nominal tensile strength(NTS,obtained from the load P_(i) when the diametral fracture commences in the tested BD specimen)was applied to quantitatively evaluating the overload phenomenon.The Griffith criterion was used to rectify the calculation of the tensile stress at the disc center under triaxial stress states.The results demonstrate that the overload ratio(s)increases with the loading rate(σ)and decreases with the hydrostatic pressure(σ_(s)).The TTS corrected by the Griffith criterion is independent of theσ_(s)due to the overload phenomenon,while the NTS corrected by the Griffith criterion is sensitive to both the andσ.Therefore,it is essential to modify the tensile stress in dynamic confined BD tests using both the overload correction and the Griffith criterion rectification to obtain the accurate dynamic BTS of rocks.
文摘Short-time critical behavior of the random n-vector model is studied by the theoretic renormalization-group approach.Asymptotic scaling laws are studied in a frame of the expansion in e = 4 - d for n ≠ 1 and for n = 1respectively.In d ＜ 4,the initial slip exponents θ′ for the order parameter and θ for the response function are calculated up to the second order in e ＝ 4 - d for n ≠ 1 and for n ＝ 1 at the random fixed point respectively.Our results show that the random impurities exert a strong influence on the short-time dynamics for d ＜ 4 and n ＜ nc.
文摘By means of conceptual model prediction, two short-time strong precipitation processes in Xiamen on June 12th and 14th, 2008 were analyzed from the aspects of real precipitation, weather situation, physical parameter and radar echo. The results showed that two short-time strong precipitation processes had complete different weather backgrounds, so physical quantities which could reflect atmospheric thermal and dynamic characteristic were different, as well as the characteristic and evolution process of radar echo, and it revealed that two short-time strong precipitation processes in Xiamen had various formation mechanisms and evolution processes. Therefore, many data should be combined to grasp different vantage points in precipitation forecast.
文摘The high-rise frame structure has become more and more widespread, like its damage from the complication of the environment. The traditional method of damage detection, which is only suitable for the stationary signal, does not apply to a high-rise frame structure because its damage signal is non-stationary. Thus, this paper presents an application of the short-time Fourier transform(STFT) to damage detection of high-rise frame structures. Compared with the fast Fourier transform, STFT is found to be able to express the frequency spectrum property of the time interval using the signal within this interval. Application of STFT to analyzing a Matlab model and the shaking table test with a twelve-story frame-structure model reveals that there is a positive correlation between the slope of the frequency versus time and the damage level. If the slope is equal to or greater than zero, the structure is not damaged. If the slope is smaller than zero, the structure is damaged, and the less the slope is, the more serious the damage is. The damage results from calculation based on the Matlab model are consistent with those from the shaking table test, demonstrating that STFT can be a reliable tool for the damage detection of high-rise frame structures.
