Ectopic thymic tissue can be present in the thyroid gland and a carcinoma showing thymus-like differentiation(CASTLE) may arise from such tissue. We are reported the case of a 26-year-old man with CASTLE, with cervica...Ectopic thymic tissue can be present in the thyroid gland and a carcinoma showing thymus-like differentiation(CASTLE) may arise from such tissue. We are reported the case of a 26-year-old man with CASTLE, with cervical subcutaneous nodules relapse, who showed a good response to treatment with surgery, chemotherapy and radiotherapy. The problematic aspect of this case was the diagnosis; only on review were we able to make a final diagnosis. CASTLE is a very rare neoplasm. It is important to differentiate this cancer from others tumors such as primary or metastatic squamous cell carcinoma of the head and neck or squamous cell thyroid carcinoma, because the therapy and prognosis are different.Diagnosis is complicated and requires careful histological analysis(CD5- and P63-positive with presence of Hassall's corpuscles); unfortunately there is no gold standard treatment so, in this case, we administered a sandwich of chemotherapy and radiotherapy.展开更多
T he jubilee60th MSV(International Engineering Fair)has showcased cutting-edge technology and the best of the history and present of the Czech and Slovak industry.From1to5October2018,six industrial fairs were held at ...T he jubilee60th MSV(International Engineering Fair)has showcased cutting-edge technology and the best of the history and present of the Czech and Slovak industry.From1to5October2018,six industrial fairs were held at the Brno Exhibition Centre,together with a unique exhibition commemorating the100th anniversary of Czechoslovakia.展开更多
Long-persistent luminescence(LPL)has received significant focus due to its exceptional applications in high-contrast molecular imaging,photodynamic therapy,data encryption and information storage,and among many others...Long-persistent luminescence(LPL)has received significant focus due to its exceptional applications in high-contrast molecular imaging,photodynamic therapy,data encryption and information storage,and among many others^([1]).Ultralong room-temperature phosphorescence(RTP),as a form of LPL.展开更多
Dear Editor,Ion gradients are characteristic features of a living cell that do not represent thermodynamic equilibrium.These unequilibrium status are maintained by various ion pumps such as Na-K-ATPase,which are known...Dear Editor,Ion gradients are characteristic features of a living cell that do not represent thermodynamic equilibrium.These unequilibrium status are maintained by various ion pumps such as Na-K-ATPase,which are known as the P-type ATPases.Working mechanism of Na-K-ATPase is described as Post-Albers cycle1(Fig.1a).However,the reaction scheme is non-Michaelis-Menten kinetics assembled from transient-state results,which can hardly be used to rebuild the real reaction cycle.展开更多
艺术家乔希·辛普森制作玻璃球,并且他做的玻璃球会藏在地球上的任意一个地方等待人们发现。Artist Josh Simpson creates tiny glass planets that are meant to delight his audi-ence.Decades ago,he gave glassblowing demonstr...艺术家乔希·辛普森制作玻璃球,并且他做的玻璃球会藏在地球上的任意一个地方等待人们发现。Artist Josh Simpson creates tiny glass planets that are meant to delight his audi-ence.Decades ago,he gave glassblowing demonstrations to local students in his studio in Springfield,Massachusetts.Simp-son started by showing the middle-school students how to make marbles(弹子).展开更多
人生旅途的每一站,音乐如影随形。它见证并陪伴着我们的每一个情感瞬间,成为我们快乐、悲伤与沉思时刻的真挚伙伴,并构筑起生命中不朽的声音记忆。1 Music is like a friend I can always count on,showing me the way and making me fe...人生旅途的每一站,音乐如影随形。它见证并陪伴着我们的每一个情感瞬间,成为我们快乐、悲伤与沉思时刻的真挚伙伴,并构筑起生命中不朽的声音记忆。1 Music is like a friend I can always count on,showing me the way and making me feel good.When I was a little girl,it would help me fall asleep with calm songs.As I grew up,the tunes my mom and dad loved filled our house,getting me to like old hits and learn about new ones.展开更多
Chinese premier’s European trip helps boost the EU’s efforts to cope with the debt crisis Chinese Premier Wen Jiabao’s recent European tour injected confidence into the EU as it battles a debt crisist hat began 18 ...Chinese premier’s European trip helps boost the EU’s efforts to cope with the debt crisis Chinese Premier Wen Jiabao’s recent European tour injected confidence into the EU as it battles a debt crisist hat began 18 months ago,Chinese analysts said." The sovereign debt crisis continues to escalate in the EU,"said Li Weiwei,Deputy Director of the Department for EU Studieso f the China Institute of International Studies(CIIS)."Take Greece for instance.If the crisis goes on,the country may bef orced to declare bankruptcy and withdraw from the euro zone.If a domino展开更多
The "rich second generation" is a sensitive topic among modern Chinese. In manycases, the identity brings condemnation on this special group of young people. However,a 10-year-old girl from a wealthy family
Located at the center of Beijing near Tiananmen Square,Qianmen Street, no more than 2 km long,has been a prosperous area for more than 600 years and has accumulated some long-standing stores.Many well-known Chinese st...Located at the center of Beijing near Tiananmen Square,Qianmen Street, no more than 2 km long,has been a prosperous area for more than 600 years and has accumulated some long-standing stores.Many well-known Chinese stores started their operations there.The reconstruction project aims to preserve the Qianmen Street’s history in its entirety. Qianshi hutong-the narrowest hutong in Beijing-is located there.At its展开更多
The dust is slowly settling after the Sichuan quake and as restructuring work gets into full swing,the billions of yuan in donations is slowly finding their way to the
On November 19, 1999, a seminar on developing mini vehicle market was held in Beijing, with almost all major Chinese mini vehi-cle makers participating in. They are Chana Automobile (Group) Li-ability Corp., Ltd., Cha...On November 19, 1999, a seminar on developing mini vehicle market was held in Beijing, with almost all major Chinese mini vehi-cle makers participating in. They are Chana Automobile (Group) Li-ability Corp., Ltd., Changhe Air-craft Industries (Group), Ltd., Harbin Dong’An Engine Manufac-turing Company, Harbin Aircraft Manufacturing Corp. and Liuzhou Wuling Auto Co., Ltd.. The boss-es of the five enterprises展开更多
According to data collected from statistics-worthy Chinese textile enterprises surveyed by China National Textile and Apparel Council,from Jan.to Jun.,2011,the industry witnessed a balanced production to sales ratio a...According to data collected from statistics-worthy Chinese textile enterprises surveyed by China National Textile and Apparel Council,from Jan.to Jun.,2011,the industry witnessed a balanced production to sales ratio and the prof-itability has improved signiFicantly.展开更多
Output continued recovery China’s cotton textile industry saw a a slight slump in growth rate of cotton yarn production and cotton cloth production in the first half of 2010 comparedto the Jan.
Profit turned positive According to data collected from 11,773 statistics-worthy Chinese cotton textile enterprises surveyed by National Bureau of Statistics of China,
INTRODUCTION The past two decades have witnessed one of the most contentious scientific debates in the field of temperature management after cardiac arrest in adults.It started in 2002,following the publication of two...INTRODUCTION The past two decades have witnessed one of the most contentious scientific debates in the field of temperature management after cardiac arrest in adults.It started in 2002,following the publication of two groundbreaking trials showing lower mortality rates and improved neurologic recovery with the use of active cooling.[1,2]International recommendations advocate active cooling in the range of 32–34℃for comatose survivors of out-of-hospital cardiac arrest (OHCA).[3,4]The year2013 marked the tipping point with the release of the TTM 1 trial.展开更多
Historically,patients with cancer were told to avoid physical exertion.This dogma has changed over the last 2 decades,with an exponential growth in the number of studies showing not only the safety,but also the benefi...Historically,patients with cancer were told to avoid physical exertion.This dogma has changed over the last 2 decades,with an exponential growth in the number of studies showing not only the safety,but also the benefits of regular physical activity/exercise in the cancer continuum,notably for attenuating treatment-related toxicities and side effects.展开更多
The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human palate.Sixty-four CTGs belonging to anterior deep(AD),ant...The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human palate.Sixty-four CTGs belonging to anterior deep(AD),anterior superficial(AS),posterior deep(PD),and posterior superficial(PS)groups were subjected to RNA-Sequencing and their transcriptomes were analyzed computationally.Functional correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts(HPFs)extracted from the CTGs.A clearly more pronounced location-dependent than depth-dependent difference between the grafts,with a minimal number of genes(4)showing no dependence on the location,was revealed.Epithelial,endothelial,and monocytic cell migration was strongly(P<0.001)potentiated by AD-and PS-HPFs.Moreover,significantly increased expression of genes encoding C-C and C-X-C motif chemokine ligands as well as significantly(P<0.01)activated p38 signaling suggested immunomodulatory phenotype for AD-and PS-HPFs.Increased growth factor gene expression and significantly activated(P<0.001)Erk and Akt signaling in HPFs originating from A-CTGs implied their involvement in cell survival,proliferation,and motility.Prominent collagen-rich expression profile contributing to high mechanical stability,increased osteogenesis-related gene expression,and strongly activated(P<0.001)Smad1/5/8 signaling characterized HPFs originating from P-CTGs.The present data indicate that in humans,differences between palatal CTGs harvested from different locations and depths appear to be location-rather than depth-dependent.Our findings provide the basis for future personalization of the therapeutic strategy by selecting an optimal graft type depending on the clinical indications.展开更多
文摘Ectopic thymic tissue can be present in the thyroid gland and a carcinoma showing thymus-like differentiation(CASTLE) may arise from such tissue. We are reported the case of a 26-year-old man with CASTLE, with cervical subcutaneous nodules relapse, who showed a good response to treatment with surgery, chemotherapy and radiotherapy. The problematic aspect of this case was the diagnosis; only on review were we able to make a final diagnosis. CASTLE is a very rare neoplasm. It is important to differentiate this cancer from others tumors such as primary or metastatic squamous cell carcinoma of the head and neck or squamous cell thyroid carcinoma, because the therapy and prognosis are different.Diagnosis is complicated and requires careful histological analysis(CD5- and P63-positive with presence of Hassall's corpuscles); unfortunately there is no gold standard treatment so, in this case, we administered a sandwich of chemotherapy and radiotherapy.
文摘T he jubilee60th MSV(International Engineering Fair)has showcased cutting-edge technology and the best of the history and present of the Czech and Slovak industry.From1to5October2018,six industrial fairs were held at the Brno Exhibition Centre,together with a unique exhibition commemorating the100th anniversary of Czechoslovakia.
文摘Long-persistent luminescence(LPL)has received significant focus due to its exceptional applications in high-contrast molecular imaging,photodynamic therapy,data encryption and information storage,and among many others^([1]).Ultralong room-temperature phosphorescence(RTP),as a form of LPL.
基金supported by National Natural Science Foundation of China (81970418,82272116)Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01)+3 种基金ZJLabScience and Technology Commission of Shanghai Municipality (Grant No.18JC1410403)MOE Frontiers Center for Brain ScienceShanghai Municipal Health Commission Key Research Centre (2022ZZ01006).
文摘Dear Editor,Ion gradients are characteristic features of a living cell that do not represent thermodynamic equilibrium.These unequilibrium status are maintained by various ion pumps such as Na-K-ATPase,which are known as the P-type ATPases.Working mechanism of Na-K-ATPase is described as Post-Albers cycle1(Fig.1a).However,the reaction scheme is non-Michaelis-Menten kinetics assembled from transient-state results,which can hardly be used to rebuild the real reaction cycle.
文摘艺术家乔希·辛普森制作玻璃球,并且他做的玻璃球会藏在地球上的任意一个地方等待人们发现。Artist Josh Simpson creates tiny glass planets that are meant to delight his audi-ence.Decades ago,he gave glassblowing demonstrations to local students in his studio in Springfield,Massachusetts.Simp-son started by showing the middle-school students how to make marbles(弹子).
文摘人生旅途的每一站,音乐如影随形。它见证并陪伴着我们的每一个情感瞬间,成为我们快乐、悲伤与沉思时刻的真挚伙伴,并构筑起生命中不朽的声音记忆。1 Music is like a friend I can always count on,showing me the way and making me feel good.When I was a little girl,it would help me fall asleep with calm songs.As I grew up,the tunes my mom and dad loved filled our house,getting me to like old hits and learn about new ones.
文摘Chinese premier’s European trip helps boost the EU’s efforts to cope with the debt crisis Chinese Premier Wen Jiabao’s recent European tour injected confidence into the EU as it battles a debt crisist hat began 18 months ago,Chinese analysts said." The sovereign debt crisis continues to escalate in the EU,"said Li Weiwei,Deputy Director of the Department for EU Studieso f the China Institute of International Studies(CIIS)."Take Greece for instance.If the crisis goes on,the country may bef orced to declare bankruptcy and withdraw from the euro zone.If a domino
文摘The "rich second generation" is a sensitive topic among modern Chinese. In manycases, the identity brings condemnation on this special group of young people. However,a 10-year-old girl from a wealthy family
文摘Located at the center of Beijing near Tiananmen Square,Qianmen Street, no more than 2 km long,has been a prosperous area for more than 600 years and has accumulated some long-standing stores.Many well-known Chinese stores started their operations there.The reconstruction project aims to preserve the Qianmen Street’s history in its entirety. Qianshi hutong-the narrowest hutong in Beijing-is located there.At its
文摘The dust is slowly settling after the Sichuan quake and as restructuring work gets into full swing,the billions of yuan in donations is slowly finding their way to the
文摘On November 19, 1999, a seminar on developing mini vehicle market was held in Beijing, with almost all major Chinese mini vehi-cle makers participating in. They are Chana Automobile (Group) Li-ability Corp., Ltd., Changhe Air-craft Industries (Group), Ltd., Harbin Dong’An Engine Manufac-turing Company, Harbin Aircraft Manufacturing Corp. and Liuzhou Wuling Auto Co., Ltd.. The boss-es of the five enterprises
文摘According to data collected from statistics-worthy Chinese textile enterprises surveyed by China National Textile and Apparel Council,from Jan.to Jun.,2011,the industry witnessed a balanced production to sales ratio and the prof-itability has improved signiFicantly.
文摘Output continued recovery China’s cotton textile industry saw a a slight slump in growth rate of cotton yarn production and cotton cloth production in the first half of 2010 comparedto the Jan.
文摘Profit turned positive According to data collected from 11,773 statistics-worthy Chinese cotton textile enterprises surveyed by National Bureau of Statistics of China,
文摘INTRODUCTION The past two decades have witnessed one of the most contentious scientific debates in the field of temperature management after cardiac arrest in adults.It started in 2002,following the publication of two groundbreaking trials showing lower mortality rates and improved neurologic recovery with the use of active cooling.[1,2]International recommendations advocate active cooling in the range of 32–34℃for comatose survivors of out-of-hospital cardiac arrest (OHCA).[3,4]The year2013 marked the tipping point with the release of the TTM 1 trial.
基金supported by a Sara Borrell(CD21/00138)and Miguel Servet(CP18/00034)postdoctoralcontracts,respectively,granted by Instituto de Salud CarlosⅢfunded by the Spanish Ministry of Economy and Competitiveness and Fondos Feder(Alejandro Lucia,Grant No.PI18/00139+1 种基金Carmen Fiuza-Luces,Grant No.PI20/00645)by"the Wereld Kanker Onderzoek Fonds"(WKOF),as part of the World Cancer Research Fund International grant program(Grant No.IIG_FULL_2021_007)。
文摘Historically,patients with cancer were told to avoid physical exertion.This dogma has changed over the last 2 decades,with an exponential growth in the number of studies showing not only the safety,but also the benefits of regular physical activity/exercise in the cancer continuum,notably for attenuating treatment-related toxicities and side effects.
文摘The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human palate.Sixty-four CTGs belonging to anterior deep(AD),anterior superficial(AS),posterior deep(PD),and posterior superficial(PS)groups were subjected to RNA-Sequencing and their transcriptomes were analyzed computationally.Functional correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts(HPFs)extracted from the CTGs.A clearly more pronounced location-dependent than depth-dependent difference between the grafts,with a minimal number of genes(4)showing no dependence on the location,was revealed.Epithelial,endothelial,and monocytic cell migration was strongly(P<0.001)potentiated by AD-and PS-HPFs.Moreover,significantly increased expression of genes encoding C-C and C-X-C motif chemokine ligands as well as significantly(P<0.01)activated p38 signaling suggested immunomodulatory phenotype for AD-and PS-HPFs.Increased growth factor gene expression and significantly activated(P<0.001)Erk and Akt signaling in HPFs originating from A-CTGs implied their involvement in cell survival,proliferation,and motility.Prominent collagen-rich expression profile contributing to high mechanical stability,increased osteogenesis-related gene expression,and strongly activated(P<0.001)Smad1/5/8 signaling characterized HPFs originating from P-CTGs.The present data indicate that in humans,differences between palatal CTGs harvested from different locations and depths appear to be location-rather than depth-dependent.Our findings provide the basis for future personalization of the therapeutic strategy by selecting an optimal graft type depending on the clinical indications.
