Background: Significant portal hypertension(SPH) is a relative contraindication for patients with resectable hepatocellular carcinoma(HCC). However, increasing evidence indicates that liver resection is feasible for H...Background: Significant portal hypertension(SPH) is a relative contraindication for patients with resectable hepatocellular carcinoma(HCC). However, increasing evidence indicates that liver resection is feasible for HCC patients with SPH. Methods: HCC patients with cirrhosis who underwent laparoscopic liver resection(LLR) in two centers from January 2013 to April 2018 were included. Surgical and survival outcomes were analyzed to explore potential prognostic factors. Propensity score matching(PSM) analysis was performed to minimize bias. Results: A total of 165 patients were divided into two groups based on the presence(SPH, n = 76) or absence(non-SPH, n = 89) of SPH. Patients in the SPH group had longer operative time, more blood loss, and more advanced TNM stage than patients in the non-SPH group( P < 0.05). However, there were no significant differences in the postoperative 90-day mortality rate( n = 0), overall postoperative complications(47.4% vs. 41.6%, P = 0.455), Clavien-Dindo classification( P = 0.347), conversion to open surgery(9.2% vs. 6.7%, P = 0.557), or length of hospitalization(16 vs. 15 days, P = 0.203) between the SPH and non-SPH groups before PSM. Similar results were obtained after PSM. The 1-, 3-, and 5-year overall survival(OS) and recurrence-free survival rates in the SPH group were not significantly different from those in the non-SPH group both before and after PSM(log-rank P > 0.05). After PSM, alpha-fetoprotein(AFP) ≥ 400 μg/L [hazard ratio(HR) = 4.71, 95% confidence interval(CI): 2.69-8.25], ascites(HR = 2.18, 95% CI: 1.30-3.66), American Society of Anesthesiologists(ASA) classification(Ⅲ vs. Ⅱ)(HR = 2.13, 95% CI: 1.11-4.07) and tumor diameter > 5 cm(HR = 3.91, 95% CI: 2.02-7.56) independently predicted worse OS. Conclusions: LLR for patients with HCC complicated with SPH appears feasible at the price of increasing operative time and blood loss. AFP, ascites, ASA classification and tumor diameter may predict the prognosis of HCC complicated with SPH after LLR.展开更多
As wave height is an important parameter in marine climate measurement,its accurate prediction is crucial in ocean engineering.It also plays an important role in marine disaster early warning and ship design,etc.Howev...As wave height is an important parameter in marine climate measurement,its accurate prediction is crucial in ocean engineering.It also plays an important role in marine disaster early warning and ship design,etc.However,challenges in the large demand for computing resources and the improvement of accuracy are currently encountered.To resolve the above mentioned problems,sequence-to-sequence deep learning model(Seq-to-Seq)is applied to intelligently explore the internal law between the continuous wave height data output by the model,so as to realize fast and accurate predictions on wave height data.Simultaneously,ensemble empirical mode decomposition(EEMD)is adopted to reduce the non-stationarity of wave height data and solve the problem of modal aliasing caused by empirical mode decomposition(EMD),and then improves the prediction accuracy.A significant wave height forecast method integrating EEMD with the Seq-to-Seq model(EEMD-Seq-to-Seq)is proposed in this paper,and the prediction models under different time spans are established.Compared with the long short-term memory model,the novel method demonstrates increased continuity for long-term prediction and reduces prediction errors.The experiments of wave height prediction on four buoys show that the EEMD-Seq-to-Seq algorithm effectively improves the prediction accuracy in short-term(3-h,6-h,12-h and 24-h forecast horizon)and long-term(48-h and 72-h forecast horizon)predictions.展开更多
The purpose of this article is to report that some anti-A1 that react at 37°C are IgG antibodies and are clinically significant, as they can cause the destruction of a proportion of A1 cells in vivo following the...The purpose of this article is to report that some anti-A1 that react at 37°C are IgG antibodies and are clinically significant, as they can cause the destruction of a proportion of A1 cells in vivo following the transfusion of red blood cells. Therefore, when a serum of an individual contains anti-A1, further testing of the plasma against group A1, A2, and O by referencing red blood cells and individual cells against anti-A1 lectin (Dolichos biflorus lectin) must be performed. Confirming the specificity of anti-A1 by referencing red blood cells is also important in selecting the appropriate blood for transfusion. ABO antibodies are naturally occurring and activate the complement cascade, making them more likely to cause severe transfusion reactions compared to antibodies to other RBC antigens.展开更多
·AIM:To determine the risk factors of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR) in a multi-ethnics Malaysian population. ·METHODS:We performed...·AIM:To determine the risk factors of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR) in a multi-ethnics Malaysian population. ·METHODS:We performed a case control study in which 150 patients with bilateral NPDR and CSME in either eye were compared to 150 patients with bilateral NPDR and no CSME in both eyes. CSME and NPDR were graded according to Early Treatment of Diabetic Retinopathy Study criteria. Student's t-test, odds ratio and multiple logistic regression analysis were performed to analyze the duration of diabetes, body mass index (BMI), blood pressure(BP), total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TG), fasting blood glucose (FBG), HbA1c, full blood count, serum creatinine and proteinuria between the two groups. ·RESULTS:Both groups were matched in terms of age, gender and ethnicity. Duration of diabetes, total serum cholesterol, serum LDL, FBG, HbA1c and serum creatinine were significantly higher in the CSME group (P <0.05). The hemoglobin, packed cell volume were significantly lower in the CSME group (P <0.05). There was no significant difference for serum HDL, TG, BMI, systolic and diastolic BP. Multiple logistic regression analysis showed that total serum cholesterol and HbA1c had significantly high odds of developing CSME. ·CONCLUSION:HbA1c and total cholesterol are the two most important risk factors associated with CSME in patients with NPDR.展开更多
In this study, the statistical characterization of sea conditions in the East China Sea(ECS) is investigated by analyzing a significant wave height and wind speed data at a 6-hour interval for 30 years(1980–2009), wh...In this study, the statistical characterization of sea conditions in the East China Sea(ECS) is investigated by analyzing a significant wave height and wind speed data at a 6-hour interval for 30 years(1980–2009), which was simulated and computed using the WAVEWATCH Ⅲ(WW3) model. The monthly variations of these parameters showed that the significant wave height and wind speed have minimum values of 0.73 m and 5.15 ms^(-1) and 1.73 m and 8.24 ms^(-1) in the month of May and December, respectively. The annual, seasonal, and monthly mean sea state characterizations showed that the slight sea generally prevailed in the ECS and had nearly the highest occurrence in all seasons and months. Additionally, the moderate sea prevailed in the winter months of December and January, while the smooth(wavelets) sea prevailed in May. Furthermore, the spatial variation of sea states showed that the calm and smooth sea had the largest occurrences in the northern ECS. The slight sea occurred mostly(above 30%) in parts of the ECS and the surrounding locations, while higher occurrences of the rough and very rough seas were distributed in waters between the southwest ECS and the northeast South China Sea(SCS). The occurrences of the phenomenal sea conditions are insignificant and are distributed in the northwest Pacific and its upper region, which includes the Southern Kyushu-Palau Ridge and Ryukyu Trench.展开更多
The main objective of this paper is to propose a newly developed ocean Significant Wave Height (SWH) retrieval method from Envisat Advanced Synthetic Aperture Radar (ASAR) imagery. A series of wave mode imagery from J...The main objective of this paper is to propose a newly developed ocean Significant Wave Height (SWH) retrieval method from Envisat Advanced Synthetic Aperture Radar (ASAR) imagery. A series of wave mode imagery from January, April and May of 2011 are collocated with ERA-Interim reanalysis SWH data. Based on the matched datasets, a simplified empirical relationship between 22 types of SAR imagery parameters and SWH products is developed with the Genetic Algorithms Partial Least-Squares (GA-PLS) model. Two major features of the backscattering coefficient σ0 and the frequency parameter S10 are chosen as the optimal training feature subset of SWH retrieval by using cross validation. In addition, we also present a comparison of the retrieval results of the simplified empirical relationship with the collocated ERA-Interim data. The results show that the assessment index of the correlation coefficient, the bias, the root-mean-square error of cross validation (RMSECV) and the scattering index (SI) are 0.78, 0.07 m, 0.76 m and 0.5, respectively. In addition, the comparison of the retrieved SWH data between our simplifying model and the Jason-2 radar altimeter data is proposed in our study. Moreover, we also make a comparison of the retrieval of SWH data between our developed model and the well- known CWAVE_ENV model. The results show that satisfying retrieval results are acquired in the low-moderate sea state, but major bias appears in the high sea state, especially for SWH>5 m.展开更多
Since 2015,the China Geological Survey has implemented a major program of'Geology Survey of Land Energy Mineral Resources'.Till now,a total of billions of RMB have been invested and seven engineering projects ...Since 2015,the China Geological Survey has implemented a major program of'Geology Survey of Land Energy Mineral Resources'.Till now,a total of billions of RMB have been invested and seven engineering projects have been established,all of which has greatly enhanced the geological survey and exploration of China’s continental shale gas in an展开更多
A WAVEWATCH III version 3.14(WW3) wave model is used to evaluate input/dissipation source term packages WAM3, WAM4 and TC96 considering the effect of atmospheric instability. The comparisons of a significant wave heig...A WAVEWATCH III version 3.14(WW3) wave model is used to evaluate input/dissipation source term packages WAM3, WAM4 and TC96 considering the effect of atmospheric instability. The comparisons of a significant wave height acquired from the model with different packages have been performed based on wave observation radar and HY-2 altimetry significant wave height data through five experiments in the South China Sea domain spanning latitudes of 0°–35°N and longitudes of 100°–135°E. The sensitivity of the wind speed correction parameter in the TC96 package also has been analyzed. From the results, the model is unable to dissipate the wave energy efficiently during a swell propagation with either source packages. It is found that TC96 formulation with the "effective wind speed" strategy performs better than WAM3 and WAM4 formulations. The wind speed correction parameter in the TC96 source package is very sensitive and needs to be calibrated and selected before the WW3 model can be applied to a specific region.展开更多
AIM: To evaluate related factors with the change of spherical equivalents(ΔSE) and determine the suitable predictor of clinically significant ΔSE(≥0.50 D) with cyclopentolate hydrochloride on Chinese children. METH...AIM: To evaluate related factors with the change of spherical equivalents(ΔSE) and determine the suitable predictor of clinically significant ΔSE(≥0.50 D) with cyclopentolate hydrochloride on Chinese children. METHODS: A total of 145 right eyes of 145 children aged 4 to 15 y were enrolled. Intraocular pressure, axial length and lag of accommodation(LOA) were assessed before cycloplegia induced by 3 drops of 1% cyclopentolate at 5-minute intervals. SE was measured before and 1 h after the first drop of cyclopentolate. ΔSE was compared between different gender groups and among refractive groups. Multivariate linear regression analysis was performed to find related factors with ΔSE. ROC analysis was used to figure out the suitable predictor of clinically significant ΔSE.RESULTS: For the total 145 eyes, the mean SE reached up to-0.70±1.86 D from-1.30±1.62 D, with the mean ΔSE of 0.60±0.55 D. The mean ΔSE were 0.63±0.55 D and 0.57±0.56 D respectively in the male and female group(P=0.40). The mean ΔSE was significantly different among different refractive groups(P<0.0001), with the ΔSE of hyperopia group(1.12±0.64 D) larger than that of the emmetropia(0.56±0.43 D, P=0.001) and myopia group(0.32±0.28 D, P<0.0001). The ΔSE was correlated with LOA(B=-0.54, P<0.0001), cycloplegic SE(B=0.10, P<0.0001) and age(B=-0.04, P=0.015). ROC curve indicated that LOA predicted clinically significant ΔSE by 82% [area under the curve(AUC)=0.82] alone, while the value was slightly improved to 85%(AUC=0.85) in combination with axial length and 86%(AUC=0.86) in association with axial length as well as age.CONCLUSION: After cycloplegia with cyclopentolate, the ΔSE decreases with larger LOA, longer axial length and older age. Specifically, LOA plays a more vital role in predicting clinically significant ΔSE.展开更多
1 Dinosaur Eggs in Yiwu City,Zhejiang Province In February 2017,dinosaur egg fossils were discovered in China Town part of Yiwu City,Zhejiang Province.They were confirmed by dinosaur experts from the Zhejiang Museum o...1 Dinosaur Eggs in Yiwu City,Zhejiang Province In February 2017,dinosaur egg fossils were discovered in China Town part of Yiwu City,Zhejiang Province.They were confirmed by dinosaur experts from the Zhejiang Museum of Natural History to be those of Mesozoic herbivorous dinosaurs(Fig.1).Not long before,Yiwu Museum staff had discovered dinosaur eggs close by this place.展开更多
With the arising global awareness of the ocean,relevant countries are competing to name the discovered undersea features at the international seabed areas in recent years.The Sub-Committee on Undersea Feature Names(SC...With the arising global awareness of the ocean,relevant countries are competing to name the discovered undersea features at the international seabed areas in recent years.The Sub-Committee on Undersea Feature Names(SCUFN)is a joint organization under the Intergovernmental Oceanographic Commission of United Nations Educational,Scientific and Cultural Organization and展开更多
In this short review paper, the significant and profound impacts of the Pseudo Amino Acid Composition or PseAAC have been briefly presented with crystal clear convincingness.
In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="...In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="EN-US" style="line-height: 97%;font-family:;" capt",serif;font-size:11pt;"="" pro="" minion="">been briefly recalled with crystal clear convincingness.</span></span></span>展开更多
Background:Meta-analysis of quantitative trait locus(QTL)is a computational technique to identify consensus QTL and refine QTL positions on the consensus map from multiple mapping studies.The combination of meta-QTL i...Background:Meta-analysis of quantitative trait locus(QTL)is a computational technique to identify consensus QTL and refine QTL positions on the consensus map from multiple mapping studies.The combination of meta-QTL intervals,significant SNPs and transcriptome analysis has been widely used to identify candidate genes in various plants.Results:In our study,884 QTLs associated with cotton fiber quality traits from 12 studies were used for meta-QTL analysis based on reference genome TM-1,as a result,74 meta-QTLs were identified,including 19 meta-QTLs for fiber length;18 meta-QTLs for fiber strength;11 meta-QTLs for fiber uniformity;11 meta-QTLs for fiber elongation;and 15 meta-QTLs for micronaire.Combined with 8589 significant single nucleotide polymorphisms associated with fiber quality traits collected from 15 studies,297 candidate genes were identified in the meta-QTL intervals,20 of which showed high expression levels specifically in the developing fibers.According to the function annotations,some of the 20 key candidate genes are associated with the fiber development.Conclusions:This study provides not only stable QTLs used for marker-assisted selection,but also candidate genes to uncover the molecular mechanisms for cotton fiber development.展开更多
The significant wave height(SWH)is one of the main parameters that describe wave characteristics and is widely used in wave research fields.Wave parameters measured by radar are influenced by the offshore distance and...The significant wave height(SWH)is one of the main parameters that describe wave characteristics and is widely used in wave research fields.Wave parameters measured by radar are influenced by the offshore distance and sea state.Validation and calibration are of great significance for radar data applications.The nadir beam of surface wave investigation and monitoring(SWIM)detects the global-ocean-surface SWH.To determine the product quality of SWIM SWH,this paper carried out time-space matching between SWIM and buoy data.The data qualities were evaluated under different offshore distances and sea states.An improved calibration method was proposed based on sea state segmentation,which considered the distribution of the point collocation numbers in various sea states.The results indicate that(1)the SWIM SWH accuracy at offshore distances greater than 50 km is higher than that at distances less than 50 km,with an root mean squared error(RMSE)of 0.2444 m,scatter index(SI)of 0.1156 and relative error(RE)of 9.97%at distances greater than 50 km and those of 0.4460 m,0.2230 and18.66%at distances less than 50 km.(2)SWIM SWH qualities are better in moderate and rough sea states with RMSEs of 0.2848 m and 0.3169 m but are worse in slight and very rough sea states.(3)The effect of the improved calibration method is superior to the traditional method in each sea state and overall data,and the RMSE of SWIM SWH is reduced from the raw 0.3135 m to 0.2859 m by the traditional method and 0.1982 m by the improved method.The influence of spatiotemporal window selection on data quality evaluation was analyzed in this paper.This paper provides references for SWIM SWH product applications.展开更多
The objective of this paper is to propose an empirical method to inverse significant wave height(SWH)under typhoon conditions from collected dual-polarization Gaofen(GF)-3 synthetic aperture radar(SAR)imagery.The typh...The objective of this paper is to propose an empirical method to inverse significant wave height(SWH)under typhoon conditions from collected dual-polarization Gaofen(GF)-3 synthetic aperture radar(SAR)imagery.The typhoon scenes were cap-tured from narrow scan(NSC)and wide scan(WSC)images,and collocated with European Center for Medium-Range Weather Fore-casts reanalysis data of(ECMWF).To improve the quality of GF-3 SAR images,the recalibration over rainforest and de-scalloping were carried out.To establish the empirical relationship between SAR-derived parameters and collocated SWH,the sensitivity analysis of typical parameters about the normalized radar cross section(Nrcs)and imagery variance(Cvar)were performed to both VV and VH polarized images.Four scenes from GF-3 SAR imagery under typhoon conditions were used for training the model by the multivari-ate least square regression,and one scene was used for preliminary validation.It was found that the joint retrieval model based on VV and VH polarized SAR imagery performed better than any single polarized model.These results,verified by using ECMWF data,revealed the soundness of this approach,with a correlation of 0.95,bias of 0 m,RMSE of 0.44 and SI of 0.01 when VV polarization and VH polarization data were both used.展开更多
As one of essential multimedia in quantum networks, the copyright protection of quantum audio has gradually become an important issue in the domain of quantum information hiding in the decades. In this paper, an impro...As one of essential multimedia in quantum networks, the copyright protection of quantum audio has gradually become an important issue in the domain of quantum information hiding in the decades. In this paper, an improved quantum watermarking algorithm based on quantum audio by using least significant qubit(LSQb) modification is proposed. Compared with the previous achievements, it can effectively improve the robustness and security of watermark for copyright protection of quantum audio. In the new algorithm, the least significant bites and the peripheral least significant bits of the amplitudes are modified in terms of their logical consistency and correlation to enhance watermark robustness of resisting various illegal attacks. Furthermore, the new algorithm can avoid the weak robustness defect of many previous algorithms that directly embedded the watermark into the least significant bits. In order to implement the new algorithm, some specific quantum circuits are designed to obtain better applicability and scalability for embedding and extracting watermark.Finally, the simulation results including the values of audio waveforms and signal to noise ratios(SNR) prove that the new algorithm has good transparency, robustness, and security.展开更多
Specific fluorophore was introduced into ionic liquid based on its tunability,thus a kind of novel fluorescent ionic liquid probe[P66614][HQS]was designed,synthesized and characterized.Compared with non-fluorescent HQ...Specific fluorophore was introduced into ionic liquid based on its tunability,thus a kind of novel fluorescent ionic liquid probe[P66614][HQS]was designed,synthesized and characterized.Compared with non-fluorescent HQS,ionic liquid[P66614][HQS]emitted a certain amount of fluorescence,which could be attributed to the well-delocalized frontier orbitals and its charge transfer character,as demonstrated by quantum chemical calculation.Considering the interaction of[P66614][HQS]with metal ions,the application for detecting specific substance as a chemical sensor,such as Al3+was investigated.Compared with the traditional probe HQS,significant improvements in Al^3+detecting was achieved by[P66614][HQS]with stronger binding ability,better sensitivity and selectivity.The better performance of[P66614][HQS]was contributed to the changed charge distribution,leading to the stronger binding interaction.We believe that this new fluorescent ionic liquid exhibited unique properties in detecting Al^3+in aqueous solution,which would broaden the application of ionic liquids.展开更多
In this short review paper, the significant and profound impacts of the Chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.
Prehypertension and hypertension have been considered significant public health issues worldwide[1].Disproportionate body fat distribution(excess fat stored in the liver and visceral compartment)is a well-established ...Prehypertension and hypertension have been considered significant public health issues worldwide[1].Disproportionate body fat distribution(excess fat stored in the liver and visceral compartment)is a well-established risk factor for prehypertension/hypertension[2].However,the most commonly used anthropometric indicators,such as body mass index(BMI)and waist circumference(WC)。展开更多
基金supported by grants from the National Natu-ral Science Foundation of China(81701950 and 82172135)Medi-cal Research Projects of Chongqing for staffagainst the epidemic(2020FYYX248)the Kuanren Talents Program of the Second Affiliated Hospital,Chongqing Medical University(KY2019Y002).
文摘Background: Significant portal hypertension(SPH) is a relative contraindication for patients with resectable hepatocellular carcinoma(HCC). However, increasing evidence indicates that liver resection is feasible for HCC patients with SPH. Methods: HCC patients with cirrhosis who underwent laparoscopic liver resection(LLR) in two centers from January 2013 to April 2018 were included. Surgical and survival outcomes were analyzed to explore potential prognostic factors. Propensity score matching(PSM) analysis was performed to minimize bias. Results: A total of 165 patients were divided into two groups based on the presence(SPH, n = 76) or absence(non-SPH, n = 89) of SPH. Patients in the SPH group had longer operative time, more blood loss, and more advanced TNM stage than patients in the non-SPH group( P < 0.05). However, there were no significant differences in the postoperative 90-day mortality rate( n = 0), overall postoperative complications(47.4% vs. 41.6%, P = 0.455), Clavien-Dindo classification( P = 0.347), conversion to open surgery(9.2% vs. 6.7%, P = 0.557), or length of hospitalization(16 vs. 15 days, P = 0.203) between the SPH and non-SPH groups before PSM. Similar results were obtained after PSM. The 1-, 3-, and 5-year overall survival(OS) and recurrence-free survival rates in the SPH group were not significantly different from those in the non-SPH group both before and after PSM(log-rank P > 0.05). After PSM, alpha-fetoprotein(AFP) ≥ 400 μg/L [hazard ratio(HR) = 4.71, 95% confidence interval(CI): 2.69-8.25], ascites(HR = 2.18, 95% CI: 1.30-3.66), American Society of Anesthesiologists(ASA) classification(Ⅲ vs. Ⅱ)(HR = 2.13, 95% CI: 1.11-4.07) and tumor diameter > 5 cm(HR = 3.91, 95% CI: 2.02-7.56) independently predicted worse OS. Conclusions: LLR for patients with HCC complicated with SPH appears feasible at the price of increasing operative time and blood loss. AFP, ascites, ASA classification and tumor diameter may predict the prognosis of HCC complicated with SPH after LLR.
基金The Project Supported by Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)under contract No.SML2020SP007the National Natural Science Foundation of China under contract Nos 42192562 and 62072249.
文摘As wave height is an important parameter in marine climate measurement,its accurate prediction is crucial in ocean engineering.It also plays an important role in marine disaster early warning and ship design,etc.However,challenges in the large demand for computing resources and the improvement of accuracy are currently encountered.To resolve the above mentioned problems,sequence-to-sequence deep learning model(Seq-to-Seq)is applied to intelligently explore the internal law between the continuous wave height data output by the model,so as to realize fast and accurate predictions on wave height data.Simultaneously,ensemble empirical mode decomposition(EEMD)is adopted to reduce the non-stationarity of wave height data and solve the problem of modal aliasing caused by empirical mode decomposition(EMD),and then improves the prediction accuracy.A significant wave height forecast method integrating EEMD with the Seq-to-Seq model(EEMD-Seq-to-Seq)is proposed in this paper,and the prediction models under different time spans are established.Compared with the long short-term memory model,the novel method demonstrates increased continuity for long-term prediction and reduces prediction errors.The experiments of wave height prediction on four buoys show that the EEMD-Seq-to-Seq algorithm effectively improves the prediction accuracy in short-term(3-h,6-h,12-h and 24-h forecast horizon)and long-term(48-h and 72-h forecast horizon)predictions.
文摘The purpose of this article is to report that some anti-A1 that react at 37°C are IgG antibodies and are clinically significant, as they can cause the destruction of a proportion of A1 cells in vivo following the transfusion of red blood cells. Therefore, when a serum of an individual contains anti-A1, further testing of the plasma against group A1, A2, and O by referencing red blood cells and individual cells against anti-A1 lectin (Dolichos biflorus lectin) must be performed. Confirming the specificity of anti-A1 by referencing red blood cells is also important in selecting the appropriate blood for transfusion. ABO antibodies are naturally occurring and activate the complement cascade, making them more likely to cause severe transfusion reactions compared to antibodies to other RBC antigens.
文摘·AIM:To determine the risk factors of clinically significant macular edema (CSME) in patients with non-proliferative diabetic retinopathy (NPDR) in a multi-ethnics Malaysian population. ·METHODS:We performed a case control study in which 150 patients with bilateral NPDR and CSME in either eye were compared to 150 patients with bilateral NPDR and no CSME in both eyes. CSME and NPDR were graded according to Early Treatment of Diabetic Retinopathy Study criteria. Student's t-test, odds ratio and multiple logistic regression analysis were performed to analyze the duration of diabetes, body mass index (BMI), blood pressure(BP), total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglycerides (TG), fasting blood glucose (FBG), HbA1c, full blood count, serum creatinine and proteinuria between the two groups. ·RESULTS:Both groups were matched in terms of age, gender and ethnicity. Duration of diabetes, total serum cholesterol, serum LDL, FBG, HbA1c and serum creatinine were significantly higher in the CSME group (P <0.05). The hemoglobin, packed cell volume were significantly lower in the CSME group (P <0.05). There was no significant difference for serum HDL, TG, BMI, systolic and diastolic BP. Multiple logistic regression analysis showed that total serum cholesterol and HbA1c had significantly high odds of developing CSME. ·CONCLUSION:HbA1c and total cholesterol are the two most important risk factors associated with CSME in patients with NPDR.
基金supported by the National Key Research and Development Program of China(No.2016YFC1401405)the National Natural Science Foundation of China(No.41376010)
文摘In this study, the statistical characterization of sea conditions in the East China Sea(ECS) is investigated by analyzing a significant wave height and wind speed data at a 6-hour interval for 30 years(1980–2009), which was simulated and computed using the WAVEWATCH Ⅲ(WW3) model. The monthly variations of these parameters showed that the significant wave height and wind speed have minimum values of 0.73 m and 5.15 ms^(-1) and 1.73 m and 8.24 ms^(-1) in the month of May and December, respectively. The annual, seasonal, and monthly mean sea state characterizations showed that the slight sea generally prevailed in the ECS and had nearly the highest occurrence in all seasons and months. Additionally, the moderate sea prevailed in the winter months of December and January, while the smooth(wavelets) sea prevailed in May. Furthermore, the spatial variation of sea states showed that the calm and smooth sea had the largest occurrences in the northern ECS. The slight sea occurred mostly(above 30%) in parts of the ECS and the surrounding locations, while higher occurrences of the rough and very rough seas were distributed in waters between the southwest ECS and the northeast South China Sea(SCS). The occurrences of the phenomenal sea conditions are insignificant and are distributed in the northwest Pacific and its upper region, which includes the Southern Kyushu-Palau Ridge and Ryukyu Trench.
基金The National Science Foundation for Young Scientists of China under contract No.61501130the National Key Research and Development Program of China under contract Nos 2016YFB0502504 and 2016YFB0502500the National Natural Science Foundation of China under contract Nos 41431174,61471358 and 41401427
文摘The main objective of this paper is to propose a newly developed ocean Significant Wave Height (SWH) retrieval method from Envisat Advanced Synthetic Aperture Radar (ASAR) imagery. A series of wave mode imagery from January, April and May of 2011 are collocated with ERA-Interim reanalysis SWH data. Based on the matched datasets, a simplified empirical relationship between 22 types of SAR imagery parameters and SWH products is developed with the Genetic Algorithms Partial Least-Squares (GA-PLS) model. Two major features of the backscattering coefficient σ0 and the frequency parameter S10 are chosen as the optimal training feature subset of SWH retrieval by using cross validation. In addition, we also present a comparison of the retrieval results of the simplified empirical relationship with the collocated ERA-Interim data. The results show that the assessment index of the correlation coefficient, the bias, the root-mean-square error of cross validation (RMSECV) and the scattering index (SI) are 0.78, 0.07 m, 0.76 m and 0.5, respectively. In addition, the comparison of the retrieved SWH data between our simplifying model and the Jason-2 radar altimeter data is proposed in our study. Moreover, we also make a comparison of the retrieval of SWH data between our developed model and the well- known CWAVE_ENV model. The results show that satisfying retrieval results are acquired in the low-moderate sea state, but major bias appears in the high sea state, especially for SWH>5 m.
文摘Since 2015,the China Geological Survey has implemented a major program of'Geology Survey of Land Energy Mineral Resources'.Till now,a total of billions of RMB have been invested and seven engineering projects have been established,all of which has greatly enhanced the geological survey and exploration of China’s continental shale gas in an
基金The National Natural Science Foundation of China under contract No.41406007the National Key Research and Development Project of China under contract No.2016YFC1401800+1 种基金the National Natural Science Foundation of China under contract No.41306002the Fundamental Research Funds for the Central Universities of China under contract Nos 16CX02011A and 15CX08011A
文摘A WAVEWATCH III version 3.14(WW3) wave model is used to evaluate input/dissipation source term packages WAM3, WAM4 and TC96 considering the effect of atmospheric instability. The comparisons of a significant wave height acquired from the model with different packages have been performed based on wave observation radar and HY-2 altimetry significant wave height data through five experiments in the South China Sea domain spanning latitudes of 0°–35°N and longitudes of 100°–135°E. The sensitivity of the wind speed correction parameter in the TC96 package also has been analyzed. From the results, the model is unable to dissipate the wave energy efficiently during a swell propagation with either source packages. It is found that TC96 formulation with the "effective wind speed" strategy performs better than WAM3 and WAM4 formulations. The wind speed correction parameter in the TC96 source package is very sensitive and needs to be calibrated and selected before the WW3 model can be applied to a specific region.
文摘AIM: To evaluate related factors with the change of spherical equivalents(ΔSE) and determine the suitable predictor of clinically significant ΔSE(≥0.50 D) with cyclopentolate hydrochloride on Chinese children. METHODS: A total of 145 right eyes of 145 children aged 4 to 15 y were enrolled. Intraocular pressure, axial length and lag of accommodation(LOA) were assessed before cycloplegia induced by 3 drops of 1% cyclopentolate at 5-minute intervals. SE was measured before and 1 h after the first drop of cyclopentolate. ΔSE was compared between different gender groups and among refractive groups. Multivariate linear regression analysis was performed to find related factors with ΔSE. ROC analysis was used to figure out the suitable predictor of clinically significant ΔSE.RESULTS: For the total 145 eyes, the mean SE reached up to-0.70±1.86 D from-1.30±1.62 D, with the mean ΔSE of 0.60±0.55 D. The mean ΔSE were 0.63±0.55 D and 0.57±0.56 D respectively in the male and female group(P=0.40). The mean ΔSE was significantly different among different refractive groups(P<0.0001), with the ΔSE of hyperopia group(1.12±0.64 D) larger than that of the emmetropia(0.56±0.43 D, P=0.001) and myopia group(0.32±0.28 D, P<0.0001). The ΔSE was correlated with LOA(B=-0.54, P<0.0001), cycloplegic SE(B=0.10, P<0.0001) and age(B=-0.04, P=0.015). ROC curve indicated that LOA predicted clinically significant ΔSE by 82% [area under the curve(AUC)=0.82] alone, while the value was slightly improved to 85%(AUC=0.85) in combination with axial length and 86%(AUC=0.86) in association with axial length as well as age.CONCLUSION: After cycloplegia with cyclopentolate, the ΔSE decreases with larger LOA, longer axial length and older age. Specifically, LOA plays a more vital role in predicting clinically significant ΔSE.
文摘1 Dinosaur Eggs in Yiwu City,Zhejiang Province In February 2017,dinosaur egg fossils were discovered in China Town part of Yiwu City,Zhejiang Province.They were confirmed by dinosaur experts from the Zhejiang Museum of Natural History to be those of Mesozoic herbivorous dinosaurs(Fig.1).Not long before,Yiwu Museum staff had discovered dinosaur eggs close by this place.
基金Project of Mineral Exploration and Exploitation in the Area(DY135-ZC-01)support by COMRA
文摘With the arising global awareness of the ocean,relevant countries are competing to name the discovered undersea features at the international seabed areas in recent years.The Sub-Committee on Undersea Feature Names(SCUFN)is a joint organization under the Intergovernmental Oceanographic Commission of United Nations Educational,Scientific and Cultural Organization and
文摘In this short review paper, the significant and profound impacts of the Pseudo Amino Acid Composition or PseAAC have been briefly presented with crystal clear convincingness.
文摘In this short review paper, the significant and profound impacts of the 5-steps rule have <span style="mso-bookmark:OLE_LINK2;"><span style="mso-bookmark:OLE_LINK1;"><span lang="EN-US" style="line-height: 97%;font-family:;" capt",serif;font-size:11pt;"="" pro="" minion="">been briefly recalled with crystal clear convincingness.</span></span></span>
基金This work was supported by the National Natural Science Foundation of China(31760402)Public Welfare Research Projects in the Autonomous Region(KY2019002)Special Programs for New Varieties Cultivation of Shihezi University(YZZX201701).
文摘Background:Meta-analysis of quantitative trait locus(QTL)is a computational technique to identify consensus QTL and refine QTL positions on the consensus map from multiple mapping studies.The combination of meta-QTL intervals,significant SNPs and transcriptome analysis has been widely used to identify candidate genes in various plants.Results:In our study,884 QTLs associated with cotton fiber quality traits from 12 studies were used for meta-QTL analysis based on reference genome TM-1,as a result,74 meta-QTLs were identified,including 19 meta-QTLs for fiber length;18 meta-QTLs for fiber strength;11 meta-QTLs for fiber uniformity;11 meta-QTLs for fiber elongation;and 15 meta-QTLs for micronaire.Combined with 8589 significant single nucleotide polymorphisms associated with fiber quality traits collected from 15 studies,297 candidate genes were identified in the meta-QTL intervals,20 of which showed high expression levels specifically in the developing fibers.According to the function annotations,some of the 20 key candidate genes are associated with the fiber development.Conclusions:This study provides not only stable QTLs used for marker-assisted selection,but also candidate genes to uncover the molecular mechanisms for cotton fiber development.
基金The National Key R&D Program of China under contract No.2017YFC1405600the National Natural Science Foundation of China under contract Nos 61931025,41974144 and 41976173+1 种基金the Graduate Innovation Project of China University of Petroleum(East China)under contract No.YCX2021124the Shandong Provincial Natural Science Foundation of China under contract No.ZR2019MD016。
文摘The significant wave height(SWH)is one of the main parameters that describe wave characteristics and is widely used in wave research fields.Wave parameters measured by radar are influenced by the offshore distance and sea state.Validation and calibration are of great significance for radar data applications.The nadir beam of surface wave investigation and monitoring(SWIM)detects the global-ocean-surface SWH.To determine the product quality of SWIM SWH,this paper carried out time-space matching between SWIM and buoy data.The data qualities were evaluated under different offshore distances and sea states.An improved calibration method was proposed based on sea state segmentation,which considered the distribution of the point collocation numbers in various sea states.The results indicate that(1)the SWIM SWH accuracy at offshore distances greater than 50 km is higher than that at distances less than 50 km,with an root mean squared error(RMSE)of 0.2444 m,scatter index(SI)of 0.1156 and relative error(RE)of 9.97%at distances greater than 50 km and those of 0.4460 m,0.2230 and18.66%at distances less than 50 km.(2)SWIM SWH qualities are better in moderate and rough sea states with RMSEs of 0.2848 m and 0.3169 m but are worse in slight and very rough sea states.(3)The effect of the improved calibration method is superior to the traditional method in each sea state and overall data,and the RMSE of SWIM SWH is reduced from the raw 0.3135 m to 0.2859 m by the traditional method and 0.1982 m by the improved method.The influence of spatiotemporal window selection on data quality evaluation was analyzed in this paper.This paper provides references for SWIM SWH product applications.
基金by the National Natural Science Foundation of China(No.4197060692).
文摘The objective of this paper is to propose an empirical method to inverse significant wave height(SWH)under typhoon conditions from collected dual-polarization Gaofen(GF)-3 synthetic aperture radar(SAR)imagery.The typhoon scenes were cap-tured from narrow scan(NSC)and wide scan(WSC)images,and collocated with European Center for Medium-Range Weather Fore-casts reanalysis data of(ECMWF).To improve the quality of GF-3 SAR images,the recalibration over rainforest and de-scalloping were carried out.To establish the empirical relationship between SAR-derived parameters and collocated SWH,the sensitivity analysis of typical parameters about the normalized radar cross section(Nrcs)and imagery variance(Cvar)were performed to both VV and VH polarized images.Four scenes from GF-3 SAR imagery under typhoon conditions were used for training the model by the multivari-ate least square regression,and one scene was used for preliminary validation.It was found that the joint retrieval model based on VV and VH polarized SAR imagery performed better than any single polarized model.These results,verified by using ECMWF data,revealed the soundness of this approach,with a correlation of 0.95,bias of 0 m,RMSE of 0.44 and SI of 0.01 when VV polarization and VH polarization data were both used.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61373131,61303039,61232016,and 61501247)Sichuan Youth Science and Technique Foundation,China(Grant No.2017JQ0048)+1 种基金NUIST Research Foundation for Talented Scholars of China(Grant No.2015r014)PAPD and CICAEET Funds of China
文摘As one of essential multimedia in quantum networks, the copyright protection of quantum audio has gradually become an important issue in the domain of quantum information hiding in the decades. In this paper, an improved quantum watermarking algorithm based on quantum audio by using least significant qubit(LSQb) modification is proposed. Compared with the previous achievements, it can effectively improve the robustness and security of watermark for copyright protection of quantum audio. In the new algorithm, the least significant bites and the peripheral least significant bits of the amplitudes are modified in terms of their logical consistency and correlation to enhance watermark robustness of resisting various illegal attacks. Furthermore, the new algorithm can avoid the weak robustness defect of many previous algorithms that directly embedded the watermark into the least significant bits. In order to implement the new algorithm, some specific quantum circuits are designed to obtain better applicability and scalability for embedding and extracting watermark.Finally, the simulation results including the values of audio waveforms and signal to noise ratios(SNR) prove that the new algorithm has good transparency, robustness, and security.
基金We acknowledge the support of the National Key Basic Research Program of China(2015CB251401)the Natural Science Foundation of China(21776239)+1 种基金Zhejiang Provincial Natural Science Foundation of China(LZ17B060001)the Fundamental Research Funds of the Central Universities,the instrument support of professor Peng Xiaogang,professor Jin Yizheng and associate professor Qin Haiyan.
文摘Specific fluorophore was introduced into ionic liquid based on its tunability,thus a kind of novel fluorescent ionic liquid probe[P66614][HQS]was designed,synthesized and characterized.Compared with non-fluorescent HQS,ionic liquid[P66614][HQS]emitted a certain amount of fluorescence,which could be attributed to the well-delocalized frontier orbitals and its charge transfer character,as demonstrated by quantum chemical calculation.Considering the interaction of[P66614][HQS]with metal ions,the application for detecting specific substance as a chemical sensor,such as Al3+was investigated.Compared with the traditional probe HQS,significant improvements in Al^3+detecting was achieved by[P66614][HQS]with stronger binding ability,better sensitivity and selectivity.The better performance of[P66614][HQS]was contributed to the changed charge distribution,leading to the stronger binding interaction.We believe that this new fluorescent ionic liquid exhibited unique properties in detecting Al^3+in aqueous solution,which would broaden the application of ionic liquids.
文摘In this short review paper, the significant and profound impacts of the Chou’s “invariance theorem” have been briefly presented with crystal clear convincingness.
基金supported by the Key Specialty Construction Project of Pudong Health and Family Planning Commission of Shanghai [Grant No.PWZzk2017-29]Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai [Grant No.PWRI2018-02]National Natural Science Foundation of China [81170738,81671595]
文摘Prehypertension and hypertension have been considered significant public health issues worldwide[1].Disproportionate body fat distribution(excess fat stored in the liver and visceral compartment)is a well-established risk factor for prehypertension/hypertension[2].However,the most commonly used anthropometric indicators,such as body mass index(BMI)and waist circumference(WC)。
