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Polysubstituted Isoflavonoids from Spatholobus suberectus,Flemingia macrophylla,and Cudrania cochinchinensis 被引量:8
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作者 Li-Xia Wang Hai-Rong Zheng +4 位作者 Fu-Cai Ren Tian-Gc Chen Xiang-Mei Li Xian-Jun Jiang Fei Wang 《Natural Products and Bioprospecting》 CAS 2017年第2期201-206,共6页
Four hitherto unknown polysubstituted isofiavonoids,including three isofiavans:7,4'-dihydroxy-8,2',3'-trimethoxyisofiavan(1),7,2',4'-trihydroxy-8,3'-dimethoxyisofiavan(2),and 7,2',4'-tr... Four hitherto unknown polysubstituted isofiavonoids,including three isofiavans:7,4'-dihydroxy-8,2',3'-trimethoxyisofiavan(1),7,2',4'-trihydroxy-8,3'-dimethoxyisofiavan(2),and 7,2',4'-trihydroxy-5-methoxyisofiavan(3),and one prenylated isofiavone cudraisofiavone M(4)were isolated from the ethanol extracts of Spatholobus suberectus(for 1 and 2),Flemingia macrophylla(for 3),and Cudrania cochinchinensis(for 4),respectively.Their structures were estab­lished on the basis of extensive spectroscopic analysis.Compounds 1 and 4 exhibited weak cytotoxic activity against five human cancer cell lines(HL-60,A-549,SMMC-7721,MCF-7,and SW-480). 展开更多
关键词 spatholobus suberect us Flemingia macrophylla Cudrania cochinchinensis Isofiavan Isofiavone CYTOTOXICITY
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Cultural Practices for Propagation of Spatholobus suberectus via Cutting into Polybags
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作者 Maojin YE Ribin HUANG +4 位作者 Chunyun CHEN Dachang NING Su ZHANG Shufu CHEN Qingsong DONG 《Medicinal Plant》 CAS 2021年第5期17-19,24,共4页
In this paper,the propagation of Spatholobus suberectus Dunn.was optimized based on the research results conducted in propagation for many years and the actual need for the planting materials.According to the requirem... In this paper,the propagation of Spatholobus suberectus Dunn.was optimized based on the research results conducted in propagation for many years and the actual need for the planting materials.According to the requirements of Good Agricultural Practices for Chinese Medicinal Drugs,cultural practices for propagation of S.suberectus were summed up and standardized,including the environmental requirements,land preparation,bed preparation,cutting of scions,cuttings treatment,cutting,management of cuttings at the nursery,bagged cuttings ready for transplanting,packing and handling,transportation,and preparation of records for archives. 展开更多
关键词 spatholobus suberectus Dunn. Bagged cuttings Cutting directly into bags Cultural practices Chinese traditional medicinal plants in southern China
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Stimulating effect of catechin, an active component of Spatholobus suberectus Dunn, on bioactivity of hematopoietic growth factor 被引量:9
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作者 WANG Dong-xiao Liu Ping +4 位作者 CHEN Yi-hong CHEN Ruo-yun GUO Dai-hong REN Hao-yang CHEN Meng-li 《Chinese Medical Journal》 SCIE CAS CSCD 2008年第8期752-755,共4页
Background Hematopoietic growth factor (HGF) is indispensable to hematopoiesis in the body. The proliferation and differentiation of hematopoietic cells must rely on the existence and stimulation of HGF. This study ... Background Hematopoietic growth factor (HGF) is indispensable to hematopoiesis in the body. The proliferation and differentiation of hematopoietic cells must rely on the existence and stimulation of HGF. This study investigated the effect of catechin, an active component extracted from Spatholobus suberectus Dunn (SSD), on bioactivity of granulocyte-macrophage colony-stimulating activity (GM-CSA), burst-promoting activity (BPA) and megakaryocyte colony-stimulating activity (MK-CSA) in spleen condition medium (SPCM) of mice to clarify the hematopoietic mechanism of catechin and SSD. Methods Spleen cells of mice were separated and spleen condition medium (SPCM) was prepared from spleen cell culture. Bone marrow cells of mice were separated and cultured in a culture system including 10% (v/v) SPCM (induced by catechin in vivo or ex vivo) for 6 days. Granulocyte-macrophage colony forming units (CFU-GM), erythrocyte burst-colony-forming units (BFU-E) and megakaryocyte colony-forming units (CFU-Meg) formation were employed to assay the effects of different treatment on the bioactivity of GM-CSA, BPA and MK-CSA in SPCM. Results SPCM induced by 100 mg/L catechin ex vivo could promote the growth of CFU-GM, BFU-E and CFU-Meg, which indicated that catechin could stimulate the production of GM-CSA, BPA and MK-CSA in SPCM. SPCM prepared at the fourth day of spleen cell culture showed the best stimulating activity. The bioactivity of GM-CSA, BPA and MK-CSA in the SPCM prepared after intraperitoneally injecting catechin into mice was also increased. The number of CFU-GM, BFU-E and CFU-Meg gradually increased as the dose of catechin increased and the time of administration prolonged. CFU-GM, BFU-E and CFU-Meg of the high-dose catechin group were significantly higher than those of the control group (P〈0.01) and reached the maximum at the seventh day after administration. Conclusions This study suggests that catechin extracted from the active acetic ether part of Spatholobus suberectus Dunn can regulate hematopoiesis by inducing bioactivity of GM-CSA, BPA and MK-CSA in SPCM of mice. This may be one of the mechanisms for the hematopoietic-supportive effect of catechin and Spatholobus suberectus Dunn. 展开更多
关键词 spatholobus suberectus Dunn CATECHIN hematopoietic growth factor colony stimulating activity hematopoietic progenitor cell
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Combined application of extended depth of field imaging, image stitching and polarized microscopy techniques in identification of Spatholobus suberectus 被引量:5
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作者 Ying-xian Ma Chayanis Sutcharitchan +4 位作者 Xiao-die Li Qian Meng Xin Wang Shen Ji Ya-jun Cui 《Chinese Herbal Medicines》 CAS 2020年第4期367-374,共8页
Objective:As traditional techniques for microscopic identification of Chinese medicines currently lack objective and high-quality reference images,here we developed a systemic procedure to be used in microscopic ident... Objective:As traditional techniques for microscopic identification of Chinese medicines currently lack objective and high-quality reference images,here we developed a systemic procedure to be used in microscopic identification of Chinese medicines,which would lead to more objective,effective and accurate identification process.Methods:Spatholobi Caulis(Jixueteng in Chinese)was used as the specimen in the development of such procedure.Jixueteng samples were microscopically examined in bright-and dark-field microscopy.Microscopic images were obtained by regular,EDF,and image stitching techniques.Results:The microscopic images of the characteristics in pulverized Jixueteng were captured,thanks to EDF imaging and image stitching techniques which allowed the detailed and full sighting of each characteristic to be obtained simultaneously.Different layers in anatomical transverse section,including cork,phelloderm,cortex,phloem,cambium,xylem and pith,were distinctively observed.Moreover,by comparing images of bright-and dark-field microscopy,birefringent and non-birefringent components could readily be distinguished.Conclusion:With application of the developed procedure,high-definition,panoramic and microscopic images were acquired,which could be used as the reference images for microscopic identification of Chinese medicines. 展开更多
关键词 extended depth of field imaging image stitching microscopic identification polarized light PHARMACOGNOSY spatholobus suberectus Dunn
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Antiviral Effects of Aqueous Extract from Spatholobus suberectus Dunn.against Coxsackievirus B3 in Mice 被引量:4
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作者 庞佶 郭金鹏 +3 位作者 金敏 谌志强 王新为 李君文 《Chinese Journal of Integrative Medicine》 SCIE CAS 2011年第10期764-769,共6页
Objective: To investigate the antiviral effects of the aqueous extract of Spatholobus suberectus Dunn. (A.E.), a Chinese medicinal herb, against coxsackievirus B3 (CVB3). Methods: The antiviral effects of A.E. a... Objective: To investigate the antiviral effects of the aqueous extract of Spatholobus suberectus Dunn. (A.E.), a Chinese medicinal herb, against coxsackievirus B3 (CVB3). Methods: The antiviral effects of A.E. against CVB3 in vitro (primarily cultured myocardial cells) and in vivo (BALB/c mice) were determined. Serum pharmacological method was also adopted by in vitro experiments. The effects of A.E. inhibiting the CVB3 mRNA expression were compared by RT-PCR in mice in vivo. Results: A.E. exhibited obvious antiviral effects in vivo, and serum samples obtained from the rats with oral administration of A.E. (10 μg/mL, 5 μg/mL) reduced the virus titers in the infected myocardial cells (3.00±0.70, 3.55±0.52, P〈0.01). Meanwhile, the viral myocarditis induced by CVB3 was inhibited significantly by A.E., and the 15-day mortality was reduced to 40% and 45% (P〈0.01) in mice treated with A.E. at doses of 50 mg/kg and 100 mg/kg, respectively, while the 30-day mortality was decreased to 45% and 50%, respectively (P〈0.01). Moreover, the mRNA expression of Coxsackie virus B3 was significantly inhibited by A.E. Conclusion: Aqueous extract of Spatho/obus suberectus Dunn. (A.E.) has inhibitory effect on CVB3 both in vitro and in vivo. 展开更多
关键词 aqueous extract of spatholobus suberectus Dunn. coxsackievirus B3 viral myocarditis
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Clinical and Pathological Observation of 106 Aplastic Anemia Patients Treated by Spatholobus Suberectus Composita 被引量:1
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作者 苏尔云 陈辉树 《Chinese Journal of Integrative Medicine》 SCIE CAS 1998年第4期251-254,共4页
Objective: To investigate the pharmaceutical effect of Spatholobus suberectus composita (SSC) on bone marrow hematopoiesis and microenvironment of aplastic anemia. Methods: One hundred and six cases of aplastic anemia... Objective: To investigate the pharmaceutical effect of Spatholobus suberectus composita (SSC) on bone marrow hematopoiesis and microenvironment of aplastic anemia. Methods: One hundred and six cases of aplastic anemia patients were treated by SSC for 24 months, and the pathological changes of bone marrow of 45 patients were observed before and after treatment, and compared with those of 17 cases of normal volunteers as control. Results: The total effective rate was 77. 4 %. The volume of nucleated cells changed from 15. 7 ± 10. 2 vol% to 39. 2 ± 13. 9 vol%, the percentage of the granulocytes from 31. 4 ± 12. 4 % to 39. 9 ± 10. 4% ), the erythroblasts from 19. 8 ± 15. 9 % to 36. 7 ± 13. 5 %, megakaryocytes from 1. 4 ± 2. 3 cell/section to 24. 0 ± 24. 6 cell/section), and the microvessel number from 40. 0 ± 23. 4 .es/100mm2 to 201. 0 ± 141. 0 ves/100mm2 ), all the criteria increased significantly (P < 0. 01 or P < 0. 05 ). Conclusion: SSC could not only irritate the hematopoiesis, but also exert reconstructive action to marrow microenvironment. 展开更多
关键词 aplastic anemia spatholobus suberectus composita pathology of bone marrow
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鸡血藤原花青素的提取工艺和体外抗氧化活性 被引量:15
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作者 董攀 罗泽欣 王冬梅 《中山大学学报(自然科学版)》 CAS CSCD 北大核心 2017年第1期8-13,共6页
在单因素试验的基础上,运用响应面法优化鸡血藤Spatholobus suberectus Dunn原花青素的超声波辅助提取工艺。以料液比、丙酮体积分数、提取时间为考察因素,以原花青素的提取率为响应因子,进行Box-behnken中心组合试验,得到最佳提取工艺... 在单因素试验的基础上,运用响应面法优化鸡血藤Spatholobus suberectus Dunn原花青素的超声波辅助提取工艺。以料液比、丙酮体积分数、提取时间为考察因素,以原花青素的提取率为响应因子,进行Box-behnken中心组合试验,得到最佳提取工艺参数为:室温下,超声功率500 W,提取时间30 min,料液比1∶45(m/V),丙酮体积分数70%,提取1次。在此条件下,鸡血藤原花青素提取得率为25.59%。制得的原花青素对DPPH·、ABTS·的IC_(50)分别为8.42,10.55μg/m L。 展开更多
关键词 鸡血藤spatholobus suberectus Dunn 原花青素 响应面法 抗氧化活性
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In vitro screening of traditionally used medicinal plants in China against Enteroviruses 被引量:13
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作者 Jin-Peng Guo Ji Pang Xin-Wei Wang Zhi-Qiang Shen Min Jin Jun-Wen Li 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第25期4078-4081,共4页
AIM: To search for new antiviral agents from traditional Chinese medicine, specifically anti-enterovirosuses agents. METHODS: The aqueous extracts (AE) of more than 100 traditionally used medicinal plants in China... AIM: To search for new antiviral agents from traditional Chinese medicine, specifically anti-enterovirosuses agents. METHODS: The aqueous extracts (AE) of more than 100 traditionally used medicinal plants in China were evaluated for their in vitro anti-Coxsackie virus B3 activities with a MTT-based colorimetric assay. RESULTS: The test for AE of 16 plants exhibited anti- Coxsackie virus B3 activities at different magnitudes of potency. They can inhibit three steps (inactivation, adsorption and replication) during the infection. Among the 16 plants, Sargentodoxa cuneata (Oliv.) Rehd. et Wils., Sophora tonkinensis Gapnep., Paeonia veitchii Lynch, Spatholobus suberectus Dunn. and Cyrtorniurn fortunei J, sm. also have activity against other enterovirus, including Coxsackie virus 135, Polio virus I, Echo virus 9 and Echo virus 29. Cell cytotoxic assay demonstrated that all tested AE had CC50 values higher than their EC50 values. CONCLUSION: The sixteen traditionally used medicinal plants in China possessed antMral activity, and some of them merit further investigations. 展开更多
关键词 Traditional used medicinal plant China Antiviral activity Enterovirus Sargentodoxa cuneata(O/iv) Reid. et. W/Is. Sophora tonkinensis Gapnep. Paeonia veitchii Lynch. Cyrtomium fortunei J. sm. spatholobus suberectus Dunn
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鸡血藤林下栽培技术 被引量:5
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作者 席飞飞 何钢 +3 位作者 刘贤桂 刘杰 倪尚格 张世良 《林业科技通讯》 2017年第8期56-59,共4页
介绍了鸡血藤(Spatholobus suberectus Dunn)的形态学特征及生物学特性,并主要从林地选择、整地、苗木繁育、栽植及抚育、病虫害防治、采收及加工等方面总结了鸡血藤林下栽培关键技术,林分透光率是关键因子。
关键词 林下栽培 鸡血藤 spatholobus suberectus 广东从化
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Hematopoietic-supportive effect of (2S, 3R)-ent-catechin on marrow-depressed mice
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作者 CHENYi-hong WANGDong-xiao +5 位作者 LIUPing CHENRuo-yun CHENMeng-li CHENGLiu-fang YINJian-fen CHENGui-yun 《Chinese Medical Journal》 SCIE CAS CSCD 2005年第13期1118-1122,共5页
Hematopoiesis is an active process of cell proliferation, differentiation andrelease. It is the process during which hematopoietic stem cells (HSCs) proliferate anddifferentiate to mature blood cells under the effect ... Hematopoiesis is an active process of cell proliferation, differentiation andrelease. It is the process during which hematopoietic stem cells (HSCs) proliferate anddifferentiate to mature blood cells under the effect of hemetopoietic growth factors (HGFs) incertain hematopoietic microenvironment. HSCs are sources of hematopoiesis of a body that canself-renew, differentiate to blood cells of every lineage and maintain the constancy of them. As themajor tissue of hematopoiesis bone marrow is filled with all kinds of blood cells in variousdevelopmental stages. Under the normal conditions, the ordered proliferation and differentiation ofhematopoietic stem cells/hematopoietic progenitor cells ( HSC/HPC) depend on the regulation ofcytokine network. In present, Spatholobus suberectus Dunn (SSD), a traditional Chinese herb medicinethat has been used to invigorate the blood circulation for thousands years, is widely used torebuild blood after chemotherapy and radiotherapy and to treat hematopoietic diseases. Previousreports from our laboratory indicated that (2S,3R)-ent-catechin, epi (2S, 3R )-ent-catechin, gallic( 2S, 3R )-ent-catechin, et al extracted from SSD all could stimulate the proliferation of HPC inmarrow depressed mice, among which (2S, 3R)-ent-catechin obtained from spatholobus genus for thefirst time and whose content was the maxim showed the best effect. In this study, firstly, theeffect of (2S,3R)-ent-catechin on the quality and quantity of HSCs were assayed by detectingCD_(34)^+ expression. Secondly, we investigated the variation of cytokine (GM-CSF and IL-6)sero-level in mice treated with (2S,3R)- ent-catechin by ELISA. And IL-6 mRNA and GM-CSF mRNAexpressions induced by (2S,3R)-ent-catechin were detected simultaneously by RT-PCR technique inorder to clarify its mechanism. 展开更多
关键词 spatholobus suberectus dunn (2S 3R)-ent-catechin hematopoietic stem cell hematopoietic progenitor cell hematopoietic growth factor
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