Traumatic Spinal Cord Injury (TSCI) remains a significant cause of human suffering. The World Health Organization estimates that there are between 250,000 to 500,000 new cases every year. Magnetic Resonance Imaging (M...Traumatic Spinal Cord Injury (TSCI) remains a significant cause of human suffering. The World Health Organization estimates that there are between 250,000 to 500,000 new cases every year. Magnetic Resonance Imaging (MRI) has been an important advancement in the diagnosis and management of TSCI. Nevertheless, there is a lack of literature correlating the radiological abnormalities and histopathological findings in the first hour (i.e., hyperacute period) after injury. The aim of this preliminary study is to elucidate the relationship between the MRI abnormalities and histopathological abnormalities in the hyperacute time period. In this study, a non-human primate model (NHP) primate model is used to characterize the histopathological and radiological features. Specifically, an experimental TSCI is created with an epidural catheter. This is followed by MRI imaging. The subject is then humanely euthanized and a post-mortem examination is completed. These results suggest that the noted radiological abnormalities are consistent with a combination of hemorrhage, edema as well as eosinophilic cellular matter in the central canal.展开更多
Objective: In the present study, spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis were quantitatively analyzed using dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) to assess the v...Objective: In the present study, spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis were quantitatively analyzed using dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) to assess the value of DCE-MRI in the differential diagnosis of these diseases.Methods: Patients with brucellar spondylitis, spinal tuberculosis or a spinal metastatic tumor(30 cases of each)received conventional MRI and DCE-MRI examination. The volume transfer constant(K^(trans)), rate constant(K_(ep)),extravascular extracellular volume fraction(V_e) and plasma volume fraction(V_p) of the diseased vertebral bodies were measured on the perfusion parameter map, and the differences in these parameters between the patients were compared.Results: For pathological vertebrae in cases of spinal metastatic tumor, brucellar spondylitis and spinal tuberculosis, respectively, the K^(trans) values(median ± quartile pitch) were 0.989±0.014, 0.720±0.011 and0.317±0.005 min^(–1); the K_(ep) values were 2.898±0.055, 1.327±0.017 and 0.748±0.006 min^(–1); the V_e values were 0.339±0.008, 0.542±0.013 and 0.428±0.018; the V_p values were 0.048±0.008, 0.035±0.004 and 0.028±0.009; the corresponding H values were 50.25(for K_(trans)), 52.47(for K_(ep)), 48.33(for V_e) and 46.56(for V_p), and all differences were statistically significant(two-sided P<0.05).Conclusions: The quantitative analysis of DCE-MRI has a certain value in the differential diagnosis of spinal metastatic tumor, brucellar spondylitis and spinal tuberculosis.展开更多
Objective To approach the effect of microgene pSVPoMcat modified Schwan n cell (SC) on the regeneration and repair of injured spinal cord.Method Spinal cord hemi－transection models were made with the cutting method i...Objective To approach the effect of microgene pSVPoMcat modified Schwan n cell (SC) on the regeneration and repair of injured spinal cord.Method Spinal cord hemi－transection models were made with the cutting method in healthy SD ra ts. Microgene pSVPoMcat modified SC(group A),highly purified SC(group B),and glu tin sponge (control group C)were randomly implanted into the cut. After 3 month living ,the host rats were scanned by MRI, and observed under EM. Result Spinal signals at the injury region nearly recovered to normal in group A.No recovery w as found in group B.Malacosis was found in group C.TEM findings: regeneration of large number of myelinated and nonmyelinated axons and SC proliferation in grou p A, myelinated axon regeneration and SC necrosis in group B, non myelinated and nonmyelinated axon in group C.Conclusion Implantation of microgene pSVPoMcat mo dified SC could promote the repair of injured spinal cord.展开更多
Background: Magnetic resonance imaging is the primary imaging modality for the evaluation of spinal cord and spinal column disorder. Aims: to assess the prevalence of bony structure and spinal disorders in the Saudi p...Background: Magnetic resonance imaging is the primary imaging modality for the evaluation of spinal cord and spinal column disorder. Aims: to assess the prevalence of bony structure and spinal disorders in the Saudi population and to find a correlation between patient age and gender. Material and Methods: A retrospective study was conducted using magnetic resonance imaging in Al-Taif city from November 2020 to February 2021 at King Abdul-Aziz Specialist Hospital and King Faisal Hospital in Taif City, Kingdom of Saudi Arabia, to assess the prevalence of bony structure and spinal disorders in the Saudi population. The data was collected after gaining ethical approval from the directorate of health affairs in Taif’s administration of research and studies, and then analyzed using SPSS version 25 to determine the frequency and percentage of disorder. To check if there was a significant difference between the two groups, the Pearson’s chi square test was utilized. Results: One hundred young adults underwent MR examination of the spine. The results show that the most common age group affected by spinal disorders is over 50 years (53%), the most common bony structural spinal disorders are straightening 59%, followed by lordosis (20%), and the most common disc disorders are disc bulges (15%), and the most common degenerative changes are spondylo-degenerative changes (21%), and there is no significant correlation between genders and MRI findings (p-value). Conclusion: The study found that straightening is the most prevalent MRI-diagnosed spine disorder, followed by degenerative illnesses and that there is no significant association between gender and the type of MRI-diagnosed spinal disorders.展开更多
Primary germinoma in the spinal cord is very rare. Preoperative diagnosis is important because germinomas are sensitive to radiation therapy and chemotherapy so that treatment trends and prognosis differ from other in...Primary germinoma in the spinal cord is very rare. Preoperative diagnosis is important because germinomas are sensitive to radiation therapy and chemotherapy so that treatment trends and prognosis differ from other intramedullary spinal cord tumors. Preoperative radiologic diagnosis is very difficult because of this rarity. In this case a 22-year-old woman with a 4-month history of gradual numbness and weakness of both lower extremities was found to have a solid tumor in the thoracic cord between the T9 and T11 vertebral bodies. No other neoplastic lesion was found inside or outside the central nervous system. The patient underwent surgery,and the intramedullary lesion was almost totally resected. Serum HCG was elevated postoperatively without pregnancy. The pathological diagnosis was conclusively that of a germinoma. The previous 23 cases of primary spinal cord germinoma were reviewed for comparison.展开更多
Introduction: Spinal cord infarction (SCI) is a relatively rare disease. Abnormality on magnetic resonance imaging (MRI) is an important diagnostic criterion. It may be normal on the first day. Then abnormal signal wi...Introduction: Spinal cord infarction (SCI) is a relatively rare disease. Abnormality on magnetic resonance imaging (MRI) is an important diagnostic criterion. It may be normal on the first day. Then abnormal signal will appear a few days later. There were some reports with negative MRI findings at the beginning. However, those reports were neither found abnormalities on repeat MRI nor without repeat MRI. Case Presentation: We report a case of SCI presented as paralysis of lower limbs and chest pain with no abnormalities on MRI through the course of disease in a 74-year-old female. Anti-platelet aggregation drugs, stabilizing plaque treatments and rehabilitation exercise were performed. The patient recovered significantly. She could walk independently a month after the onset. Conclusions: Although MRI provides important evidence for diagnosis, clinical manifestations are the most important when diagnosing. For patients who were highly suspected of SCI clinically, treatment for vascular diseases should be applied as soon as possible even if no lesion is found on imaging examination.展开更多
文摘Traumatic Spinal Cord Injury (TSCI) remains a significant cause of human suffering. The World Health Organization estimates that there are between 250,000 to 500,000 new cases every year. Magnetic Resonance Imaging (MRI) has been an important advancement in the diagnosis and management of TSCI. Nevertheless, there is a lack of literature correlating the radiological abnormalities and histopathological findings in the first hour (i.e., hyperacute period) after injury. The aim of this preliminary study is to elucidate the relationship between the MRI abnormalities and histopathological abnormalities in the hyperacute time period. In this study, a non-human primate model (NHP) primate model is used to characterize the histopathological and radiological features. Specifically, an experimental TSCI is created with an epidural catheter. This is followed by MRI imaging. The subject is then humanely euthanized and a post-mortem examination is completed. These results suggest that the noted radiological abnormalities are consistent with a combination of hemorrhage, edema as well as eosinophilic cellular matter in the central canal.
基金funded by the National Natural Science Foundation of China (No. 81460259)
文摘Objective: In the present study, spinal metastatic tumors, brucellar spondylitis and spinal tuberculosis were quantitatively analyzed using dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) to assess the value of DCE-MRI in the differential diagnosis of these diseases.Methods: Patients with brucellar spondylitis, spinal tuberculosis or a spinal metastatic tumor(30 cases of each)received conventional MRI and DCE-MRI examination. The volume transfer constant(K^(trans)), rate constant(K_(ep)),extravascular extracellular volume fraction(V_e) and plasma volume fraction(V_p) of the diseased vertebral bodies were measured on the perfusion parameter map, and the differences in these parameters between the patients were compared.Results: For pathological vertebrae in cases of spinal metastatic tumor, brucellar spondylitis and spinal tuberculosis, respectively, the K^(trans) values(median ± quartile pitch) were 0.989±0.014, 0.720±0.011 and0.317±0.005 min^(–1); the K_(ep) values were 2.898±0.055, 1.327±0.017 and 0.748±0.006 min^(–1); the V_e values were 0.339±0.008, 0.542±0.013 and 0.428±0.018; the V_p values were 0.048±0.008, 0.035±0.004 and 0.028±0.009; the corresponding H values were 50.25(for K_(trans)), 52.47(for K_(ep)), 48.33(for V_e) and 46.56(for V_p), and all differences were statistically significant(two-sided P<0.05).Conclusions: The quantitative analysis of DCE-MRI has a certain value in the differential diagnosis of spinal metastatic tumor, brucellar spondylitis and spinal tuberculosis.
文摘Objective To approach the effect of microgene pSVPoMcat modified Schwan n cell (SC) on the regeneration and repair of injured spinal cord.Method Spinal cord hemi－transection models were made with the cutting method in healthy SD ra ts. Microgene pSVPoMcat modified SC(group A),highly purified SC(group B),and glu tin sponge (control group C)were randomly implanted into the cut. After 3 month living ,the host rats were scanned by MRI, and observed under EM. Result Spinal signals at the injury region nearly recovered to normal in group A.No recovery w as found in group B.Malacosis was found in group C.TEM findings: regeneration of large number of myelinated and nonmyelinated axons and SC proliferation in grou p A, myelinated axon regeneration and SC necrosis in group B, non myelinated and nonmyelinated axon in group C.Conclusion Implantation of microgene pSVPoMcat mo dified SC could promote the repair of injured spinal cord.
文摘Background: Magnetic resonance imaging is the primary imaging modality for the evaluation of spinal cord and spinal column disorder. Aims: to assess the prevalence of bony structure and spinal disorders in the Saudi population and to find a correlation between patient age and gender. Material and Methods: A retrospective study was conducted using magnetic resonance imaging in Al-Taif city from November 2020 to February 2021 at King Abdul-Aziz Specialist Hospital and King Faisal Hospital in Taif City, Kingdom of Saudi Arabia, to assess the prevalence of bony structure and spinal disorders in the Saudi population. The data was collected after gaining ethical approval from the directorate of health affairs in Taif’s administration of research and studies, and then analyzed using SPSS version 25 to determine the frequency and percentage of disorder. To check if there was a significant difference between the two groups, the Pearson’s chi square test was utilized. Results: One hundred young adults underwent MR examination of the spine. The results show that the most common age group affected by spinal disorders is over 50 years (53%), the most common bony structural spinal disorders are straightening 59%, followed by lordosis (20%), and the most common disc disorders are disc bulges (15%), and the most common degenerative changes are spondylo-degenerative changes (21%), and there is no significant correlation between genders and MRI findings (p-value). Conclusion: The study found that straightening is the most prevalent MRI-diagnosed spine disorder, followed by degenerative illnesses and that there is no significant association between gender and the type of MRI-diagnosed spinal disorders.
文摘Primary germinoma in the spinal cord is very rare. Preoperative diagnosis is important because germinomas are sensitive to radiation therapy and chemotherapy so that treatment trends and prognosis differ from other intramedullary spinal cord tumors. Preoperative radiologic diagnosis is very difficult because of this rarity. In this case a 22-year-old woman with a 4-month history of gradual numbness and weakness of both lower extremities was found to have a solid tumor in the thoracic cord between the T9 and T11 vertebral bodies. No other neoplastic lesion was found inside or outside the central nervous system. The patient underwent surgery,and the intramedullary lesion was almost totally resected. Serum HCG was elevated postoperatively without pregnancy. The pathological diagnosis was conclusively that of a germinoma. The previous 23 cases of primary spinal cord germinoma were reviewed for comparison.
文摘Introduction: Spinal cord infarction (SCI) is a relatively rare disease. Abnormality on magnetic resonance imaging (MRI) is an important diagnostic criterion. It may be normal on the first day. Then abnormal signal will appear a few days later. There were some reports with negative MRI findings at the beginning. However, those reports were neither found abnormalities on repeat MRI nor without repeat MRI. Case Presentation: We report a case of SCI presented as paralysis of lower limbs and chest pain with no abnormalities on MRI through the course of disease in a 74-year-old female. Anti-platelet aggregation drugs, stabilizing plaque treatments and rehabilitation exercise were performed. The patient recovered significantly. She could walk independently a month after the onset. Conclusions: Although MRI provides important evidence for diagnosis, clinical manifestations are the most important when diagnosing. For patients who were highly suspected of SCI clinically, treatment for vascular diseases should be applied as soon as possible even if no lesion is found on imaging examination.
