The discrimination of synonyms has always been one of the great challenges for English learners.Taking assessment and evaluation as examples,this study analyses the similarities and differences of the two words,as wel...The discrimination of synonyms has always been one of the great challenges for English learners.Taking assessment and evaluation as examples,this study analyses the similarities and differences of the two words,as well as their usage from the perspectives of frequency,stylistics,collocation and semantic prosody with the help of British National Corpus,and demonstrates the importance of corpus retrieval tools in synonyms discrimination.Furthermore,this paper will give some suggestions for English learners and teachers in English vocabulary teaching.展开更多
Based on comparison of the type specimens, Parapolytrechus [sic] flavotarsus Wang ＆ Zheng, 2002 is a new junior synonym ofNeoxenicotela mausoni Breuning, 1947.
In this study, a comparative analysis of the codon usage bias was performed in Aeropyrum pernix K1 and two other phylogenetically related Crenarchaeota microorganisms （i.e., Pyrobaculum aerophilum str. IM2 and Sulfol...In this study, a comparative analysis of the codon usage bias was performed in Aeropyrum pernix K1 and two other phylogenetically related Crenarchaeota microorganisms （i.e., Pyrobaculum aerophilum str. IM2 and Sulfolobus acidocaldarius DSM 639）. The results indicated that the synonymous codon usage in A. pernix K1 was less biased, which was highly correlated with the GC3s value. The codon usage patterns were phylogenetically conserved among these Crenarchaeota microorganisms. Comparatively, it is the species function rather than the gene function that determines their gene codon usage patterns. A. pernix K1, P. aerophilum str. IM2, and S. acidocaldarius DSM 639 live in differently extreme conditions. It is presumed that the hving environment played an important role in determining the codon usage pattern of these microorganisms. Besides, there was no strain-specific codon usage among these microorganisms. The extent of codon bias in A. pernix K1 and S. acidocaldarius DSM 639 were highly correlated with the gene expression level, but no such association was detected in P. aerophilum str. IM2 genomes.展开更多
Apple（Malus×domestica） has been proposed as an important woody plant and the major cultivated fruit trees in temperate regions. Apple whole genome sequencing has been completed, which provided an excellent oppo...Apple（Malus×domestica） has been proposed as an important woody plant and the major cultivated fruit trees in temperate regions. Apple whole genome sequencing has been completed, which provided an excellent opportunity for genome-wide analysis of the synonymous codon usage patterns. In this study, a multivariate bioinformatics analysis was performed to reveal the characteristics of synonymous codon usage and the main factors affecting codon bias in apple. The neutrality, correspondence, and correlation analyses were performed by Codon W and SPSS（Statistical Product and Service Solutions） programs, indicating that the apple genome codon usage patterns were affected by mutational pressure and selective constraint. Meanwhile, coding sequence length and the hydrophobicity of proteins could also influence the codon usage patterns. In short, codon usage pattern analysis and determination of optimal codons has laid an important theoretical basis for genetic engineering, gene prediction and molecular evolution studies in apple.展开更多
A comparative analysis of the codon usage bias was conducted in Methanosarcina mazei str. Goel and two related Euryarchaeota microorganisms （Picrophilus torridus str. DSM 9790 and Natronomonas pharaonis str. DSM 2160...A comparative analysis of the codon usage bias was conducted in Methanosarcina mazei str. Goel and two related Euryarchaeota microorganisms （Picrophilus torridus str. DSM 9790 and Natronomonas pharaonis str. DSM 2160）. Results revealed that synonymous codon usage in Methanosarcina mazei str. Goel was less biased, which was highly correlated with the GC3S value. And the codon usage patterns were phylogenetically conserved among those Euryarchaeota microorganisms. By employing a hierarchical clustering analysis, it can be seen that it is more the species than the gene function that determines their gene codon usage pattems. Considering that those microorganisms live in different environments where the pH conditions vary quite a lot, it can be presumed that their living environments, especially the pH conditions, play an important role in determining those microorganisms＇ codon usage pattems.展开更多
For protecting the copyright of a text and recovering its original content harmlessly,this paper proposes a novel reversible natural language watermarking method that combines arithmetic coding and synonym substitutio...For protecting the copyright of a text and recovering its original content harmlessly,this paper proposes a novel reversible natural language watermarking method that combines arithmetic coding and synonym substitution operations.By analyzing relative frequencies of synonymous words,synonyms employed for carrying payload are quantized into an unbalanced and redundant binary sequence.The quantized binary sequence is compressed by adaptive binary arithmetic coding losslessly to provide a spare for accommodating additional data.Then,the compressed data appended with the watermark are embedded into the cover text via synonym substitutions in an invertible manner.On the receiver side,the watermark and compressed data can be extracted by decoding the values of synonyms in the watermarked text,as a result of which the original context can be perfectly recovered by decompressing the extracted compressed data and substituting the replaced synonyms with their original synonyms.Experimental results demonstrate that the proposed method can extract the watermark successfully and achieve a lossless recovery of the original text.Additionally,it achieves a high embedding capacity.展开更多
With the verification of the type specimen by six experts from the Nanjing Institute of Geology and Palaeontology, the specimen of Xianfengella prima He and Yang, 1982 described by Qian （Qian, 2001, flge2： la-c） is...With the verification of the type specimen by six experts from the Nanjing Institute of Geology and Palaeontology, the specimen of Xianfengella prima He and Yang, 1982 described by Qian （Qian, 2001, flge2： la-c） is confirmed to be the holotype specimen （NIGP. 84430） of Yangtzedonta primitiva Yu, 1985, and consequently, Yu Wen＇s view that they are not the same specimen is impractical. This fact demonstrates that Yangtzedonta primitiva Yu, 1985 is undoubtedly a junior synonym of Xianftngella prima He and Yang, 1982, and is invalid. Qian＇s conclusion （Qian, 2001 ） that no bivalve appeared in the early Meishucunian Stage of the Early Cambrian is rational.展开更多
Distinguishing the meanings of near synonyms always seems to be a challenging task for Chinese EFL learners,as is the case with bring about and give rise to be exemplified in the paper.I will use a corpus approach to ...Distinguishing the meanings of near synonyms always seems to be a challenging task for Chinese EFL learners,as is the case with bring about and give rise to be exemplified in the paper.I will use a corpus approach to unveil some implied semantic patterns and pragmatic features of the two phrases,and generalize their semantic prosodies as used by native English speakers by analyzing what kinds of nouns tend to co-occur with them,and also discuss whether there is a transfer of negative semantic prosody from the word cause to the two phrases under discussion.展开更多
Corpus-based studies show that near-synonyms differ in their collocational behavior and semantic prosody which causes deviation in Chinese EFL learners’English using.This paper attempts to investigate the effectivene...Corpus-based studies show that near-synonyms differ in their collocational behavior and semantic prosody which causes deviation in Chinese EFL learners’English using.This paper attempts to investigate the effectiveness of a corpus-based approach to the teaching and learning of near synonyms and their collocations.By using internet accessible computers to log on to websites of BNC and COCA,learners can view real language data and study the usage of targeted near synonyms.This empirical study tends to show that a corpus based approach is positively effective to the learning of near synonyms.It also provides some pedagogical implications that learners can play a major and active role in DDL and teachers only act as assistants.展开更多
Word similarity(WS)is a fundamental and critical task in natural language processing.Existing approaches to WS are mainly to calculate the similarity or relatedness of word pairs based on word embedding obtained by ma...Word similarity(WS)is a fundamental and critical task in natural language processing.Existing approaches to WS are mainly to calculate the similarity or relatedness of word pairs based on word embedding obtained by massive and high-quality corpus.However,it may suffer from poor performance for insufficient corpus in some specific fields,and cannot capture rich semantic and sentimental information.To address these above problems,we propose an enhancing embedding-based word similarity evaluation with character-word concepts and synonyms knowledge,namely EWS-CS model,which can provide extra semantic information to enhance word similarity evaluation.The core of our approach contains knowledge encoder and word encoder.In knowledge encoder,we incorporate the semantic knowledge extracted from knowledge resources,including character-word concepts,synonyms and sentiment lexicons,to obtain knowledge representation.Word encoder is to learn enhancing embedding-based word representation from pre-trained model and knowledge representation based on similarity task.Finally,compared with baseline models,the experiments on four similarity evaluation datasets validate the effectiveness of our EWS-CS model in WS task.展开更多
Objective:Autosomal dominant polycystic kidney disease(ADPKD)is mainly caused by the pathogenic mutation of PKD1 or PKD2 gene and usually affects bilateral kidneys.Synonymous mutations are generally assumed to be neut...Objective:Autosomal dominant polycystic kidney disease(ADPKD)is mainly caused by the pathogenic mutation of PKD1 or PKD2 gene and usually affects bilateral kidneys.Synonymous mutations are generally assumed to be neutral as they do not alter amino acids.Herein,we described an extremely rare ADPKD child caused by a heterozygous synonymous mutation of PKD2 gene accompanied by massive proteinuria and congenital solitary kidney.Methods:Clinical characteristics of the patients were summarized.Whole-exome sequencing was performed to screen the disease-causing gene mutation,and reverse transcription polymerase chain reaction(RT-PCR)and Sanger sequencing were applied to analyze the impact of the identified mutation on gene transcription and splicing.Results:Polycystic changes were found in the solitary kidney of a girl initially presented with nephrotic-range proteinuria.Thereafter her mother and 2 other family members were diagnosed to be ADPKD.Whole-exome sequencing of the proband identified a heterozygous synonymous mutation(c.1716G>A,p.Lys572=)located in the splicing site of exon 7 in PKD2 gene,which was co-segregated with the PKD phenotype in the family.RT-PCR and direct sequencing of amplified products revealed that this heterozygous synonymous mutation led to exon7 skipping in PKD2 gene.Conclusion:We reported an extremely rare child case of ADPKD2 in combination with solitary kidney and nephrotic-range proteinuria,and firstly confirmed the pathogenicity of a heterozygous synonymous mutation(c.1716G>A)in PKD2 gene.The results indicate that synonymous mutations should not be excluded from disease-causing if they are located in splicing site of an exon.展开更多
To investigate how synonymous codons have been adapted to the formation of ribonucleic acid(RNA)G-quadruplex(rG4)structure,a computational searching algorithm G4Hunter was applied to detect rG4 structures in protein-c...To investigate how synonymous codons have been adapted to the formation of ribonucleic acid(RNA)G-quadruplex(rG4)structure,a computational searching algorithm G4Hunter was applied to detect rG4 structures in protein-coding sequences of mRNAs in five eukaryotic species.The native sequences forming rG4s were then compared with randomized sequences to evaluate selection on synonymous codons.Factors that may influence the formation of rG4 were also investigated,and the selection pressures of rG4 in different gene regions were compared to explore its potential roles in gene regulation.The results show universal selective pressure acts on synonymous codons in rG4 regions to facilitate rG4 formation in five eukaryotic organisms.While G-rich codon combinations are preferred in the rG4 structural region,C-rich codon combinations are selectively unfavorable for rG4 formation.Gene's codon usage bias,nucleotide composition,and evolutionary rate can account for the selective variations on synonymous codons among rG4 structures within a species.Moreover,rG4 structures in the translational initiation region showed significantly higher selective pressures than those in the translational elongation region.展开更多
A textual research on materia medica of origin of orthonym and synonym of Cuscutae Semen and synonym of Nu Luo was conducted in this study,and the trade name,regional synonym and nickname of Cuscutae Semen were review...A textual research on materia medica of origin of orthonym and synonym of Cuscutae Semen and synonym of Nu Luo was conducted in this study,and the trade name,regional synonym and nickname of Cuscutae Semen were reviewed.The records of orthonym and synonym of Cuscutae Semen in the past dynasties,and the first published literature and writing date of orthodox and synonym were summarized.The textual research showed that Nu Luo and Cuscutae Semen were not the same plant,which had positive significance for the identification of the origin and modern application of Cuscutae Semen.展开更多
In this work,an approach is proposed to acquire synonymous attribute phrases of named entities(NEs) from an online encyclopedia.Synonymous attribute phrases are the phrases that express the same attribute with differe...In this work,an approach is proposed to acquire synonymous attribute phrases of named entities(NEs) from an online encyclopedia.Synonymous attribute phrases are the phrases that express the same attribute with different surface forms for a class of NEs.Specifically,the proposed approach is composed of three stages.Firstly,the entries related to a given NE class are automatically selected from an online encyclopedia.Secondly,attribute phrases are extracted based on the statistics of phrase frequency.Thirdly,synonymous attributes are identified in a pairwise manner through a classification framework combining multiple features.The proposed approach is applied on Baidu Baike,a Chinese online encyclopedia,for four different NE classes.Experimental results show that the approach obtains an average precision of 74%and an average F-value of 65%for the four NE classes.In particular,thousands of synonymous attribute phrase pairs are acquired for each class,which demonstrates the effectiveness of the proposed approach.展开更多
Languages embody a lot of words that are considered as synonyms, and people just take it for granted that such words are identical in meaning without any discrimination. However, a corpus-based approach to the study o...Languages embody a lot of words that are considered as synonyms, and people just take it for granted that such words are identical in meaning without any discrimination. However, a corpus-based approach to the study of the collocational behavior of the two frequently-used pairs of synonyms （selection and option, ill and sick） reveals significant discrepancies in the use of these two pairs of synonyms by Chinese English learners and native speakers. According to the analysis, the major problems lie in the current ways of vocabulary teaching and learning. This paper aims to highlight the important role of the corpus-based collocational research in English vocabulary teaching and learning. In the end, some suggestions concerning vocabulary teaching and leaming are put forward on the basis of corpus-based research.展开更多
This paper investigates Chinese EFL learners＇ acquisition of completely, totally and absolutely through a contrastive analysis of their collocation, colligation, semantic preference and semantic prosody based on the ...This paper investigates Chinese EFL learners＇ acquisition of completely, totally and absolutely through a contrastive analysis of their collocation, colligation, semantic preference and semantic prosody based on the Ten-thousand English Compositions of Chinese Learners （TECCL Corpus） and Corpus of Contemporary American English （COCA）. The results show that adjective and verb are two major words frequently co-occurring with the group of synonyms, but only a few of them meet the default collocation criterion （frequency〉3, MI〉3）, and many co-occurring words used by Chinese learners don＇t appear in COCA. Besides, the co-occurring adjectives and verbs in TECCL are so diverse that they don＇t establish fixed semantic relations as in COCA, therefore, there is a big difference in semantic preference and semantic prosody between Chinese learners and native speakers. With the advance of English proficiency, more collocates are used by college learners than middle school learners, but there is no clear and significant improvement in semantic preference and semantic prosody.展开更多
In order to better apply the semantic prosody theory to distinguish synonyms,this article chooses to use analysis software and corpus to specifically compare and analyze the difference between“weichi(维持)”and“baoc...In order to better apply the semantic prosody theory to distinguish synonyms,this article chooses to use analysis software and corpus to specifically compare and analyze the difference between“weichi(维持)”and“baochi(保持)”.Although both“weichi(维持)”and“baochi(保持)”show neutral colors in the dictionary,through analysis of collocation words,it is found that“baochi(保持)”is often matched with positively colored words,so it has positive semantic characteristics,while“weichi(维持)”is more neutral and negative semantic prosody characteristics,and in the diachronic and synchronic word frequency survey,the word frequency of“baochi(保持)”is higher than that of“weichi(维持)”.展开更多
The APCDDI （adenomatosis polyposis coli down-regulated 1） gene is an inhibitor of the Wnt signaling pathway, and a rare mutation of this gene has been associated with hereditary hypotrichosis simplex. In this study,...The APCDDI （adenomatosis polyposis coli down-regulated 1） gene is an inhibitor of the Wnt signaling pathway, and a rare mutation of this gene has been associated with hereditary hypotrichosis simplex. In this study, the authors aimed to investigate whether common APCDD1 gene polymorphisms contribute to the development of androgenic alopecia. Patients （n = 210） with androgenic alopecia and 98 controls were investigated. SNPs （Single nucleotide polymorphisms） in the coding region of the gene were sequenced. A significant difference in genotype distribution was found for the c. 1781C/T, p.L476L SNP （rs3185480） of the APCDD1 gene. This SNP is located in exon 5 and is associated with a 3.5- and a 2.8-fold increase in risk for the development of androgenic alopecia for homozygote （CI 0.933-13.125; nominal regression P = 0.063） and heterozygote （CI 1.086-7.217; nominal regression P = 0.033） carriers, respectively. These data suggest that the rs3185480 polymorphism contributes to the development of androgenic alopecia. Protein expression experiments revealed that the polymorphism is associated with reduced APCDDI protein abundance. This reduction is likely due to altered codon usage for leucine from a preferred codon （CTC） to a rare codon （CTT）, which might influence translation efficiency and, thus, APCDDI protein level.展开更多
This paper first points out the deficiency of listing synonyms by some dictionaries,such as the Cobuild Dictionary and Merriam-Webster’s Dictionary of Synonyms,which,however,have actually failed in distinguishing bet...This paper first points out the deficiency of listing synonyms by some dictionaries,such as the Cobuild Dictionary and Merriam-Webster’s Dictionary of Synonyms,which,however,have actually failed in distinguishing between some synonyms.Then,the paper attempts to solve the problem by providing a brief review of relevant studies in the past few decades on near synonyms with a focus on differences in denotation,connotation and semantic prosody of words as well as various definitions of semantic prosody and related researches.By evaluating the relevant research and defintions of semantic prosody,the review concluded that the alleged dictionaries would be perfected with the provision of connotations or semantic prosodies for near synonyms before suggesting out the focus of future and further research into near synonyms.展开更多
文摘The discrimination of synonyms has always been one of the great challenges for English learners.Taking assessment and evaluation as examples,this study analyses the similarities and differences of the two words,as well as their usage from the perspectives of frequency,stylistics,collocation and semantic prosody with the help of British National Corpus,and demonstrates the importance of corpus retrieval tools in synonyms discrimination.Furthermore,this paper will give some suggestions for English learners and teachers in English vocabulary teaching.
基金supported by the National Natural Science Foundation of China (31000967,31010103913)
文摘Based on comparison of the type specimens, Parapolytrechus [sic] flavotarsus Wang ＆ Zheng, 2002 is a new junior synonym ofNeoxenicotela mausoni Breuning, 1947.
基金The work is supported by National Natural Science Foundation of China (No. 60121101).
文摘In this study, a comparative analysis of the codon usage bias was performed in Aeropyrum pernix K1 and two other phylogenetically related Crenarchaeota microorganisms （i.e., Pyrobaculum aerophilum str. IM2 and Sulfolobus acidocaldarius DSM 639）. The results indicated that the synonymous codon usage in A. pernix K1 was less biased, which was highly correlated with the GC3s value. The codon usage patterns were phylogenetically conserved among these Crenarchaeota microorganisms. Comparatively, it is the species function rather than the gene function that determines their gene codon usage patterns. A. pernix K1, P. aerophilum str. IM2, and S. acidocaldarius DSM 639 live in differently extreme conditions. It is presumed that the hving environment played an important role in determining the codon usage pattern of these microorganisms. Besides, there was no strain-specific codon usage among these microorganisms. The extent of codon bias in A. pernix K1 and S. acidocaldarius DSM 639 were highly correlated with the gene expression level, but no such association was detected in P. aerophilum str. IM2 genomes.
基金supported by the National Natural Science Foundation of China (31401822)
文摘Apple（Malus×domestica） has been proposed as an important woody plant and the major cultivated fruit trees in temperate regions. Apple whole genome sequencing has been completed, which provided an excellent opportunity for genome-wide analysis of the synonymous codon usage patterns. In this study, a multivariate bioinformatics analysis was performed to reveal the characteristics of synonymous codon usage and the main factors affecting codon bias in apple. The neutrality, correspondence, and correlation analyses were performed by Codon W and SPSS（Statistical Product and Service Solutions） programs, indicating that the apple genome codon usage patterns were affected by mutational pressure and selective constraint. Meanwhile, coding sequence length and the hydrophobicity of proteins could also influence the codon usage patterns. In short, codon usage pattern analysis and determination of optimal codons has laid an important theoretical basis for genetic engineering, gene prediction and molecular evolution studies in apple.
文摘A comparative analysis of the codon usage bias was conducted in Methanosarcina mazei str. Goel and two related Euryarchaeota microorganisms （Picrophilus torridus str. DSM 9790 and Natronomonas pharaonis str. DSM 2160）. Results revealed that synonymous codon usage in Methanosarcina mazei str. Goel was less biased, which was highly correlated with the GC3S value. And the codon usage patterns were phylogenetically conserved among those Euryarchaeota microorganisms. By employing a hierarchical clustering analysis, it can be seen that it is more the species than the gene function that determines their gene codon usage pattems. Considering that those microorganisms live in different environments where the pH conditions vary quite a lot, it can be presumed that their living environments, especially the pH conditions, play an important role in determining those microorganisms＇ codon usage pattems.
基金This project is supported by National Natural Science Foundation of China(No.61202439)partly supported by Scientific Research Foundation of Hunan Provincial Education Department of China(No.16A008)partly supported by Hunan Key Laboratory of Smart Roadway and Cooperative Vehicle-Infrastructure Systems(No.2017TP1016).
文摘For protecting the copyright of a text and recovering its original content harmlessly,this paper proposes a novel reversible natural language watermarking method that combines arithmetic coding and synonym substitution operations.By analyzing relative frequencies of synonymous words,synonyms employed for carrying payload are quantized into an unbalanced and redundant binary sequence.The quantized binary sequence is compressed by adaptive binary arithmetic coding losslessly to provide a spare for accommodating additional data.Then,the compressed data appended with the watermark are embedded into the cover text via synonym substitutions in an invertible manner.On the receiver side,the watermark and compressed data can be extracted by decoding the values of synonyms in the watermarked text,as a result of which the original context can be perfectly recovered by decompressing the extracted compressed data and substituting the replaced synonyms with their original synonyms.Experimental results demonstrate that the proposed method can extract the watermark successfully and achieve a lossless recovery of the original text.Additionally,it achieves a high embedding capacity.
基金This work was supported by the Major State Basic Research Project(Grant No.G200007 7700)the National Natural Science Foundation of China(Grant Nos.40572006 and 40232020).
文摘With the verification of the type specimen by six experts from the Nanjing Institute of Geology and Palaeontology, the specimen of Xianfengella prima He and Yang, 1982 described by Qian （Qian, 2001, flge2： la-c） is confirmed to be the holotype specimen （NIGP. 84430） of Yangtzedonta primitiva Yu, 1985, and consequently, Yu Wen＇s view that they are not the same specimen is impractical. This fact demonstrates that Yangtzedonta primitiva Yu, 1985 is undoubtedly a junior synonym of Xianftngella prima He and Yang, 1982, and is invalid. Qian＇s conclusion （Qian, 2001 ） that no bivalve appeared in the early Meishucunian Stage of the Early Cambrian is rational.
文摘Distinguishing the meanings of near synonyms always seems to be a challenging task for Chinese EFL learners,as is the case with bring about and give rise to be exemplified in the paper.I will use a corpus approach to unveil some implied semantic patterns and pragmatic features of the two phrases,and generalize their semantic prosodies as used by native English speakers by analyzing what kinds of nouns tend to co-occur with them,and also discuss whether there is a transfer of negative semantic prosody from the word cause to the two phrases under discussion.
文摘Corpus-based studies show that near-synonyms differ in their collocational behavior and semantic prosody which causes deviation in Chinese EFL learners’English using.This paper attempts to investigate the effectiveness of a corpus-based approach to the teaching and learning of near synonyms and their collocations.By using internet accessible computers to log on to websites of BNC and COCA,learners can view real language data and study the usage of targeted near synonyms.This empirical study tends to show that a corpus based approach is positively effective to the learning of near synonyms.It also provides some pedagogical implications that learners can play a major and active role in DDL and teachers only act as assistants.
基金This work is supported by the National Natural Science Foundation of China(No.61801440),the High-quality and Cutting-edge Disciplines Construction Project for Universities in Beijing(Internet Information,Communication University of China),State Key Laboratory of Media Convergence and Communication(Communication University of China),and the Fundamental Research Funds for the Central Universities.
文摘Word similarity(WS)is a fundamental and critical task in natural language processing.Existing approaches to WS are mainly to calculate the similarity or relatedness of word pairs based on word embedding obtained by massive and high-quality corpus.However,it may suffer from poor performance for insufficient corpus in some specific fields,and cannot capture rich semantic and sentimental information.To address these above problems,we propose an enhancing embedding-based word similarity evaluation with character-word concepts and synonyms knowledge,namely EWS-CS model,which can provide extra semantic information to enhance word similarity evaluation.The core of our approach contains knowledge encoder and word encoder.In knowledge encoder,we incorporate the semantic knowledge extracted from knowledge resources,including character-word concepts,synonyms and sentiment lexicons,to obtain knowledge representation.Word encoder is to learn enhancing embedding-based word representation from pre-trained model and knowledge representation based on similarity task.Finally,compared with baseline models,the experiments on four similarity evaluation datasets validate the effectiveness of our EWS-CS model in WS task.
基金supported by the National Natural Science Foundation of China(No.81873596).
文摘Objective:Autosomal dominant polycystic kidney disease(ADPKD)is mainly caused by the pathogenic mutation of PKD1 or PKD2 gene and usually affects bilateral kidneys.Synonymous mutations are generally assumed to be neutral as they do not alter amino acids.Herein,we described an extremely rare ADPKD child caused by a heterozygous synonymous mutation of PKD2 gene accompanied by massive proteinuria and congenital solitary kidney.Methods:Clinical characteristics of the patients were summarized.Whole-exome sequencing was performed to screen the disease-causing gene mutation,and reverse transcription polymerase chain reaction(RT-PCR)and Sanger sequencing were applied to analyze the impact of the identified mutation on gene transcription and splicing.Results:Polycystic changes were found in the solitary kidney of a girl initially presented with nephrotic-range proteinuria.Thereafter her mother and 2 other family members were diagnosed to be ADPKD.Whole-exome sequencing of the proband identified a heterozygous synonymous mutation(c.1716G>A,p.Lys572=)located in the splicing site of exon 7 in PKD2 gene,which was co-segregated with the PKD phenotype in the family.RT-PCR and direct sequencing of amplified products revealed that this heterozygous synonymous mutation led to exon7 skipping in PKD2 gene.Conclusion:We reported an extremely rare child case of ADPKD2 in combination with solitary kidney and nephrotic-range proteinuria,and firstly confirmed the pathogenicity of a heterozygous synonymous mutation(c.1716G>A)in PKD2 gene.The results indicate that synonymous mutations should not be excluded from disease-causing if they are located in splicing site of an exon.
基金The National Key Research and Development Program of China(No.2018YFC1314900,2018YFC1314902)the National Natural Science Foundation of China(No.61571109)the Fundamental Research Funds for the Central Universities(No.2242017K3DN04).
文摘To investigate how synonymous codons have been adapted to the formation of ribonucleic acid(RNA)G-quadruplex(rG4)structure,a computational searching algorithm G4Hunter was applied to detect rG4 structures in protein-coding sequences of mRNAs in five eukaryotic species.The native sequences forming rG4s were then compared with randomized sequences to evaluate selection on synonymous codons.Factors that may influence the formation of rG4 were also investigated,and the selection pressures of rG4 in different gene regions were compared to explore its potential roles in gene regulation.The results show universal selective pressure acts on synonymous codons in rG4 regions to facilitate rG4 formation in five eukaryotic organisms.While G-rich codon combinations are preferred in the rG4 structural region,C-rich codon combinations are selectively unfavorable for rG4 formation.Gene's codon usage bias,nucleotide composition,and evolutionary rate can account for the selective variations on synonymous codons among rG4 structures within a species.Moreover,rG4 structures in the translational initiation region showed significantly higher selective pressures than those in the translational elongation region.
基金Supported by Construction of Herbal Knowledge Base of Ancient Books of Asiatic plantain,Astragalus membranaceus and the Bulb of Fritillary Based on Neo4j(S202010162013).
文摘A textual research on materia medica of origin of orthonym and synonym of Cuscutae Semen and synonym of Nu Luo was conducted in this study,and the trade name,regional synonym and nickname of Cuscutae Semen were reviewed.The records of orthonym and synonym of Cuscutae Semen in the past dynasties,and the first published literature and writing date of orthodox and synonym were summarized.The textual research showed that Nu Luo and Cuscutae Semen were not the same plant,which had positive significance for the identification of the origin and modern application of Cuscutae Semen.
基金Supported by the National High Technology Research and Development Programme of China(No.2008AA01Z144)the National NaturalScience Foundation of China(No.61073126,61073129)
文摘In this work,an approach is proposed to acquire synonymous attribute phrases of named entities(NEs) from an online encyclopedia.Synonymous attribute phrases are the phrases that express the same attribute with different surface forms for a class of NEs.Specifically,the proposed approach is composed of three stages.Firstly,the entries related to a given NE class are automatically selected from an online encyclopedia.Secondly,attribute phrases are extracted based on the statistics of phrase frequency.Thirdly,synonymous attributes are identified in a pairwise manner through a classification framework combining multiple features.The proposed approach is applied on Baidu Baike,a Chinese online encyclopedia,for four different NE classes.Experimental results show that the approach obtains an average precision of 74%and an average F-value of 65%for the four NE classes.In particular,thousands of synonymous attribute phrase pairs are acquired for each class,which demonstrates the effectiveness of the proposed approach.
文摘Languages embody a lot of words that are considered as synonyms, and people just take it for granted that such words are identical in meaning without any discrimination. However, a corpus-based approach to the study of the collocational behavior of the two frequently-used pairs of synonyms （selection and option, ill and sick） reveals significant discrepancies in the use of these two pairs of synonyms by Chinese English learners and native speakers. According to the analysis, the major problems lie in the current ways of vocabulary teaching and learning. This paper aims to highlight the important role of the corpus-based collocational research in English vocabulary teaching and learning. In the end, some suggestions concerning vocabulary teaching and leaming are put forward on the basis of corpus-based research.
文摘This paper investigates Chinese EFL learners＇ acquisition of completely, totally and absolutely through a contrastive analysis of their collocation, colligation, semantic preference and semantic prosody based on the Ten-thousand English Compositions of Chinese Learners （TECCL Corpus） and Corpus of Contemporary American English （COCA）. The results show that adjective and verb are two major words frequently co-occurring with the group of synonyms, but only a few of them meet the default collocation criterion （frequency〉3, MI〉3）, and many co-occurring words used by Chinese learners don＇t appear in COCA. Besides, the co-occurring adjectives and verbs in TECCL are so diverse that they don＇t establish fixed semantic relations as in COCA, therefore, there is a big difference in semantic preference and semantic prosody between Chinese learners and native speakers. With the advance of English proficiency, more collocates are used by college learners than middle school learners, but there is no clear and significant improvement in semantic preference and semantic prosody.
文摘In order to better apply the semantic prosody theory to distinguish synonyms,this article chooses to use analysis software and corpus to specifically compare and analyze the difference between“weichi(维持)”and“baochi(保持)”.Although both“weichi(维持)”and“baochi(保持)”show neutral colors in the dictionary,through analysis of collocation words,it is found that“baochi(保持)”is often matched with positively colored words,so it has positive semantic characteristics,while“weichi(维持)”is more neutral and negative semantic prosody characteristics,and in the diachronic and synchronic word frequency survey,the word frequency of“baochi(保持)”is higher than that of“weichi(维持)”.
文摘The APCDDI （adenomatosis polyposis coli down-regulated 1） gene is an inhibitor of the Wnt signaling pathway, and a rare mutation of this gene has been associated with hereditary hypotrichosis simplex. In this study, the authors aimed to investigate whether common APCDD1 gene polymorphisms contribute to the development of androgenic alopecia. Patients （n = 210） with androgenic alopecia and 98 controls were investigated. SNPs （Single nucleotide polymorphisms） in the coding region of the gene were sequenced. A significant difference in genotype distribution was found for the c. 1781C/T, p.L476L SNP （rs3185480） of the APCDD1 gene. This SNP is located in exon 5 and is associated with a 3.5- and a 2.8-fold increase in risk for the development of androgenic alopecia for homozygote （CI 0.933-13.125; nominal regression P = 0.063） and heterozygote （CI 1.086-7.217; nominal regression P = 0.033） carriers, respectively. These data suggest that the rs3185480 polymorphism contributes to the development of androgenic alopecia. Protein expression experiments revealed that the polymorphism is associated with reduced APCDDI protein abundance. This reduction is likely due to altered codon usage for leucine from a preferred codon （CTC） to a rare codon （CTT）, which might influence translation efficiency and, thus, APCDDI protein level.
文摘This paper first points out the deficiency of listing synonyms by some dictionaries,such as the Cobuild Dictionary and Merriam-Webster’s Dictionary of Synonyms,which,however,have actually failed in distinguishing between some synonyms.Then,the paper attempts to solve the problem by providing a brief review of relevant studies in the past few decades on near synonyms with a focus on differences in denotation,connotation and semantic prosody of words as well as various definitions of semantic prosody and related researches.By evaluating the relevant research and defintions of semantic prosody,the review concluded that the alleged dictionaries would be perfected with the provision of connotations or semantic prosodies for near synonyms before suggesting out the focus of future and further research into near synonyms.
