Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared dr...Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared drug implant prototype consists of a doublelayer structure, of which the upper region is a reservoir system containing RFP and the lower region is a matrix one containing LVFX. The release test in vivo revealed that LVFX was released in the early stage; no RFP was detected until 8th day; both of them continuously released more than 6 weeks. Therefore, 3D printing technology provides a precise and feasible method to fabricate a controlled-releasing drug implant with complicated architectures and this drug implant may present a new strategy for the prophylaxis and treatment of bone diseases such as combined bone infections and bone tuberculosis in the near future.展开更多
The research progress and major achievements on genetic breeding, het- erosis utilization of rapeseed in Henan Province were summarized, with the aim to provide technical guidance for rapeseed genetic breeding in the ...The research progress and major achievements on genetic breeding, het- erosis utilization of rapeseed in Henan Province were summarized, with the aim to provide technical guidance for rapeseed genetic breeding in the future work. Faced with the problems of lack of special varieties, highly demand for healthy oil and high production cost in rapeseed production in recent years, the breeding goals of rapeseed have been adjusted from high yield, high quality and disease resistance to high oil, high oleic acid, adaptative to mechanization, late planting resistance. The breeding technologies mainly focused on the isolated microspore culture, molecular marker assisted selection, and the corresponding high efficiency technical systems were constructed. The innovative research on excellent germplasm resources were carried on, which created and established breeding populations and distinctive new germplasm resources with diverse variations such as high oil content, high oleic acid content and low linolenic acid, cold resistance, drought resistance, pod shatter resistance and different flower color variations. A series of rapeseed hybrids of dou- ble low varieties with strong heterosis and high oil contents were released and these hybrids significantly improved seed yield, quality and resistance. The average yield of rapeseed in Henan Province was 22.49% higher than the national average yield in 2003-2015. All of the achievements provided strong technical support for the upgrading of rapeseed varieties and increasing both production and income.展开更多
基金Funded by the Graduate Innovation Fund of the Huazhong University of Science and Technology, the "863" Key Project of the National High Technology Research and Development Program of China (No.2006AA02A124)the Program for New Century Excellent Talents in University from the Ministry of Education of China( NCET-05-0647)
文摘Three dimensional （3D） printing technology was utilized to fabricate a new type of drug implant with complicated architectures, employing levofloxacin （LVFX） and rifampicine （RFP） as model drugs. The prepared drug implant prototype consists of a doublelayer structure, of which the upper region is a reservoir system containing RFP and the lower region is a matrix one containing LVFX. The release test in vivo revealed that LVFX was released in the early stage; no RFP was detected until 8th day; both of them continuously released more than 6 weeks. Therefore, 3D printing technology provides a precise and feasible method to fabricate a controlled-releasing drug implant with complicated architectures and this drug implant may present a new strategy for the prophylaxis and treatment of bone diseases such as combined bone infections and bone tuberculosis in the near future.
基金Supported by the Key Scientific and Technological Project of Henan Province(151100111200)the National Natural Science Foundation of China(31271763)the China Agriculture Research System(CARS-13)~~
文摘The research progress and major achievements on genetic breeding, het- erosis utilization of rapeseed in Henan Province were summarized, with the aim to provide technical guidance for rapeseed genetic breeding in the future work. Faced with the problems of lack of special varieties, highly demand for healthy oil and high production cost in rapeseed production in recent years, the breeding goals of rapeseed have been adjusted from high yield, high quality and disease resistance to high oil, high oleic acid, adaptative to mechanization, late planting resistance. The breeding technologies mainly focused on the isolated microspore culture, molecular marker assisted selection, and the corresponding high efficiency technical systems were constructed. The innovative research on excellent germplasm resources were carried on, which created and established breeding populations and distinctive new germplasm resources with diverse variations such as high oil content, high oleic acid content and low linolenic acid, cold resistance, drought resistance, pod shatter resistance and different flower color variations. A series of rapeseed hybrids of dou- ble low varieties with strong heterosis and high oil contents were released and these hybrids significantly improved seed yield, quality and resistance. The average yield of rapeseed in Henan Province was 22.49% higher than the national average yield in 2003-2015. All of the achievements provided strong technical support for the upgrading of rapeseed varieties and increasing both production and income.
