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Proteomics Study of Benzene Metabolite Hydroquinone Induced Hematotoxicity in K562 Cells
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作者 JIN Yi Shan YI Zong Chun +2 位作者 ZHANG Yu Jing RONG Long YU Chun Hong 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第4期341-353,共13页
Objective Hydroquinone(HQ),one of the phenolic metabolites of benzene,is widely recognized as an important participant in benzene-induced hematotoxicity.However,there are few relevant proteomics in HQ-induced hematoto... Objective Hydroquinone(HQ),one of the phenolic metabolites of benzene,is widely recognized as an important participant in benzene-induced hematotoxicity.However,there are few relevant proteomics in HQ-induced hematotoxicity and the mechanism hasn’t been fully understood yet.Methods In this study,we treated K562 cells with 40μmol/L HQ for 72 h,examined and validated protein expression changes by Label-free proteomic analysis and Parallel reaction monitoring(PRM),and performed bioinformatics analysis to identify interaction networks.Results One hundred and eighty-seven upregulated differentially expressed proteins(DEPs)and 279 downregulated DEPs were identified in HQ-exposed K562 cells,which were involved in neutrophilmediated immunity,blood microparticle,and other GO terms,as well as the lysosome,metabolic,cell cycle,and cellular senescence-related pathways.Focusing on the 23 DEGs and 5 DEPs in erythroid differentiation-related pathways,we constructed the network of protein interactions and determined 6 DEPs(STAT1,STAT3,CASP3,KIT,STAT5B,and VEGFA)as main hub proteins with the most interactions,among which STATs made a central impact and may be potential biomarkers of HQ-induced hematotoxicity.Conclusion Our work reinforced the use of proteomics and bioinformatic approaches to advance knowledge on molecular mechanisms of HQ-induced hematotoxicity at the protein level and provide a valuable basis for further clarification. 展开更多
关键词 hydroquinone PROTEOMICS HEMATOTOXICITY K562 cells
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Metal organic framework(ZIF-67)-derived Co nanoparticles/Ndoped carbon nanotubes composites for electrochemical detecting of tert-butyl hydroquinone 被引量:5
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作者 Jing Tang Sheng-Biao Zheng +3 位作者 Si-Xun Jiang Jie Li Teng Guo Jia-Hao Guo 《Rare Metals》 SCIE EI CAS CSCD 2021年第2期478-488,共11页
In this work,the framework of Co nanoparticles and nitrogen-doped carbon nanotubes(Co/NCNTs)derived from metal-organic frameworks(MOFs)through solid pyrolysis was successfully synthesized in the atmosphere of H2 and A... In this work,the framework of Co nanoparticles and nitrogen-doped carbon nanotubes(Co/NCNTs)derived from metal-organic frameworks(MOFs)through solid pyrolysis was successfully synthesized in the atmosphere of H2 and Ar gases.The Co/NCNTs composites exhibited superior electrocatalytic performance for tert-butyl hydroquinone(TBHQ)oxidation due to the synergistic effect between chemical composition and the specific structure of Co nanoparticles and nitrogen-doped carbon nanotubes.It was found that the reaction underwent a quasi-reversible redox reaction with 37-fold higher anodic current for TBHQ at Co/NCNT-modified electrode when compared to bare glassy carbon electrode(GCE).In optimal condition,Co/NCNTs/GCE exhibited a linear range of0.05-80.00μmol·L^(-1) for detecting TBHQ,and the limit of detection(LOD)was estimated to be as low as10 nmol·L^(-1)(signal/noise of S/N=3).Moreover,the asobtained modified electrode was successfully used to assay the content of TBHQ in edible oil samples. 展开更多
关键词 Nitrogen-doped carbon nanotubes(NCNTs) ZIF-67 tert-butyl hydroquinone Modified electrode
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Possible Role of DNA Polymerase beta in Protecting Human Bronchial Epithelial Cells Against Cytotoxicity of Hydroquinone 被引量:2
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作者 DA-LIN HU HUAN-WEN TANG +11 位作者 HAI-RONG LIANG DONG-SHENG TANG YI-MING LIU WEI-DONG JI JIAN-HUI YUAN YUN HE ZHENG-Yu ZHU JIAN-PING YANG DAO-KUI FANG YAN SHA XIAO-ZHI TU ZHI-XIONG ZHUANG 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2007年第2期171-177,共7页
Objective To explore the toxicological mechanism of hydroquinone in human bronchial epithelial cells and to investigate whether DNA polymerase beta is involved in protecting cells from damage caused by hydroquinone. M... Objective To explore the toxicological mechanism of hydroquinone in human bronchial epithelial cells and to investigate whether DNA polymerase beta is involved in protecting cells from damage caused by hydroquinone. Methods DNA polymerase beta knock-down cell line was established via RNA interference as an experimental group. Normal human bronchial epithelial cells and cells transfected with the empty vector of pEGFP-C1 were used as controls. Cells were treated with different concentrations of hydroquinone (ranged from 10 μmol/L to 120 μmol/L) for 4 hours. MTT assay and Comet assay [single-cell gel electrophoresis (SCGE)] were performed respectively to detect the toxicity of hydroquinone. Results assay showed that DNA polymerase beta knock-down cells treated with different concentrations of hydroquinone had a lower absorbance value at 490 nm than the control cells in a dose-dependant manner. Comet assay revealed that different concentrations of hydroquinone caused more severe DNA damage in DNA polymerase beta knock-down cell line than in control cells and there was no significant difference in the two control groups. Conclusions Hydroquinone has significant toxicity to human bronchial epithelial cells and causes DNA damage. DNA polymerase beta knock-down cell line appears more sensitive to hydroquinone than the control cells. The results suggest that DNA polymerase beta is involved in protecting cells from damage caused by hydroquinone. 展开更多
关键词 Human bronchial epithelial cells RNA interference hydroquinone TOXICOLOGY DNA polymerase beta
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Electrochemistry of Hydroquinone Derivatives at Metal and Iodine-modified Metal Electrodes 被引量:1
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作者 HOU Peng HAN Dong-xue +1 位作者 NIU Li LIN Hai-bo 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2006年第4期493-499,共7页
The difference in the electrochemical behavior of hydroquinone and pyrocatechol at platinum and gold surfaces was analyzed using voltammetry and attenuated total reflection Fourier transform infrared spectroscopy. The... The difference in the electrochemical behavior of hydroquinone and pyrocatechol at platinum and gold surfaces was analyzed using voltammetry and attenuated total reflection Fourier transform infrared spectroscopy. The results show that the hydroquinone derivatives are adsorbed on a gold surface with vertical orientation, which makes the electron transfer between the bulk species and the electrode surface easier than that in the case of flat adsorption of hydroquinone derivatives that occurs at a platinum electrode. The formation of the vertical conformation and the rapid process of electron transfer were also confirmed by quantum chemistry calculations. In addition, the pre-adsorbed iodine on the electrodes played a key role on the adsorbed configuration and electron transfer of redox species. 展开更多
关键词 hydroquinone derivatives Iodine-modified ELECTROCHEMISTRY
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Selection of the Mutants with High Hydroquinone Degradation Ability of Serratia Marcesscen by Plasma Mutation
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作者 姚日生 尤启冬 +1 位作者 何炜静 朱慧霞 《Plasma Science and Technology》 SCIE EI CAS CSCD 2009年第3期364-367,共4页
In this study, an efficient way by plasma induced mutation was applied to improve the hydroquinone degradation capacity of Serratia marcescens AB 90027 (SM27). The results showed that combined with the selection of ... In this study, an efficient way by plasma induced mutation was applied to improve the hydroquinone degradation capacity of Serratia marcescens AB 90027 (SM27). The results showed that combined with the selection of hydroquinone tolerance, the mutant with high hy- droquinone degradation ability induced by plasma could be achieved. The best dose for plasma mutation was 15 s, which showed a 47.0% higher positive mutation ratio. Besides, the aimed mutant was markedly different from the parent strain (SM27) in colonial traits while cultivated on Kings media. Finally, the hydroquinone degradation ratio reached 70.5~o using the induced mutant strain with 1500 mg/L hydroquinone (HQ) after 15 days of cultivation as the selective conditions; however, it was only 46.7% for SM27. The improvement of the degradation capacity by the induced mutant with a high concentration of HQ selection was attributed to its faster growth and higher hydroquinone tolerance compared with that of the parent strain. 展开更多
关键词 serratia marcescens PLASMA MUTATION hydroquinone degradation
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Investigation of the oxidation of hydroquinone at the liquid/liquid interface
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作者 Lu, Xiao Quan Dong, De Fang +3 位作者 Liu, Xiu Hui Yao, Dong Na Wang, Wen Ting Xu, Yu Mei 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第2期225-228,共4页
The oxidation of hydroquinone(QH_2) was investigated for the first time at liquid/liquid(L/L) interface by scanning electrochemical microscopy(SECM).In this study,electron transfer(ET) from QH_2 in aqueous to ferrocen... The oxidation of hydroquinone(QH_2) was investigated for the first time at liquid/liquid(L/L) interface by scanning electrochemical microscopy(SECM).In this study,electron transfer(ET) from QH_2 in aqueous to ferrocene(Fc) in nitrobenzene (NB) was probed.The apparent heterogeneous rate constants for ET reactions were obtained by fitting the experimental approach curves to the theoretical values.The results showed that the rate constants for oxidation reaction of QH_2 were sensitive to the changes of the dri... 展开更多
关键词 SECM Electron transfer Liquid/liquid interface hydroquinone
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The First Total Synthesis of Triprenylquinone and Hydroquinones
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作者 Chun Hong LI Xue Song CHEN +2 位作者 Guang Lian ZHOU Zhi Xiang XIE Ying LI 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第8期1024-1026,共3页
First total synthesis of triprenylquinone and hydroquinones, three naturally occurringcompound 1, 2 and (±) 3, have been achieved from readily available 2-bromo-5-methyl-1,4-dimethoxybenzene 4 and geranyl bromi... First total synthesis of triprenylquinone and hydroquinones, three naturally occurringcompound 1, 2 and (±) 3, have been achieved from readily available 2-bromo-5-methyl-1,4-dimethoxybenzene 4 and geranyl bromide. The triprenylquinone and hydroquinones precursor were readily prepared with use of a Julia reaction. 展开更多
关键词 Sesquiterpene triprenylquinones and hydroquinones total synthesis Julia coupling.
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An Estimation Study to Determine the Percentage of Hydroquinone Levels in situ Skin Lightening Creams Using GC-MS and HPLC Spectroscopic Instruments
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作者 Maha Abdallah Alnuwaiser 《光谱学与光谱分析》 SCIE EI CAS CSCD 北大核心 2020年第6期1984-1987,共4页
Hydroquinone(HQ)is an phenolic aromatic compound used in cosmetic medicine as skin lightening material since long time ago.Accordingly the several pathological conditions that observed,the use of HQ for this purpose w... Hydroquinone(HQ)is an phenolic aromatic compound used in cosmetic medicine as skin lightening material since long time ago.Accordingly the several pathological conditions that observed,the use of HQ for this purpose was recently contraindicated.The commonly noted health problem associated with hydroquinone use was contact dermatitis.The present study was designed and conducted to determine the HQ presence and concentrations in ten samples of skin lightening cosmetics available in the local market.GC-MS analysis was employed for detection of HQ qualitatively while HPLC analysis was used as a quantitative analysis for determination of the HQ concentrations in each sample.The results obtained indicated that the overall range of HQ levels in all respected samples ranged from 0.0039%to 0.14%. 展开更多
关键词 Skin lightening COSMETICS hydroquinone GC-MS HPLC Assay
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Chemical analysis of hydroquinone and retinoic acid contents in facial whitening creams
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作者 Aung Myo Htet Ei Ei Thin +1 位作者 Mi Mi Saw Soe Win 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2016年第1期89-90,共2页
Hydroquinone is potentially carcinogenic and is known to be a skin and respiratory irritant.Hydroquinone is carcinogenic it has been banned in some countries because of fears of a cancer risk[1,2].Animal studies have ... Hydroquinone is potentially carcinogenic and is known to be a skin and respiratory irritant.Hydroquinone is carcinogenic it has been banned in some countries because of fears of a cancer risk[1,2].Animal studies have shown that topically applied retinoic acid can be photocarcinogenic[3].The aim of this study was qualitative and quantitative determination of hydroquinone and retinoic acid contents in facial whitening creams by colour reaction tests,FT-IR after TLC separation and HPLC. 展开更多
关键词 hydroquinone and RETINOIC ACID HPLC FACIAL WHITENING creams
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Molecular Cloning and Characterization of a Candidate Plant Growth-Related and Time-Keeping Constitutive Cell Surface Hydroquinone (NADH) Oxidase (ENOX1) from <i>Arabidopsis lyrata</i>
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作者 Xiaoyu Tang Laura M. C. Ades +1 位作者 Dorothy M. Morré D. James Morré 《Advances in Biological Chemistry》 2015年第1期1-15,共15页
ENOX (ECTO-NOX) proteins are proteins of the external surface of the plasma membrane that catalyze oxidation of both NADH and hydroquinones as well as carry out protein disulfidethiol interchange. They exhibit both pr... ENOX (ECTO-NOX) proteins are proteins of the external surface of the plasma membrane that catalyze oxidation of both NADH and hydroquinones as well as carry out protein disulfidethiol interchange. They exhibit both prion-like and time-keeping (clock) properties. The oxidative and interchange activities alternate to generate a regular period of 24 min in length. Here we report the cloning, expression, and characterization of a plant candidate constitutive ENOX (CNOX or ENOX1) protein from Arabidopsis lyrata. The gene encoding the 335 (165) amino acid protein is found in accession XP-002882467. Functional motifs characteristics of ENOX proteins previously identified by site-directed mutagenesis and present in the candidate ENOX1 protein from plants include adenine nucleotide and copper binding motifs along with essential cysteines. However, the drug binding motif (EEMTE) sequence of human ENOX2 is absent. The activities of the recombinant protein expressed in E. coli were unaffected by capsaicin, EGCg, and other ENOX2-inhibiting substances. Periodic oxidative activity was exhibited both with NAD(P)H and reduced coenzyme Q as substrate. Bound copper was necessary for activity and activity was inhibited by the ENOX1-specific inhibitor simalikalactone D. Addition of melatonin phased the 24-min period such that the next complete period began 24 min after the melatonin addition as appeared to be characteristic of ENOX1 activities in general. Periodic protein disulfide-thiol interchange activity also was demonstrated along with the 2 oxidative plus 3 interchange activity pattern characteristics of the 24-min ENOX1 protein period. Concentrated solutions of the purified plant ENOX1 protein formed insoluble aggregates, devoid of enzymatic activity, resembling amyloid. Activity was restored to aggregate preparations by isoelectric focusing. 展开更多
关键词 ENOX1 ECTO-NOX Proteins Plant Growth hydroquinone (NADH) Oxidation Plasma Membrane Electron Transport Arabadopsis lyrata
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Qualitative and Quantitative Estimation of Hydroquinone in Skin Whitening Cosmetics
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作者 Saima Siddique Zahida Parveen +1 位作者 Zeeshan Ali Muhammad Zaheer 《Journal of Cosmetics, Dermatological Sciences and Applications》 2012年第3期224-228,共5页
Hydroquinone has been used for decades as a skin lightening agent. Its use in cosmetics has been banned as a result of skin problems including contact dermatitis and ochronosis. A total of 22 samples of different skin... Hydroquinone has been used for decades as a skin lightening agent. Its use in cosmetics has been banned as a result of skin problems including contact dermatitis and ochronosis. A total of 22 samples of different skin whitening cosmetics were collected from local market. They were analyzed by using thin layer chromatography and HPLC for qualitative and quantitative determination of their hydroquinone contents. The hydroquinone was extracted from samples by using 96% ethanol and was subjected to TLC analysis. Eleven out of 22 samples were found to contain hydroquinone. The HPLC analysis showed the concentration of hydroquinone ranged from 0.002% to 0.092% in the cosmetic samples. 展开更多
关键词 hydroquinone HPLC WHITENING COSMETICS THIN Layer CHROMATOGRAPHY
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Assessment of Using Cosmetics Containing Hydroquinone among Sudanese Women
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作者 H. M. Osman M. E. Shayoub +1 位作者 Munzir M. E. Ahmed E. M. Babiker 《Journal of Cosmetics, Dermatological Sciences and Applications》 2015年第2期73-77,共5页
Many countries in the world wide banned hydroquinone in cosmetics skin lightening but it is still used in most of Africa countries, including Sudan. Few studies were carried out on the side effect of hydroquinone on S... Many countries in the world wide banned hydroquinone in cosmetics skin lightening but it is still used in most of Africa countries, including Sudan. Few studies were carried out on the side effect of hydroquinone on Sudanese women. Therefore, the present study was carried out in Khartoum state in April to May/2014 to assess the awareness of Sudanese women about using hydroquinone and its probable risks. The results revealed that, highly using cosmetics containing hydroquinone by women aged between 20 - 29 years (78.3%) as well as by those classified as single (69.6%). The results also showed that the highest percentage of women was using it during evening (81.2%) and a high percentage of them was using it for skin lightening (65.2%), followed by elimination acne (20.3%) and about 10.1% for both skin lightening and elimination of acne and very little (4.3%) for freckle elimination. Moreover, the results showed a very high percentage of women (94.2%) used the chemical without being prescribed by doctors and about (85.5%) of them didn’t know its nature and risks on human health. Consequently, (50.7%) of women have had sides effects, (44.9 %) used more than one and (44.1%) used it regularly. In addition, the results revealed that a wide range of products of this chemical was available in local market with amalico (34.8%) being highly used. The study can conclude that the awareness of Sudanese women about this compound was poor and needs to be raised by health authorities. 展开更多
关键词 COSMETICS SIDE Effects hydroquinone SKIN Lightening
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One-Pot Process of Naphthoquinones Synthesis from Hydroquinone in the Presence of Solutions of Mo-V-P Heteropolyacids as Bifunctional Catalysts
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作者 Leonid L. Gogin Elena G. Zhizhina Zinaida P. Pai 《Modern Research in Catalysis》 2019年第1期1-9,共9页
1,4-Naphthoquinones (NQ) is a class of organic compounds with a number of important properties. However, the existing methods of their synthesis either give a low NQ yield or multistage and require a lot of time. In t... 1,4-Naphthoquinones (NQ) is a class of organic compounds with a number of important properties. However, the existing methods of their synthesis either give a low NQ yield or multistage and require a lot of time. In the present work new one-pot process of NQ synthesis from hydroquinone (HQ) and substituted 1,3-dienes at room temperature is proposed. The solution of heteropolyacid H7PMo8V4O40 (HPA-4) is used as a bifunctional (acid and redox) catalyst for this process. The influence of a number of factors on key process parameters has been studied. It is demonstrated that unsubstituted and a number of alkyl substituted NQ with the yields of 50% - 80% and purity of 92% - 99% can be obtained by this method. The results obtained allow to significantly simplify the synthesis of NQ directly from HQ in comparison with the described similar methods. 展开更多
关键词 hydroquinone NAPHTHOQUINONES HETEROPOLYACID DIENE SYNTHESIS
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Combination (5% Hydroquinone, 0.1% Tretinoin and 1% Hydrocortisone) Cream in Treating Facial Hyperpigmentation: A Retrospective Patient Satisfaction Survey
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作者 John Fleming Saqib Bashir 《Journal of Cosmetics, Dermatological Sciences and Applications》 2014年第5期329-331,共3页
Background: Melasma and post-inflammatory hyperpigmentation provide a significant source of psychosocial morbidity, especially in those with Fitzpatrick skin types III-VI. In Europe, a proprietary product aimed at tre... Background: Melasma and post-inflammatory hyperpigmentation provide a significant source of psychosocial morbidity, especially in those with Fitzpatrick skin types III-VI. In Europe, a proprietary product aimed at treating these conditions, similar to Kligman’s formula but with a longer expiry date, has become available. Objectives: To assess patient satisfaction with a newly available combination de-pigmenting preparation. Methods: We conducted a small study to see if patients felt that this new product affected their quality of life and skin symptoms from hyperpigmentation. 41 subjects, who had all been prescribed a 15 g tube to use sparingly at night for 90 days within the last 12 months were telephoned to rate the effect the cream had on their quality of life and skin symptom improvement. Each patient also had their Dermatology Life Quality Index (DLQI) score assessed. Results: Out of the 29 patients who responded to the study, 22 had melasma and 7 had post-inflammatory hyperpigmentation from acne. 21 subjects felt that the cream made either a marked or moderate improvement on their quality of life and 23 subjects felt that the cream made either a marked or moderate improvement on their skin symptoms. Conclusion: Patients reported improvement in both hyperpigmentation and quality of life, suggesting a high level of satisfaction with treatment. The long shelf life of the product may also promote compliance and reduce health-care costs. 展开更多
关键词 MELASMA CHLOASMA Acne-Scarring hydroquinone TRETINOIN Kligman’s Solution
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Removal from Water and Adsorption onto Natural Quartz Sand of Hydroquinone
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作者 Hassan Ouachtak Rachid Ait Akbour +2 位作者 Jamaa Douch Amane Jada Mohamed Hamdani 《Journal of Encapsulation and Adsorption Sciences》 2015年第3期131-143,共13页
Hydroquinone (HQ) is the most important hydroxy aromatic compound which is produced on a large scale. Understanding its fate in the environment is therefore of primary importance to prevent its migration in the soil a... Hydroquinone (HQ) is the most important hydroxy aromatic compound which is produced on a large scale. Understanding its fate in the environment is therefore of primary importance to prevent its migration in the soil and/or the contamination of the aquatic ecosystems. Here we present a column based method to investigate the physicochemical processes controlling the removal from the aqueous phase and the adsorption onto natural quartz sand (NQS), of organic pollutant such as HQ molecules. We will focus on the interactions that occur between the organic pollutant and the NQS substrate. Thus, column reactors filled with NQS were used to investigate the influence of physicochemical parameters such as the ionic strength, the pH, the flow rate, and the nature of the electrolyte cation, on the HQ adsorption from water onto NQS substrate. The data indicate that, when divalent instead of monovalent cations, are present in the effluent water injection phase, and/or when the ionic strength of the effluent increases, the adsorbed HQ amount decreases. Similar decrease of the adsorbed HQ amount was also observed, at constant ionic strength, by increasing either, the pH from 3 to 9, the flow rate Q from 1 to 3 ml·mn-1, or by decreasing the HQ initial concentration, C0 from 30 to 6 mg·L-1. Further, large amount of the organic pollutant (up to 93 wt% of HQ molecules) was removed from the effluent water phase by using NQS column. The overall data seem to indicate that the adsorption of HQ molecules on the NQS surface is mainly controlled by electrostatic interaction forces occurring between the organic molecule polar groups and the inorganic matrix silanol groups. 展开更多
关键词 ADSORPTION hydroquinone NATURAL QUARTZ SAND Migration Porous Medium Surface CHARGE
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Preparation of Temperature and Water Responsive Microcapsules Containing Hydroquinone with Spray Drying Method
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作者 Kuniko Shirokawa Yoshinari Taguchi +2 位作者 Hiroshi Yokoyama Fumiyasu Ono Masato Tanaka 《Journal of Cosmetics, Dermatological Sciences and Applications》 2013年第3期49-54,共6页
It was tried to prepare temperature and water responsive microcapsules containing hydroquinone as a water soluble core material with the spray drying method. Microcapsules were composed of ethyl cellulose (EC), methyl... It was tried to prepare temperature and water responsive microcapsules containing hydroquinone as a water soluble core material with the spray drying method. Microcapsules were composed of ethyl cellulose (EC), methyl cellulose (MC) and P-N-isopropylacrylamid (PNIPAM). P-N-isopropylacrylamid and methyl cellulose were used as a temperature responsive polymer and as a water responsive polymer, respectively. Ethyl cellulose was the main shell material of microcapsule. At the microencapsulation process, the core and shell materials were dissolved in ethyl alcohol dissolving water (20 wt%) and then, spray-dried to prepare microcapsules. In the fundamental operation, the concentration and molecular weight of methyl cellulose were mainly changed. The releasing rate of hydroquinone was repressed at 40°C and increased at 20°C due to temperature responsive PNIPAM. Furthermore, responsibility to water was increased with the concentration of methyl cellulose. 展开更多
关键词 Stimuli RESPONSIVE MICROCAPSULE Spray Drying Method hydroquinone Controlled Release METHYL CELLULOSE
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CATALYTIC WET PEROXIDE OXIDATION OF HYDROQUINONE WITH Co(II)/ACTIVE CARBON CATALYST LOADED IN STATIC BED
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作者 LI Chunxiang YAN Yongsheng XU Wanzhen 《Chinese Journal of Reactive Polymers》 2008年第1期42-47,共6页
Catalysts based on Co(II) supported on active carbon were prepared and loaded in static bed. The hydroquinone would be degraded completely after treated by Catalytic wet peroxide oxidation method with Co(II)/active ca... Catalysts based on Co(II) supported on active carbon were prepared and loaded in static bed. The hydroquinone would be degraded completely after treated by Catalytic wet peroxide oxidation method with Co(II)/active carbon catalyst. After activate treatment, the active carbon was immerged in cobaltous nitrate solution, then put into a drying oven, Co(II) could be loaded on the micro-surface of carbon. Taking the static bed as the equipment, the absorption of active carbon and catalysis of Co(II) was used to reduce activation energy of hydroquinone. Thus hydroquinone could be drastically degraded and the effluent can be drained under the standard. Referring to Fenton reaction mechanism, experiment had been done to study the heterogeneous catalyzed oxidation mechanism of Co(II). The degradation rate of hydroquinone effluent could be achieved to 92% when treated in four columns at H2O2 concentration 10%, reaction temperature 40℃ , pH 5 and reaction time 2.5h. 展开更多
关键词 Catalytic wet peroxide oxidation hydroquinone Activate carbon Static bed.
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小鼠白癜风疾病模型的构建及初步研究
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作者 曾令娥 李林英 +3 位作者 王世全 李海涛 王俊亚 赵艳芝 《现代中西医结合杂志》 CAS 2024年第11期1496-1500,共5页
目的比较氢醌乳膏和莫诺苯宗乳膏诱导野生型C57BL/6J小鼠产生白癜风样表型的作用,构建组织病理学相似度高、脱色效果持久稳定且成本低、易操作的白癜风样小鼠模型,为选择白癜风疾病动物模型以研究人类白癜风疾病的发病机制以及药物治疗... 目的比较氢醌乳膏和莫诺苯宗乳膏诱导野生型C57BL/6J小鼠产生白癜风样表型的作用,构建组织病理学相似度高、脱色效果持久稳定且成本低、易操作的白癜风样小鼠模型,为选择白癜风疾病动物模型以研究人类白癜风疾病的发病机制以及药物治疗效果、药物作用机制提供依据。方法将30只C57BL/6J小鼠随机分为3组,每组10只。3组小鼠于背部相同部位去毛后,对照组涂抹乳膏基质,莫诺苯宗组涂抹40%莫诺苯宗乳膏,氢醌组涂抹2.5%氢醌乳膏,均1次/d,建模周期为50 d。肉眼观察造模部位皮肤变化;建模结束后处死各组小鼠,取病变部位皮肤组织,进行酪氨酸酶(TYR)免疫荧光染色观察;摘眼球取血,ELISA法检测血清中TYR、干扰素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、基质金属蛋白酶-9(MMP-9)水平。结果莫诺苯宗组和氢醌组小鼠均出现明显皮肤脱色,TYR表达平均光密度值明显降低。莫诺苯宗组和氢醌组小鼠血清TYR水平均明显低于对照组(P均<0.05),莫诺苯宗组和氢醌组比较差异无统计学意义(P>0.05);氢醌组小鼠血清IFN-γ、MMP-9水平均明显高于对照组和莫诺苯宗组(P均<0.05),血清TNF-α水平与对照组比较差异无统计学意义(P>0.05);莫诺苯宗组小鼠血清TNF-α水平明显高于对照组(P均<0.05),血清IFN-γ、MMP-9水平与对照组比较差异均无统计学意义(P均>0.05)。结论2.5%氢醌乳膏和40%莫诺苯宗乳膏涂抹法均可成功建立野生型C57BL/6J小鼠白癜风模型,其中2.5%氢醌乳膏更易诱导建立白癜风表观模型。 展开更多
关键词 白癜风 氢醌 莫诺苯宗 C57BL/6J小鼠 干扰素-Γ 基质金属蛋白酶-9
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ZIF纳米材料的制备及其电化学传感应用
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作者 刘建波 晁佳敏 +4 位作者 郑敏燕 许锦琼 程述章 魏欣悦 张立珺 《当代化工》 CAS 2024年第10期2433-2436,共4页
采用沉淀法制备了ZIF-67沸石咪唑酯纳米材料,利用扫描电镜对材料的微观形貌进行了表征。使用ZIF-67纳米材料,成功地构建了一种用于对苯二酚检测的电化学传感器。采用循环伏安法、安培法等方法测定了该电化学传感器的电化学性能。结果表... 采用沉淀法制备了ZIF-67沸石咪唑酯纳米材料,利用扫描电镜对材料的微观形貌进行了表征。使用ZIF-67纳米材料,成功地构建了一种用于对苯二酚检测的电化学传感器。采用循环伏安法、安培法等方法测定了该电化学传感器的电化学性能。结果表明:ZIF-67/GCE测量对苯二酚的线性范围2.5μmol·L^(-1)~34.5 mmol·L^(-1),检出限是0.83μmol·L^(-1)。研究结果提供了一种检测对苯二酚的新方法,也为其他电化学传感器构置提供了一定的参考与帮助。 展开更多
关键词 ZIF-67 对苯二酚 电化学传感 循环伏安法
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苯酚选择性氧化还原合成对苯二酚研究
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作者 王芳 黄杰军 +1 位作者 徐林 刘相李 《广州化工》 CAS 2024年第2期137-139,共3页
苯酚选择性氧化还原制备对苯二酚反应具有潜在的工业应用价值。本文使用复合型催化剂有机硒醚/CNTs将苯酚选择性地定向氧化为对苯醌,对苯醌在Pt/C催化剂的作用下还原为对苯二酚。为了提高对苯醌的收率,本文将硒催化组分固定在中空多孔... 苯酚选择性氧化还原制备对苯二酚反应具有潜在的工业应用价值。本文使用复合型催化剂有机硒醚/CNTs将苯酚选择性地定向氧化为对苯醌,对苯醌在Pt/C催化剂的作用下还原为对苯二酚。为了提高对苯醌的收率,本文将硒催化组分固定在中空多孔的碳纳米管上以增大催化剂的比表面积,苯酚氧化制备对苯醌选择性高达92.5%,具有催化剂制备简单、原料转化率和产物选择性高和废水排放量少等优势。 展开更多
关键词 苯酚 氧化还原 对苯醌 对苯二酚
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