[Objective]This study was to establish a rapid,specific and simple method for quantitative determination of tetrachlorantraniliprole by 1H NMR.[Method]1H NMR spectroscopy was acquired with deuterium DMSO as the solven...[Objective]This study was to establish a rapid,specific and simple method for quantitative determination of tetrachlorantraniliprole by 1H NMR.[Method]1H NMR spectroscopy was acquired with deuterium DMSO as the solvent and maleic acid as internal standard under the conditions of temperature 25℃,pulses width 8.0μs,delay time 5 s,and scanning times 8.[Result]The hydrogen proton peaks of tetrachlorantraniliprole(δ=10.55)and maleic acid(δ=6.27)were taken as quantitative peaks.The peak area ratio y(As/Ar)and mass ratio x(ms/mr)were linearly regressed,and the correlation coefficient was 0.9999.The RSD value of repeatability test was 0.38%,and the RSD value of stability test was 0.77%.The content of tetrachlorantraniliprole was determined as 99.6%.[Conclusion]1H NMR spectroscopy can be used for quantitative determination of tetrachlorantraniliprole without standard reference,which is rapid,accurate and simple.展开更多
Given the development of insects’resistance and deteriorative ecological environment,the discovery of insecticides with a new mode of action has been proven to be an important tool for comprehensive pest management.H...Given the development of insects’resistance and deteriorative ecological environment,the discovery of insecticides with a new mode of action has been proven to be an important tool for comprehensive pest management.Herein,a novel anthranilic diamides containing 3,5-dichloropyridylpyrazole group were designed and synthesized.Their insecticidal potency was assayed against beet armyworm(Spodoptera exigua).Moreover,the structure-activity relationship of these new compounds was also discussed.Of them,compound 15g exhibited potential insecticidal activity.Because of the excellent efficacy against a series of Lepidoptera and low toxicity to mammals,compound 15g,namely tetrachlorantraniliprole,has been developed and launched into the market as an insecticide.展开更多
文摘[Objective]This study was to establish a rapid,specific and simple method for quantitative determination of tetrachlorantraniliprole by 1H NMR.[Method]1H NMR spectroscopy was acquired with deuterium DMSO as the solvent and maleic acid as internal standard under the conditions of temperature 25℃,pulses width 8.0μs,delay time 5 s,and scanning times 8.[Result]The hydrogen proton peaks of tetrachlorantraniliprole(δ=10.55)and maleic acid(δ=6.27)were taken as quantitative peaks.The peak area ratio y(As/Ar)and mass ratio x(ms/mr)were linearly regressed,and the correlation coefficient was 0.9999.The RSD value of repeatability test was 0.38%,and the RSD value of stability test was 0.77%.The content of tetrachlorantraniliprole was determined as 99.6%.[Conclusion]1H NMR spectroscopy can be used for quantitative determination of tetrachlorantraniliprole without standard reference,which is rapid,accurate and simple.
基金supported by the National Key Research&Development Pillar Program of China during the 13th Five-Year Plan Period(Grant No.2016YFD0300708,2016YFD0300709).
文摘Given the development of insects’resistance and deteriorative ecological environment,the discovery of insecticides with a new mode of action has been proven to be an important tool for comprehensive pest management.Herein,a novel anthranilic diamides containing 3,5-dichloropyridylpyrazole group were designed and synthesized.Their insecticidal potency was assayed against beet armyworm(Spodoptera exigua).Moreover,the structure-activity relationship of these new compounds was also discussed.Of them,compound 15g exhibited potential insecticidal activity.Because of the excellent efficacy against a series of Lepidoptera and low toxicity to mammals,compound 15g,namely tetrachlorantraniliprole,has been developed and launched into the market as an insecticide.
