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The big data challenge-and how polypharmacology supports the translation from pre-clinical research into clinical use against neurodegenerative diseases and beyond
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作者 Sven Marcel Stefan Muhammad Rafehi 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第8期1647-1648,共2页
Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However,the m ultifactority of n eurodegen era tive diseases poses a real challenge for... Introductory comments:The identification and validation of disease-modifying proteins are fundamental aspects in drug development.However,the m ultifactority of n eurodegen era tive diseases poses a real challenge for targeted therapies.Furthermore,the behavior of individually(over-)expressed to rget proteins in vitro is likely to differ from their actual functional behavior when embedded in cascades and pathways in vivo. 展开更多
关键词 translation BEYOND LIKELY
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RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac^(4)C modification
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作者 Xiaochen Wang Rongsong Ling +2 位作者 Yurong Peng Weiqiong Qiu Demeng Chen 《International Journal of Oral Science》 SCIE CAS CSCD 2024年第1期73-84,共12页
Existing studies have underscored the pivotal role of N-acetyltransferase 10(NAT10) in various cancers. However, the outcomes of protein-protein interactions between NAT10 and its protein partners in head and neck squ... Existing studies have underscored the pivotal role of N-acetyltransferase 10(NAT10) in various cancers. However, the outcomes of protein-protein interactions between NAT10 and its protein partners in head and neck squamous cell carcinoma(HNSCC) remain unexplored. In this study, we identified a significant upregulation of RNA-binding protein with serine-rich domain 1(RNPS1) in HNSCC, where RNPS1 inhibits the ubiquitination degradation of NAT10 by E3 ubiquitin ligase, zinc finger SWIM domain-containing protein 6(ZSWIM6), through direct protein interaction, thereby promoting high NAT10 expression in HNSCC. This upregulated NAT10 stability mediates the enhancement of specific tRNA ac^(4)C modifications, subsequently boosting the translation process of genes involved in pathways such as IL-6 signaling, IL-8 signaling, and PTEN signaling that play roles in regulating HNSCC malignant progression, ultimately influencing the survival and prognosis of HNSCC patients. Additionally, we pioneered the development of TRMC-seq, leading to the discovery of novel t RNA-ac^(4)C modification sites, thereby providing a potent sequencing tool for tRNAac^(4)C research. Our findings expand the repertoire of tRNA ac^(4)C modifications and identify a role of tRNA ac^(4)C in the regulation of mRNA translation in HNSCC. 展开更多
关键词 NAT1 thereby translation
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Effective extraction of polyribosomes from astrocytes enables future discoveries on translation regulation
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作者 Orna Elroy-Stein 《Neural Regeneration Research》 SCIE CAS 2025年第4期1083-1084,共2页
Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain compl... Translation regulation is an important layer of gene expression:Generation of genome-wide expression datasets at multi-omics levels in spatial,temporal,and cell-type resolution is essential for deciphering brain complexity.Regulation of gene expression is a highly dynamic process aiming at the production of precise levels of gene products to guarantee optimal cellular function,in response to physiological cues.Speedy advances in next-generation sequencing enabled the understanding of epigenomic and transcriptomic dynamic landscapes of different brain regions along development,aging,and disease progression.However,the correlation of the“transcriptome”with protein levels is poor because numerous mRNAs are subjected to manipulation of their translation efficiency,to warrant a favorable result under certain conditions.Hence,it is widely accepted that regulation at the translation level is a vital layer of gene expression.Quantification of actively translated mRNA populations(i.e.,“translatome”)is a more reliable predictor of the“proteome”(Wang et al.,2020). 展开更多
关键词 translation enable LANDSCAPE
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语料库翻译研究背景下的“translationese”与“翻译共性”刍议
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作者 杨晓琳 李德超 《山东外语教学》 北大核心 2024年第3期108-119,共12页
近年来,在基于语料库的翻译研究背景下,翻译语言特征描写中的两个关键词——“translationese”与“翻译共性”备受关注,两者之间既有区别,亦有交织重叠的地方。在国内翻译研究领域,“translationese”的译名和定义也不尽一致。本研究... 近年来,在基于语料库的翻译研究背景下,翻译语言特征描写中的两个关键词——“translationese”与“翻译共性”备受关注,两者之间既有区别,亦有交织重叠的地方。在国内翻译研究领域,“translationese”的译名和定义也不尽一致。本研究梳理了语料库研究方法背景下两者的概念和研究模式的发展,进而探讨了translationese的连续性特征以及它与翻译共性假设的关系问题,提出以“特征译语”为译名以突出其特点,并阐明了本研究在理论与实践方面的意义。 展开更多
关键词 语料库翻译研究 源语干扰 连续性 翻译共性假设
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Translation Strategies of Red Tourism Terms in the Central Plains-Taking Red Central Plains as an Example
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作者 YUN Meng-nan 《Journal of Literature and Art Studies》 2024年第2期133-137,共5页
In recent years,the Red Tourism in Central Plains has gradually become a new type of thematic tourism form,which is an important carrier to carry out patriotism and revolutionary traditional education and carry forwar... In recent years,the Red Tourism in Central Plains has gradually become a new type of thematic tourism form,which is an important carrier to carry out patriotism and revolutionary traditional education and carry forward the national spirit.The translation of red tourism publicity is an important window for spreading Chinese culture,and the translation of professional terms is an important link in the red tourism publicity.How to spread the red culture of the Central Plains,glow the charm of the Central Plains culture,enhance the influence of the Central Plains culture,and spread the Central Plains culture to the world has become the mission of every child of the Central Plains.This paper adopts the case analysis method,combined with the specific and typical cases in“Red Central Plains”,and uses different translation strategies and methods to explore the difficulties and solutions of the translation of terms in the red tourism text. 展开更多
关键词 Red tourism Publicity translation Central Plains culture translation strategy
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A Study of English Translation Strategies of Subtitles of the Domestic Animated Film Chang’an from the Perspective of Eco-translatology
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作者 LIU Ya-ru 《Journal of Literature and Art Studies》 2024年第3期220-225,共6页
This article conducts an analysis and exploration of the English subtitles translation of the domestic animated film Chang’an from the perspective of eco-translatology.Taking three-dimensional transformation as the e... This article conducts an analysis and exploration of the English subtitles translation of the domestic animated film Chang’an from the perspective of eco-translatology.Taking three-dimensional transformation as the entry point,it analyzes the adaptation and selection of subtitle translators in the translation process from the dimensions of language,culture,and communication in Chang’an,aiming to enrich the practical analysis of eco-translatology and provide valuable insights and references for the theoretical construction and practical application of eco-translatology.This article enriches the practical analysis of eco-translatology and also validates to a certain extent the applicability of“three-dimensional”transformation. 展开更多
关键词 subtitle translation ECO-translatOLOGY Chang’an three-dimensional transformation translation as adaptation and selection
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Translation Theory and Techniques in Optometry Literature: A Case Study of the “Optoform 80 Installation and Maintenance Manual”
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作者 JIANG Fangzhou 《Sino-US English Teaching》 2024年第2期94-97,共4页
Translation of specialized documents in optometry presents unique challenges,requiring a deep understanding of the professional context,terminology,and adherence to specific translation styles.This paper delves into t... Translation of specialized documents in optometry presents unique challenges,requiring a deep understanding of the professional context,terminology,and adherence to specific translation styles.This paper delves into the translation theory and techniques employed in the English-to-Chinese translation of the“Optoform 80 Installation and Maintenance Manual”,serving as a case study.Emphasizing Nida’s theory of functional equivalence,the paper explores the complexities of translating professional optometry literature,focusing on key points and common issues in translating installation and maintenance manuals for optometric devices.Special attention is given to the translation of professional terminology,employing methods such as addition,omission,conversion,and repetition.The translation process aims to meet specific requirements,ensuring accuracy and coherence while aligning with Chinese language conventions.The paper also analyzes translation methods and techniques concerning terminology,prepositions,conjunctions,and handling parallel elements based on practical insights from the Optoform 80 Manual. 展开更多
关键词 optometry translation functional equivalence installation and maintenance manual translation
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A Comparative Study of Chinese Translations of Tagore’s Stray Birds From the Perspective of the“Three Beauties Theory”
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作者 YANG Ziye ZENG Shuang 《Sino-US English Teaching》 2024年第4期194-199,共6页
For more than 60 years,Mr.Xu Yuanchong has been devoted to education.He has not only made remarkable achievements in translating from and into Chinese,English,French and other languages,but has also developed his own ... For more than 60 years,Mr.Xu Yuanchong has been devoted to education.He has not only made remarkable achievements in translating from and into Chinese,English,French and other languages,but has also developed his own unique concept of translation.Since 1950,he has always adhered to the“Three Beauties Theory”,believing that translation should not only rely on the original text,but also realize the“beauty of meaning”,“beauty of sound”,and“beauty of form”.Based on Xu Yuanchong’s“Three Beauties Theory”,this paper takes Zheng Zhenduo’s and Feng Tang’s Chinese translations of Stray Birds as an example to explore in depth the specifics of poetry translation theory.The study summarizes the similarities and differences between these two translations in embodying the“three beauties”,providing insights into the Chinese translation techniques of philosophical prose poems.This endeavor seeks to offer valuable insights for the comparative study of Stray Birds translations。 展开更多
关键词 “Three Beauties Theory” Stray Birds translation of Zheng Zhenduo translation of Feng Tang
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A Descriptive Translation Study of Chinese Translation of French Musical Roméo et Juliette
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作者 SHI Xiao-wen 《Journal of Literature and Art Studies》 2024年第6期462-467,共6页
This paper presents a Descriptive Translation Study(DTS)analysis of the Chinese translation of the French musical adaptation of Romeo and Juliet,titled Roméo et Juliette:de la Haineàl’Amour.Romeo and Juliet... This paper presents a Descriptive Translation Study(DTS)analysis of the Chinese translation of the French musical adaptation of Romeo and Juliet,titled Roméo et Juliette:de la Haineàl’Amour.Romeo and Juliet,a timeless play by Shakespeare,has captivated audiences since its premiere in 1597 and has been adapted into various forms,including stage productions,films,musicals,and operas.The focus of this study is to analyze the Chinese translation of the French musical adaptation from a DTS perspective.DTS is an approach that aims to understand the translation process and its reception in the target culture.By examining language choices,cultural references,and adaptation strategies,this study seeks to shed light on how the Chinese translation of the French musical functions within the target culture and influences the reception and interpretation of the source text.This analysis is expected to gain insights into the challenges and strategies employed in translating a musical adaptation of Romeo and Juliet into Chinese.The findings of this study will contribute to the field of translation studies and provide a deeper understanding of the complexities involved in the translation of musical works. 展开更多
关键词 Descriptive translation Study(DTS) Chinese translation musical adaption of classics Romeo and Juliet reception and interpretation
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The Translation of Allusions in Political Discourse:An Intertextuality Perspective
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作者 LI Hai-long 《Journal of Literature and Art Studies》 2024年第5期343-348,共6页
drawn from ancient classics are the treasures of traditional Chinese culture.The allusions used in Xi Jinping:The Governance of China illustrate a distinctive feature of political discourse,and the publication of its ... drawn from ancient classics are the treasures of traditional Chinese culture.The allusions used in Xi Jinping:The Governance of China illustrate a distinctive feature of political discourse,and the publication of its English version provides a valuable opportunity for the study of allusions in translated political discourse.With the English translations of 241 allusions collected from two volumes of the book,we classified these allusions into three categories of history,culture,and literature based on their original sources.Then we analyzed the strategies used in translating the allusions,and provided typical examples to illustrate the use of such translation strategies for each category.Finally,we tried to account for the use of these strategies in light of the intertextuality theory. 展开更多
关键词 ALLUSION political discourse INTERTEXTUALITY translation strategies
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Exploring the groundwater response to rainfall in a translational landslide using the master recession curve method and cross-correlation function
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作者 Cheng-peng Ling Qiang Zhang 《Journal of Groundwater Science and Engineering》 2024年第3期237-252,共16页
Rainfall is a common trigger for landslide reactivation,as it raises groundwater levels and reduces bedrock or soil shear resistance.This study focuses on the Kualiangzi landslide in the southern region of Sichuan Pro... Rainfall is a common trigger for landslide reactivation,as it raises groundwater levels and reduces bedrock or soil shear resistance.This study focuses on the Kualiangzi landslide in the southern region of Sichuan Province,China.Real-time monitoring of groundwater levels and rainfall from July 2013 to September 2016 is analyzed.Groundwater table increments,considering groundwater drainage rate,were calculated using the water-table fluctuation and master recession curve method and the response time of the groundwater table to rainfall events was estimated using the cross-correlation function.Results reveal that groundwater level declines from tension troughs to landslide fronts in the rainy season,with a significant positive correlation between the groundwater level in the tension trough and landslide surface displacement.Evaluated spring elevations for groundwater discharge range from 410 m to 440 m,which is in agreement with the actual spring elevations(390-423 m).Lag times of groundwater response to rainfall decreases with cumulative rainfall of the rainy periods.In the middle part of the landslide,two responses between rainfall and groundwater levels indicate two water movement pathways:Vertical cracks or fractures resulting from the slow landslide movement,and matrix pore space in unconsolidated sediment.Variations in peak values of the cross-correlation function suggest early dominance of the uniform matrix flow and later dominance of preferential flow during the rainy period. 展开更多
关键词 translational landslide RAINFALL GROUNDWATER Lag response Water table fluctuation Recharge pathway
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Beyond Gender Perspectives:A More Comprehensive Examination of Yang Yi’s Translation of Wuthering Heights
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作者 LIU Miao 《Sino-US English Teaching》 2024年第7期332-336,共5页
The renowned translator Yang Yi passed away in 2023.Many scholars argue that,influenced by their biological gender,female translators often employ translation methods in adherence to feminist translation or reflect ch... The renowned translator Yang Yi passed away in 2023.Many scholars argue that,influenced by their biological gender,female translators often employ translation methods in adherence to feminist translation or reflect characteristics typical of female translators.This study examines the translation of Wuthering Heights by Yang Yi,focusing on whether there is a definite influence of gender on translator behavior.While existing literature primarily analyzes Yang Yi’s work through a feminist lens,this research takes a broader approach.By considering the translator’s social background and translation practice,this paper challenges the assumption that her work strictly aligns with feminist translation theories.Instead,this study emphasizes the importance of considering diverse factors when interpreting translated works,moving beyond a singular gender-based standpoint. 展开更多
关键词 GENDER translation Yang Yi Wuthering Heights FEMINISM
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A Case Study of Periodical Terminologies’Mis-translations in History of Chinese Journalism by Ko Kung-chen under Analysis-Synthesis Translation Mode
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作者 XIANG Shao-jing WANG Hai 《Journal of Literature and Art Studies》 2024年第1期54-78,共25页
From the perspective of analysis-synthesis translation mode,this paper discusses the translator’s responsibility and the translator’s role in the translation of historiography,based on the case of Ko Kung-chen’s Hi... From the perspective of analysis-synthesis translation mode,this paper discusses the translator’s responsibility and the translator’s role in the translation of historiography,based on the case of Ko Kung-chen’s History of Chinese Journalism.Missionary J.S.Roberts believed that translation is the logical combination of two processes of analysis and synthesis.The analysis process is characterized by understanding,emphasizing accurate understanding and professional analysis of the source text,while the synthesis process focuses on the transformation of language and culture.The two processes are dependent,forming the whole process of translation altogether.As the indisputable subject of translation,the translator should assume his own subjective responsibility in the two processes.The translator should be responsible for the fact and professional academics in the analysis process,and language and culture and translation itself in the synthesis process,playing the role of a reviewer,disseminator and translator to ensure that the translation text would be correct,accurate and professional so as to realize the value of himself and translation. 展开更多
关键词 analysis-synthesis translation mode History of Chinese Journalism by Ko Kung-chen translation of periodical terminology
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Analysis on the Translation Methods of the Reported Speech in German Academic Papers-Taking the Translation of“Die Internationalisierung der deutschen Hochschulen”as an Example
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作者 WANG Rui CHEN Qi 《Journal of Literature and Art Studies》 2024年第9期802-807,共6页
Reporting is essential in language use,including the re-expression of other people’s or self’s words,opinions,psychological activities,etc.Grasping the translation methods of reported speech in German academic paper... Reporting is essential in language use,including the re-expression of other people’s or self’s words,opinions,psychological activities,etc.Grasping the translation methods of reported speech in German academic papers is very important to improve the accuracy of academic paper translation.This study takes the translation of“Internationalization of German Universities”(Die Internationalisierung der deutschen Hochschulen),an academic paper of higher education,as an example to explore the translation methods of reported speech in German academic papers.It is found that the use of word order conversion,part of speech conversion and split translation methods can make the translation more accurate and fluent.This paper helps to grasp the rules and characteristics of the translation of reported speech in German academic papers,and also provides a reference for improving the quality of German-Chinese translation. 展开更多
关键词 academic paper reported speech translation
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Transcreation in Advertisement Slogans from the Perspective of Communicative Translation Theory
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作者 ZHU Wei-jia 《Journal of Literature and Art Studies》 2024年第5期349-354,共6页
Through in-depth analysis of advertisement slogans,the present study probes into the unique contribution of trancreation in conveying brand messages and triggering emotional resonance of the audience.The study firstly... Through in-depth analysis of advertisement slogans,the present study probes into the unique contribution of trancreation in conveying brand messages and triggering emotional resonance of the audience.The study firstly outlines theoretical basis of transcreation from the perspective of Communicative Translation Theory,emphasizing its uniqueness in the traditional translation paradigm.Then the four key steps of transcreation,including in-depth understanding of the brand essence,sensitive response to cultural differences,flexible use of language skills,and incorporation of creative elements,are examined by means of case analysis in advertisement translation.Finally,the article sums up the positive impact of transcreation on cultural exchange,brand communication and translation field,particularly in the era of globalisation. 展开更多
关键词 transcreation advertisment slogans communicative translation theory
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Review of Research on English Translation of Chinese Running Sentences
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作者 ZHANG Wen-hui 《Journal of Literature and Art Studies》 2024年第7期624-627,共4页
In order to convey complete meanings,there is a phenomenon in Chinese of using multiple running sentences.Xu Jingning(2023,p.66)states,“In communication,a complete expression of meaning often requires more than one c... In order to convey complete meanings,there is a phenomenon in Chinese of using multiple running sentences.Xu Jingning(2023,p.66)states,“In communication,a complete expression of meaning often requires more than one clause,which is common in human languages.”Domestic research on running sentences includes discussions on defining the concept and structural features of running sentences,sentence properties,sentence pattern classifications and their criteria,as well as issues related to translating running sentences into English.This article primarily focuses on scholarly research into the English translation of running sentences in China,highlighting recent achievements and identifying existing issues in the study of running sentence translation.However,by reviewing literature on the translation of running sentences,it is found that current research in the academic community on non-core running sentences is limited.Therefore,this paper proposes relevant strategies to address this issue. 展开更多
关键词 Chinese running sentences TOPICS English-Chinese translation
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Research on the Chinese Translation of Brand Advertisements from the Perspective of Skopos Theory
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作者 DONG Xue-mei 《Journal of Literature and Art Studies》 2024年第2期128-132,共5页
This study is based on the Skopos theory,using the translation of selected brand advertising slogans as examples.It analyzes the characteristics of advertising slogans and summarizes translation strategies to illustra... This study is based on the Skopos theory,using the translation of selected brand advertising slogans as examples.It analyzes the characteristics of advertising slogans and summarizes translation strategies to illustrate the research value of translating advertising slogans into Chinese.This research aims to help domestic consumers accurately understand the meaning of imported product advertisements and provide reference for the translation of domestic brand advertisements,thereby contributing to the development of national enterprises. 展开更多
关键词 skopos theory brand advertising translation strategies
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A Study on the Translation of Plant Images in Qu Yuan’s Li Sao
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作者 ZHANG Fang-fang CAI Ke-ying +1 位作者 YANG Lei BAO De-wang 《Journal of Literature and Art Studies》 2024年第5期325-329,共5页
The renowned masterpiece“Li Sao”by Qu Yuan contains numerous plant images for“expressing emotions and aspirations.”Exploring methods of translating plant imagery has greatly assisted in disseminating Chinese class... The renowned masterpiece“Li Sao”by Qu Yuan contains numerous plant images for“expressing emotions and aspirations.”Exploring methods of translating plant imagery has greatly assisted in disseminating Chinese classical culture and facilitating cross-cultural communication.This study conducts a comparative analysis of three translations of“Li Sao”by Xu Yuanchong,Yang Xianyi,and Hawkes,aiming to understand the different approaches to translating plant imagery and explore variations in translation effectiveness.Through data collection,comparative analysis,and case studies,this research reveals that Xu Yuanchong emphasizes free translation,Yang Xianyi tends towards literal translation,and Hawkes adopts a combination of literal,free,and phonetic translation methods. 展开更多
关键词 Li Sao plant imagery translation strategies
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On Translation Strategies of Commercial Advertisements From the Perspective of Skopos Theory
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作者 ZHENG Hanyue GAO Jun 《Sino-US English Teaching》 2024年第6期296-301,共6页
In a highly competitive market,excellent advertising translation can better promote brands.By adopting the three principles of Skopos Theory,this paper discusses the E-C translation strategies of commercial advertisem... In a highly competitive market,excellent advertising translation can better promote brands.By adopting the three principles of Skopos Theory,this paper discusses the E-C translation strategies of commercial advertisements based on specific advertising translation cases,and proposes translation methods of literal translation,free translation,paraphrase,and augmentation,as well as rhetorical methods of homophonic puns,aiming to improve the quality of commercial advertisement translations,enhance the publicity effect,and achieve brand marketing. 展开更多
关键词 commercial advertisement Skopos Theory translation strategy rhetorical method
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A Translator’s Feed-Back About the Practice of Pun-Translation-From the Chinese Version of The Life of Napoleon Bonaparte
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作者 ZHANG Li 《Sino-US English Teaching》 2024年第2期89-93,共5页
It has been acknowledged by Chinese translators that in translating English puns the center should be put on the thorough comprehension of the original expression that more often than not has more than one meanings an... It has been acknowledged by Chinese translators that in translating English puns the center should be put on the thorough comprehension of the original expression that more often than not has more than one meanings and the flexible handling of conversion from the native language to the target one. Literal translation will often be impossible, annotation redundant, and the restructuring and remaking of new ways that create and maintain balance or similarity in function and value will be more preferred as a possible way-out for pun-translation. Examples attached are from the writer of this article who is also the translator of a published historical book where punning can be found. 展开更多
关键词 PUN translation The Life of Napoleon Bonaparte
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