BACKGROUND Pegylated liposomal doxorubicin(PLD)uses the hydrophilic layer of liposomes to reach the sweat on the skin surface or accumulate in the sweat glands,producing toxic free radicals and oxidative damage,result...BACKGROUND Pegylated liposomal doxorubicin(PLD)uses the hydrophilic layer of liposomes to reach the sweat on the skin surface or accumulate in the sweat glands,producing toxic free radicals and oxidative damage,resulting in hand-foot syndrome(HFS).Regional cooling can induce vasoconstriction to reduce the release of drugs in the limbs and reduce the accumulation of drugs in sweat glands;thus,decreasing the incidence and severity of HFS.AIM To study the efficacy of cooling patches to prevent HFS caused by PLD in the short-term.METHODS This is a retrospective cohort study.Female breast cancer patients(n=101)who were treated with PLD in two breast wards at our department from February 2020 to February 2021 were enrolled in the study and were randomly divided into the cooling group(51 patients)and the control group(50 patients).Patients in the control group only received routine care,while the patients in the cooling group applied cooling patches,based on routine care,to the palm and back of the hands 15 min before chemotherapy infusion for 10 h.All patients took a corresponding dose of dexamethasone orally one day before chemotherapy,on the day of chemotherapy,and one day after chemotherapy.SPSS23.0 version was used to analyze the data in this study.The occurrence and severity of HFS was analyzed by the Mann-Whitney U test,and scores were analyzed by the Student’s t test or Wilcoxon rank-sum test.A P value<0.05 was regarded as statistically significant.RESULTS In this study,neither group of patients developed Grade 3 HFS.In the control group,the incidence of Grade 1 HFS and Grade 2 HFS was 38%and 2%,respectively.However,in the cooling group,only one person developed Grade 1 HFS(2%),and none of the patients developed Grade 2 HFS.These findings showed that cooling patches can effectively reduce the frequency and severity of HFS(P<0.0001)in the short-term.Before the fourth chemotherapy cycle,although general self-efficacy scale scores in the cooling group were low,they were still significantly higher than those in the control group(17.22±5.16 vs 19.63±6.42,P=0.041).Compared with the control group,the mean Hand-Foot Skin Reaction and Quality of Life Questionnaire score in the cooling group was significantly lower(18.08±7.01 vs 14.20±7.39,P=0.008).CONCLUSION Cooling patches can effectively reduce the frequency and severity of HFS caused by PLD in the short-term.In addition,it may help delay the decline in patients’self-efficacy.展开更多
This article presents an innovative facade system designed to increase the thermal comfort inside an office room and to enhance the cooling capacity of the suspended cooling ceiling. A series of measurements is conduc...This article presents an innovative facade system designed to increase the thermal comfort inside an office room and to enhance the cooling capacity of the suspended cooling ceiling. A series of measurements is conducted in an existing office building with different facade systems （i.e., a combination of grazing and shading）. An innovative facade system is devetoped based on this intensive set of measurements. The new system enhances the thermal comfort and cooling capacity of the suspended cooling ceiling. The main usage of the new system is the refurbishment and improvement of existing facade systems.展开更多
a＇-Sr2SiO4：Eu2＋ phase always coexists with the Sr3SiO5：Eu2＋ phase when it is synthesized by a high-temperature solid-state method. This may affect the luminescent properties of the Sr3SiO5：Eu2＋ phosphors. We in...a＇-Sr2SiO4：Eu2＋ phase always coexists with the Sr3SiO5：Eu2＋ phase when it is synthesized by a high-temperature solid-state method. This may affect the luminescent properties of the Sr3SiO5：Eu2＋ phosphors. We investigated the decomposition reaction of Sr3SiO5 during the cooling process with the quenching method. The results indicated that Sr3SiO5 was a stable compound above 1250℃. The Sr3SiO5 phase decomposed into a＇-Sr2SiO4 and SrO below 1250℃. The a＇-Sr2SiO4：Eu2＋ phase would coexist with the Sr3SiOs：Eu2＋ phase because of the decomposition reaction of Sr3SiO5, making the luminescent wavelength of coexistence sample move to the short-wavelength compared with the luminescent wavelength of Sr3SiO5：Eu2＋. Pure phase Sr3SiO5：Eu2＋ could be obtained by the rapid cooling method to suppress Sr3SiO5 decomposition. When the cooling rate was 20℃/min, nearly pure phase Sr3SiO5：Eu2＋ could be produced.展开更多
文摘BACKGROUND Pegylated liposomal doxorubicin(PLD)uses the hydrophilic layer of liposomes to reach the sweat on the skin surface or accumulate in the sweat glands,producing toxic free radicals and oxidative damage,resulting in hand-foot syndrome(HFS).Regional cooling can induce vasoconstriction to reduce the release of drugs in the limbs and reduce the accumulation of drugs in sweat glands;thus,decreasing the incidence and severity of HFS.AIM To study the efficacy of cooling patches to prevent HFS caused by PLD in the short-term.METHODS This is a retrospective cohort study.Female breast cancer patients(n=101)who were treated with PLD in two breast wards at our department from February 2020 to February 2021 were enrolled in the study and were randomly divided into the cooling group(51 patients)and the control group(50 patients).Patients in the control group only received routine care,while the patients in the cooling group applied cooling patches,based on routine care,to the palm and back of the hands 15 min before chemotherapy infusion for 10 h.All patients took a corresponding dose of dexamethasone orally one day before chemotherapy,on the day of chemotherapy,and one day after chemotherapy.SPSS23.0 version was used to analyze the data in this study.The occurrence and severity of HFS was analyzed by the Mann-Whitney U test,and scores were analyzed by the Student’s t test or Wilcoxon rank-sum test.A P value<0.05 was regarded as statistically significant.RESULTS In this study,neither group of patients developed Grade 3 HFS.In the control group,the incidence of Grade 1 HFS and Grade 2 HFS was 38%and 2%,respectively.However,in the cooling group,only one person developed Grade 1 HFS(2%),and none of the patients developed Grade 2 HFS.These findings showed that cooling patches can effectively reduce the frequency and severity of HFS(P<0.0001)in the short-term.Before the fourth chemotherapy cycle,although general self-efficacy scale scores in the cooling group were low,they were still significantly higher than those in the control group(17.22±5.16 vs 19.63±6.42,P=0.041).Compared with the control group,the mean Hand-Foot Skin Reaction and Quality of Life Questionnaire score in the cooling group was significantly lower(18.08±7.01 vs 14.20±7.39,P=0.008).CONCLUSION Cooling patches can effectively reduce the frequency and severity of HFS caused by PLD in the short-term.In addition,it may help delay the decline in patients’self-efficacy.
文摘This article presents an innovative facade system designed to increase the thermal comfort inside an office room and to enhance the cooling capacity of the suspended cooling ceiling. A series of measurements is conducted in an existing office building with different facade systems （i.e., a combination of grazing and shading）. An innovative facade system is devetoped based on this intensive set of measurements. The new system enhances the thermal comfort and cooling capacity of the suspended cooling ceiling. The main usage of the new system is the refurbishment and improvement of existing facade systems.
基金supported by Jilin Provincial Science and Technology Department(20090348,20080511,20101117)Jilin Province Project Development and Reform Commission(2011FGW03)the "Eleventh-Five" Science and Technology Project of Jilin Province Education Department(200938)
文摘a＇-Sr2SiO4：Eu2＋ phase always coexists with the Sr3SiO5：Eu2＋ phase when it is synthesized by a high-temperature solid-state method. This may affect the luminescent properties of the Sr3SiO5：Eu2＋ phosphors. We investigated the decomposition reaction of Sr3SiO5 during the cooling process with the quenching method. The results indicated that Sr3SiO5 was a stable compound above 1250℃. The Sr3SiO5 phase decomposed into a＇-Sr2SiO4 and SrO below 1250℃. The a＇-Sr2SiO4：Eu2＋ phase would coexist with the Sr3SiOs：Eu2＋ phase because of the decomposition reaction of Sr3SiO5, making the luminescent wavelength of coexistence sample move to the short-wavelength compared with the luminescent wavelength of Sr3SiO5：Eu2＋. Pure phase Sr3SiO5：Eu2＋ could be obtained by the rapid cooling method to suppress Sr3SiO5 decomposition. When the cooling rate was 20℃/min, nearly pure phase Sr3SiO5：Eu2＋ could be produced.
