The measurement of stratum corneum (SC) thickness from in-vivo Raman water concentration depth profiles is gaining in popularity and appeal due to the availability and ease of use of in-vivo confocal Raman measurement...The measurement of stratum corneum (SC) thickness from in-vivo Raman water concentration depth profiles is gaining in popularity and appeal due to the availability and ease of use of in-vivo confocal Raman measurement systems. The foundation of these measurements relies on high-quality confocal Raman spectroscopy of skin and the robust numerical analysis of water profiles, which allow for accurate determination of SC thickness. These measurements are useful for studying intrinsic skin hydration profiles at different body sites and for determining hydration properties of skin related to topically applied materials. While the use of high-quality in-vivo Raman instrumentation has become routine and its use for SC thickness measurement widely reported, there is lack of agreement as to the best method of computing SC thickness values from Raman water profiles. Several methods have been proposed and are currently in use for such computations, but none of these methods has been critically evaluated. The work reported in this paper describes a new method for the determination of stratum corneum thickness from in-vivo confocal Raman water profiles. The method represents a consensus approach to the problem, which was found necessary to apply in order to properly model and quantify the large diversity of water profile types encountered in typical in-vivo Raman water measurement. The methodology is evaluated for performance using three criteria: 1) frequency of minimum fitting error on modeling to a standard numerical function;2) frequency of minimum model error for consensus vs. individual SC thickness values;and 3) correlation with reflectance confocal microscopy (RCM) values for SC thickness. The correlation study shows this approach to be a reasonable replacement for the more tedious and time-consuming RCM method with R2 = 0.68 and RMS error = 3.7 microns over the three body sites tested (cheek, forearm and leg).展开更多
1 Preface In the northern and northwestern parts of China, quite a large portion of area, approximately 630,000 km^2, is covered by loess and loess-liked soils. The loess thickness ranges from several meters to severa...1 Preface In the northern and northwestern parts of China, quite a large portion of area, approximately 630,000 km^2, is covered by loess and loess-liked soils. The loess thickness ranges from several meters to several hundred meters along the river’s terraces to those geomorphologic plateaus. In geology, "China Loess" has become a geologic term, because the loess in China has evolved with the widest distribution and greatest thickness in the world, and is also a typical and significant deposit in Quaternary Period.展开更多
The existence of loose landslides not only poses a huge safety hazard to the construction of tunnel entrances, but also significantly increases the difficulty of site construction. In this paper, we investigate the co...The existence of loose landslides not only poses a huge safety hazard to the construction of tunnel entrances, but also significantly increases the difficulty of site construction. In this paper, we investigate the comprehensive slope reinforcement management technology for tunnel entrances in thick landslide strata, using the finite element analysis software ABAQUS to study the slope safety coefficients, displacements and plastic zone changes under different management conditions, propose a design structure for slope stability enhancement in thick landslide strata, and analyse the effect of the application of slope stability enhancement measures for thick landslide strata. The results show that the enhanced design structure is used to enhance slope stability. The results show that after the landslide treatment with the enhanced design structure, the slope safety factor was increased from 0.961 to 1.512, the maximum horizontal tangential displacement was reduced from 330.2 mm to 32.74 mm, and the area of plastic zone was significantly reduced, and the landslide support effect was remarkable.展开更多
Water-and-mud inrush disasters have become a major challenge in underground engineering for the construction of tunnels in sandstone and slate interbedded Presinian strata.Disaster prediction and prevention rely in pa...Water-and-mud inrush disasters have become a major challenge in underground engineering for the construction of tunnels in sandstone and slate interbedded Presinian strata.Disaster prediction and prevention rely in part on realistic modeling and observation of the disaster process,as well as the identification and examination of the underlying mechanisms.Based on the geological conditions and the historical records of the Xinping Tunnel on the China–Laos Railway,an engineering geological model of the water-and-mud inrush was established.A physical model test that accurately reproduced water-and-mud inrush during tunnel excavation in sandstone and slate interbedded strata was also carried out.Then,testing was conducted that examined the stress and strain,seepage pressure,and high-leakage flow of the surrounding rock.The results indicated that the water-and-mud inrush proceeded through three stages:seepage stage,high-leakage flow stage,and attenuation stage.In essence,the disaster was a catastrophic process,during which the water-resistant stratum was reduced to a critical safety thickness,a water-inrush channel formed,and the water-resistant stratum gradually failed under the influence of excavation unloading and in situ stress–seepage coupling.Parameters such as the stress and strain,seepage pressure,and flow of the surrounding rock had evident stage-related features during water-and-mud inrush,and their variation indicated the formation,development,and evolution of the disaster.As the tunnel face advanced,the trend of the stress–strain curve of the surrounding rock shifted from sluggish to rapid in its speed of increase.The characteristics of strain energy density revealed the erosion and weakening effect of groundwater on the surrounding rock.The seepage pressure and the thickness of the water-resistant stratum had a positive linear relationship,and the flow and thickness a negative linear relationship.There was a pivotal point at which the seepage pressure changed from high to low and the flow shifted from low to high.The thickness of the water-resistant stratum corresponding to the pivotal point was deemed the critical safety thickness.展开更多
文摘The measurement of stratum corneum (SC) thickness from in-vivo Raman water concentration depth profiles is gaining in popularity and appeal due to the availability and ease of use of in-vivo confocal Raman measurement systems. The foundation of these measurements relies on high-quality confocal Raman spectroscopy of skin and the robust numerical analysis of water profiles, which allow for accurate determination of SC thickness. These measurements are useful for studying intrinsic skin hydration profiles at different body sites and for determining hydration properties of skin related to topically applied materials. While the use of high-quality in-vivo Raman instrumentation has become routine and its use for SC thickness measurement widely reported, there is lack of agreement as to the best method of computing SC thickness values from Raman water profiles. Several methods have been proposed and are currently in use for such computations, but none of these methods has been critically evaluated. The work reported in this paper describes a new method for the determination of stratum corneum thickness from in-vivo confocal Raman water profiles. The method represents a consensus approach to the problem, which was found necessary to apply in order to properly model and quantify the large diversity of water profile types encountered in typical in-vivo Raman water measurement. The methodology is evaluated for performance using three criteria: 1) frequency of minimum fitting error on modeling to a standard numerical function;2) frequency of minimum model error for consensus vs. individual SC thickness values;and 3) correlation with reflectance confocal microscopy (RCM) values for SC thickness. The correlation study shows this approach to be a reasonable replacement for the more tedious and time-consuming RCM method with R2 = 0.68 and RMS error = 3.7 microns over the three body sites tested (cheek, forearm and leg).
文摘1 Preface In the northern and northwestern parts of China, quite a large portion of area, approximately 630,000 km^2, is covered by loess and loess-liked soils. The loess thickness ranges from several meters to several hundred meters along the river’s terraces to those geomorphologic plateaus. In geology, "China Loess" has become a geologic term, because the loess in China has evolved with the widest distribution and greatest thickness in the world, and is also a typical and significant deposit in Quaternary Period.
文摘The existence of loose landslides not only poses a huge safety hazard to the construction of tunnel entrances, but also significantly increases the difficulty of site construction. In this paper, we investigate the comprehensive slope reinforcement management technology for tunnel entrances in thick landslide strata, using the finite element analysis software ABAQUS to study the slope safety coefficients, displacements and plastic zone changes under different management conditions, propose a design structure for slope stability enhancement in thick landslide strata, and analyse the effect of the application of slope stability enhancement measures for thick landslide strata. The results show that the enhanced design structure is used to enhance slope stability. The results show that after the landslide treatment with the enhanced design structure, the slope safety factor was increased from 0.961 to 1.512, the maximum horizontal tangential displacement was reduced from 330.2 mm to 32.74 mm, and the area of plastic zone was significantly reduced, and the landslide support effect was remarkable.
基金the National High-Speed Rail United Foundation of China(No.U1934213)。
文摘Water-and-mud inrush disasters have become a major challenge in underground engineering for the construction of tunnels in sandstone and slate interbedded Presinian strata.Disaster prediction and prevention rely in part on realistic modeling and observation of the disaster process,as well as the identification and examination of the underlying mechanisms.Based on the geological conditions and the historical records of the Xinping Tunnel on the China–Laos Railway,an engineering geological model of the water-and-mud inrush was established.A physical model test that accurately reproduced water-and-mud inrush during tunnel excavation in sandstone and slate interbedded strata was also carried out.Then,testing was conducted that examined the stress and strain,seepage pressure,and high-leakage flow of the surrounding rock.The results indicated that the water-and-mud inrush proceeded through three stages:seepage stage,high-leakage flow stage,and attenuation stage.In essence,the disaster was a catastrophic process,during which the water-resistant stratum was reduced to a critical safety thickness,a water-inrush channel formed,and the water-resistant stratum gradually failed under the influence of excavation unloading and in situ stress–seepage coupling.Parameters such as the stress and strain,seepage pressure,and flow of the surrounding rock had evident stage-related features during water-and-mud inrush,and their variation indicated the formation,development,and evolution of the disaster.As the tunnel face advanced,the trend of the stress–strain curve of the surrounding rock shifted from sluggish to rapid in its speed of increase.The characteristics of strain energy density revealed the erosion and weakening effect of groundwater on the surrounding rock.The seepage pressure and the thickness of the water-resistant stratum had a positive linear relationship,and the flow and thickness a negative linear relationship.There was a pivotal point at which the seepage pressure changed from high to low and the flow shifted from low to high.The thickness of the water-resistant stratum corresponding to the pivotal point was deemed the critical safety thickness.
