In the field of robotics to enhance the interaction with humans in real-time and in the bioengineering field to develop prosthetic devices, the need for artificial skin is in high demand. In this work, the hydrogen-bo...In the field of robotics to enhance the interaction with humans in real-time and in the bioengineering field to develop prosthetic devices, the need for artificial skin is in high demand. In this work, the hydrogen-bonded complex network structure of the Pectin/PEG composite has been designed, resulting in the free-standing film functioning as a temperature-sensing device. With the gelation technique and the addition of PEG, the film’s flexibility and conductivity were enhanced. The fabricated device worked at a low voltage of 1 V supply with high throughput. With different dimensions, three devices were fabricated, and the maximum-induced ionic current was 34 µA ± 5%. The device has an average sensitivity of 1.3–2.7 µA/°C over the range of 30 °C to 42 °C. The device's fastest response time to sense the temperature change was 2 s ± 5%. The present device exhibits good stability for a long duration of time. These pectin/PEG films can be used as biomimetic skin to improve the efficiency in sensing the temperature.展开更多
Biofilms are closely associated with the tough healing and dysfunctional inflammation of chronic wounds.Photothermal therapy(PTT)emerged as a suitable alternative which could destroy the structure of biofilms with loc...Biofilms are closely associated with the tough healing and dysfunctional inflammation of chronic wounds.Photothermal therapy(PTT)emerged as a suitable alternative which could destroy the structure of biofilms with local physical heat.However,the efficacy of PTT is limited because the excessive hyperthermia could damage surrounding tissues.Besides,the difficult reserve and delivery of photothermal agents makes PTT hard to eradicate biofilms as expectation.Herein,we present a GelMA-EGF/Gelatin-MPDA-LZM bilayer hydrogel dressing to perform lysozyme-enhanced PTT for biofilms eradication and a further acceleration to the repair of chronic wounds.Gelatin was used as inner layer hydrogel to reserve lysozyme(LZM)loaded mesoporous polydopamine(MPDA)(MPDA-LZM)nanoparticles,which could rapidly liquefy while temperature rising so as to achieve a bulk release of nanoparticles.MPDA-LZM nanoparticles serve as photothermal agents with antibacterial capability,could deeply penetrate and destroy biofilms.In addition,the outer layer hydrogel consisted of gelatin methacryloyl(GelMA)and epidermal growth factor(EGF)promoted wound healing and tissue regeneration.It displayed remarkable efficacy on alleviating infection and accelerating wound healing in vivo.Overall,the innovative therapeutic strategy we came up with has significant effect on biofilms eradication and shows promising application in promoting the repair of clinical chronic wounds.展开更多
文摘In the field of robotics to enhance the interaction with humans in real-time and in the bioengineering field to develop prosthetic devices, the need for artificial skin is in high demand. In this work, the hydrogen-bonded complex network structure of the Pectin/PEG composite has been designed, resulting in the free-standing film functioning as a temperature-sensing device. With the gelation technique and the addition of PEG, the film’s flexibility and conductivity were enhanced. The fabricated device worked at a low voltage of 1 V supply with high throughput. With different dimensions, three devices were fabricated, and the maximum-induced ionic current was 34 µA ± 5%. The device has an average sensitivity of 1.3–2.7 µA/°C over the range of 30 °C to 42 °C. The device's fastest response time to sense the temperature change was 2 s ± 5%. The present device exhibits good stability for a long duration of time. These pectin/PEG films can be used as biomimetic skin to improve the efficiency in sensing the temperature.
基金supported by the National Natural Science Foundation of China(Nos.51773231,81572726,and 82102977)Science and Technology Planning Project of Shenzhen Municipality(JCYJ20190807160801664,China)。
文摘Biofilms are closely associated with the tough healing and dysfunctional inflammation of chronic wounds.Photothermal therapy(PTT)emerged as a suitable alternative which could destroy the structure of biofilms with local physical heat.However,the efficacy of PTT is limited because the excessive hyperthermia could damage surrounding tissues.Besides,the difficult reserve and delivery of photothermal agents makes PTT hard to eradicate biofilms as expectation.Herein,we present a GelMA-EGF/Gelatin-MPDA-LZM bilayer hydrogel dressing to perform lysozyme-enhanced PTT for biofilms eradication and a further acceleration to the repair of chronic wounds.Gelatin was used as inner layer hydrogel to reserve lysozyme(LZM)loaded mesoporous polydopamine(MPDA)(MPDA-LZM)nanoparticles,which could rapidly liquefy while temperature rising so as to achieve a bulk release of nanoparticles.MPDA-LZM nanoparticles serve as photothermal agents with antibacterial capability,could deeply penetrate and destroy biofilms.In addition,the outer layer hydrogel consisted of gelatin methacryloyl(GelMA)and epidermal growth factor(EGF)promoted wound healing and tissue regeneration.It displayed remarkable efficacy on alleviating infection and accelerating wound healing in vivo.Overall,the innovative therapeutic strategy we came up with has significant effect on biofilms eradication and shows promising application in promoting the repair of clinical chronic wounds.
