To determine the risk, malignant degree and clinical progression of prostate cancer （PCa） associated with mouse double-minute 2 protein （MDM2） T309G variants, a meta-analysis was performed on all eligible publishe...To determine the risk, malignant degree and clinical progression of prostate cancer （PCa） associated with mouse double-minute 2 protein （MDM2） T309G variants, a meta-analysis was performed on all eligible published studies. Odds ratios （ORs） with 95% confidence intervals （CIs） were estimated to assess these associations in seven studies that included 5151 cases and 1003 controls. In the overall analysis, the 309G allele was significantly associated with a decreased PCa risk （0R=0.85, 95% CI： 0.74-0.97）; this was also the case for the homozygous comparison （0R--0.72, 95% Ch 0.55-0.95） and the dominant genetic model （0R=0.79, 95% Ch 0.65-0.96）. The 309G allele was also found to be significantly associated with lower degrees of PCa malignancy （0R=0.85, 95% Ch 0.75-0.96） in the overall analysis, as well as in the heterozygous comparison （0R=0.79, 95% Ch 0.65-0.96）, homozygous comparison （0R=0.76, 95% Ch 0.58-0.98） and dominant genetic model （0R=0.81, 95% CI： 0.68-0.96）. Furthermore, grouping analysis showed that the 309G allele in Caucasians was significantly correlated with a decreased PCa risk （0R=0.77, 95% Ch 0.61-0.96）; this was also the case in the homozygous comparison （0R=0.51, 95% Ch 0.31-0.86）. The grouping analysis also showed that the 309G variant in Caucasians was significantly associated with a lower degree of PCa malignancy in all of the genetic models. In addition, we found that the 309G variant in Caucasians was significantly associated with a slower PCa clinical progression in all of the genetic models. In summary, our meta-analysis showed that the MDM2 309G variant was significantly associated with a decreased PCa risk, lower malignant degree and slower clinical progression in Caucasians, but there was no obvious association in the Asian population.展开更多
The agricultural climate risk in the geographical transitional zones is very sensitive to climate change. Based on previous researches, this article established the cotton climate suitability model and the risk index ...The agricultural climate risk in the geographical transitional zones is very sensitive to climate change. Based on previous researches, this article established the cotton climate suitability model and the risk index to analyze the cotton climate risk degree in Henan Province. The result shows that, in the last 40 years, the cotton climate risk degree has a gradual increasing trend in which the precipitation plays a very important role, and the climate suitability and its deviation have different performances in the influence on the risk change in different phases; the increase rate of risk degree has significant regional and transitional characteristics, for example, from the eastern plain to the western mountains, the risk change rate becomes slower and slower, so the contrast between the central-southern Huang-Huai plain and the Funiu mountains is the most remarkable; and in the north-south direction, the contrast between the fast increase belt from the central-southern Huang-Huai plain to the middle Yellow River and the slow increase belt near the Yellow River is particularly remarkable, which is possibly the results of topographic and climatic transitional belt; and the risk change process also has obvious regional difference. For instance, abrupt change is an important characteristic in eastern Henan where this sudden change type has notable latitudinal difference, while in the western mountainous area it is very rare. Although the temperature change over the 40 years is still increasing in this area, the trend has reduced gradually since the end of the 1980s.展开更多
A theoretical model considering the relationship between fault characteristics and tectonic stress is proposed to quantify earthquake risk degree. The model is applied in practice to the fault along the southern margi...A theoretical model considering the relationship between fault characteristics and tectonic stress is proposed to quantify earthquake risk degree. The model is applied in practice to the fault along the southern margin of Weihe basin in Shaanxi Province, Northwestern China and fitted well with reality.展开更多
Crude oil spills have inflicted extensive disruption upon the Niger Delta ecosystem, resulting in crop loss and severe environmental damage. Such spills exacerbate heavy metal concentration within soil due to the pres...Crude oil spills have inflicted extensive disruption upon the Niger Delta ecosystem, resulting in crop loss and severe environmental damage. Such spills exacerbate heavy metal concentration within soil due to the presence of metallic ions. The Okpare-Olomu community has borne the brunt of crude oil pollution from illicit bunkering, sabotage, and equipment malfunction. This study targets an evaluation of ecological hazards linked to heavy metals (HMs) in crude oil impacted agriculturally soils within Okpare-Olomu in Ughelli South LGA of Delta State. In this study, 24 topsoil samples were obtained from areas affected by crude oil pollution;the heavy metal content was evaluated through atomic absorption spectrometry. The concentration ranges for HMs (mg/kg) in soil were: 24.1 - 23,174 (Cu);0.54 - 37.1 (Cd);9.05 - 54 (Cr);12 - 174 (Ni);18.5 - 8611 (Pb);and 148 - 9078 (Zn) at a soil depth of 0 - 15 cm. Notably, metal concentrations were recorded to be above permissible World Health Organization limits. Predominantly, Zn and Pb recorded higher heavy metal concentration when compared to other heavy metals analysed, notably at sampling points PT7 through PT24. Zinc and Pb contamination exhibited highly significant contamination factors, and contamination severity was evidenced across all sample points, signifying a grave risk level. Pollution load indices indicated pervasive extreme pollution levels. Geoaccumulation indices signaled moderate to strong pollution, mainly by Pb and Zn. Ecological risk assessments revealed variable levels of heavy metal contamination, from low to very high, with potential ecological risk reflecting markedly elevated levels. This study underscores the imperative for soil remediation to rectify ecological imbalances in agriculturally affected soil constituents.展开更多
Based on Input-Output Table in 2010 issued by National Bureau of Statistics of China, with the help of input-output model and with the calculation of indexes of industrial relevance degree in Chinese information techn...Based on Input-Output Table in 2010 issued by National Bureau of Statistics of China, with the help of input-output model and with the calculation of indexes of industrial relevance degree in Chinese information technology industry, the paper reveals the industrial relevance in Chinese information technology industry. The paper also selects the relevant industries which are highly associated with the development of Chinese information technology industry based on industrial relevance degree to analyze the influences of these industries on the financial situation risk fluctuation in information technology industry and to design the matrix of financial situation risk in information technology industry. Then, the paper offers countermeasures and suggestions for the development of our information technology industry.展开更多
This study lies within the scope of a strategy of prevention from inundations by the contribution of new technology in stage of the hydrological and geomorphological modeling for protection against the floods in a med...This study lies within the scope of a strategy of prevention from inundations by the contribution of new technology in stage of the hydrological and geomorphological modeling for protection against the floods in a medium of weak at the average risk in South-eastern Tunisia, starting from the catchment area of Zeuss-Koutine. Considering the lack of studies we were brought to extract the area catchment in question, and to deduce its geomorphological and hydrometric characteristics, starting from the digital terrain model. We could obtain, by overlaying maps of slopes, indices and flows, the hydrological zonation of the catchment area of Zeuss-Koutine. The hydrological study of the basin’s slopes of Zeuss-Koutine is not lying out that very little physical information rests primarily on cartographic processes. The use of the latter can be regarded as an allowing indicator, by the crossing of the explanatory factors of the surface flow (slopes and direction of flow), to define a set of homogeneous hydrological zones in the level of the hydrological characteristics (average slopes, altitudes, roughness, etc). It is mainly a question of better taking account of the physical properties of the basins slopes.展开更多
Based on the natural disaster risk evaluation mode, a quantitative danger degree evaluation model was developed to evaluate the danger degree of earth dam reservoir staged operation in the flood season. A formula for ...Based on the natural disaster risk evaluation mode, a quantitative danger degree evaluation model was developed to evaluate the danger degree of earth dam reservoir staged operation in the flood season. A formula for the overtopping risk rate of the earth dam reservoir staged operation was established, with consideration of the joint effect of flood and wind waves in the flood sub-seasons with the Monte Carlo method, and the integrated overtopping risk rate for the whole flood season was obtained via the total probability approach. A composite normalized function was used to transform the dam overtopping risk rate into the danger degree, on a scale of 0-1. Danger degree gradating criteria were divided by four significant characteristic values of the dam overtopping rate, and corresponding guidelines for danger evaluation are explained in detail in this paper. Examples indicated that the dam overtopping danger degree of the Chengbihe Reservoir in China was 0.33-0.57, within the range of moderate danger level, and the flood-limiting water level （FLWL） can be adjusted to 185.00 m for the early and main flood seasons, and 185.00-187.50 m for the late flood season. The proposed quantitative model offers a theoretical basis for determination of the value of the danger degree of an earth dam reservoir under normal operation as well as the optimal scheduling scheme for the reservoir in each stage of the flood season.展开更多
Using the International Country Risk Guide(ICRG)index to represent countries’political risk,the time-varying effect of political risk on copper prices was examined based on the time-varying parameter structural vecto...Using the International Country Risk Guide(ICRG)index to represent countries’political risk,the time-varying effect of political risk on copper prices was examined based on the time-varying parameter structural vector autoregression with stochastic volatility(TVP-SVAR-SV)model.The empirical results show that the impact of political risk on copper prices is time-varying and has tended to increase gradually in recent years.There are significant country-level differences in the impact of political risk on copper prices.Political risk has a stronger and longer-lasting impact on copper prices in exporting countries.In terms of risk sources,external and internal conflicts contribute most to international copper price fluctuations in the sample period.The impact of political risk on copper prices reaches an extreme level during the international financial crisis,the European debt crisis,and the election of Donald Trump.展开更多
BACKGROUND Type 2 diabetes mellitus(T2DM)has high morbidity and mortality worldwide,therefore there is of paramount importance to identify the risk factors in the populations at risk early in the course of illness.A s...BACKGROUND Type 2 diabetes mellitus(T2DM)has high morbidity and mortality worldwide,therefore there is of paramount importance to identify the risk factors in the populations at risk early in the course of illness.A strong correlation between severity of metabolic syndrome(MetS)and HbA1c,fasting insulin and insulin resistance has been reported.Accordingly,the MetS severity score(or MestS Zscore)can potentially be used to predict the risk of T2DM progression over time.AIM To evaluate the association the of MestS Z-score in first degree relatives(FDRs)of T2DM with the risk of prediabetes and type 2 diabetes in future.METHODS A prospective open cohort study was conducted between 2003-2018.At baseline,the sample comprised of 1766 FDRs of patients with T2DM who had a normal glucose tolerance test.Relative risk(RR)and 95%confidence interval were calculated based on logistic regression.The receiver-operator characteristic analysis and area under the curve based on MetS Z-score were used to evaluate the risk of prediabetes and diabetes among the FDR population.RESULTS Baseline MetS Z-scores were associated with the its latest values(P<0.0001).Compared with individuals who were T2DM free at the end of follow up,those who developed T2DM had higher MetS Z-score at baseline(P<0.001).In multivariable logistic regression analyses for every unit elevation in MetS Z-score at the baseline,the RR for developing future T2DM and prediabetes was(RR=1.94,RR=3.84),(RR=1.5,RR=2.17)in total population and female group,respectively(P<0.05).The associations remained significant after adjusting the potential confounding variables.A cut off value of 0.97 and 0.94 was defined in the receiver-operator characteristic curve based on the MetS Z-score for differentiating female patients with diabetes and prediabetes from the normal population,respectively.CONCLUSION The MetS Z-score was associated with an increased risk of future T2DM.Appropriate interventions at earlier stages for preventing and attenuating MetS effects may be considered as an effective strategy for FDR as at-risk population.展开更多
目的分析与评价乳腺癌患者一级亲属对感知癌症风险后的感受、对风险的认识等,为改善其风险感知水平,提高癌症预防意识和采取健康行为提供参考。方法计算机检索建库至2022年11月1日发表在中国知网、万方、维普、中国生物医学文献网、Emb...目的分析与评价乳腺癌患者一级亲属对感知癌症风险后的感受、对风险的认识等,为改善其风险感知水平,提高癌症预防意识和采取健康行为提供参考。方法计算机检索建库至2022年11月1日发表在中国知网、万方、维普、中国生物医学文献网、Embase、PubMed、Web of Science等数据库中乳腺癌患者一级亲属风险感知的质性研究文献,采用JBI质性研究质量评价工具对文献进行质量评价,采用Meta整合方法对结果进行整合分析。结果共纳入9篇研究,提炼出28个主题,归纳为7个类别,最终形成3个整合结果,即乳腺癌患者一级亲属感知自身患癌风险存在多重情绪、乳腺癌患者一级亲属感知自身患癌风险存在认知差异、乳腺癌患者一级亲属面对患癌风险态度差别较大。结论医护人员应提高对乳腺癌患者一级亲属的重视,关注其心理情绪及对风险的认识,给予其个体化指导,提高其预防管理态度。展开更多
文摘To determine the risk, malignant degree and clinical progression of prostate cancer （PCa） associated with mouse double-minute 2 protein （MDM2） T309G variants, a meta-analysis was performed on all eligible published studies. Odds ratios （ORs） with 95% confidence intervals （CIs） were estimated to assess these associations in seven studies that included 5151 cases and 1003 controls. In the overall analysis, the 309G allele was significantly associated with a decreased PCa risk （0R=0.85, 95% CI： 0.74-0.97）; this was also the case for the homozygous comparison （0R--0.72, 95% Ch 0.55-0.95） and the dominant genetic model （0R=0.79, 95% Ch 0.65-0.96）. The 309G allele was also found to be significantly associated with lower degrees of PCa malignancy （0R=0.85, 95% Ch 0.75-0.96） in the overall analysis, as well as in the heterozygous comparison （0R=0.79, 95% Ch 0.65-0.96）, homozygous comparison （0R=0.76, 95% Ch 0.58-0.98） and dominant genetic model （0R=0.81, 95% CI： 0.68-0.96）. Furthermore, grouping analysis showed that the 309G allele in Caucasians was significantly correlated with a decreased PCa risk （0R=0.77, 95% Ch 0.61-0.96）; this was also the case in the homozygous comparison （0R=0.51, 95% Ch 0.31-0.86）. The grouping analysis also showed that the 309G variant in Caucasians was significantly associated with a lower degree of PCa malignancy in all of the genetic models. In addition, we found that the 309G variant in Caucasians was significantly associated with a slower PCa clinical progression in all of the genetic models. In summary, our meta-analysis showed that the MDM2 309G variant was significantly associated with a decreased PCa risk, lower malignant degree and slower clinical progression in Caucasians, but there was no obvious association in the Asian population.
基金The Key Project of Science and Technology of Henan Province, No.0324100014
文摘The agricultural climate risk in the geographical transitional zones is very sensitive to climate change. Based on previous researches, this article established the cotton climate suitability model and the risk index to analyze the cotton climate risk degree in Henan Province. The result shows that, in the last 40 years, the cotton climate risk degree has a gradual increasing trend in which the precipitation plays a very important role, and the climate suitability and its deviation have different performances in the influence on the risk change in different phases; the increase rate of risk degree has significant regional and transitional characteristics, for example, from the eastern plain to the western mountains, the risk change rate becomes slower and slower, so the contrast between the central-southern Huang-Huai plain and the Funiu mountains is the most remarkable; and in the north-south direction, the contrast between the fast increase belt from the central-southern Huang-Huai plain to the middle Yellow River and the slow increase belt near the Yellow River is particularly remarkable, which is possibly the results of topographic and climatic transitional belt; and the risk change process also has obvious regional difference. For instance, abrupt change is an important characteristic in eastern Henan where this sudden change type has notable latitudinal difference, while in the western mountainous area it is very rare. Although the temperature change over the 40 years is still increasing in this area, the trend has reduced gradually since the end of the 1980s.
文摘A theoretical model considering the relationship between fault characteristics and tectonic stress is proposed to quantify earthquake risk degree. The model is applied in practice to the fault along the southern margin of Weihe basin in Shaanxi Province, Northwestern China and fitted well with reality.
文摘Crude oil spills have inflicted extensive disruption upon the Niger Delta ecosystem, resulting in crop loss and severe environmental damage. Such spills exacerbate heavy metal concentration within soil due to the presence of metallic ions. The Okpare-Olomu community has borne the brunt of crude oil pollution from illicit bunkering, sabotage, and equipment malfunction. This study targets an evaluation of ecological hazards linked to heavy metals (HMs) in crude oil impacted agriculturally soils within Okpare-Olomu in Ughelli South LGA of Delta State. In this study, 24 topsoil samples were obtained from areas affected by crude oil pollution;the heavy metal content was evaluated through atomic absorption spectrometry. The concentration ranges for HMs (mg/kg) in soil were: 24.1 - 23,174 (Cu);0.54 - 37.1 (Cd);9.05 - 54 (Cr);12 - 174 (Ni);18.5 - 8611 (Pb);and 148 - 9078 (Zn) at a soil depth of 0 - 15 cm. Notably, metal concentrations were recorded to be above permissible World Health Organization limits. Predominantly, Zn and Pb recorded higher heavy metal concentration when compared to other heavy metals analysed, notably at sampling points PT7 through PT24. Zinc and Pb contamination exhibited highly significant contamination factors, and contamination severity was evidenced across all sample points, signifying a grave risk level. Pollution load indices indicated pervasive extreme pollution levels. Geoaccumulation indices signaled moderate to strong pollution, mainly by Pb and Zn. Ecological risk assessments revealed variable levels of heavy metal contamination, from low to very high, with potential ecological risk reflecting markedly elevated levels. This study underscores the imperative for soil remediation to rectify ecological imbalances in agriculturally affected soil constituents.
基金Key project of National Social Scientific Fund--"Study on Financing Early-warning and Fixation of Listed Corporations in Information Technology Industry based on the Dynamic Monitoring of Industrial Risk"(Project approval Number:15AGL008)
文摘Based on Input-Output Table in 2010 issued by National Bureau of Statistics of China, with the help of input-output model and with the calculation of indexes of industrial relevance degree in Chinese information technology industry, the paper reveals the industrial relevance in Chinese information technology industry. The paper also selects the relevant industries which are highly associated with the development of Chinese information technology industry based on industrial relevance degree to analyze the influences of these industries on the financial situation risk fluctuation in information technology industry and to design the matrix of financial situation risk in information technology industry. Then, the paper offers countermeasures and suggestions for the development of our information technology industry.
文摘This study lies within the scope of a strategy of prevention from inundations by the contribution of new technology in stage of the hydrological and geomorphological modeling for protection against the floods in a medium of weak at the average risk in South-eastern Tunisia, starting from the catchment area of Zeuss-Koutine. Considering the lack of studies we were brought to extract the area catchment in question, and to deduce its geomorphological and hydrometric characteristics, starting from the digital terrain model. We could obtain, by overlaying maps of slopes, indices and flows, the hydrological zonation of the catchment area of Zeuss-Koutine. The hydrological study of the basin’s slopes of Zeuss-Koutine is not lying out that very little physical information rests primarily on cartographic processes. The use of the latter can be regarded as an allowing indicator, by the crossing of the explanatory factors of the surface flow (slopes and direction of flow), to define a set of homogeneous hydrological zones in the level of the hydrological characteristics (average slopes, altitudes, roughness, etc). It is mainly a question of better taking account of the physical properties of the basins slopes.
基金supported by the National Natural Science Foundation of China(Grants No.51569003 and 51579059)the Natural Science Foundation of Guangxi Province(Grant No.2017GXNSFAA198361)the Innovation Project of Guangxi Graduate Education(Grant No.YCSW2017052)
文摘Based on the natural disaster risk evaluation mode, a quantitative danger degree evaluation model was developed to evaluate the danger degree of earth dam reservoir staged operation in the flood season. A formula for the overtopping risk rate of the earth dam reservoir staged operation was established, with consideration of the joint effect of flood and wind waves in the flood sub-seasons with the Monte Carlo method, and the integrated overtopping risk rate for the whole flood season was obtained via the total probability approach. A composite normalized function was used to transform the dam overtopping risk rate into the danger degree, on a scale of 0-1. Danger degree gradating criteria were divided by four significant characteristic values of the dam overtopping rate, and corresponding guidelines for danger evaluation are explained in detail in this paper. Examples indicated that the dam overtopping danger degree of the Chengbihe Reservoir in China was 0.33-0.57, within the range of moderate danger level, and the flood-limiting water level （FLWL） can be adjusted to 185.00 m for the early and main flood seasons, and 185.00-187.50 m for the late flood season. The proposed quantitative model offers a theoretical basis for determination of the value of the danger degree of an earth dam reservoir under normal operation as well as the optimal scheduling scheme for the reservoir in each stage of the flood season.
基金financial supports from the National Natural Science Foundation of China(Nos.71633006,71874210,71874207,71974208)the Natural Science Founda-tion of Hunan Province,China(No.2020JJ5784)the Innovation-Driven Foundation of Central South University,China(No.2020CX049)。
文摘Using the International Country Risk Guide(ICRG)index to represent countries’political risk,the time-varying effect of political risk on copper prices was examined based on the time-varying parameter structural vector autoregression with stochastic volatility(TVP-SVAR-SV)model.The empirical results show that the impact of political risk on copper prices is time-varying and has tended to increase gradually in recent years.There are significant country-level differences in the impact of political risk on copper prices.Political risk has a stronger and longer-lasting impact on copper prices in exporting countries.In terms of risk sources,external and internal conflicts contribute most to international copper price fluctuations in the sample period.The impact of political risk on copper prices reaches an extreme level during the international financial crisis,the European debt crisis,and the election of Donald Trump.
基金Supported by Isfahan Endocrine and Metabolism Research Center,No. 95017.
文摘BACKGROUND Type 2 diabetes mellitus(T2DM)has high morbidity and mortality worldwide,therefore there is of paramount importance to identify the risk factors in the populations at risk early in the course of illness.A strong correlation between severity of metabolic syndrome(MetS)and HbA1c,fasting insulin and insulin resistance has been reported.Accordingly,the MetS severity score(or MestS Zscore)can potentially be used to predict the risk of T2DM progression over time.AIM To evaluate the association the of MestS Z-score in first degree relatives(FDRs)of T2DM with the risk of prediabetes and type 2 diabetes in future.METHODS A prospective open cohort study was conducted between 2003-2018.At baseline,the sample comprised of 1766 FDRs of patients with T2DM who had a normal glucose tolerance test.Relative risk(RR)and 95%confidence interval were calculated based on logistic regression.The receiver-operator characteristic analysis and area under the curve based on MetS Z-score were used to evaluate the risk of prediabetes and diabetes among the FDR population.RESULTS Baseline MetS Z-scores were associated with the its latest values(P<0.0001).Compared with individuals who were T2DM free at the end of follow up,those who developed T2DM had higher MetS Z-score at baseline(P<0.001).In multivariable logistic regression analyses for every unit elevation in MetS Z-score at the baseline,the RR for developing future T2DM and prediabetes was(RR=1.94,RR=3.84),(RR=1.5,RR=2.17)in total population and female group,respectively(P<0.05).The associations remained significant after adjusting the potential confounding variables.A cut off value of 0.97 and 0.94 was defined in the receiver-operator characteristic curve based on the MetS Z-score for differentiating female patients with diabetes and prediabetes from the normal population,respectively.CONCLUSION The MetS Z-score was associated with an increased risk of future T2DM.Appropriate interventions at earlier stages for preventing and attenuating MetS effects may be considered as an effective strategy for FDR as at-risk population.
文摘目的分析与评价乳腺癌患者一级亲属对感知癌症风险后的感受、对风险的认识等,为改善其风险感知水平,提高癌症预防意识和采取健康行为提供参考。方法计算机检索建库至2022年11月1日发表在中国知网、万方、维普、中国生物医学文献网、Embase、PubMed、Web of Science等数据库中乳腺癌患者一级亲属风险感知的质性研究文献,采用JBI质性研究质量评价工具对文献进行质量评价,采用Meta整合方法对结果进行整合分析。结果共纳入9篇研究,提炼出28个主题,归纳为7个类别,最终形成3个整合结果,即乳腺癌患者一级亲属感知自身患癌风险存在多重情绪、乳腺癌患者一级亲属感知自身患癌风险存在认知差异、乳腺癌患者一级亲属面对患癌风险态度差别较大。结论医护人员应提高对乳腺癌患者一级亲属的重视,关注其心理情绪及对风险的认识,给予其个体化指导,提高其预防管理态度。
