In the past decade,boron neutron capture therapy utilizing an accelerator-based neutron source(ABNS)designed primarily for producing epithermal neutrons has been implemented in the treatment of brain tumors and other ...In the past decade,boron neutron capture therapy utilizing an accelerator-based neutron source(ABNS)designed primarily for producing epithermal neutrons has been implemented in the treatment of brain tumors and other cancers.The specifications for designing an epithermal beam are primarily based on the IAEA-TECODC-1223 report,issued in 2001 for reactor neutron sources.Based on this report,the latest perspectives and clinical requirements,we designed an ABNS capable of adjusting the average neutron beam energy.The design was based on a 2.8 MeV,20 mA proton beam bombarding a lithium target to produce neutrons that were subsequently moderated and tuned through a tunable beam shaping assembly(BSA)which can modify the thicknesses and materials of the coin-shaped moderators,back reflectors,filters,and collimators.The simulation results demonstrated that epithermal neutron beams for deep seated tumor treatment,which were generated by utilizing magnesium fluoride with lengths ranging between 28 and 36 cm as the moderator,possessed a treatment depth of 5.6 cm although the neutron flux peak shifts from 4.5 to 1.0 keV.When utilizing a thinner moderator,a less accelerated beam power can meet the treatment requirements.However,higher powers reduced the treatment time.In contrast,employing a thick moderator can reduce the skin dose.In scenarios that required relatively low energy neutron beams,the removal of the thermal neutron filter can raise the thermal neutron flux at the beam port.And the depth of the dose rate peak could be adjusted between 0.25 and 2.20 cm by combining magnesium fluoride and polyethylene coins of different thicknesses.Hence,this device has a better adaptability for the treatment of superficial tumors.Overall,the tunable BSA provides greater flexibility for clinical treatment than common BSA designs that can only adjust the port size.展开更多
Based on a highway reconstruction project in southern China,this study aims to put forward a method to determine the proper treatment depth of the existing subgrade.First,some field tests including the Beckman beam de...Based on a highway reconstruction project in southern China,this study aims to put forward a method to determine the proper treatment depth of the existing subgrade.First,some field tests including the Beckman beam deflection test and portable falling weight deflectometer(PFWD)test were carried out.The results showed that there was a good correlation between the Beckman beam deflection(L)and PFWD modulus(Ep).Subsequently,a subgrade section was excavated and backfilled with cement-stabilized soil in layers.Compaction test,dynamic cone penetrometer rate test,plate load test and Beckman beam deflection test were performed to evaluate the treatment effect.To make sure,the subgrade was treated deeply enough,the Beckman beam deflection(L)was used as the controlled indicator among all the measured indexes for it was the hardest metric to meet.According to the design deflection and decreasing law of the measured deflections with the different number of the stabilized layers,the treatment depth was finally determined.As the PFWD test is superior to the deflection test in the detection efficiency,and the deflection value can be calculated from PFWD modulus by correlation formulas,thus the latter index can be used as a more suitable parameter for estimating the treatment depth instead of the former.Consequently,based on the measured PFWD moduli of the existing subgrade,six treatment schemes considering different treatment depths were proposed.It was confirmed that the method developed from this study is feasible and worth being extensively applied.展开更多
Laser heat treatment is considered to be one of best-performing manufacturing processes used currently due to its flexibility and its ability to develop parts with complex geometries. In fact, this process is able to ...Laser heat treatment is considered to be one of best-performing manufacturing processes used currently due to its flexibility and its ability to develop parts with complex geometries. In fact, this process is able to produce reliable parts with hard, thin martensite and compressive residual stresses. This paper explores the heat treatment applied to 4340 cylindrical parts heated using a Nd: Yag 3 kW laser source. In this case, the hardness profile is correlated to process parameters such as the laser source power, the beam scanning speed and the revolution speed of the part during heating. Based on preliminary tests stipulating that each parameter is varied alone within a specific range, a systematic design of final tests is performed using Taguchi matrix. The obtained results are analyzed using ANOVA method to extract the effects, the contributions and the interaction between the factors. The results are then exploited to study the sensitivity of the case depth according the variation of the process parameters. The developed model exhibits good potential for converging towards a robust model able to predict the hardness curve and to generalize it for other dimensions of cylindrical parts.展开更多
Aim: This study aims to evaluate the difference between depth data from an intraoral cone and a conventional irradiation tube calculated using a treatment planning system (TPS), and that measured using an intraoral co...Aim: This study aims to evaluate the difference between depth data from an intraoral cone and a conventional irradiation tube calculated using a treatment planning system (TPS), and that measured using an intraoral cone for electron radiotherapy. Background: A TPS is only compatible with conventional irradiation tubes. However, such systems are not suitable for determining dose distributions when a special cone is employed. Materials and Methods: Dose distributions were calculated using the beam data for mounted intraoral cones using a TPS. Then, the dose distribution by field size was calculated for a low-melting-point lead alloy using the beam data for a mounted conventional tube. The calculated data were evaluated against the measured intraoral-cone depth data based on the dose and depth differences. Results: The calculated data for the intraoral cone case did not match the measured data. However, the depth data obtained considering the field size determined for the lead alloy using the conventional tube were close to the measured values for the intraoral cone case. The difference in the depth at which the absorbed dose was 50% of the maximum value of the percentage depth dose was less than ±4 mm for the generalized Gaussian pencil beam convolution algorithm and less than ±1 mm for the electron Monte Carlo algorithm. Conclusion: It was found that the measured and calculated dose distributions were in agreement, especially when then electron Monte Carlo algorithm was used. Thus, the TPS can be employed to determine dose distributions for intraoral cone applications.展开更多
基金supported by the National Nature Science Foundation of China(No.1210050454)the program of Chinese Scholarship Council(No.202106280126)。
文摘In the past decade,boron neutron capture therapy utilizing an accelerator-based neutron source(ABNS)designed primarily for producing epithermal neutrons has been implemented in the treatment of brain tumors and other cancers.The specifications for designing an epithermal beam are primarily based on the IAEA-TECODC-1223 report,issued in 2001 for reactor neutron sources.Based on this report,the latest perspectives and clinical requirements,we designed an ABNS capable of adjusting the average neutron beam energy.The design was based on a 2.8 MeV,20 mA proton beam bombarding a lithium target to produce neutrons that were subsequently moderated and tuned through a tunable beam shaping assembly(BSA)which can modify the thicknesses and materials of the coin-shaped moderators,back reflectors,filters,and collimators.The simulation results demonstrated that epithermal neutron beams for deep seated tumor treatment,which were generated by utilizing magnesium fluoride with lengths ranging between 28 and 36 cm as the moderator,possessed a treatment depth of 5.6 cm although the neutron flux peak shifts from 4.5 to 1.0 keV.When utilizing a thinner moderator,a less accelerated beam power can meet the treatment requirements.However,higher powers reduced the treatment time.In contrast,employing a thick moderator can reduce the skin dose.In scenarios that required relatively low energy neutron beams,the removal of the thermal neutron filter can raise the thermal neutron flux at the beam port.And the depth of the dose rate peak could be adjusted between 0.25 and 2.20 cm by combining magnesium fluoride and polyethylene coins of different thicknesses.Hence,this device has a better adaptability for the treatment of superficial tumors.Overall,the tunable BSA provides greater flexibility for clinical treatment than common BSA designs that can only adjust the port size.
基金the financial support offered by the National Key Research and Development Program of China(2017YFC0805307)the National Natural Science Foundation of China(51878078,51911530215,51838001,51878070)+6 种基金the Excellent Youth Foundation of Natural Science Foundation of Hunan Province(2018JJ1026)the Key Project of Education Department of Hunan Province(17A008)This work was also supported by the Key Project of Open Research Fund of National Engineering Laboratory of Highway Maintenance Technology(kfj150103)the Open Fund of Engineering Research Center of Catastrophic Prophylaxis and Treatment of Road&Traffic Safety of Ministry of Education(Changsha University of Science&Technology)(kfj170404)Open Research Fund of National Engineering Laboratory of Highway Maintenance Technology,Changsha University of Science&Technology(kfj170104)Graduate Research Innovation Project of Hunan Province(CX20190644)Training Program for High-level Technical Personnel in Transportation Industry(2018-025).
文摘Based on a highway reconstruction project in southern China,this study aims to put forward a method to determine the proper treatment depth of the existing subgrade.First,some field tests including the Beckman beam deflection test and portable falling weight deflectometer(PFWD)test were carried out.The results showed that there was a good correlation between the Beckman beam deflection(L)and PFWD modulus(Ep).Subsequently,a subgrade section was excavated and backfilled with cement-stabilized soil in layers.Compaction test,dynamic cone penetrometer rate test,plate load test and Beckman beam deflection test were performed to evaluate the treatment effect.To make sure,the subgrade was treated deeply enough,the Beckman beam deflection(L)was used as the controlled indicator among all the measured indexes for it was the hardest metric to meet.According to the design deflection and decreasing law of the measured deflections with the different number of the stabilized layers,the treatment depth was finally determined.As the PFWD test is superior to the deflection test in the detection efficiency,and the deflection value can be calculated from PFWD modulus by correlation formulas,thus the latter index can be used as a more suitable parameter for estimating the treatment depth instead of the former.Consequently,based on the measured PFWD moduli of the existing subgrade,six treatment schemes considering different treatment depths were proposed.It was confirmed that the method developed from this study is feasible and worth being extensively applied.
文摘Laser heat treatment is considered to be one of best-performing manufacturing processes used currently due to its flexibility and its ability to develop parts with complex geometries. In fact, this process is able to produce reliable parts with hard, thin martensite and compressive residual stresses. This paper explores the heat treatment applied to 4340 cylindrical parts heated using a Nd: Yag 3 kW laser source. In this case, the hardness profile is correlated to process parameters such as the laser source power, the beam scanning speed and the revolution speed of the part during heating. Based on preliminary tests stipulating that each parameter is varied alone within a specific range, a systematic design of final tests is performed using Taguchi matrix. The obtained results are analyzed using ANOVA method to extract the effects, the contributions and the interaction between the factors. The results are then exploited to study the sensitivity of the case depth according the variation of the process parameters. The developed model exhibits good potential for converging towards a robust model able to predict the hardness curve and to generalize it for other dimensions of cylindrical parts.
文摘Aim: This study aims to evaluate the difference between depth data from an intraoral cone and a conventional irradiation tube calculated using a treatment planning system (TPS), and that measured using an intraoral cone for electron radiotherapy. Background: A TPS is only compatible with conventional irradiation tubes. However, such systems are not suitable for determining dose distributions when a special cone is employed. Materials and Methods: Dose distributions were calculated using the beam data for mounted intraoral cones using a TPS. Then, the dose distribution by field size was calculated for a low-melting-point lead alloy using the beam data for a mounted conventional tube. The calculated data were evaluated against the measured intraoral-cone depth data based on the dose and depth differences. Results: The calculated data for the intraoral cone case did not match the measured data. However, the depth data obtained considering the field size determined for the lead alloy using the conventional tube were close to the measured values for the intraoral cone case. The difference in the depth at which the absorbed dose was 50% of the maximum value of the percentage depth dose was less than ±4 mm for the generalized Gaussian pencil beam convolution algorithm and less than ±1 mm for the electron Monte Carlo algorithm. Conclusion: It was found that the measured and calculated dose distributions were in agreement, especially when then electron Monte Carlo algorithm was used. Thus, the TPS can be employed to determine dose distributions for intraoral cone applications.
