Objective To explore the differences in three different registration methods of cone beam computed tomography(CBCT)-guided down-regulated intense radiation therapy for lung cancer as well as the effects of tumor locat...Objective To explore the differences in three different registration methods of cone beam computed tomography(CBCT)-guided down-regulated intense radiation therapy for lung cancer as well as the effects of tumor location,treatment mode,and tumor size on registration.Methods This retrospective analysis included 80 lung cancer patients undergoing radiotherapy in our hospital from November 2017 to October 2019 and compared automatic bone registration,automatic grayscale(t+r)registration,and automatic grayscale(t)positioning error on the X-,Y-,and Z-axes under three types of registration methods.The patients were also grouped according to tumor position,treatment mode,and tumor size to compare positioning errors.Results On the X-,Y-,and Z-axes,automatic grayscale(t+r)and automatic grayscale(t)registration showed a better trend.Analysis of the different treatment modes showed differences in the three registration methods;however,these were not statistically significant.Analysis according to tumor sizes showed significant differences between the three registration methods(P<0.05).Analysis according to tumor positions showed differences in the X-and Y-axes that were not significant(P>0.05),while the autopsy registration in the Z-axis showed the largest difference in the mediastinal and hilar lymph nodes(P<0.05).Conclusion The treatment mode was not the main factor affecting registration error in lung cancer.Three registration methods are available for tumors in the upper and lower lungs measuring<3 cm;among these,automatic gray registration is recommended,while any gray registration method is recommended for tumors located in the mediastinal hilar site measuring<3 cm and in the upper and lower lungs≥3 cm.展开更多
According to different mechanisms of dormancy,seeds of Gagea nigra L.Z.Shue were treated with different methods so as to investigate the effects of different treatments on seed germination of G.nigra.The results showe...According to different mechanisms of dormancy,seeds of Gagea nigra L.Z.Shue were treated with different methods so as to investigate the effects of different treatments on seed germination of G.nigra.The results showed that at 4 ℃,the seeds of G.nigra began to germinate on day 32 with germination period of 80 d and germination rate of 72%;room temperature（25 ℃） and acid and alkali treatments were all unsuitable for the germination of G.nigra seeds;no significant differences were found in germination rate of G.nigra seeds among warm water（50℃）,ultrasound and 200 mg/L GA_3treatments（P 0.05）;seed coat-removing treatment effectively promoted the germination of G.nigra seeds（P =0.002 0.01） with germination rate of 88%;seed coat piercing ＋ 200 mg/L GA_3 and 500 mg/L GA_3＋15% H_2O_2 treatments effectively promoted the germination of G.nigra seeds with germination rates of 84% and 82%,respectively（P0.05）;the germination vigor of G.nigra seeds in the seed coat piercing ＋ 200 mg/L GA_3 treatment was highest,and it was significantly higher than those in the other treatments.展开更多
As per randomized block design, the research had different fertilizer treatments, and the organic matter, respiration, enzyme activity and microbial carbon and nitrogen in reclaimed soil were studied. Fertilization sc...As per randomized block design, the research had different fertilizer treatments, and the organic matter, respiration, enzyme activity and microbial carbon and nitrogen in reclaimed soil were studied. Fertilization schemes were as follows： The treatment without fertilizers（CK）, the treatment with chemical fertilizers（C）, the treatment with chemical fertilizers and bacterial fertilizer（CB）, the treatment with organic fertilizer and chemical fertilizers（CM）, and the treatment with chemical fertilizers, organic fertilizer and bacterial fertilizer（CMB）. The results showed： Four fertilization treatments could improve the content of soil organic matter. CMB, CM and CB could significantly improve the soil respiration. Organic fertilizer and fertilizer could significantly improve soil enzyme activity, In different growth stages the CMB treatment had highest urease and phosphatase.The most significant in the treatment content of sucrose was CM. Organic fertilizer and microbial fertilizer can significantly improve the microbial carbon and nitrogen in soil. For the microbial biomass carbon, the CMB treatment increased by 11%-34% than CB treatment, and 35%-63% than C treatment. In terms of microbial nitrogen CMB, CM respectively increased by 31%-51% than CB treatment, and 52%-100% compared with C. In the process of land reclamation, we should combine the organic fertilizer, microbial fertilizer and inorganic fertilizer. Only in this way can soil biological activity be accelerated, soil microbial environment improved, and the ripening increased soil nutrient and soil cultivation be enhanced.展开更多
The purpose of the experiment is to research the effect of different rapeseed treatments feeding on activity of cellulose enzyme in sheep. Eight male adults of semi-fine wool sheep breeds with the same weight and perm...The purpose of the experiment is to research the effect of different rapeseed treatments feeding on activity of cellulose enzyme in sheep. Eight male adults of semi-fine wool sheep breeds with the same weight and permanent rurnen cannulas were selected according to 4×4 Latin square design to determine the effect of different rapeseed treatment groups including crushed rapeseed, whole rapeseed, extruded rapeseed （dietary lipid content of =67 g·kg^-1） and control group （dietary lipid content of =30 g·kg^-1） on activity dynamic variation of ruminal celluolytic enzyme in sheep. The results showed that ruminal fluid pH matched up to the condition of fiber degradation and growth of cellulolytic bacterium when fed four diets; but there was significant difference （P〈0.05） for the activity of microcrystalline cellulose, glucanase, salicin enzyme involved in ruminal fiber degradation after fed 2, 4, 6 h.展开更多
BACKGROUND： Central coordination disturbance is regarded as the early-stage symptom of brain injury-induced cerebral palsy. This disease manifests itself as motor disorder, abnormal attitudinal reflex and muscular te...BACKGROUND： Central coordination disturbance is regarded as the early-stage symptom of brain injury-induced cerebral palsy. This disease manifests itself as motor disorder, abnormal attitudinal reflex and muscular tension. Early intervention may improve its prognosis. OBJECTIVE： To observe the effects of intervention treatment from different stages on the prognosis of central coordination disturbance following brain injury in children patients. DESIGN： A contrast observation experiment SETTING： Department of Neurology and Rehabilitation, Urumqi Children＇s Hospital PARTICIPANTS ： Totally 151 children who were diagnosed as central coordination disturbance from January 2002 to December 2003 in the Department of Neurology and Rehabilitation of Urumqi Children＇s Hospital were recruited. All the children patients, including 101 male and 50 female, aged from 3 months to 1 year old, met the diagnosis criteria of central coordination disturbance from Vojta. They were divided into slight, moderate and severe abnormity according to Vojta attitudinal reflex. All 151 patients were divided into 2 groups according to their age at diagnosis： 3-6 months old group （n=74）, 62 severe, 10 moderate and 2 slight; 7-12 months old group （n=77）, 66 severe, 7 moderate and 4 slight. All the relatives of children patients were informed of the experiment. METHODS： ① Both groups received physical training （PT） as the main treatment; Hand training was given if necessary. All of the patients received additional hyperbaric oxygen therapy, bioelectric therapy, scalp acupuncture, drug treatment and family training. The importance of integration of hospital and family based rehabilitation was stressed. Those who did not catch up with the normal development or had abnormal reflexes continued to receive treatment. ② Around the age of 2 years old, all children did a final evaluation using Bayley Scales of Infant Development （BSID）. Mental development index （MDI） and physical development index （PDI） were taken as evaluative criteria. Children with scores 80 and above on MDI and PDI were considered to have normal motor and mental development; 79 and below were considered delayers. The Diagnostic Criteria of Cerebral Palsy and Infantecondary School Social Adaptation Scale were used in the final evaluation[scores ≤5 was extremely severe （extremely severe cerebral palsy）, 6 was severe（severe cerebral palsy）, 7 was moderate（moderate cerebral palsy）, 8 was slight（slight cerebral palsy）, 9 was borderline（slight cerebral palsy）, 10 was normal, 11 was above average, 12 was excellent and ≥13 was extremely excellent]. ③ Final evaluative results of 2 groups were compared. And u test was used for the comparison of Bayley development index and Chi-square test for the comparison of normalization rate. MAIN OUTCOME MEASURES： BSID MDI and PDI as well as the normalization rate of motor function and mental behavior of children patients at 2 years old. RESULTS： Totally 151 children patients entered the stage of result analysis. ①Two groups of children patients were given integrated rehabilitation therapy , and evaluated at 2 years old . The 3-6 months old group had higher MDI and PDI than the 7-12 months old group （91.81＋19.99 vs 71.93＋18.98;91.55＋23.61 vs 68.95＋23.51, u=6.265,5.894,P 〈 0.01 ）.②After being given integrated rehabilitation therapy, children patients of 3-6 months old group had significantly higher normalization rate of motor function and mental behavior than 7-12 months old group （73% ,27%,X2=29.723 9,P 〈 0.01 ）. ③Six slight and 17 moderate central coordination disturbance children of 2 groups all completely recovered; After intervention treatment, among 128 severe central coordination disturbance children, 52 recovered and 76 were still abnormal, in which, 43 slight cerebral palsy, 18 moderate cerebral palsy, 5 severe cerebral palsy and 10 extremely severe cerebral palsy. CONCLUSION： To perform integrated intervention treatment before 6 months old can better improve and promote mental and physical development levels of children patients with central coordination disturbance after brain injury than 6 months later.展开更多
Purification of surface water is widely practiced with conventional water treatment processes like coagulation-flocculation, sedimentation, filtration,and disinfection. Some reports have specified that conventional wa...Purification of surface water is widely practiced with conventional water treatment processes like coagulation-flocculation, sedimentation, filtration,and disinfection. Some reports have specified that conventional wastewater purification processes do not effectively remove many chemical contaminants,展开更多
Objective:To analyze the effect of different treatment schemes on the quality of life of patients with Helicobacter pylori infection.Methods:From June 2019 to November 2020,96 patients with Helicobacter pylori infecti...Objective:To analyze the effect of different treatment schemes on the quality of life of patients with Helicobacter pylori infection.Methods:From June 2019 to November 2020,96 patients with Helicobacter pylori infection were selected and randomly assigned Combined treatment with omeprazole,amoxicillin and clarithromycin was named group A;Group B was treated with omeprazole,amoxicillin,clarithromycin and colloidal bismuth pectin;Group C was given omeprazole,amoxicillin,clarithromycin and metronidazole.Results:The symptom score and gastroscope score of group B or C were lower than those of group A(P<0.05);The incidence of adverse reactions and HP eradication rate in group C were lower than those in group B,and those in group B were lower than those in group A(P<0.05);The quality of life score of group C was higher than that of group B,and that of group B was higher than that of group A,P<0.05.Conclusions:The sequential therapy of omeprazole,amoxicillin,clarithromycin and metronidazole in patients with Helicobacter pylori infection can improve the HP eradication rate,improve the quality of life of patients,which is safe and efficient.展开更多
Since medical insurance of our country developed, it is continued to deepen reform and became the basic form of the pcrfcct medical insurance system. However, regional differences still exist. The current medical insu...Since medical insurance of our country developed, it is continued to deepen reform and became the basic form of the pcrfcct medical insurance system. However, regional differences still exist. The current medical insurance system of China＇s urban and rural structure background of two structures of serious, city residents, workers and rural residents is significantly difference in the payment period ,for this question ,the difference between our country will solve the basic medical insurance payment period, the relative level of regulating wages and medical people in our country and develop the medical insurance level, narrow the regional differences, reduce cost problem caused by population flow management, the basic medical insurance system for suggestions to improve the unified and promoting the social and economic level, people＇s medical security level, perfect improvement of physical insurance system of medical insurance according to the long-term sustainable development has a far-reaching significance.展开更多
Objective To predict the molecular mechanism of Dihuang(Rehmanniae Radix)in the treatment of diabetic nephropathy(DN)complicated with depression based on network pharmacology.Methods The components of Dihuang(Rehmanni...Objective To predict the molecular mechanism of Dihuang(Rehmanniae Radix)in the treatment of diabetic nephropathy(DN)complicated with depression based on network pharmacology.Methods The components of Dihuang(Rehmanniae Radix)were identified from the Integrated Pharmacology-based Research Platform of Traditional Chinese Medicine(TCMIP),Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and relevant literature.The component targets were detected by combining the SwissTargetPrediction and Pub Chem databases.Disease targets were collected from the Therapeutic Target Database(TTD),Dis Ge NET,and Ensembl databases with“diabetic nephropathy”and“depression”as keywords.The disease-component targets were mapped using Venny 2.1.0 to obtain potential targets.A protein-protein interaction(PPI)network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins(STRING)database and Cytoscape 3.7.2.The co-expression genes of the key targets were collected based on the COXPRESdb 7.3.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were performed for potential targets using R language.Target-component docking was verified and evaluated using Discovery Studio 4.5.Results According to the databases and literature reports,Dihuang(Rehmanniae Radix)contained 65 active components,and had 155 related targets for the treatment of DN complicated with depression.PPI screening showed that the key targets included serine/threonine protein kinase 1(AKT1),signal transducer and activator transcription 3(STAT3),interleukin 6(IL-6),mitogen-activated protein kinase 1(MAPK1),and vascular endothelial growth factor A(VEGFA),etc.GO enrichment analysis mainly involved biological processes,such as lipid metabolism,protein secretion regulation,cell homeostasis,and phosphatidylinositol 3 kinase activity.KEGG pathway enrichment analysis included the role of the AGE-RAGE signaling pathway in diabetic complements,insulin resistance(IR),neurotrophin signal path,Toll-like receptor signaling pathway,relaxin signaling pathway,epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs),etc.Molecular docking showed that the target had high affinity for stachyose,manninotriose,verbascose,nigerose,etc.Conclusion Based on network parmacology,this study preliminarily predict the effects of Dihuang(Rehmanniae Radix)in treating DN complicated with depression by regulating inflammation,glucose metabolism,nution nerve,etc.展开更多
Objective To observe the efficacy of combining therapy in treatment of 90 patients with scapulohumeral periarthritis in different phases. Method Ninety patients with scapulohumeral periarthritis were treated with Fu＇...Objective To observe the efficacy of combining therapy in treatment of 90 patients with scapulohumeral periarthritis in different phases. Method Ninety patients with scapulohumeral periarthritis were treated with Fu＇s subcutaneous needling（FSN） combined with physiotherapy in painful phase, acupotomology and massage in adhesion phase, and appropriate functional exercise in rehabilitation phase. Seven days were considered as one course of treatment, and efficacy evaluation was performed after three courses. Function evaluation of shoulder joint was made. Result The total effective rate was 100%（38/38） in acute phase, 93.5%（29/31） in adhesion phase, and 100%（21/21） in rehabilitation phase. After treatment, the range of motion（ROM） of shoulder joint, pain, muscle force, activities of daily living（ADL） and joint local morphology of the patient have been improved obviously. Conclusion Better clinical efficacy is achieved in treatment of scapulohumeral periarthritis in different phases by combining therapy centering on FSN.展开更多
Objective: "Same treatment for different diseases" is a unique treatment strategy under the guidance of traditional Chinese medicine(TCM) theory.Codonopsis Radix(Codonopsis pilosula,Dangshen in Chinese)with ...Objective: "Same treatment for different diseases" is a unique treatment strategy under the guidance of traditional Chinese medicine(TCM) theory.Codonopsis Radix(Codonopsis pilosula,Dangshen in Chinese)with spleen-fortifying effect was employed to understand the strategy of "Same treatment for different diseases",based on its common mechanism in the treatment of gastric diseases including gastric ulcer,gastritis and gastric cancer via network pharmacology research.Methods:Network pharmacology research methods were used to analyze the interaction network and potential mechanisms of Dangshen in treating gastric ulcer,gastritis and gastric cancer.The active components and their target proteins of Dangshen were integrated from TCMSP,BATMAN-TCM databases.The targets of gastric ulcer,gastritis and gastric cancer were collected through GeneCards,PubMed,TDD and DisGeNET Database.Through screening,the key components and the key targets of Dangshen in treating gastric ulcer,gastritis and gastric cancer were obtained.After KEGG pathway analysis and GO analysis,the important pathways and biological processes were analyzed.Results:Through data and literature mining,the common and specific pharmaceutical effects and mechanism of Dangshen were summarized in these three gastric lesions.It was shown that Dangshen mainly acted on gastric ulcer,gastritis and gastric cancer through the overall regulation of the PI3K-AkT signaling pathway.With the development of the disease,it will gradually increase the control of inflammation through TNF,NF-κB and other inflammation-related signaling pathways to reduce inflammatory damage.For tumorigenesis,it pays more attention to inhibiting the ErbB signaling pathways to reduce the proliferation and migration of tumor cells.In addition,Dangshen's regulation of HIF-1 signaling pathway may also be beneficial for the treatment of gastric ulcer,gastritis and gastric cancer.Conclusion:Dangshen achieves spleen-fortifying effect on gastric diseases including gastric ulcer,gastritis and gastric cancer through multiple targets in multiple pathways,especially PI3K-AKT pathway and HIF-1 pathway.It could provide a scientific basis for understanding the strategy of "Same treatment for different diseases" in traditional Chinese medicine.展开更多
Many studies on methane emissions from animal manure have revealed that animal manure is a major source of methane emissions to the atmosphere that can have negative consequences for people, animals and environment. I...Many studies on methane emissions from animal manure have revealed that animal manure is a major source of methane emissions to the atmosphere that can have negative consequences for people, animals and environment. In general, the release of methane can be influenced by the type of feed taken by animals, temperature, manure characteristics and so on. This study aimed at quantifying and comparing methane release from dairy manure with different piling treatments. Four treatments were designed including manure piling height 30, 45, 60 cm and adding 6 cm manure every day until the piling height was 60 cm. Static chamber method and gas chromatography were adopted to measure the methane emissions from April to June in 2009. Methane emission rates of all four manure treatments were low in the first week and then increased sharply until reaching the peak values. Subsequently, all the methane emission rates decreased and fluctuated within the steady range till the end of the experiment. Wilcoxon nonparametfic tests analysis indicated that methane emission rate was greatly influenced by manure piling height and manner. There were no significant relationships between methane emission rates and the temperatures of ambience and heap. However, regression analysis showed that the quadratic equations were found between emission rates of all treatments and the gas temperature in the barrels.展开更多
Objective： To identify the commonalities between rheumatoid arthritis （RA） and diabetes mellitus （DM） to understand the mechanisms of Chinese medicine （CM） in different diseases with the same treatment. Methods...Objective： To identify the commonalities between rheumatoid arthritis （RA） and diabetes mellitus （DM） to understand the mechanisms of Chinese medicine （CM） in different diseases with the same treatment. Methods： A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identified via text mining was used as the intervention. Results： Similarities were identified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Conclusion： Commonalities between the biological activities involved in RA and DM were identified through text mining, and both RA and DM might be responsive to the same intervention at a specific stage.展开更多
According to differentiating syndrome and dividing patter, 41 cases of Facial Chloasma by Auricular Pressure in Shen (MA-AH), Fei (MA-IC 1), Neifenmi (MA-IC 3), Luanchao (MA-AT), Mianjia (MA-L) and Xia’erbei (MA-IC),...According to differentiating syndrome and dividing patter, 41 cases of Facial Chloasma by Auricular Pressure in Shen (MA-AH), Fei (MA-IC 1), Neifenmi (MA-IC 3), Luanchao (MA-AT), Mianjia (MA-L) and Xia’erbei (MA-IC), the total effective rate was 87.8%. Key Words Skin Pigmentation, Chloasma - Auricular Point Sticking - Syndrome Differ Treatment Author: Liu Guang-xia (1954-), female, associate professorTranslator: Xiao Yuan-chun展开更多
Objective:"Same treatment for different diseases"is a unique treatment strategy in traditional Chinese medicine.Two kinds of malignant respiratory diseases endanger human health-chronic obstructive pulmonary...Objective:"Same treatment for different diseases"is a unique treatment strategy in traditional Chinese medicine.Two kinds of malignant respiratory diseases endanger human health-chronic obstructive pulmonary disease(COPD)and lung cancer.Citrus Grandis Exocarpium(Huajuhong in Chinese,HJH),a famous herbal,is always applied by Chinese medicine practitioners to dispersion the lung to resolve phlegm based on"syndrome differentiation and treatment"theory.However,the common mechanism for HJH’s treatment of COPD and lung cancer is not clear.Methods:In this study,based on network pharmacology and molecular docking technology,the common mechanism of HJH in the treatment of COPD and lung cancer was studied.The active ingredients and related targets of HJH were integrated from TCMSP,BATMAN-TAM,STP,and Pubchem databases.The standard names of these targets were united by Uni Prot database.Targets of COPD and lung cancer were enriched through Gene Cards,NCBI(Gene),Therapeutic Target Database,and Dis Ge NET(v7.0)databases.Then the intersection targets of HJH and diseases were obtained.The STRING network and the Cytoscape 3.7.2 were used to construct PPI network,the DAVID database was used to perform GO and KEGG analysis.Then Cytoscape 3.6.1 was used to build"ingredient-target-signal pathway"network.Finally,Auto Dock 1.5.6 software was used to perform molecular docking of key proteins and molecules.Results:Eleven active ingredients in HJH were obtained by searching the database,corresponding to 184 HJH-COPD-lung cancer targets intersection.The results of biological network analysis showed that naringenin,the active component in HJH,could mainly act on target proteins such as AKT1,EGFR.Then through positive regulation of vasoconstriction and other biological processes,naringenin could regulate estrogen signaling pathway,VEGF signaling pathway,HIF-1 signaling pathway,Erb B signaling pathway,PI3K-Akt signaling pathway to play an important role in the treatment of both COPD and lung cancer.Conclusion:Network pharmacology was employed to systematically investigate the active ingredients and targets of HJH in treatment of COPD and lung cancer.And then,the common pharmacodynamic network of HJH for the two malignant respiratory diseases was firstly described.Furthermore,naringenin was proved to strongly bind with AKT1 and EGFR.It may provide the scientific basis for understanding the"Same treatment for different diseases"strategy in traditional Chinese medicine and inspirit subsequent drug discovery for COPD,lung cancer and other malignant lung diseases.展开更多
There is worrying about current clinical situation on diagnosis and treatment based on an overall analysis of symptoms and signs in acupuncture. Japanese specialists in the acupuncture field have pointed out that suff...There is worrying about current clinical situation on diagnosis and treatment based on an overall analysis of symptoms and signs in acupuncture. Japanese specialists in the acupuncture field have pointed out that sufficient attention should be paid to its various malpractices. Responding to their questioning, the author put forward some main problems existing and made certain analysis. Diagnosis and treatment based on an overall analysis of symptoms and signs should be expressed in their application according to successive theories, methods, prescriptions, acupoints and techniques. In order to elevate therapeutic effects of acupuncture, forth effort should be put to various aspects, such as clinical skills, functional regularity, indications and affected factors.展开更多
Objective To compare the efficacy differences between acupuncture and western medicine in treating osteoarthritis of knee joints.Methods One hundred and twenty cases were randomly divided into an acupuncture group and...Objective To compare the efficacy differences between acupuncture and western medicine in treating osteoarthritis of knee joints.Methods One hundred and twenty cases were randomly divided into an acupuncture group and a western medication group with 60 cases in each group.In the acupuncture group,acupuncture was applied mainly at Nèixīyǎn（内膝眼 EX-LE 4）,Dúbí（犊鼻 ST 35）,Yīnlíngquán（阴陵泉 SP 9） and Yánglíngquán（阳陵泉 GB 34） plus other acupoints selected according to syndrome differentiation.In the medication group,Glucosamine Hydrochloride capsules were orally given 3 times daily with 2 capsules each time.Western Ontario and McMaster Universities Osteoarthritis Index（WOMAC）,Medical Outcomes Study 36-Item Short Form Health Survey（SF-36,Chinese version） were used to assess therapeutic effects before treatment,after 4 weeks treatment and 9 weeks after treatment,respectively.Results After 4 weeks of treatment,the total effective rates were 86.7%（52/60） and 88.3%（53/60） in the acupuncture group and the western medication group,respectively,without significant difference（P〈0.05）.In 9 weeks after treatment,the total effective rates were 83.3%（50/60） and 61.7%（37/60） in the acupuncture group and the western medication group,respectively,with significant difference between the two groups（P〈0.05）.According to WOMAC and SF-36,the scores were all improved in both groups（P〈0.05,P〈0.01）,with significant difference in follow-up visit of 9 weeks after treatment between the two groups（P〈0.05,P〈0.01）,but not after 4 weeks of treatments（both P〈0.05）.Conclusion Short-term of therapeutic effects of acupuncture and oral administration of Glucosamine Hydrochloride on osteoarthritis of knee joints are similar,but long-term efficacy in the acupuncture group is better than that in the western medication group.展开更多
OBJECTIVE: To compare the effects of integrated Chinese-Western therapy versus Western therapy alone on the survival rate of patients with non-small-cell lung cancer (NSCLC) at middle-late stage and to evaluate progno...OBJECTIVE: To compare the effects of integrated Chinese-Western therapy versus Western therapy alone on the survival rate of patients with non-small-cell lung cancer (NSCLC) at middle-late stage and to evaluate prognostic factors. METHODS: We selected 98 inpatients with middle-late stage NSCLC diagnosed from March 2009 to March 2011 and randomly divided them into two groups, with 49 cases in each group, and the clinical data were analyzed retrospectively.The control group was treated by the combined methods of Western Medicine, including chemotherapy, supportive treatment and symptomatic treatment. The observation group was treated by injection and prescriptions of Chinese medicine based on Traditional Chinese Medicine syndrome differentiation and by the same combined methods of western treatment used in the control group. After treatment, the survival rates of the patients were compared by the stage of cancer and evaluation of 24 prognostic factors analyzed by a Cox regressionmodel, and the clinical data were statistically analyzed. RESULTS: The survival rates of all patients were over 90.0% at 1 and 3 months after treatment with no significant differences between the two groups (P>0.05); In the observation group the survival rates at 6 months and 1 year were 93.4% and 42.8%, respectively, being superior to 85.6% and 18.3% in the control group (P<0.05). The median survival time in the observation group was superior to the control group (P<0.05); The effects of 24 prognostic factors were significantly better in the observation group than in the control group (P<0.05). CONCLUSION: Integrated Chinese-western therapy can significantly improve the survival rate in patients with middle-late stage NSCLC and improve prognostic factors compared with western therapy alone.展开更多
基金Supported by grants from the Nanchong City School Cooperation Project(No.18SXHZ0542)Hubei Chen Xiaoping Science and Technology Development Foundation Project(No.CXPJJH11900002-037)Sichuan Medical Research Youth Innovation Project(No.Q18031).
文摘Objective To explore the differences in three different registration methods of cone beam computed tomography(CBCT)-guided down-regulated intense radiation therapy for lung cancer as well as the effects of tumor location,treatment mode,and tumor size on registration.Methods This retrospective analysis included 80 lung cancer patients undergoing radiotherapy in our hospital from November 2017 to October 2019 and compared automatic bone registration,automatic grayscale(t+r)registration,and automatic grayscale(t)positioning error on the X-,Y-,and Z-axes under three types of registration methods.The patients were also grouped according to tumor position,treatment mode,and tumor size to compare positioning errors.Results On the X-,Y-,and Z-axes,automatic grayscale(t+r)and automatic grayscale(t)registration showed a better trend.Analysis of the different treatment modes showed differences in the three registration methods;however,these were not statistically significant.Analysis according to tumor sizes showed significant differences between the three registration methods(P<0.05).Analysis according to tumor positions showed differences in the X-and Y-axes that were not significant(P>0.05),while the autopsy registration in the Z-axis showed the largest difference in the mediastinal and hilar lymph nodes(P<0.05).Conclusion The treatment mode was not the main factor affecting registration error in lung cancer.Three registration methods are available for tumors in the upper and lower lungs measuring<3 cm;among these,automatic gray registration is recommended,while any gray registration method is recommended for tumors located in the mediastinal hilar site measuring<3 cm and in the upper and lower lungs≥3 cm.
文摘According to different mechanisms of dormancy,seeds of Gagea nigra L.Z.Shue were treated with different methods so as to investigate the effects of different treatments on seed germination of G.nigra.The results showed that at 4 ℃,the seeds of G.nigra began to germinate on day 32 with germination period of 80 d and germination rate of 72%;room temperature（25 ℃） and acid and alkali treatments were all unsuitable for the germination of G.nigra seeds;no significant differences were found in germination rate of G.nigra seeds among warm water（50℃）,ultrasound and 200 mg/L GA_3treatments（P 0.05）;seed coat-removing treatment effectively promoted the germination of G.nigra seeds（P =0.002 0.01） with germination rate of 88%;seed coat piercing ＋ 200 mg/L GA_3 and 500 mg/L GA_3＋15% H_2O_2 treatments effectively promoted the germination of G.nigra seeds with germination rates of 84% and 82%,respectively（P0.05）;the germination vigor of G.nigra seeds in the seed coat piercing ＋ 200 mg/L GA_3 treatment was highest,and it was significantly higher than those in the other treatments.
基金Supported by Natural Science Foundation of Shanxi Province(2014011001-4)~~
文摘As per randomized block design, the research had different fertilizer treatments, and the organic matter, respiration, enzyme activity and microbial carbon and nitrogen in reclaimed soil were studied. Fertilization schemes were as follows： The treatment without fertilizers（CK）, the treatment with chemical fertilizers（C）, the treatment with chemical fertilizers and bacterial fertilizer（CB）, the treatment with organic fertilizer and chemical fertilizers（CM）, and the treatment with chemical fertilizers, organic fertilizer and bacterial fertilizer（CMB）. The results showed： Four fertilization treatments could improve the content of soil organic matter. CMB, CM and CB could significantly improve the soil respiration. Organic fertilizer and fertilizer could significantly improve soil enzyme activity, In different growth stages the CMB treatment had highest urease and phosphatase.The most significant in the treatment content of sucrose was CM. Organic fertilizer and microbial fertilizer can significantly improve the microbial carbon and nitrogen in soil. For the microbial biomass carbon, the CMB treatment increased by 11%-34% than CB treatment, and 35%-63% than C treatment. In terms of microbial nitrogen CMB, CM respectively increased by 31%-51% than CB treatment, and 52%-100% compared with C. In the process of land reclamation, we should combine the organic fertilizer, microbial fertilizer and inorganic fertilizer. Only in this way can soil biological activity be accelerated, soil microbial environment improved, and the ripening increased soil nutrient and soil cultivation be enhanced.
基金Supported by Project of Dairy Cows System of Chinese Agricultural Department
文摘The purpose of the experiment is to research the effect of different rapeseed treatments feeding on activity of cellulose enzyme in sheep. Eight male adults of semi-fine wool sheep breeds with the same weight and permanent rurnen cannulas were selected according to 4×4 Latin square design to determine the effect of different rapeseed treatment groups including crushed rapeseed, whole rapeseed, extruded rapeseed （dietary lipid content of =67 g·kg^-1） and control group （dietary lipid content of =30 g·kg^-1） on activity dynamic variation of ruminal celluolytic enzyme in sheep. The results showed that ruminal fluid pH matched up to the condition of fiber degradation and growth of cellulolytic bacterium when fed four diets; but there was significant difference （P〈0.05） for the activity of microcrystalline cellulose, glucanase, salicin enzyme involved in ruminal fiber degradation after fed 2, 4, 6 h.
文摘BACKGROUND： Central coordination disturbance is regarded as the early-stage symptom of brain injury-induced cerebral palsy. This disease manifests itself as motor disorder, abnormal attitudinal reflex and muscular tension. Early intervention may improve its prognosis. OBJECTIVE： To observe the effects of intervention treatment from different stages on the prognosis of central coordination disturbance following brain injury in children patients. DESIGN： A contrast observation experiment SETTING： Department of Neurology and Rehabilitation, Urumqi Children＇s Hospital PARTICIPANTS ： Totally 151 children who were diagnosed as central coordination disturbance from January 2002 to December 2003 in the Department of Neurology and Rehabilitation of Urumqi Children＇s Hospital were recruited. All the children patients, including 101 male and 50 female, aged from 3 months to 1 year old, met the diagnosis criteria of central coordination disturbance from Vojta. They were divided into slight, moderate and severe abnormity according to Vojta attitudinal reflex. All 151 patients were divided into 2 groups according to their age at diagnosis： 3-6 months old group （n=74）, 62 severe, 10 moderate and 2 slight; 7-12 months old group （n=77）, 66 severe, 7 moderate and 4 slight. All the relatives of children patients were informed of the experiment. METHODS： ① Both groups received physical training （PT） as the main treatment; Hand training was given if necessary. All of the patients received additional hyperbaric oxygen therapy, bioelectric therapy, scalp acupuncture, drug treatment and family training. The importance of integration of hospital and family based rehabilitation was stressed. Those who did not catch up with the normal development or had abnormal reflexes continued to receive treatment. ② Around the age of 2 years old, all children did a final evaluation using Bayley Scales of Infant Development （BSID）. Mental development index （MDI） and physical development index （PDI） were taken as evaluative criteria. Children with scores 80 and above on MDI and PDI were considered to have normal motor and mental development; 79 and below were considered delayers. The Diagnostic Criteria of Cerebral Palsy and Infantecondary School Social Adaptation Scale were used in the final evaluation[scores ≤5 was extremely severe （extremely severe cerebral palsy）, 6 was severe（severe cerebral palsy）, 7 was moderate（moderate cerebral palsy）, 8 was slight（slight cerebral palsy）, 9 was borderline（slight cerebral palsy）, 10 was normal, 11 was above average, 12 was excellent and ≥13 was extremely excellent]. ③ Final evaluative results of 2 groups were compared. And u test was used for the comparison of Bayley development index and Chi-square test for the comparison of normalization rate. MAIN OUTCOME MEASURES： BSID MDI and PDI as well as the normalization rate of motor function and mental behavior of children patients at 2 years old. RESULTS： Totally 151 children patients entered the stage of result analysis. ①Two groups of children patients were given integrated rehabilitation therapy , and evaluated at 2 years old . The 3-6 months old group had higher MDI and PDI than the 7-12 months old group （91.81＋19.99 vs 71.93＋18.98;91.55＋23.61 vs 68.95＋23.51, u=6.265,5.894,P 〈 0.01 ）.②After being given integrated rehabilitation therapy, children patients of 3-6 months old group had significantly higher normalization rate of motor function and mental behavior than 7-12 months old group （73% ,27%,X2=29.723 9,P 〈 0.01 ）. ③Six slight and 17 moderate central coordination disturbance children of 2 groups all completely recovered; After intervention treatment, among 128 severe central coordination disturbance children, 52 recovered and 76 were still abnormal, in which, 43 slight cerebral palsy, 18 moderate cerebral palsy, 5 severe cerebral palsy and 10 extremely severe cerebral palsy. CONCLUSION： To perform integrated intervention treatment before 6 months old can better improve and promote mental and physical development levels of children patients with central coordination disturbance after brain injury than 6 months later.
基金supported by grants from Science and Technology Planning Project of Shenzhen [No.200703079]
文摘Purification of surface water is widely practiced with conventional water treatment processes like coagulation-flocculation, sedimentation, filtration,and disinfection. Some reports have specified that conventional wastewater purification processes do not effectively remove many chemical contaminants,
文摘Objective:To analyze the effect of different treatment schemes on the quality of life of patients with Helicobacter pylori infection.Methods:From June 2019 to November 2020,96 patients with Helicobacter pylori infection were selected and randomly assigned Combined treatment with omeprazole,amoxicillin and clarithromycin was named group A;Group B was treated with omeprazole,amoxicillin,clarithromycin and colloidal bismuth pectin;Group C was given omeprazole,amoxicillin,clarithromycin and metronidazole.Results:The symptom score and gastroscope score of group B or C were lower than those of group A(P<0.05);The incidence of adverse reactions and HP eradication rate in group C were lower than those in group B,and those in group B were lower than those in group A(P<0.05);The quality of life score of group C was higher than that of group B,and that of group B was higher than that of group A,P<0.05.Conclusions:The sequential therapy of omeprazole,amoxicillin,clarithromycin and metronidazole in patients with Helicobacter pylori infection can improve the HP eradication rate,improve the quality of life of patients,which is safe and efficient.
文摘Since medical insurance of our country developed, it is continued to deepen reform and became the basic form of the pcrfcct medical insurance system. However, regional differences still exist. The current medical insurance system of China＇s urban and rural structure background of two structures of serious, city residents, workers and rural residents is significantly difference in the payment period ,for this question ,the difference between our country will solve the basic medical insurance payment period, the relative level of regulating wages and medical people in our country and develop the medical insurance level, narrow the regional differences, reduce cost problem caused by population flow management, the basic medical insurance system for suggestions to improve the unified and promoting the social and economic level, people＇s medical security level, perfect improvement of physical insurance system of medical insurance according to the long-term sustainable development has a far-reaching significance.
基金National Natural Science Foundation of China(81960714)Jiangxi University of Chinese Medicine Graduate Innovation Project(JZYC21S52)。
文摘Objective To predict the molecular mechanism of Dihuang(Rehmanniae Radix)in the treatment of diabetic nephropathy(DN)complicated with depression based on network pharmacology.Methods The components of Dihuang(Rehmanniae Radix)were identified from the Integrated Pharmacology-based Research Platform of Traditional Chinese Medicine(TCMIP),Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and relevant literature.The component targets were detected by combining the SwissTargetPrediction and Pub Chem databases.Disease targets were collected from the Therapeutic Target Database(TTD),Dis Ge NET,and Ensembl databases with“diabetic nephropathy”and“depression”as keywords.The disease-component targets were mapped using Venny 2.1.0 to obtain potential targets.A protein-protein interaction(PPI)network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins(STRING)database and Cytoscape 3.7.2.The co-expression genes of the key targets were collected based on the COXPRESdb 7.3.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were performed for potential targets using R language.Target-component docking was verified and evaluated using Discovery Studio 4.5.Results According to the databases and literature reports,Dihuang(Rehmanniae Radix)contained 65 active components,and had 155 related targets for the treatment of DN complicated with depression.PPI screening showed that the key targets included serine/threonine protein kinase 1(AKT1),signal transducer and activator transcription 3(STAT3),interleukin 6(IL-6),mitogen-activated protein kinase 1(MAPK1),and vascular endothelial growth factor A(VEGFA),etc.GO enrichment analysis mainly involved biological processes,such as lipid metabolism,protein secretion regulation,cell homeostasis,and phosphatidylinositol 3 kinase activity.KEGG pathway enrichment analysis included the role of the AGE-RAGE signaling pathway in diabetic complements,insulin resistance(IR),neurotrophin signal path,Toll-like receptor signaling pathway,relaxin signaling pathway,epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs),etc.Molecular docking showed that the target had high affinity for stachyose,manninotriose,verbascose,nigerose,etc.Conclusion Based on network parmacology,this study preliminarily predict the effects of Dihuang(Rehmanniae Radix)in treating DN complicated with depression by regulating inflammation,glucose metabolism,nution nerve,etc.
文摘Objective To observe the efficacy of combining therapy in treatment of 90 patients with scapulohumeral periarthritis in different phases. Method Ninety patients with scapulohumeral periarthritis were treated with Fu＇s subcutaneous needling（FSN） combined with physiotherapy in painful phase, acupotomology and massage in adhesion phase, and appropriate functional exercise in rehabilitation phase. Seven days were considered as one course of treatment, and efficacy evaluation was performed after three courses. Function evaluation of shoulder joint was made. Result The total effective rate was 100%（38/38） in acute phase, 93.5%（29/31） in adhesion phase, and 100%（21/21） in rehabilitation phase. After treatment, the range of motion（ROM） of shoulder joint, pain, muscle force, activities of daily living（ADL） and joint local morphology of the patient have been improved obviously. Conclusion Better clinical efficacy is achieved in treatment of scapulohumeral periarthritis in different phases by combining therapy centering on FSN.
基金financially supported by the National Key Research and Development Program of China (2018YFC1706300 and 2018YFC17063005)the Fundamental Research Funds for the Central Universities (lzujbky-2019-92, lzujbky-2020-sp13)+2 种基金the Project for Longyuan Youth Innovation and Entrepreneurship TalentScience the Special funds for Innovation and Guidance of Gansu (2017ZX-02)the Science-Technology Plan Project from Lanzhou Science and Technology Bureau (2017-RC115)。
文摘Objective: "Same treatment for different diseases" is a unique treatment strategy under the guidance of traditional Chinese medicine(TCM) theory.Codonopsis Radix(Codonopsis pilosula,Dangshen in Chinese)with spleen-fortifying effect was employed to understand the strategy of "Same treatment for different diseases",based on its common mechanism in the treatment of gastric diseases including gastric ulcer,gastritis and gastric cancer via network pharmacology research.Methods:Network pharmacology research methods were used to analyze the interaction network and potential mechanisms of Dangshen in treating gastric ulcer,gastritis and gastric cancer.The active components and their target proteins of Dangshen were integrated from TCMSP,BATMAN-TCM databases.The targets of gastric ulcer,gastritis and gastric cancer were collected through GeneCards,PubMed,TDD and DisGeNET Database.Through screening,the key components and the key targets of Dangshen in treating gastric ulcer,gastritis and gastric cancer were obtained.After KEGG pathway analysis and GO analysis,the important pathways and biological processes were analyzed.Results:Through data and literature mining,the common and specific pharmaceutical effects and mechanism of Dangshen were summarized in these three gastric lesions.It was shown that Dangshen mainly acted on gastric ulcer,gastritis and gastric cancer through the overall regulation of the PI3K-AkT signaling pathway.With the development of the disease,it will gradually increase the control of inflammation through TNF,NF-κB and other inflammation-related signaling pathways to reduce inflammatory damage.For tumorigenesis,it pays more attention to inhibiting the ErbB signaling pathways to reduce the proliferation and migration of tumor cells.In addition,Dangshen's regulation of HIF-1 signaling pathway may also be beneficial for the treatment of gastric ulcer,gastritis and gastric cancer.Conclusion:Dangshen achieves spleen-fortifying effect on gastric diseases including gastric ulcer,gastritis and gastric cancer through multiple targets in multiple pathways,especially PI3K-AKT pathway and HIF-1 pathway.It could provide a scientific basis for understanding the strategy of "Same treatment for different diseases" in traditional Chinese medicine.
基金supported by the Special Environmental Research Fund for Public Welfare(No.200809087)
文摘Many studies on methane emissions from animal manure have revealed that animal manure is a major source of methane emissions to the atmosphere that can have negative consequences for people, animals and environment. In general, the release of methane can be influenced by the type of feed taken by animals, temperature, manure characteristics and so on. This study aimed at quantifying and comparing methane release from dairy manure with different piling treatments. Four treatments were designed including manure piling height 30, 45, 60 cm and adding 6 cm manure every day until the piling height was 60 cm. Static chamber method and gas chromatography were adopted to measure the methane emissions from April to June in 2009. Methane emission rates of all four manure treatments were low in the first week and then increased sharply until reaching the peak values. Subsequently, all the methane emission rates decreased and fluctuated within the steady range till the end of the experiment. Wilcoxon nonparametfic tests analysis indicated that methane emission rate was greatly influenced by manure piling height and manner. There were no significant relationships between methane emission rates and the temperatures of ambience and heap. However, regression analysis showed that the quadratic equations were found between emission rates of all treatments and the gas temperature in the barrels.
基金Supported by the National Natural Science Foundation of China(No.81573845,81473367,81403209,30825047)China Academy of Chinese Medical Sciences Project(No.Z0412)Beijing Nova Program(No.xx2014B073)
文摘Objective： To identify the commonalities between rheumatoid arthritis （RA） and diabetes mellitus （DM） to understand the mechanisms of Chinese medicine （CM） in different diseases with the same treatment. Methods： A text mining approach was adopted to analyze the commonalities between RA and DM according to CM and biological elements. The major commonalities were subsequently verified in RA and DM rat models, in which herbal formula for the treatment of both RA and DM identified via text mining was used as the intervention. Results： Similarities were identified between RA and DM regarding the CM approach used for diagnosis and treatment, as well as the networks of biological activities affected by each disease, including the involvement of adhesion molecules, oxidative stress, cytokines, T-lymphocytes, apoptosis, and inflammation. The Ramulus Cinnamomi-Radix Paeoniae Alba-Rhizoma Anemarrhenae is an herbal combination used to treat RA and DM. This formula demonstrated similar effects on oxidative stress and inflammation in rats with collagen-induced arthritis, which supports the text mining results regarding the commonalities between RA and DM. Conclusion： Commonalities between the biological activities involved in RA and DM were identified through text mining, and both RA and DM might be responsive to the same intervention at a specific stage.
文摘According to differentiating syndrome and dividing patter, 41 cases of Facial Chloasma by Auricular Pressure in Shen (MA-AH), Fei (MA-IC 1), Neifenmi (MA-IC 3), Luanchao (MA-AT), Mianjia (MA-L) and Xia’erbei (MA-IC), the total effective rate was 87.8%. Key Words Skin Pigmentation, Chloasma - Auricular Point Sticking - Syndrome Differ Treatment Author: Liu Guang-xia (1954-), female, associate professorTranslator: Xiao Yuan-chun
基金financially supported by the National Key Research and Development Program of China (2018YFC1706300 and 2018YFC17063005)the Science and Technology Planning Project of Gansu Province (20JR10RA586)+2 种基金the Fundamental Research Funds for the Central Universities (lzujbky-2021-kb40)the Project for Longyuan Youth Innovation and Entrepreneurship Talentthe Science and Technology Planning Project of Guangdong Province of China (2019B090905002)
文摘Objective:"Same treatment for different diseases"is a unique treatment strategy in traditional Chinese medicine.Two kinds of malignant respiratory diseases endanger human health-chronic obstructive pulmonary disease(COPD)and lung cancer.Citrus Grandis Exocarpium(Huajuhong in Chinese,HJH),a famous herbal,is always applied by Chinese medicine practitioners to dispersion the lung to resolve phlegm based on"syndrome differentiation and treatment"theory.However,the common mechanism for HJH’s treatment of COPD and lung cancer is not clear.Methods:In this study,based on network pharmacology and molecular docking technology,the common mechanism of HJH in the treatment of COPD and lung cancer was studied.The active ingredients and related targets of HJH were integrated from TCMSP,BATMAN-TAM,STP,and Pubchem databases.The standard names of these targets were united by Uni Prot database.Targets of COPD and lung cancer were enriched through Gene Cards,NCBI(Gene),Therapeutic Target Database,and Dis Ge NET(v7.0)databases.Then the intersection targets of HJH and diseases were obtained.The STRING network and the Cytoscape 3.7.2 were used to construct PPI network,the DAVID database was used to perform GO and KEGG analysis.Then Cytoscape 3.6.1 was used to build"ingredient-target-signal pathway"network.Finally,Auto Dock 1.5.6 software was used to perform molecular docking of key proteins and molecules.Results:Eleven active ingredients in HJH were obtained by searching the database,corresponding to 184 HJH-COPD-lung cancer targets intersection.The results of biological network analysis showed that naringenin,the active component in HJH,could mainly act on target proteins such as AKT1,EGFR.Then through positive regulation of vasoconstriction and other biological processes,naringenin could regulate estrogen signaling pathway,VEGF signaling pathway,HIF-1 signaling pathway,Erb B signaling pathway,PI3K-Akt signaling pathway to play an important role in the treatment of both COPD and lung cancer.Conclusion:Network pharmacology was employed to systematically investigate the active ingredients and targets of HJH in treatment of COPD and lung cancer.And then,the common pharmacodynamic network of HJH for the two malignant respiratory diseases was firstly described.Furthermore,naringenin was proved to strongly bind with AKT1 and EGFR.It may provide the scientific basis for understanding the"Same treatment for different diseases"strategy in traditional Chinese medicine and inspirit subsequent drug discovery for COPD,lung cancer and other malignant lung diseases.
文摘There is worrying about current clinical situation on diagnosis and treatment based on an overall analysis of symptoms and signs in acupuncture. Japanese specialists in the acupuncture field have pointed out that sufficient attention should be paid to its various malpractices. Responding to their questioning, the author put forward some main problems existing and made certain analysis. Diagnosis and treatment based on an overall analysis of symptoms and signs should be expressed in their application according to successive theories, methods, prescriptions, acupoints and techniques. In order to elevate therapeutic effects of acupuncture, forth effort should be put to various aspects, such as clinical skills, functional regularity, indications and affected factors.
文摘Objective To compare the efficacy differences between acupuncture and western medicine in treating osteoarthritis of knee joints.Methods One hundred and twenty cases were randomly divided into an acupuncture group and a western medication group with 60 cases in each group.In the acupuncture group,acupuncture was applied mainly at Nèixīyǎn（内膝眼 EX-LE 4）,Dúbí（犊鼻 ST 35）,Yīnlíngquán（阴陵泉 SP 9） and Yánglíngquán（阳陵泉 GB 34） plus other acupoints selected according to syndrome differentiation.In the medication group,Glucosamine Hydrochloride capsules were orally given 3 times daily with 2 capsules each time.Western Ontario and McMaster Universities Osteoarthritis Index（WOMAC）,Medical Outcomes Study 36-Item Short Form Health Survey（SF-36,Chinese version） were used to assess therapeutic effects before treatment,after 4 weeks treatment and 9 weeks after treatment,respectively.Results After 4 weeks of treatment,the total effective rates were 86.7%（52/60） and 88.3%（53/60） in the acupuncture group and the western medication group,respectively,without significant difference（P〈0.05）.In 9 weeks after treatment,the total effective rates were 83.3%（50/60） and 61.7%（37/60） in the acupuncture group and the western medication group,respectively,with significant difference between the two groups（P〈0.05）.According to WOMAC and SF-36,the scores were all improved in both groups（P〈0.05,P〈0.01）,with significant difference in follow-up visit of 9 weeks after treatment between the two groups（P〈0.05,P〈0.01）,but not after 4 weeks of treatments（both P〈0.05）.Conclusion Short-term of therapeutic effects of acupuncture and oral administration of Glucosamine Hydrochloride on osteoarthritis of knee joints are similar,but long-term efficacy in the acupuncture group is better than that in the western medication group.
文摘OBJECTIVE: To compare the effects of integrated Chinese-Western therapy versus Western therapy alone on the survival rate of patients with non-small-cell lung cancer (NSCLC) at middle-late stage and to evaluate prognostic factors. METHODS: We selected 98 inpatients with middle-late stage NSCLC diagnosed from March 2009 to March 2011 and randomly divided them into two groups, with 49 cases in each group, and the clinical data were analyzed retrospectively.The control group was treated by the combined methods of Western Medicine, including chemotherapy, supportive treatment and symptomatic treatment. The observation group was treated by injection and prescriptions of Chinese medicine based on Traditional Chinese Medicine syndrome differentiation and by the same combined methods of western treatment used in the control group. After treatment, the survival rates of the patients were compared by the stage of cancer and evaluation of 24 prognostic factors analyzed by a Cox regressionmodel, and the clinical data were statistically analyzed. RESULTS: The survival rates of all patients were over 90.0% at 1 and 3 months after treatment with no significant differences between the two groups (P>0.05); In the observation group the survival rates at 6 months and 1 year were 93.4% and 42.8%, respectively, being superior to 85.6% and 18.3% in the control group (P<0.05). The median survival time in the observation group was superior to the control group (P<0.05); The effects of 24 prognostic factors were significantly better in the observation group than in the control group (P<0.05). CONCLUSION: Integrated Chinese-western therapy can significantly improve the survival rate in patients with middle-late stage NSCLC and improve prognostic factors compared with western therapy alone.
