Doubled haploid(DH)plants have been widely used for breeding and biological research in crops.Pop ulus spp.have been used as model woody plant species for biological research.However,the induction of DH poplar plants ...Doubled haploid(DH)plants have been widely used for breeding and biological research in crops.Pop ulus spp.have been used as model woody plant species for biological research.However,the induction of DH poplar plants is onerous,and limited biological or breeding work has been carried out on DH individuals or populations.In this study,we provide an effective protocol for poplar haploid induction based on an anther culture method.A total of 96 whole DH plant lines were obtained using an F1hybrid of Populus simonii×P.nigra as a donor tree.The phenotypes of the DH population showed exceptionally high variance when compared to those of half-sib progeny of the donor tree.Each DH line displayed distinct features compared to those of the other DH lines or the donor tree.Additionally,some excellent homozygous lines have the potential to be model plants in genetic and breeding studies.展开更多
The inter-cycle correlation of fission source distributions(FSDs)in the Monte Carlo power iteration process results in variance underestimation of tallied physical quantities,especially in large local tallies.This stu...The inter-cycle correlation of fission source distributions(FSDs)in the Monte Carlo power iteration process results in variance underestimation of tallied physical quantities,especially in large local tallies.This study provides a mesh-free semiquantitative variance underestimation elimination method to obtain a credible confidence interval for the tallied results.This method comprises two procedures:Estimation and Elimination.The FSD inter-cycle correlation length is estimated in the Estimation procedure using the Sliced Wasserstein distance algorithm.The batch method was then used in the elimination procedure.The FSD inter-cycle correlation length was proved to be the optimum batch length to eliminate the variance underestimation problem.We exemplified this method using the OECD sphere array model and 3D PWR BEAVRS model.The results showed that the average variance underestimation ratios of local tallies declined from 37 to 87%to within±5%in these models.展开更多
The zero-energy variance principle can be exploited in variational quantum eigensolvers for solving general eigenstates but its capacity for obtaining a specified eigenstate,such as ground state,is limited as all eige...The zero-energy variance principle can be exploited in variational quantum eigensolvers for solving general eigenstates but its capacity for obtaining a specified eigenstate,such as ground state,is limited as all eigenstates are of zero energy variance.We propose a variance-based variational quantum eigensolver for solving the ground state by searching in an enlarged space of wavefunction and Hamiltonian.With a mutual variance-Hamiltonian optimization procedure,the Hamiltonian is iteratively updated to guild the state towards to the ground state of the target Hamiltonian by minimizing the energy variance in each iteration.We demonstrate the performance and properties of the algorithm with numeral simulations.Our work suggests an avenue for utilizing guided Hamiltonian in hybrid quantum-classical algorithms.展开更多
As modern weapons and equipment undergo increasing levels of informatization,intelligence,and networking,the topology and traffic characteristics of battlefield data networks built with tactical data links are becomin...As modern weapons and equipment undergo increasing levels of informatization,intelligence,and networking,the topology and traffic characteristics of battlefield data networks built with tactical data links are becoming progressively complex.In this paper,we employ a traffic matrix to model the tactical data link network.We propose a method that utilizes the Maximum Variance Unfolding(MVU)algorithm to conduct nonlinear dimensionality reduction analysis on high-dimensional open network traffic matrix datasets.This approach introduces novel ideas and methods for future applications,including traffic prediction and anomaly analysis in real battlefield network environments.展开更多
A mixed distribution of empirical variances, composed of two distributions the basic and contaminating ones, and referred to as PERG mixed distribution of empirical variances, is considered. In the paper a robust inve...A mixed distribution of empirical variances, composed of two distributions the basic and contaminating ones, and referred to as PERG mixed distribution of empirical variances, is considered. In the paper a robust inverse problem solution is given, namely a (new) robust method for estimation of variances of both distributions—PEROBVC Method, as well as the estimates for the numbers of observations for both distributions and, in this way also the estimate of contamination degree.展开更多
Background:Large area forest inventories often use regular grids(with a single random start)of sample locations to ensure a uniform sampling intensity across the space of the surveyed populations.A design-unbiased est...Background:Large area forest inventories often use regular grids(with a single random start)of sample locations to ensure a uniform sampling intensity across the space of the surveyed populations.A design-unbiased estimator of variance does not exist for this design.Oftentimes,a quasi-default estimator applicable to simple random sampling(SRS)is used,even if it carries with it the likely risk of overestimating the variance by a practically important margin.To better exploit the precision of systematic sampling we assess the performance of five estimators of variance,including the quasi default.In this study,simulated systematic sampling was applied to artificial populations with contrasting covariance structures and with or without linear trends.We compared the results obtained with the SRS,Matern’s,successive difference replication,Ripley’s,and D’Orazio’s variance estimators.Results:The variances obtained with the four alternatives to the SRS estimator of variance were strongly correlated,and in all study settings consistently closer to the target design variance than the estimator for SRS.The latter always produced the greatest overestimation.In populations with a near zero spatial autocorrelation,all estimators,performed equally,and delivered estimates close to the actual design variance.Conclusion:Without a linear trend,the SDR and DOR estimators were best with variance estimates more narrowly distributed around the benchmark;yet in terms of the least average absolute deviation,Matern’s estimator held a narrow lead.With a strong or moderate linear trend,Matern’s estimator is choice.In large populations,and a low sampling intensity,the performance of the investigated estimators becomes more similar.展开更多
Generalized Least Squares (least squares with prior information) requires the correct assignment of two prior covariance matrices: one associated with the uncertainty of measurements;the other with the uncertainty of ...Generalized Least Squares (least squares with prior information) requires the correct assignment of two prior covariance matrices: one associated with the uncertainty of measurements;the other with the uncertainty of prior information. These assignments often are very subjective, especially when correlations among data or among prior information are believed to occur. However, in cases in which the general form of these matrices can be anticipated up to a set of poorly-known parameters, the data and prior information may be used to better-determine (or “tune”) the parameters in a manner that is faithful to the underlying Bayesian foundation of GLS. We identify an objective function, the minimization of which leads to the best-estimate of the parameters and provide explicit and computationally-efficient formula for calculating the derivatives needed to implement the minimization with a gradient descent method. Furthermore, the problem is organized so that the minimization need be performed only over the space of covariance parameters, and not over the combined space of model and covariance parameters. We show that the use of trade-off curves to select the relative weight given to observations and prior information is not a form of tuning, because it does not, in general maximize the posterior probability of the model parameters, and can lead to a different weighting than the procedure described here. We also provide several examples that demonstrate the viability, and discuss both the advantages and limitations of the method.展开更多
The current standard for measuring tumor response using X-ray, CT and MRI is based on the response evaluation criterion in solid tumors (RECIST) which, while providing simplifications over previous (WHO) 2-D methods, ...The current standard for measuring tumor response using X-ray, CT and MRI is based on the response evaluation criterion in solid tumors (RECIST) which, while providing simplifications over previous (WHO) 2-D methods, stipulate four response categories: CR (complete response), PR (partial response), PD (progressive disease), SD (stable disease) based purely on percentage changes without consideration of any measurement uncertainty. In this paper, we propose a statistical procedure for tumor response assessment based on uncertainty measures of radiologist’s measurement data. We present several variance estimation methods using time series methods and empirical Bayes methods when a small number of serial observations are available on each member of a group of subjects. We use a publically available database which contains a set of over 100 CT scan images on 23 patients with annotated RECIST measurements by two radiologist readers. We show that despite of bias in each individual reader’s measurements, statistical decisions on tumor change can be made on each individual subject. The consistency of the two readers can be established based on the intra-reader change assessments. Our proposal compares favorably with the RECIST standard protocol, raising the hope that, statistically sound decision on change analysis can be made in future based on careful variability and measurement uncertainty analysis.展开更多
Background:A new variance estimator is derived and tested for big BAF(Basal Area Factor)sampling which is a forest inventory system that utilizes Bitterlich sampling(point sampling)with two BAF sizes,a small BAF for t...Background:A new variance estimator is derived and tested for big BAF(Basal Area Factor)sampling which is a forest inventory system that utilizes Bitterlich sampling(point sampling)with two BAF sizes,a small BAF for tree counts and a larger BAF on which tree measurements are made usually including DBHs and heights needed for volume estimation.Methods:The new estimator is derived using the Delta method from an existing formulation of the big BAF estimator as consisting of three sample means.The new formula is compared to existing big BAF estimators including a popular estimator based on Bruce’s formula.Results:Several computer simulation studies were conducted comparing the new variance estimator to all known variance estimators for big BAF currently in the forest inventory literature.In simulations the new estimator performed well and comparably to existing variance formulas.Conclusions:A possible advantage of the new estimator is that it does not require the assumption of negligible correlation between basal area counts on the small BAF factor and volume-basal area ratios based on the large BAF factor selection trees,an assumption required by all previous big BAF variance estimation formulas.Although this correlation was negligible on the simulation stands used in this study,it is conceivable that the correlation could be significant in some forest types,such as those in which the DBH-height relationship can be affected substantially by density perhaps through competition.We derived a formula that can be used to estimate the covariance between estimates of mean basal area and the ratio of estimates of mean volume and mean basal area.We also mathematically derived expressions for bias in the big BAF estimator that can be used to show the bias approaches zero in large samples on the order of 1n where n is the number of sample points.展开更多
This paper presents a new method for detection of edges in digital angiographic images. It is found that variances of local regions across edges of images are statistically different from that of those where no edge i...This paper presents a new method for detection of edges in digital angiographic images. It is found that variances of local regions across edges of images are statistically different from that of those where no edge is crossed. This difference can be utilized for the detection of edges of angiographic images. An algorithm based on local variance is proposed. As a result, the edge-detection algorithm is not sensitive to noise and low-level textures of images. A computer program based on the new algorithm has been developed and used by several hospitals.展开更多
Our purpose is twofold: to present a prototypical example of the conditioning technique to obtain the best estimator of a parameter and to show that th</span><span style="font-family:Verdana;">is...Our purpose is twofold: to present a prototypical example of the conditioning technique to obtain the best estimator of a parameter and to show that th</span><span style="font-family:Verdana;">is technique resides in the structure of an inner product space. Th</span><span style="font-family:Verdana;">e technique uses conditioning </span></span><span style="font-family:Verdana;">of</span><span style="font-family:Verdana;"> an unbiased estimator </span><span style="font-family:Verdana;">on</span><span style="font-family:Verdana;"> a sufficient statistic. This procedure is founded upon the conditional variance formula, which leads to an inner product space and a geometric interpretation. The example clearly illustrates the dependence on the sampling methodology. These advantages show the power and centrality of this process.展开更多
Peak ground acceleration(PGA) estimation is an important task in earthquake engineering practice.One of the most well-known models is the Boore-Joyner-Fumal formula,which estimates the PGA using the moment magnitude,t...Peak ground acceleration(PGA) estimation is an important task in earthquake engineering practice.One of the most well-known models is the Boore-Joyner-Fumal formula,which estimates the PGA using the moment magnitude,the site-to-fault distance and the site foundation properties.In the present study,the complexity for this formula and the homogeneity assumption for the prediction-error variance are investigated and an effi ciency-robustness balanced formula is proposed.For this purpose,a reduced-order Monte Carlo simulation algorithm for Bayesian model class selection is presented to obtain the most suitable predictive formula and prediction-error model for the seismic attenuation relationship.In this approach,each model class(a predictive formula with a prediction-error model) is evaluated according to its plausibility given the data.The one with the highest plausibility is robust since it possesses the optimal balance between the data fi tting capability and the sensitivity to noise.A database of strong ground motion records in the Tangshan region of China is obtained from the China Earthquake Data Center for the analysis.The optimal predictive formula is proposed based on this database.It is shown that the proposed formula with heterogeneous prediction-error variance is much simpler than the attenuation model suggested by Boore,Joyner and Fumal(1993).展开更多
Underwater acoustic signal processing is one of the research hotspots in underwater acoustics.Noise reduction of underwater acoustic signals is the key to underwater acoustic signal processing.Owing to the complexity ...Underwater acoustic signal processing is one of the research hotspots in underwater acoustics.Noise reduction of underwater acoustic signals is the key to underwater acoustic signal processing.Owing to the complexity of marine environment and the particularity of underwater acoustic channel,noise reduction of underwater acoustic signals has always been a difficult challenge in the field of underwater acoustic signal processing.In order to solve the dilemma,we proposed a novel noise reduction technique for underwater acoustic signals based on complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN),minimum mean square variance criterion(MMSVC) and least mean square adaptive filter(LMSAF).This noise reduction technique,named CEEMDAN-MMSVC-LMSAF,has three main advantages:(i) as an improved algorithm of empirical mode decomposition(EMD) and ensemble EMD(EEMD),CEEMDAN can better suppress mode mixing,and can avoid selecting the number of decomposition in variational mode decomposition(VMD);(ii) MMSVC can identify noisy intrinsic mode function(IMF),and can avoid selecting thresholds of different permutation entropies;(iii) for noise reduction of noisy IMFs,LMSAF overcomes the selection of deco mposition number and basis function for wavelet noise reduction.Firstly,CEEMDAN decomposes the original signal into IMFs,which can be divided into noisy IMFs and real IMFs.Then,MMSVC and LMSAF are used to detect identify noisy IMFs and remove noise components from noisy IMFs.Finally,both denoised noisy IMFs and real IMFs are reconstructed and the final denoised signal is obtained.Compared with other noise reduction techniques,the validity of CEEMDAN-MMSVC-LMSAF can be proved by the analysis of simulation signals and real underwater acoustic signals,which has the better noise reduction effect and has practical application value.CEEMDAN-MMSVC-LMSAF also provides a reliable basis for the detection,feature extraction,classification and recognition of underwater acoustic signals.展开更多
In order to enhance the robustness and contrast in the minimum variance(MV) beamformer, adaptive diagonal loading method was proposed. The conventional diagonal loading technique has already been used in the MV beamfo...In order to enhance the robustness and contrast in the minimum variance(MV) beamformer, adaptive diagonal loading method was proposed. The conventional diagonal loading technique has already been used in the MV beamformer, but has the drawback that its level is specified by predefined parameter and without consideration of input-data. To alleviate this problem, the level of diagonal loading was computed appropriately and automatically from the given data by shrinkage method in the proposed adaptive diagonal loaded beamformer. The performance of the proposed beamformer was tested on the simulated point target and cyst phantom was obtained using Field II. In the point target simulation, it is shown that the proposed method has higher lateral resolution than the conventional delay-and-sum beamformer and could be more robust in estimating the amplitude peak than the MV beamformer when acoustic velocity error exists. In the cyst phantom simulation, the proposed beamformer has shown that it achieves an improvement in contrast ratio and without distorting the edges of cyst.展开更多
Suppression effect in multiple regression analysis may be more common in research than what is currently recognized. We have reviewed several literatures of interest which treats the concept and types of suppressor va...Suppression effect in multiple regression analysis may be more common in research than what is currently recognized. We have reviewed several literatures of interest which treats the concept and types of suppressor variables. Also, we have highlighted systematic ways to identify suppression effect in multiple regressions using statistics such as: R2, sum of squares, regression weight and comparing zero-order correlations with Variance Inflation Factor (VIF) respectively. We also establish that suppression effect is a function of multicollinearity;however, a suppressor variable should only be allowed in a regression analysis if its VIF is less than five (5).展开更多
This paper studies the estimation of variance and covariance compo-nents for GPS baseline network by MINQUE method.The fundamental rule forselecting variance-covariance model has been presented,and the alternative alg...This paper studies the estimation of variance and covariance compo-nents for GPS baseline network by MINQUE method.The fundamental rule forselecting variance-covariance model has been presented,and the alternative algo-rithm which simultaneouly estimates fixed variance components and scalled vari-ance components of the distance,azimuth and geodetic height difference for a GPSbaseline vector has been developed.展开更多
This paper aims to the debate on the nexus between informal economies and the environment by investigating the long-term dynamic impacts of China’s informal economies on pollution and considering regional differences...This paper aims to the debate on the nexus between informal economies and the environment by investigating the long-term dynamic impacts of China’s informal economies on pollution and considering regional differences in informal economies’ pollution.This paper uses the Multiple Indicators Multiple Causes(MIMIC) model to estimate the size of informal economies and employs econometric models to examine their relationships to pollution based on provincial-level panel data from 2000 to 2017. The results indicate that informal economies’ effects on environmental pollution are not purely positive or negative. Rather, our model indicates that there is an inverted U-shaped relationship between informal economies and pollution in the long run in China;this means that the level of environmental pollution increases at first and then decreases with the growth of informal economies. Further analysis shows that while this inverted, U-shaped relationship is significant in different regions of China, it is affected by different environmental impact factors. The paper concludes by discussing the policy implications for environmental protection and sustainable development.展开更多
The type 2 modified augmented design(MAD2) is an efficient unreplicated experimental design used for evaluating large numbers of lines in plant breeding and for assessing genetic variation in a population. Statistical...The type 2 modified augmented design(MAD2) is an efficient unreplicated experimental design used for evaluating large numbers of lines in plant breeding and for assessing genetic variation in a population. Statistical methods and data adjustment for soil heterogeneity have been previously described for this design. In the absence of replicated test genotypes in MAD2, their total variance cannot be partitioned into genetic and error components as required to estimate heritability and genetic correlation of quantitative traits, the two conventional genetic parameters used for breeding selection. We propose a method of estimating the error variance of unreplicated genotypes that uses replicated controls, and then of estimating the genetic parameters. Using the Delta method, we also derived formulas for estimating the sampling variances of the genetic parameters.Computer simulations indicated that the proposed method for estimating genetic parameters and their sampling variances was feasible and the reliability of the estimates was positively associated with the level of heritability of the trait. A case study of estimating the genetic parameters of three quantitative traits, iodine value, oil content, and linolenic acid content, in a biparental recombinant inbred line population of flax with 243 individuals, was conducted using our statistical models. A joint analysis of data over multiple years and sites was suggested for genetic parameter estimation. A pipeline module using SAS and Perl was developed to facilitate data analysis and appended to the previously developed MAD data analysis pipeline(http://probes.pw.usda.gov/bioinformatics_ tools/MADPipeline/index.html).展开更多
Data collected from truck payload management systems at various surface mines shows that the payload variance is significant and must be considered in analysing the mine productivity,energy consumption,greenhouse gas ...Data collected from truck payload management systems at various surface mines shows that the payload variance is significant and must be considered in analysing the mine productivity,energy consumption,greenhouse gas emissions and associated cost.Payload variance causes significant differences in gross vehicle weights.Heavily loaded trucks travel slower up ramps than lightly loaded trucks.Faster trucks are slowed by the presence of slower trucks,resulting in‘bunching’,production losses and increasing fuel consumptions.This paper simulates the truck bunching phenomena in large surface mines to improve truck and shovel systems’efficiency and minimise fuel consumption.The study concentrated on completing a practical simulation model based on a discrete event method which is most commonly used in this field of research in other industries.The simulation model has been validated by a dataset collected from a large surface mine in Arizona state,USA.The results have shown that there is a good agreement between the actual and estimated values of investigated parameters.展开更多
基金supported by the National Key R&D Program of China(2021YFD2200203)Heilongjiang Province Key R&D Program of China(GA21B010)+1 种基金Heilongjiang Touyan Innovation Team Program(Tree Genetics and Breeding Innovation Team)Heilongjiang Postdoctoral Financial Assistance(LBH-Z21097)。
文摘Doubled haploid(DH)plants have been widely used for breeding and biological research in crops.Pop ulus spp.have been used as model woody plant species for biological research.However,the induction of DH poplar plants is onerous,and limited biological or breeding work has been carried out on DH individuals or populations.In this study,we provide an effective protocol for poplar haploid induction based on an anther culture method.A total of 96 whole DH plant lines were obtained using an F1hybrid of Populus simonii×P.nigra as a donor tree.The phenotypes of the DH population showed exceptionally high variance when compared to those of half-sib progeny of the donor tree.Each DH line displayed distinct features compared to those of the other DH lines or the donor tree.Additionally,some excellent homozygous lines have the potential to be model plants in genetic and breeding studies.
基金supported by China Nuclear Power Engineering Co.,Ltd.Scientific Research Project(No.KY22104)the fellowship of China Postdoctoral Science Foundation(No.2022M721793).
文摘The inter-cycle correlation of fission source distributions(FSDs)in the Monte Carlo power iteration process results in variance underestimation of tallied physical quantities,especially in large local tallies.This study provides a mesh-free semiquantitative variance underestimation elimination method to obtain a credible confidence interval for the tallied results.This method comprises two procedures:Estimation and Elimination.The FSD inter-cycle correlation length is estimated in the Estimation procedure using the Sliced Wasserstein distance algorithm.The batch method was then used in the elimination procedure.The FSD inter-cycle correlation length was proved to be the optimum batch length to eliminate the variance underestimation problem.We exemplified this method using the OECD sphere array model and 3D PWR BEAVRS model.The results showed that the average variance underestimation ratios of local tallies declined from 37 to 87%to within±5%in these models.
基金supported by the National Natural Science Foundation of China(Grant No.12005065)the Guangdong Basic and Applied Basic Research Fund(Grant No.2021A1515010317)。
文摘The zero-energy variance principle can be exploited in variational quantum eigensolvers for solving general eigenstates but its capacity for obtaining a specified eigenstate,such as ground state,is limited as all eigenstates are of zero energy variance.We propose a variance-based variational quantum eigensolver for solving the ground state by searching in an enlarged space of wavefunction and Hamiltonian.With a mutual variance-Hamiltonian optimization procedure,the Hamiltonian is iteratively updated to guild the state towards to the ground state of the target Hamiltonian by minimizing the energy variance in each iteration.We demonstrate the performance and properties of the algorithm with numeral simulations.Our work suggests an avenue for utilizing guided Hamiltonian in hybrid quantum-classical algorithms.
文摘As modern weapons and equipment undergo increasing levels of informatization,intelligence,and networking,the topology and traffic characteristics of battlefield data networks built with tactical data links are becoming progressively complex.In this paper,we employ a traffic matrix to model the tactical data link network.We propose a method that utilizes the Maximum Variance Unfolding(MVU)algorithm to conduct nonlinear dimensionality reduction analysis on high-dimensional open network traffic matrix datasets.This approach introduces novel ideas and methods for future applications,including traffic prediction and anomaly analysis in real battlefield network environments.
文摘A mixed distribution of empirical variances, composed of two distributions the basic and contaminating ones, and referred to as PERG mixed distribution of empirical variances, is considered. In the paper a robust inverse problem solution is given, namely a (new) robust method for estimation of variances of both distributions—PEROBVC Method, as well as the estimates for the numbers of observations for both distributions and, in this way also the estimate of contamination degree.
文摘Background:Large area forest inventories often use regular grids(with a single random start)of sample locations to ensure a uniform sampling intensity across the space of the surveyed populations.A design-unbiased estimator of variance does not exist for this design.Oftentimes,a quasi-default estimator applicable to simple random sampling(SRS)is used,even if it carries with it the likely risk of overestimating the variance by a practically important margin.To better exploit the precision of systematic sampling we assess the performance of five estimators of variance,including the quasi default.In this study,simulated systematic sampling was applied to artificial populations with contrasting covariance structures and with or without linear trends.We compared the results obtained with the SRS,Matern’s,successive difference replication,Ripley’s,and D’Orazio’s variance estimators.Results:The variances obtained with the four alternatives to the SRS estimator of variance were strongly correlated,and in all study settings consistently closer to the target design variance than the estimator for SRS.The latter always produced the greatest overestimation.In populations with a near zero spatial autocorrelation,all estimators,performed equally,and delivered estimates close to the actual design variance.Conclusion:Without a linear trend,the SDR and DOR estimators were best with variance estimates more narrowly distributed around the benchmark;yet in terms of the least average absolute deviation,Matern’s estimator held a narrow lead.With a strong or moderate linear trend,Matern’s estimator is choice.In large populations,and a low sampling intensity,the performance of the investigated estimators becomes more similar.
文摘Generalized Least Squares (least squares with prior information) requires the correct assignment of two prior covariance matrices: one associated with the uncertainty of measurements;the other with the uncertainty of prior information. These assignments often are very subjective, especially when correlations among data or among prior information are believed to occur. However, in cases in which the general form of these matrices can be anticipated up to a set of poorly-known parameters, the data and prior information may be used to better-determine (or “tune”) the parameters in a manner that is faithful to the underlying Bayesian foundation of GLS. We identify an objective function, the minimization of which leads to the best-estimate of the parameters and provide explicit and computationally-efficient formula for calculating the derivatives needed to implement the minimization with a gradient descent method. Furthermore, the problem is organized so that the minimization need be performed only over the space of covariance parameters, and not over the combined space of model and covariance parameters. We show that the use of trade-off curves to select the relative weight given to observations and prior information is not a form of tuning, because it does not, in general maximize the posterior probability of the model parameters, and can lead to a different weighting than the procedure described here. We also provide several examples that demonstrate the viability, and discuss both the advantages and limitations of the method.
文摘The current standard for measuring tumor response using X-ray, CT and MRI is based on the response evaluation criterion in solid tumors (RECIST) which, while providing simplifications over previous (WHO) 2-D methods, stipulate four response categories: CR (complete response), PR (partial response), PD (progressive disease), SD (stable disease) based purely on percentage changes without consideration of any measurement uncertainty. In this paper, we propose a statistical procedure for tumor response assessment based on uncertainty measures of radiologist’s measurement data. We present several variance estimation methods using time series methods and empirical Bayes methods when a small number of serial observations are available on each member of a group of subjects. We use a publically available database which contains a set of over 100 CT scan images on 23 patients with annotated RECIST measurements by two radiologist readers. We show that despite of bias in each individual reader’s measurements, statistical decisions on tumor change can be made on each individual subject. The consistency of the two readers can be established based on the intra-reader change assessments. Our proposal compares favorably with the RECIST standard protocol, raising the hope that, statistically sound decision on change analysis can be made in future based on careful variability and measurement uncertainty analysis.
基金Support was provided by Research Joint Venture Agreement 17-JV-11242306045,“Old Growth Forest Dynamics and Structure,”between the USDA Forest Service and the University of New HampshireAdditional support to MJD was provided by the USDA National Institute of Food and Agriculture McIntire-Stennis Project Accession Number 1020142,“Forest Structure,Volume,and Biomass in the Northeastern United States.”+1 种基金supported by the USDA National Institute of Food and Agriculture,McIntire-Stennis project OKL02834the Division of Agricultural Sciences and Natural Resources at Oklahoma State University.
文摘Background:A new variance estimator is derived and tested for big BAF(Basal Area Factor)sampling which is a forest inventory system that utilizes Bitterlich sampling(point sampling)with two BAF sizes,a small BAF for tree counts and a larger BAF on which tree measurements are made usually including DBHs and heights needed for volume estimation.Methods:The new estimator is derived using the Delta method from an existing formulation of the big BAF estimator as consisting of three sample means.The new formula is compared to existing big BAF estimators including a popular estimator based on Bruce’s formula.Results:Several computer simulation studies were conducted comparing the new variance estimator to all known variance estimators for big BAF currently in the forest inventory literature.In simulations the new estimator performed well and comparably to existing variance formulas.Conclusions:A possible advantage of the new estimator is that it does not require the assumption of negligible correlation between basal area counts on the small BAF factor and volume-basal area ratios based on the large BAF factor selection trees,an assumption required by all previous big BAF variance estimation formulas.Although this correlation was negligible on the simulation stands used in this study,it is conceivable that the correlation could be significant in some forest types,such as those in which the DBH-height relationship can be affected substantially by density perhaps through competition.We derived a formula that can be used to estimate the covariance between estimates of mean basal area and the ratio of estimates of mean volume and mean basal area.We also mathematically derived expressions for bias in the big BAF estimator that can be used to show the bias approaches zero in large samples on the order of 1n where n is the number of sample points.
文摘This paper presents a new method for detection of edges in digital angiographic images. It is found that variances of local regions across edges of images are statistically different from that of those where no edge is crossed. This difference can be utilized for the detection of edges of angiographic images. An algorithm based on local variance is proposed. As a result, the edge-detection algorithm is not sensitive to noise and low-level textures of images. A computer program based on the new algorithm has been developed and used by several hospitals.
文摘Our purpose is twofold: to present a prototypical example of the conditioning technique to obtain the best estimator of a parameter and to show that th</span><span style="font-family:Verdana;">is technique resides in the structure of an inner product space. Th</span><span style="font-family:Verdana;">e technique uses conditioning </span></span><span style="font-family:Verdana;">of</span><span style="font-family:Verdana;"> an unbiased estimator </span><span style="font-family:Verdana;">on</span><span style="font-family:Verdana;"> a sufficient statistic. This procedure is founded upon the conditional variance formula, which leads to an inner product space and a geometric interpretation. The example clearly illustrates the dependence on the sampling methodology. These advantages show the power and centrality of this process.
基金Research Committee of University of Macao under Research Grant No.MYRG081(Y1-L2)-FST13-YKVthe Science and Technology Development Fund of the Macao SAR government under Grant No.012/2013/A1
文摘Peak ground acceleration(PGA) estimation is an important task in earthquake engineering practice.One of the most well-known models is the Boore-Joyner-Fumal formula,which estimates the PGA using the moment magnitude,the site-to-fault distance and the site foundation properties.In the present study,the complexity for this formula and the homogeneity assumption for the prediction-error variance are investigated and an effi ciency-robustness balanced formula is proposed.For this purpose,a reduced-order Monte Carlo simulation algorithm for Bayesian model class selection is presented to obtain the most suitable predictive formula and prediction-error model for the seismic attenuation relationship.In this approach,each model class(a predictive formula with a prediction-error model) is evaluated according to its plausibility given the data.The one with the highest plausibility is robust since it possesses the optimal balance between the data fi tting capability and the sensitivity to noise.A database of strong ground motion records in the Tangshan region of China is obtained from the China Earthquake Data Center for the analysis.The optimal predictive formula is proposed based on this database.It is shown that the proposed formula with heterogeneous prediction-error variance is much simpler than the attenuation model suggested by Boore,Joyner and Fumal(1993).
基金The authors gratefully acknowledge the support of the National Natural Science Foundation of China(No.11574250).
文摘Underwater acoustic signal processing is one of the research hotspots in underwater acoustics.Noise reduction of underwater acoustic signals is the key to underwater acoustic signal processing.Owing to the complexity of marine environment and the particularity of underwater acoustic channel,noise reduction of underwater acoustic signals has always been a difficult challenge in the field of underwater acoustic signal processing.In order to solve the dilemma,we proposed a novel noise reduction technique for underwater acoustic signals based on complete ensemble empirical mode decomposition with adaptive noise(CEEMDAN),minimum mean square variance criterion(MMSVC) and least mean square adaptive filter(LMSAF).This noise reduction technique,named CEEMDAN-MMSVC-LMSAF,has three main advantages:(i) as an improved algorithm of empirical mode decomposition(EMD) and ensemble EMD(EEMD),CEEMDAN can better suppress mode mixing,and can avoid selecting the number of decomposition in variational mode decomposition(VMD);(ii) MMSVC can identify noisy intrinsic mode function(IMF),and can avoid selecting thresholds of different permutation entropies;(iii) for noise reduction of noisy IMFs,LMSAF overcomes the selection of deco mposition number and basis function for wavelet noise reduction.Firstly,CEEMDAN decomposes the original signal into IMFs,which can be divided into noisy IMFs and real IMFs.Then,MMSVC and LMSAF are used to detect identify noisy IMFs and remove noise components from noisy IMFs.Finally,both denoised noisy IMFs and real IMFs are reconstructed and the final denoised signal is obtained.Compared with other noise reduction techniques,the validity of CEEMDAN-MMSVC-LMSAF can be proved by the analysis of simulation signals and real underwater acoustic signals,which has the better noise reduction effect and has practical application value.CEEMDAN-MMSVC-LMSAF also provides a reliable basis for the detection,feature extraction,classification and recognition of underwater acoustic signals.
基金Project(2013GZX0147-3)supported by the Science and Technology Pillar Program of Sichuan Province,China
文摘In order to enhance the robustness and contrast in the minimum variance(MV) beamformer, adaptive diagonal loading method was proposed. The conventional diagonal loading technique has already been used in the MV beamformer, but has the drawback that its level is specified by predefined parameter and without consideration of input-data. To alleviate this problem, the level of diagonal loading was computed appropriately and automatically from the given data by shrinkage method in the proposed adaptive diagonal loaded beamformer. The performance of the proposed beamformer was tested on the simulated point target and cyst phantom was obtained using Field II. In the point target simulation, it is shown that the proposed method has higher lateral resolution than the conventional delay-and-sum beamformer and could be more robust in estimating the amplitude peak than the MV beamformer when acoustic velocity error exists. In the cyst phantom simulation, the proposed beamformer has shown that it achieves an improvement in contrast ratio and without distorting the edges of cyst.
文摘Suppression effect in multiple regression analysis may be more common in research than what is currently recognized. We have reviewed several literatures of interest which treats the concept and types of suppressor variables. Also, we have highlighted systematic ways to identify suppression effect in multiple regressions using statistics such as: R2, sum of squares, regression weight and comparing zero-order correlations with Variance Inflation Factor (VIF) respectively. We also establish that suppression effect is a function of multicollinearity;however, a suppressor variable should only be allowed in a regression analysis if its VIF is less than five (5).
文摘This paper studies the estimation of variance and covariance compo-nents for GPS baseline network by MINQUE method.The fundamental rule forselecting variance-covariance model has been presented,and the alternative algo-rithm which simultaneouly estimates fixed variance components and scalled vari-ance components of the distance,azimuth and geodetic height difference for a GPSbaseline vector has been developed.
基金Under the auspices of the National Natural Science Foundation of China(No.41930646,41771137)the Guangdong Academy of Sciences(GDAS)Project of Science and Technology Development(No.2019GDASYL-0104004)Fundamental Research Funds for the Central Universities(No.20lgpy31)。
文摘This paper aims to the debate on the nexus between informal economies and the environment by investigating the long-term dynamic impacts of China’s informal economies on pollution and considering regional differences in informal economies’ pollution.This paper uses the Multiple Indicators Multiple Causes(MIMIC) model to estimate the size of informal economies and employs econometric models to examine their relationships to pollution based on provincial-level panel data from 2000 to 2017. The results indicate that informal economies’ effects on environmental pollution are not purely positive or negative. Rather, our model indicates that there is an inverted U-shaped relationship between informal economies and pollution in the long run in China;this means that the level of environmental pollution increases at first and then decreases with the growth of informal economies. Further analysis shows that while this inverted, U-shaped relationship is significant in different regions of China, it is affected by different environmental impact factors. The paper concludes by discussing the policy implications for environmental protection and sustainable development.
基金partly supported by an A-base project funded by Agriculture and Agri-Food Canadathe TUFGEN project funded by Genome Canada and other stakeholdersfunds from the Western Grains Research Foundation
文摘The type 2 modified augmented design(MAD2) is an efficient unreplicated experimental design used for evaluating large numbers of lines in plant breeding and for assessing genetic variation in a population. Statistical methods and data adjustment for soil heterogeneity have been previously described for this design. In the absence of replicated test genotypes in MAD2, their total variance cannot be partitioned into genetic and error components as required to estimate heritability and genetic correlation of quantitative traits, the two conventional genetic parameters used for breeding selection. We propose a method of estimating the error variance of unreplicated genotypes that uses replicated controls, and then of estimating the genetic parameters. Using the Delta method, we also derived formulas for estimating the sampling variances of the genetic parameters.Computer simulations indicated that the proposed method for estimating genetic parameters and their sampling variances was feasible and the reliability of the estimates was positively associated with the level of heritability of the trait. A case study of estimating the genetic parameters of three quantitative traits, iodine value, oil content, and linolenic acid content, in a biparental recombinant inbred line population of flax with 243 individuals, was conducted using our statistical models. A joint analysis of data over multiple years and sites was suggested for genetic parameter estimation. A pipeline module using SAS and Perl was developed to facilitate data analysis and appended to the previously developed MAD data analysis pipeline(http://probes.pw.usda.gov/bioinformatics_ tools/MADPipeline/index.html).
基金CRC MiningThe University of Queensland for their financial support for this study
文摘Data collected from truck payload management systems at various surface mines shows that the payload variance is significant and must be considered in analysing the mine productivity,energy consumption,greenhouse gas emissions and associated cost.Payload variance causes significant differences in gross vehicle weights.Heavily loaded trucks travel slower up ramps than lightly loaded trucks.Faster trucks are slowed by the presence of slower trucks,resulting in‘bunching’,production losses and increasing fuel consumptions.This paper simulates the truck bunching phenomena in large surface mines to improve truck and shovel systems’efficiency and minimise fuel consumption.The study concentrated on completing a practical simulation model based on a discrete event method which is most commonly used in this field of research in other industries.The simulation model has been validated by a dataset collected from a large surface mine in Arizona state,USA.The results have shown that there is a good agreement between the actual and estimated values of investigated parameters.
