目的:以临床文献数据为基础挖掘中医药治疗尿浊方剂的组方用药规律。方法:检索中国知网、万方与维普数据库,时间为2020年1月1日至2024年9月10日,收集中医药治疗尿浊的临床资料,运用频次分析、关联规则分析、聚类分析及因子分析等数据挖...目的:以临床文献数据为基础挖掘中医药治疗尿浊方剂的组方用药规律。方法:检索中国知网、万方与维普数据库,时间为2020年1月1日至2024年9月10日,收集中医药治疗尿浊的临床资料,运用频次分析、关联规则分析、聚类分析及因子分析等数据挖掘手段探究抗尿浊方剂的配伍规律。结果:共得到991首治疗尿浊的方剂,共涉及449味中药,使用频率排在前6位的中药为黄芪、茯苓、白术、丹参、山药、山茱萸,常用中药类别以补虚药、活血化瘀药、利水渗湿药、清热药为主。药性集中于平、温、寒,药味以甘为主,归经主要在肝、脾、肾经关联规则的网络可视化提示黄芪–茯苓在处方中出现频次最高(448次)。对高频药物(≥70)进行聚类分析,共得到5个聚类组合,反映了“黄芪–丹参–当归–大黄–川芎–水蛭–地龙–土茯苓–桃仁–赤芍–淫羊藿”等在经典方的基础上加减药味的特色组方,体现了气运血行,肾络复通,精行其道,则尿浊症状自消的治法。因子分析共提取18个公因子,挖掘得到“水蛭–地龙–蝉蜕”等虫类药组在尿浊中的运用,体现了破血逐瘀、通经利尿等配伍特点。结论:尿浊方剂的用药规律以补益脾肾、清利湿热为主。中医治疗尿浊应先辨虚实,初期多为实证,治以清利湿热;久病多虚,宜培补脾肾,固摄下元,实夹杂者,补益之中可加以渗湿,渗湿之法又可兼以补益,应标本兼顾。Objective: Based on the data of clinical literature, the composition and medication rules of traditional Chinese medicine for the treatment of urine turbidity prescriptions were explored. Methods: CNKI, Wanfang and VIP databases were searched from January 1, 2020 to September 10, 2024, to collect clinical data of traditional Chinese medicine in the treatment of urine turbidity, and the compatibility of anti-urine turbidity prescriptions was explored by frequency analysis, association rule analysis, cluster analysis and factor analysis. Results: A total of 991 formulas for the treatment of urine turbidity were obtained, involving a total of 449 traditional Chinese medicines, and the top 6 Chinese medicines with the highest frequency of use were Astragalus membranaceus, Poria cocos, Atractylodes macrocephalus, Salvia miltiorrhizae, Chinese yam and Cornus officinalis. The medicinal properties were concentrated in flat, warm and cold, the medicinal taste was mainly sweet, and the network visualization of the association rules of the liver, spleen and kidney meridians showed that Astragalus-Poria cocos appeared most frequently in the prescription (448 times). Cluster analysis of high-frequency drugs (≥70) was carried out, and a total of 5 cluster combinations were obtained, reflecting the characteristic formulas of “Astragalus membranaceus-Salvia miltiorrhizae-Angelica-Rhubarb-Chuanxiong-Leech-Dilong-Poria cocos-Peach kernel-Red Paeoniae-Epimedium weed” on the basis of the classic formula, which reflected the treatment method of qi luck and blood, kidney recirculation, and the self-elimination of urine turbidity symptoms. A total of 18 common factors were extracted from the factor analysis, and the application of insect groups such as “leech-Dilong-cicada molt” in urine turbidity was obtained, which reflected the compatibility characteristics of blood breaking and stasis, and meridian diuresis. Conclusion: The medication rules for urine turbidity prescriptions primarily aim to nourish the spleen and kidney, and to clear dampness and heat. Traditional Chinese medicine should first distinguish between deficiency and excess in the treatment of urine turbidity, with most initial evidence being empirical. The treatment focuses on clearing and benefiting dampness and heat;for long-term illness and deficiency, it is advisable to cultivate and replenish the spleen and kidney, solidify the lower yuan, and ensure proper inclusion. The tonic can be moist, and the method for addressing dampness can be combined with the tonic, taking the specimen into account.展开更多
目的 使用数据挖掘探索中医药治疗精索静脉曲张(VC)的临床用药规律。方法搜寻中国知网(CNKI)、万方数据知识服务平台(Wanfang Data Knowledge Service Platform)、维普(CQVIP)自建库起至2023年8月的中医药治疗VC的文献,通过挑选并运用Ex...目的 使用数据挖掘探索中医药治疗精索静脉曲张(VC)的临床用药规律。方法搜寻中国知网(CNKI)、万方数据知识服务平台(Wanfang Data Knowledge Service Platform)、维普(CQVIP)自建库起至2023年8月的中医药治疗VC的文献,通过挑选并运用Excel规范后的药方材料输入“中医传承辅助平台(V2.5)”后予统算剖析,对中医证候、用药频次、性味归经、组方规律和新处方进行统算剖析,总结并研究中医药治疗VC的用药规律。结果共纳入60篇文献中的80首合格处方,包括147味中药,出现频次较高的中医证候依次是肾虚血瘀证、瘀血阻络证、气虚血瘀证、气滞血瘀证;频次≥20的中药共有11味;性味多为温、甘,归经多是肝、肾、脾;频次较高的药对是“菟丝子-枸杞子”“丹参-当归”,置信度最高药物为淫羊藿、枸杞子与菟丝子;最后重组13个新药方。结论 目前中医药治疗VC以活血祛瘀为主,同时兼顾补肾、疏肝、健脾、理气、补气等治法。展开更多
目的通过知识图谱可视化探究近20年来中医药治疗化疗所致恶心呕吐的研究现状、研究热点以及研究成果,为该领域的进一步研究提供参考。方法以“中医药”“化疗呕吐”等为主题词,以2002年1月1日-2021年12月31日为时间段,检索中国知网数据...目的通过知识图谱可视化探究近20年来中医药治疗化疗所致恶心呕吐的研究现状、研究热点以及研究成果,为该领域的进一步研究提供参考。方法以“中医药”“化疗呕吐”等为主题词,以2002年1月1日-2021年12月31日为时间段,检索中国知网数据库(Chinese National Knowledge Infrastructure,CNKI)、万方医学网、维普网以及中国生物医学文献服务系统所收录的相关文献,应用CiteSpace.6.1.R1软件对文献进行计量学分析,并绘制、分析相关的知识图谱。结果总共纳入分析文献1116篇。2002年至2021年,国内中医药治疗化疗所致恶心呕吐的文献数量总体呈上升趋势,其中2014年至2021年间增长最快(年平均发文量为82.38篇);核心作者发文量总计567篇,占总发文量的50.8%(>50%);共形成5个合作紧密的作者机构;中医药治疗化疗所致恶心呕吐的高频关键词为:化疗呕吐、肿瘤、乳腺癌、穴位贴敷、穴位注射等;聚类图谱可见所有关键词被聚类成12类;共16个关键词参与突现,其中近两年研究热点包括肺癌、不良反应、穴位贴敷等。结论中医药与止吐剂的联用,穴位敷贴、耳穴压贴等中医外治法的应用以及针对高发肿瘤的对症治疗是国内中医药治疗化疗所致恶心呕吐的研究热点;中西医结合、中医特色治疗等多元化的治疗方案是未来研究的发展趋势。展开更多
文摘目的:以临床文献数据为基础挖掘中医药治疗尿浊方剂的组方用药规律。方法:检索中国知网、万方与维普数据库,时间为2020年1月1日至2024年9月10日,收集中医药治疗尿浊的临床资料,运用频次分析、关联规则分析、聚类分析及因子分析等数据挖掘手段探究抗尿浊方剂的配伍规律。结果:共得到991首治疗尿浊的方剂,共涉及449味中药,使用频率排在前6位的中药为黄芪、茯苓、白术、丹参、山药、山茱萸,常用中药类别以补虚药、活血化瘀药、利水渗湿药、清热药为主。药性集中于平、温、寒,药味以甘为主,归经主要在肝、脾、肾经关联规则的网络可视化提示黄芪–茯苓在处方中出现频次最高(448次)。对高频药物(≥70)进行聚类分析,共得到5个聚类组合,反映了“黄芪–丹参–当归–大黄–川芎–水蛭–地龙–土茯苓–桃仁–赤芍–淫羊藿”等在经典方的基础上加减药味的特色组方,体现了气运血行,肾络复通,精行其道,则尿浊症状自消的治法。因子分析共提取18个公因子,挖掘得到“水蛭–地龙–蝉蜕”等虫类药组在尿浊中的运用,体现了破血逐瘀、通经利尿等配伍特点。结论:尿浊方剂的用药规律以补益脾肾、清利湿热为主。中医治疗尿浊应先辨虚实,初期多为实证,治以清利湿热;久病多虚,宜培补脾肾,固摄下元,实夹杂者,补益之中可加以渗湿,渗湿之法又可兼以补益,应标本兼顾。Objective: Based on the data of clinical literature, the composition and medication rules of traditional Chinese medicine for the treatment of urine turbidity prescriptions were explored. Methods: CNKI, Wanfang and VIP databases were searched from January 1, 2020 to September 10, 2024, to collect clinical data of traditional Chinese medicine in the treatment of urine turbidity, and the compatibility of anti-urine turbidity prescriptions was explored by frequency analysis, association rule analysis, cluster analysis and factor analysis. Results: A total of 991 formulas for the treatment of urine turbidity were obtained, involving a total of 449 traditional Chinese medicines, and the top 6 Chinese medicines with the highest frequency of use were Astragalus membranaceus, Poria cocos, Atractylodes macrocephalus, Salvia miltiorrhizae, Chinese yam and Cornus officinalis. The medicinal properties were concentrated in flat, warm and cold, the medicinal taste was mainly sweet, and the network visualization of the association rules of the liver, spleen and kidney meridians showed that Astragalus-Poria cocos appeared most frequently in the prescription (448 times). Cluster analysis of high-frequency drugs (≥70) was carried out, and a total of 5 cluster combinations were obtained, reflecting the characteristic formulas of “Astragalus membranaceus-Salvia miltiorrhizae-Angelica-Rhubarb-Chuanxiong-Leech-Dilong-Poria cocos-Peach kernel-Red Paeoniae-Epimedium weed” on the basis of the classic formula, which reflected the treatment method of qi luck and blood, kidney recirculation, and the self-elimination of urine turbidity symptoms. A total of 18 common factors were extracted from the factor analysis, and the application of insect groups such as “leech-Dilong-cicada molt” in urine turbidity was obtained, which reflected the compatibility characteristics of blood breaking and stasis, and meridian diuresis. Conclusion: The medication rules for urine turbidity prescriptions primarily aim to nourish the spleen and kidney, and to clear dampness and heat. Traditional Chinese medicine should first distinguish between deficiency and excess in the treatment of urine turbidity, with most initial evidence being empirical. The treatment focuses on clearing and benefiting dampness and heat;for long-term illness and deficiency, it is advisable to cultivate and replenish the spleen and kidney, solidify the lower yuan, and ensure proper inclusion. The tonic can be moist, and the method for addressing dampness can be combined with the tonic, taking the specimen into account.
文摘目的 使用数据挖掘探索中医药治疗精索静脉曲张(VC)的临床用药规律。方法搜寻中国知网(CNKI)、万方数据知识服务平台(Wanfang Data Knowledge Service Platform)、维普(CQVIP)自建库起至2023年8月的中医药治疗VC的文献,通过挑选并运用Excel规范后的药方材料输入“中医传承辅助平台(V2.5)”后予统算剖析,对中医证候、用药频次、性味归经、组方规律和新处方进行统算剖析,总结并研究中医药治疗VC的用药规律。结果共纳入60篇文献中的80首合格处方,包括147味中药,出现频次较高的中医证候依次是肾虚血瘀证、瘀血阻络证、气虚血瘀证、气滞血瘀证;频次≥20的中药共有11味;性味多为温、甘,归经多是肝、肾、脾;频次较高的药对是“菟丝子-枸杞子”“丹参-当归”,置信度最高药物为淫羊藿、枸杞子与菟丝子;最后重组13个新药方。结论 目前中医药治疗VC以活血祛瘀为主,同时兼顾补肾、疏肝、健脾、理气、补气等治法。
文摘目的通过知识图谱可视化探究近20年来中医药治疗化疗所致恶心呕吐的研究现状、研究热点以及研究成果,为该领域的进一步研究提供参考。方法以“中医药”“化疗呕吐”等为主题词,以2002年1月1日-2021年12月31日为时间段,检索中国知网数据库(Chinese National Knowledge Infrastructure,CNKI)、万方医学网、维普网以及中国生物医学文献服务系统所收录的相关文献,应用CiteSpace.6.1.R1软件对文献进行计量学分析,并绘制、分析相关的知识图谱。结果总共纳入分析文献1116篇。2002年至2021年,国内中医药治疗化疗所致恶心呕吐的文献数量总体呈上升趋势,其中2014年至2021年间增长最快(年平均发文量为82.38篇);核心作者发文量总计567篇,占总发文量的50.8%(>50%);共形成5个合作紧密的作者机构;中医药治疗化疗所致恶心呕吐的高频关键词为:化疗呕吐、肿瘤、乳腺癌、穴位贴敷、穴位注射等;聚类图谱可见所有关键词被聚类成12类;共16个关键词参与突现,其中近两年研究热点包括肺癌、不良反应、穴位贴敷等。结论中医药与止吐剂的联用,穴位敷贴、耳穴压贴等中医外治法的应用以及针对高发肿瘤的对症治疗是国内中医药治疗化疗所致恶心呕吐的研究热点;中西医结合、中医特色治疗等多元化的治疗方案是未来研究的发展趋势。
