随着现代生物医药产业的快速发展,对专业人才的需求也日益增长。产教融合作为一种创新的教育模式,对培养适应行业发展的高素质人才具有重要意义。本研究旨在探讨如何通过产教融合优化现代生物医药产业学院的课程设置,以提高学生的就业...随着现代生物医药产业的快速发展,对专业人才的需求也日益增长。产教融合作为一种创新的教育模式,对培养适应行业发展的高素质人才具有重要意义。本研究旨在探讨如何通过产教融合优化现代生物医药产业学院的课程设置,以提高学生的就业竞争力和职业发展潜力。本研究采用问卷调查、定性访谈和文献调研方法发现,目前生物医药产业学院课程设置存在的不足之处有:产教融合不紧密,课程设置未能以岗位胜任力为目标导向;课程体系落后、课程内容与产业实际需求脱节;实践实训课程比例不足,实践实训条件薄弱;课程思政环节薄弱,缺乏系统性;缺少岗位特异性的职业发展规划和就业指导课程。针对上述不足,基于产教融合背景,本研究提出了现代生物医药产业学院课程设置优化策略:以产业需求和岗位胜任力为导向进行课程设置,系统构建科学合理的模块化课程体系,系统构建产教融合的课程思政体系,拓宽优化实践实训基地,构建多元化的实践课程体系,建立完善的职业发展支持体系。实施这些策略进行课程设置优化有望提升教育质量,培养学生的岗位胜任力,满足现代生物医药产业对人才的多元化需求。With the rapid development of the modern biomedical industry, the demand for professional talents is also growing. As an innovative education model, the integration of industry and education is of great significance in cultivating high-quality talents that adapt to industry development. This study aims to explore how to optimize the curriculum of modern biomedical industry colleges through the integration of industry and education to improve students’ employment competitiveness and career development potential. This study used questionnaire surveys, qualitative interviews and literature research methods to find that the current deficiencies in the curriculum of the College of Biomedical Industry include: the integration of industry and education is not close, the curriculum fails to be goal-oriented towards job competency, the curriculum system is backward, the content of the courses is out of touch with the actual needs of the industry;the proportion of practical training courses is insufficient, weak ideological and political links in the curriculum, and there is a lack of job-specific career development planning and employment guidance courses. In response to the above shortcomings, based on the background of industry-education integration, this study proposes an optimization strategy for the curriculum of modern biomedical industry colleges: curriculum setting based on industry needs and job competency, systematically constructing a scientific and reasonable modular curriculum system, and systematically constructing industry-leading courses. The ideological and political curriculum system that integrates teaching and learning, expands and optimizes the practical training base, builds a diversified practical curriculum system, and establishes a complete career development support system. Implementing these strategies to optimize curriculum is expected to improve the quality of education, cultivate students’ job competencies, and meet the diverse needs for talents in the modern biomedical industry.展开更多
本文强调早期科研诚信价值观在生物医药产业复合型人才培养中的核心地位,分析了科研诚信对于生物医药产业发展的重要性,指出科研诚信不仅是提升个人职业素养和学术水平的关键,也是推动该产业创新发展和维护公共健康的基础。通过对医药学...本文强调早期科研诚信价值观在生物医药产业复合型人才培养中的核心地位,分析了科研诚信对于生物医药产业发展的重要性,指出科研诚信不仅是提升个人职业素养和学术水平的关键,也是推动该产业创新发展和维护公共健康的基础。通过对医药学类84名学生的科研诚信现状进行调查,发现学生对科研诚信有一定认识,但缺乏对科研规范的深入了解。针对这些问题,文章提出了五点培育路径:加强科研诚信教育、建设科研诚信制度和监督体系、开展科研诚信实践活动、强化导师责任制以及建立科研诚信激励机制,旨在提升本科生的科研诚信意识,促进其科研活动的健康发展,为我国生物医药产业新质生产力和国际竞争力的提升奠定坚实的人才基础。This article underscores the pivotal role of early scientific integrity values in the cultivation of versatile talents in the biopharmaceutical industry. It analyzes the significance of scientific integrity for the development of the biopharmaceutical industry, highlighting that it is not only crucial for enhancing individual professional ethics and academic standards but also essential for driving innovation and safeguarding public health within the sector. A survey of the scientific integrity status among 84 students in pharmaceutical sciences revealed a basic understanding of scientific integrity but a lack of in-depth knowledge of research norms. In response to these issues, the article proposes five pathways for cultivation: strengthening scientific integrity education, establishing systems and oversight for scientific integrity, conducting practical activities to promote scientific integrity, reinforcing the responsibility of mentors, and creating incentives for scientific integrity. These measures aim to enhance undergraduate students’ awareness of scientific integrity, foster healthy research activities, and lay a solid talent foundation for enhancing the new quality productive forces and international competitiveness of China’s biopharmaceutical industry.展开更多
木犀草素(3',4',5,7-四羟基黄酮)是一种天然的黄酮类化合物,通常以糖苷的形式广泛分布于多种水果和蔬菜中。木犀草素具有显著的抗肿瘤活性,具体作用机制主要包括抑制细胞增殖、促进细胞凋亡、阻止细胞周期进程、抑制细胞迁移与...木犀草素(3',4',5,7-四羟基黄酮)是一种天然的黄酮类化合物,通常以糖苷的形式广泛分布于多种水果和蔬菜中。木犀草素具有显著的抗肿瘤活性,具体作用机制主要包括抑制细胞增殖、促进细胞凋亡、阻止细胞周期进程、抑制细胞迁移与侵袭、抑制血管新生以及诱导自噬等。然而,由于木犀草素的生物利用度较低,这限制了其临床应用。因此,通过化学结构修饰,获得木犀草素的一系列衍生物,提高其生物利用度,保持或增强其原有的抗肿瘤活性已成为研究热点。本文综述了木犀草素及其衍生物的研究进展,旨在探讨其抗肿瘤作用的分子机制,为从天然产物出发进行药物设计和结构优化提供理论依据。Luteolin (3',4',5,7-tetrahydroxyflavones) are naturally occurring flavonoids, usually in the form of glycosides, widely distributed in a variety of fruits and vegetables. Luteolin have significant anti-tumor activity, and the specific mechanism of action mainly includes inhibition of cell proliferation, promotion of apoptosis, blocking cell cycle progression, inhibition of cell migration and invasion, inhibition of vascular neogenesis, and induction of autophagy. However, due to the low bioavailability of luteolin, this limits its clinical application. Therefore, it has become a research hotspot to obtain a series of derivatives of luteolin through chemical structure modification to improve their bioavailability and maintain or enhance their original antitumor activities. This paper reviews the research progress of luteolin and their derivatives, aiming at exploring the molecular mechanism of their antitumor effects and providing theoretical basis for drug design and structure optimization from natural products.展开更多
线上线下混合式教学是一种线上教学与课堂教学有效整合的教学模式。雨课堂作为一种智慧型教学工具,为天然药物化学改革带来新的体验。文章分析了天然药物化学的教学现状,结合继续教育学院药学/药物制剂专升本学生学习特点,以天然药物化...线上线下混合式教学是一种线上教学与课堂教学有效整合的教学模式。雨课堂作为一种智慧型教学工具,为天然药物化学改革带来新的体验。文章分析了天然药物化学的教学现状,结合继续教育学院药学/药物制剂专升本学生学习特点,以天然药物化学第五章“黄酮类化合物”为例,分别从教学内容、教学目标、教学设计、考核评价等方面,探讨雨课堂教学模式在天然药物化学中的具体应用,为其他药学专业课程的改革提供参考。Blended online and offline teaching is a teaching model that effectively integrates online and classroom teaching. Rain classroom, as an intelligent teaching tool, brings new experiences to the reform of medicinal chemistry of natural products. The article analyzes the current teaching situation of medicinal chemistry of natural products, combined with the learning characteristics of pharmacy/pharmaceutical preparation undergraduate students in the continuing education college. Taking chapter five “flavonoids” of medicinal chemistry of natural products as an example, it explores the specific application of the rain classroom teaching mode in medicinal chemistry of natural products from the aspects of teaching content, teaching objectives, teaching design, and assessment evaluation, providing reference for the reform of other pharmaceutical professional courses.展开更多
酚苷类化合物广泛存在于自然界多种植物中,具有抗氧化、抗炎、抗菌、抗癌、血糖血脂调节作用、美白和保护身体各器官等多种药理作用,但口服生物利用度低是其主要问题。本文概述了酚苷类化合物的药理作用,以及制备脂质体、纳米颗粒、乳...酚苷类化合物广泛存在于自然界多种植物中,具有抗氧化、抗炎、抗菌、抗癌、血糖血脂调节作用、美白和保护身体各器官等多种药理作用,但口服生物利用度低是其主要问题。本文概述了酚苷类化合物的药理作用,以及制备脂质体、纳米颗粒、乳液、磷脂复合物、环糊精包合物等提高生物利用度的技术方法,以期为酚苷类化合物的活性研究及临床应用提供参考。Phenolic glycosides are widely found in many plants in nature, with antioxidant, anti-inflammatory, antibacterial, anticancer, blood glucose and lipid regulation, whitening and protective effects on various organs of the body, etc. However, low oral bioavailability has always been the main problem. In this paper, the pharmacological effects of phenolic glycosides and the methods of preparing liposomes, nanoparticles, emulsion delivery systems, phospholipid complexes and cyclodextrin inclusion complexes to improve bioavailability were summarized, in order to provide theoretical basis for the activity research and clinical application of phenolic glycosides.展开更多
恒古骨伤愈合剂(Osteoking)是一种云南彝族传统复方民族药物,临床研究表明Osteoking在骨疾病治疗方面有积极效果。本文讨论了现有Osteoking治疗骨疾病的药理机制,包括骨质疏松、股骨头坏死、膝骨关节炎和腰椎间盘突出症等骨疾病。通过查...恒古骨伤愈合剂(Osteoking)是一种云南彝族传统复方民族药物,临床研究表明Osteoking在骨疾病治疗方面有积极效果。本文讨论了现有Osteoking治疗骨疾病的药理机制,包括骨质疏松、股骨头坏死、膝骨关节炎和腰椎间盘突出症等骨疾病。通过查阅Osteoking治疗骨疾病的中、英文文献,论述Osteoking治疗以上骨疾病的临床研究进展,旨在为临床应用Osteoking治疗骨疾病提供理论参考。Osteoking is a kind of traditional compound medicine of Yi nationality in Yunnan province. Clinical research shows that Osteoking has positive effect in the treatment of bone diseases. The pharmacological mechanism of Osteoking in the treatment of bone diseases, including osteoporosis, osteonecrosis of the femoral head, osteoarthritis of the knee and protrusion of the lumbar intervertebral disc, was discussed. By reviewing the Chinese and English literatures of Osteoking in the treatment of bone diseases, this paper discusses the clinical research progress of Osteoking in the treatment of the above bone diseases in order to provide theoretical reference for the clinical application of Osteoking in the treatment of bone diseases.展开更多
文摘随着现代生物医药产业的快速发展,对专业人才的需求也日益增长。产教融合作为一种创新的教育模式,对培养适应行业发展的高素质人才具有重要意义。本研究旨在探讨如何通过产教融合优化现代生物医药产业学院的课程设置,以提高学生的就业竞争力和职业发展潜力。本研究采用问卷调查、定性访谈和文献调研方法发现,目前生物医药产业学院课程设置存在的不足之处有:产教融合不紧密,课程设置未能以岗位胜任力为目标导向;课程体系落后、课程内容与产业实际需求脱节;实践实训课程比例不足,实践实训条件薄弱;课程思政环节薄弱,缺乏系统性;缺少岗位特异性的职业发展规划和就业指导课程。针对上述不足,基于产教融合背景,本研究提出了现代生物医药产业学院课程设置优化策略:以产业需求和岗位胜任力为导向进行课程设置,系统构建科学合理的模块化课程体系,系统构建产教融合的课程思政体系,拓宽优化实践实训基地,构建多元化的实践课程体系,建立完善的职业发展支持体系。实施这些策略进行课程设置优化有望提升教育质量,培养学生的岗位胜任力,满足现代生物医药产业对人才的多元化需求。With the rapid development of the modern biomedical industry, the demand for professional talents is also growing. As an innovative education model, the integration of industry and education is of great significance in cultivating high-quality talents that adapt to industry development. This study aims to explore how to optimize the curriculum of modern biomedical industry colleges through the integration of industry and education to improve students’ employment competitiveness and career development potential. This study used questionnaire surveys, qualitative interviews and literature research methods to find that the current deficiencies in the curriculum of the College of Biomedical Industry include: the integration of industry and education is not close, the curriculum fails to be goal-oriented towards job competency, the curriculum system is backward, the content of the courses is out of touch with the actual needs of the industry;the proportion of practical training courses is insufficient, weak ideological and political links in the curriculum, and there is a lack of job-specific career development planning and employment guidance courses. In response to the above shortcomings, based on the background of industry-education integration, this study proposes an optimization strategy for the curriculum of modern biomedical industry colleges: curriculum setting based on industry needs and job competency, systematically constructing a scientific and reasonable modular curriculum system, and systematically constructing industry-leading courses. The ideological and political curriculum system that integrates teaching and learning, expands and optimizes the practical training base, builds a diversified practical curriculum system, and establishes a complete career development support system. Implementing these strategies to optimize curriculum is expected to improve the quality of education, cultivate students’ job competencies, and meet the diverse needs for talents in the modern biomedical industry.
文摘本文强调早期科研诚信价值观在生物医药产业复合型人才培养中的核心地位,分析了科研诚信对于生物医药产业发展的重要性,指出科研诚信不仅是提升个人职业素养和学术水平的关键,也是推动该产业创新发展和维护公共健康的基础。通过对医药学类84名学生的科研诚信现状进行调查,发现学生对科研诚信有一定认识,但缺乏对科研规范的深入了解。针对这些问题,文章提出了五点培育路径:加强科研诚信教育、建设科研诚信制度和监督体系、开展科研诚信实践活动、强化导师责任制以及建立科研诚信激励机制,旨在提升本科生的科研诚信意识,促进其科研活动的健康发展,为我国生物医药产业新质生产力和国际竞争力的提升奠定坚实的人才基础。This article underscores the pivotal role of early scientific integrity values in the cultivation of versatile talents in the biopharmaceutical industry. It analyzes the significance of scientific integrity for the development of the biopharmaceutical industry, highlighting that it is not only crucial for enhancing individual professional ethics and academic standards but also essential for driving innovation and safeguarding public health within the sector. A survey of the scientific integrity status among 84 students in pharmaceutical sciences revealed a basic understanding of scientific integrity but a lack of in-depth knowledge of research norms. In response to these issues, the article proposes five pathways for cultivation: strengthening scientific integrity education, establishing systems and oversight for scientific integrity, conducting practical activities to promote scientific integrity, reinforcing the responsibility of mentors, and creating incentives for scientific integrity. These measures aim to enhance undergraduate students’ awareness of scientific integrity, foster healthy research activities, and lay a solid talent foundation for enhancing the new quality productive forces and international competitiveness of China’s biopharmaceutical industry.
文摘木犀草素(3',4',5,7-四羟基黄酮)是一种天然的黄酮类化合物,通常以糖苷的形式广泛分布于多种水果和蔬菜中。木犀草素具有显著的抗肿瘤活性,具体作用机制主要包括抑制细胞增殖、促进细胞凋亡、阻止细胞周期进程、抑制细胞迁移与侵袭、抑制血管新生以及诱导自噬等。然而,由于木犀草素的生物利用度较低,这限制了其临床应用。因此,通过化学结构修饰,获得木犀草素的一系列衍生物,提高其生物利用度,保持或增强其原有的抗肿瘤活性已成为研究热点。本文综述了木犀草素及其衍生物的研究进展,旨在探讨其抗肿瘤作用的分子机制,为从天然产物出发进行药物设计和结构优化提供理论依据。Luteolin (3',4',5,7-tetrahydroxyflavones) are naturally occurring flavonoids, usually in the form of glycosides, widely distributed in a variety of fruits and vegetables. Luteolin have significant anti-tumor activity, and the specific mechanism of action mainly includes inhibition of cell proliferation, promotion of apoptosis, blocking cell cycle progression, inhibition of cell migration and invasion, inhibition of vascular neogenesis, and induction of autophagy. However, due to the low bioavailability of luteolin, this limits its clinical application. Therefore, it has become a research hotspot to obtain a series of derivatives of luteolin through chemical structure modification to improve their bioavailability and maintain or enhance their original antitumor activities. This paper reviews the research progress of luteolin and their derivatives, aiming at exploring the molecular mechanism of their antitumor effects and providing theoretical basis for drug design and structure optimization from natural products.
文摘线上线下混合式教学是一种线上教学与课堂教学有效整合的教学模式。雨课堂作为一种智慧型教学工具,为天然药物化学改革带来新的体验。文章分析了天然药物化学的教学现状,结合继续教育学院药学/药物制剂专升本学生学习特点,以天然药物化学第五章“黄酮类化合物”为例,分别从教学内容、教学目标、教学设计、考核评价等方面,探讨雨课堂教学模式在天然药物化学中的具体应用,为其他药学专业课程的改革提供参考。Blended online and offline teaching is a teaching model that effectively integrates online and classroom teaching. Rain classroom, as an intelligent teaching tool, brings new experiences to the reform of medicinal chemistry of natural products. The article analyzes the current teaching situation of medicinal chemistry of natural products, combined with the learning characteristics of pharmacy/pharmaceutical preparation undergraduate students in the continuing education college. Taking chapter five “flavonoids” of medicinal chemistry of natural products as an example, it explores the specific application of the rain classroom teaching mode in medicinal chemistry of natural products from the aspects of teaching content, teaching objectives, teaching design, and assessment evaluation, providing reference for the reform of other pharmaceutical professional courses.
文摘酚苷类化合物广泛存在于自然界多种植物中,具有抗氧化、抗炎、抗菌、抗癌、血糖血脂调节作用、美白和保护身体各器官等多种药理作用,但口服生物利用度低是其主要问题。本文概述了酚苷类化合物的药理作用,以及制备脂质体、纳米颗粒、乳液、磷脂复合物、环糊精包合物等提高生物利用度的技术方法,以期为酚苷类化合物的活性研究及临床应用提供参考。Phenolic glycosides are widely found in many plants in nature, with antioxidant, anti-inflammatory, antibacterial, anticancer, blood glucose and lipid regulation, whitening and protective effects on various organs of the body, etc. However, low oral bioavailability has always been the main problem. In this paper, the pharmacological effects of phenolic glycosides and the methods of preparing liposomes, nanoparticles, emulsion delivery systems, phospholipid complexes and cyclodextrin inclusion complexes to improve bioavailability were summarized, in order to provide theoretical basis for the activity research and clinical application of phenolic glycosides.
文摘恒古骨伤愈合剂(Osteoking)是一种云南彝族传统复方民族药物,临床研究表明Osteoking在骨疾病治疗方面有积极效果。本文讨论了现有Osteoking治疗骨疾病的药理机制,包括骨质疏松、股骨头坏死、膝骨关节炎和腰椎间盘突出症等骨疾病。通过查阅Osteoking治疗骨疾病的中、英文文献,论述Osteoking治疗以上骨疾病的临床研究进展,旨在为临床应用Osteoking治疗骨疾病提供理论参考。Osteoking is a kind of traditional compound medicine of Yi nationality in Yunnan province. Clinical research shows that Osteoking has positive effect in the treatment of bone diseases. The pharmacological mechanism of Osteoking in the treatment of bone diseases, including osteoporosis, osteonecrosis of the femoral head, osteoarthritis of the knee and protrusion of the lumbar intervertebral disc, was discussed. By reviewing the Chinese and English literatures of Osteoking in the treatment of bone diseases, this paper discusses the clinical research progress of Osteoking in the treatment of the above bone diseases in order to provide theoretical reference for the clinical application of Osteoking in the treatment of bone diseases.
