目的:评价伴错畸形的侵袭性牙周炎(aggressive periodontitis,Ag P)患者行牙周-正畸联合治疗的临床疗效及安全性。方法:纳入25名就诊于北京大学口腔医院牙周科并完成牙周-正畸治疗的Ag P患者,回顾性评价初诊(T0)、正畸治疗前(T1)、正...目的:评价伴错畸形的侵袭性牙周炎(aggressive periodontitis,Ag P)患者行牙周-正畸联合治疗的临床疗效及安全性。方法:纳入25名就诊于北京大学口腔医院牙周科并完成牙周-正畸治疗的Ag P患者,回顾性评价初诊(T0)、正畸治疗前(T1)、正畸治疗完成后(T2)的探诊深度(probing depth,PD)、出血指数(bleeding index,BI)、探诊后出血比率(percentage of sites with bleeding on probing,BOP%),通过根尖片评价正畸前后剩余牙槽骨高度(residual alveolar bone height,RBH)的变化及牙根吸收发生状况。结果:(1)在牙周治疗后、正畸治疗前(T1)及正畸治疗完成后(T2),PD、BI、BOP%以及PD>3 mm位点的百分比均有显著降低(P<0.001)。(2)T0时全口RBH均值为68.37%±15.60%,牙周-正畸治疗后RBH为70.27%±14.23%,差异有统计学意义,其中上切牙[T0为58.79%±16.71%,T2为65.54%(55.74%,78.13%)]、上尖牙[T0为77.62%(66.06%,87.17%),T2为79.57%(69.75%,86.52%)]及上磨牙[T0为74.30%(61.69%,84.45%),T2为76.76%(68.12%,85.09%)]在正畸治疗后RBH增高明显(P<0.05)。(3)正畸治疗后人均有23.94%±13.45%的牙发生牙根吸收,其中以下切牙及上切牙的发生率最高,总发生率分别为68.48%和65.31%。结论:伴错畸形的Ag P患者,在规范的牙周治疗后,正畸治疗不会引起牙周炎症加重或牙槽骨吸收;约2/3的上、下切牙可发生轻度的牙根吸收。展开更多
There were increasing studies on the association of periodontitis with preterm low birth weight(PLBW) in the recent 10 years.PLBW is associated with about half of all perinatal mortality.Known factors which could indu...There were increasing studies on the association of periodontitis with preterm low birth weight(PLBW) in the recent 10 years.PLBW is associated with about half of all perinatal mortality.Known factors which could induce PLBW include smoking,genetics,alcohol,prenatal care,nutrition,urinary tract infections,However,there are still about 25% of PLBW cases occur with etiology unknown.Many evidences supported the association between periodontitis and PLBW.Periodontitis is a risk factor of PLBW,but the mechanism is unclear.Current theory suggests that periodontal inflammation adversely affects pregnancy outcomes by one or two mechanisms.First,women with periodontal disease may expe-rience more frequent and severe bacteremia than periodontally healthy women.As a result,the uterine cavity may become exposed to or colonized by periodontal bacteria or their byproducts(e.g.lipopolysaccharides).Once they reach the maternal-fetal unit,oral bacteria may elicit an inflammatory cascade that leads to preterm labor.A second putative mechanism does not require oral bacteria to colonize the uterine cavity.Rather,cytokines generated within the diseased periodontal tissue may enter the systemic circulation and precipitate a similar cascade,again leading to spontaneous preterm labor and birth.Therefore,oral health instruction and periodontal treatment may decrease the infection of periodontal pathogens and reduce the risk of PLBW.For the present,the best advice for a woman who contemplate pregnancy is effective brushing for two times per day and regular periodontal treatment.展开更多
目的:探讨汉族人种中维生素D受体(vitamin D receptor,VDR)基因多态性与牙周炎的关系。方法:选取90名侵袭性牙周炎患者、34名慢性牙周炎患者和91名健康对照者,抽取外周静脉血,提取基因组DNA,应用TaqⅠ限制性内切酶,采用聚合酶链反应-限...目的:探讨汉族人种中维生素D受体(vitamin D receptor,VDR)基因多态性与牙周炎的关系。方法:选取90名侵袭性牙周炎患者、34名慢性牙周炎患者和91名健康对照者,抽取外周静脉血,提取基因组DNA,应用TaqⅠ限制性内切酶,采用聚合酶链反应-限制性片段长度多态性的方法检测VDR基因的多态性。结果:(1)Tt基因型在侵袭性牙周炎患者中的检出率高于健康对照者,但差异无统计学意义(16.7%vs7.7%,P=0.065),而在女性侵袭性牙周炎患者与女性健康对照者之间,Tt基因型频率的差异有统计学意义(20.8%vs4.2%,P<0.05);在男性侵袭性牙周炎患者与男性健康对照者间,Tt基因型的频率则几乎没有差异(10.8%vs11.6%,P>0.05);(2)在慢性牙周炎患者与健康对照者间,Tt基因型的频率差异无显著性(P>0.05)。结论:携带Tt型VDR基因可能是中国汉族女性患侵袭性牙周炎的危险因素。展开更多
文摘目的:评价伴错畸形的侵袭性牙周炎(aggressive periodontitis,Ag P)患者行牙周-正畸联合治疗的临床疗效及安全性。方法:纳入25名就诊于北京大学口腔医院牙周科并完成牙周-正畸治疗的Ag P患者,回顾性评价初诊(T0)、正畸治疗前(T1)、正畸治疗完成后(T2)的探诊深度(probing depth,PD)、出血指数(bleeding index,BI)、探诊后出血比率(percentage of sites with bleeding on probing,BOP%),通过根尖片评价正畸前后剩余牙槽骨高度(residual alveolar bone height,RBH)的变化及牙根吸收发生状况。结果:(1)在牙周治疗后、正畸治疗前(T1)及正畸治疗完成后(T2),PD、BI、BOP%以及PD>3 mm位点的百分比均有显著降低(P<0.001)。(2)T0时全口RBH均值为68.37%±15.60%,牙周-正畸治疗后RBH为70.27%±14.23%,差异有统计学意义,其中上切牙[T0为58.79%±16.71%,T2为65.54%(55.74%,78.13%)]、上尖牙[T0为77.62%(66.06%,87.17%),T2为79.57%(69.75%,86.52%)]及上磨牙[T0为74.30%(61.69%,84.45%),T2为76.76%(68.12%,85.09%)]在正畸治疗后RBH增高明显(P<0.05)。(3)正畸治疗后人均有23.94%±13.45%的牙发生牙根吸收,其中以下切牙及上切牙的发生率最高,总发生率分别为68.48%和65.31%。结论:伴错畸形的Ag P患者,在规范的牙周治疗后,正畸治疗不会引起牙周炎症加重或牙槽骨吸收;约2/3的上、下切牙可发生轻度的牙根吸收。
文摘There were increasing studies on the association of periodontitis with preterm low birth weight(PLBW) in the recent 10 years.PLBW is associated with about half of all perinatal mortality.Known factors which could induce PLBW include smoking,genetics,alcohol,prenatal care,nutrition,urinary tract infections,However,there are still about 25% of PLBW cases occur with etiology unknown.Many evidences supported the association between periodontitis and PLBW.Periodontitis is a risk factor of PLBW,but the mechanism is unclear.Current theory suggests that periodontal inflammation adversely affects pregnancy outcomes by one or two mechanisms.First,women with periodontal disease may expe-rience more frequent and severe bacteremia than periodontally healthy women.As a result,the uterine cavity may become exposed to or colonized by periodontal bacteria or their byproducts(e.g.lipopolysaccharides).Once they reach the maternal-fetal unit,oral bacteria may elicit an inflammatory cascade that leads to preterm labor.A second putative mechanism does not require oral bacteria to colonize the uterine cavity.Rather,cytokines generated within the diseased periodontal tissue may enter the systemic circulation and precipitate a similar cascade,again leading to spontaneous preterm labor and birth.Therefore,oral health instruction and periodontal treatment may decrease the infection of periodontal pathogens and reduce the risk of PLBW.For the present,the best advice for a woman who contemplate pregnancy is effective brushing for two times per day and regular periodontal treatment.
文摘目的:探讨汉族人种中维生素D受体(vitamin D receptor,VDR)基因多态性与牙周炎的关系。方法:选取90名侵袭性牙周炎患者、34名慢性牙周炎患者和91名健康对照者,抽取外周静脉血,提取基因组DNA,应用TaqⅠ限制性内切酶,采用聚合酶链反应-限制性片段长度多态性的方法检测VDR基因的多态性。结果:(1)Tt基因型在侵袭性牙周炎患者中的检出率高于健康对照者,但差异无统计学意义(16.7%vs7.7%,P=0.065),而在女性侵袭性牙周炎患者与女性健康对照者之间,Tt基因型频率的差异有统计学意义(20.8%vs4.2%,P<0.05);在男性侵袭性牙周炎患者与男性健康对照者间,Tt基因型的频率则几乎没有差异(10.8%vs11.6%,P>0.05);(2)在慢性牙周炎患者与健康对照者间,Tt基因型的频率差异无显著性(P>0.05)。结论:携带Tt型VDR基因可能是中国汉族女性患侵袭性牙周炎的危险因素。
