Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular...Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular sclerosis, while the phenotypic changes of tubulo-interstitial cells have close relationship with the progress of interstitial fibrosis. Understandings of these phenotypic changes and their regulations may help us know better of the mechanism of renal diseases and find out ways to block the disease development.展开更多
1维生素D在免疫功能调节方面的作用
维生素D(Vitamin D,VitD)对于感染免疫的影响在最近10年引起了广泛的关注。研究表明,VitD通过广泛表达于人类免疫细胞的维生素D受体(Vitamin D receptor,VDR),在固有免疫和适应性免疫方面均...1维生素D在免疫功能调节方面的作用
维生素D(Vitamin D,VitD)对于感染免疫的影响在最近10年引起了广泛的关注。研究表明,VitD通过广泛表达于人类免疫细胞的维生素D受体(Vitamin D receptor,VDR),在固有免疫和适应性免疫方面均发挥着重要的调节作用(图1)。展开更多
目的了解动态血压监测(ABPM)在慢性肾脏病(CKD)患者合并顽固性高血压诊疗中的应用价值。方法回顾性收集本院2006年1月至2008年6月81例CKD合并顽固性高血压患者调整降压治疗至少两周后的临床资料,药物治疗情况,诊室血压(CBP)及ABPM资料...目的了解动态血压监测(ABPM)在慢性肾脏病(CKD)患者合并顽固性高血压诊疗中的应用价值。方法回顾性收集本院2006年1月至2008年6月81例CKD合并顽固性高血压患者调整降压治疗至少两周后的临床资料,药物治疗情况,诊室血压(CBP)及ABPM资料并分析。根据每日限定剂量数(DDD)计算方法量化患者每日降压药物量。ABPM采用携带式血压监测仪(Mobil-O-GRAPHS/NB03441)完成,应用Hypertension Management Software for Windows进行数据分析。结果根据24小时平均血压与CBP测定结果比较,12.4%(10/81)的患者表现为隐性高血压;8.6%(7/81)的患者有白大衣性高血压。在均有夜间降压药物治疗的基础上,91.4%(74/81)的患者存在血压节律异常;夜间收缩压和舒张压负荷均高于白天。该组患者利尿剂使用率仅19.8%,显著低于其他种类降压药。结论ABPM能为CKD合并顽固性高血压患者血压控制水平的判断及节律观察提供重要信息。展开更多
文摘Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular sclerosis, while the phenotypic changes of tubulo-interstitial cells have close relationship with the progress of interstitial fibrosis. Understandings of these phenotypic changes and their regulations may help us know better of the mechanism of renal diseases and find out ways to block the disease development.
文摘目的了解动态血压监测(ABPM)在慢性肾脏病(CKD)患者合并顽固性高血压诊疗中的应用价值。方法回顾性收集本院2006年1月至2008年6月81例CKD合并顽固性高血压患者调整降压治疗至少两周后的临床资料,药物治疗情况,诊室血压(CBP)及ABPM资料并分析。根据每日限定剂量数(DDD)计算方法量化患者每日降压药物量。ABPM采用携带式血压监测仪(Mobil-O-GRAPHS/NB03441)完成,应用Hypertension Management Software for Windows进行数据分析。结果根据24小时平均血压与CBP测定结果比较,12.4%(10/81)的患者表现为隐性高血压;8.6%(7/81)的患者有白大衣性高血压。在均有夜间降压药物治疗的基础上,91.4%(74/81)的患者存在血压节律异常;夜间收缩压和舒张压负荷均高于白天。该组患者利尿剂使用率仅19.8%,显著低于其他种类降压药。结论ABPM能为CKD合并顽固性高血压患者血压控制水平的判断及节律观察提供重要信息。