调节活化正常T细胞表达与分泌蛋白（regulate upon activation normal T cell expressed and secreted,RANTES）是一种被最广泛研究的CC亚族趋化因子,其在调节淋巴细胞向病损部位浸润的过程中发挥着十分重要的作用。本文就其相关生物学...调节活化正常T细胞表达与分泌蛋白（regulate upon activation normal T cell expressed and secreted,RANTES）是一种被最广泛研究的CC亚族趋化因子,其在调节淋巴细胞向病损部位浸润的过程中发挥着十分重要的作用。本文就其相关生物学作用及与口腔扁平苔藓（oral lichen planus，OLP）的关系做如下简述。展开更多
To develop novel β-type biomedical titanium alloys,a series of Ti-15Mo-xNb alloys（x=0,5,10 and 15,mass fraction in%） were designed and prepared by using vacuum arc melting method.The present study focused on the ef...To develop novel β-type biomedical titanium alloys,a series of Ti-15Mo-xNb alloys（x=0,5,10 and 15,mass fraction in%） were designed and prepared by using vacuum arc melting method.The present study focused on the effect of Nb addition on the microstructure,mechanical properties and castability of Ti-15 Mo alloy.Phase analysis and microstructure observation show that all the alloys consist of single β phase and the equiaxed β grain is refined with increasing Nb content.These β-type Ti-15Mo-xNb alloys exhibit good plasticity and rather low compression elastic modulus（in the range of 18.388-19.365 GPa）.After Nb addition,the compression yield strength of the alloys increases.With increasing Nb content,the micro-hardness of the alloys decreases.The alloys exhibit obvious fibrous strip microstructure after cold compression deformation.The castability test shows that the castability of the alloys after Nb addition decreases and that of the Ti-15 Mo alloy is the highest（92.01%）.展开更多
文摘调节活化正常T细胞表达与分泌蛋白（regulate upon activation normal T cell expressed and secreted,RANTES）是一种被最广泛研究的CC亚族趋化因子,其在调节淋巴细胞向病损部位浸润的过程中发挥着十分重要的作用。本文就其相关生物学作用及与口腔扁平苔藓（oral lichen planus，OLP）的关系做如下简述。
文摘口腔鳞状细胞癌(Oral squamous cell carcinoma,OSCC)是口腔头颈部肿瘤的常见类型,显著的病理特征为免疫抑制和淋巴细胞的浸润。癌细胞常常通过激活不同的免疫检查点逃避免疫监视,从而躲过机体抗肿瘤免疫反应。目前的治疗方法都有一定的局限性,且毒副作用较大。因此,研究和开发新的治疗手段和给药途径尤为重要。免疫检查点抑制剂(Immune checkpoint inhibitors,ICIs)的引入带动了OSCC临床治疗模式的转变。在这篇综述中,我们讨论了抗细胞程序性死亡受体1(Programmed cell death protein 1,PD-1)治疗OSCC的优势,并综述了目前可用于预测疗效的生物标记物的相关进展。
基金Project(QN2010-04)supported by the Youth Startup Fund of the Second Affiliated Hospital of Harbin Medical University,ChinaProject(2010-156)supported by the Medical Scientific Research Foundation of Heilongjiang Province Health Department,ChinaProject(HIT.NSRIF.2012002)supported by the Fundamental Research Funds for the Central Universities,China
文摘To develop novel β-type biomedical titanium alloys,a series of Ti-15Mo-xNb alloys（x=0,5,10 and 15,mass fraction in%） were designed and prepared by using vacuum arc melting method.The present study focused on the effect of Nb addition on the microstructure,mechanical properties and castability of Ti-15 Mo alloy.Phase analysis and microstructure observation show that all the alloys consist of single β phase and the equiaxed β grain is refined with increasing Nb content.These β-type Ti-15Mo-xNb alloys exhibit good plasticity and rather low compression elastic modulus（in the range of 18.388-19.365 GPa）.After Nb addition,the compression yield strength of the alloys increases.With increasing Nb content,the micro-hardness of the alloys decreases.The alloys exhibit obvious fibrous strip microstructure after cold compression deformation.The castability test shows that the castability of the alloys after Nb addition decreases and that of the Ti-15 Mo alloy is the highest（92.01%）.
