Objective To systematically evaluate the efficacy of heat-sensitive moxibustion in treatment of cervical spondylotic radiculopathy（CSR）. Methods Chinese National Knowledge Infrastructure（CNKI）, China Biology Medi...Objective To systematically evaluate the efficacy of heat-sensitive moxibustion in treatment of cervical spondylotic radiculopathy（CSR）. Methods Chinese National Knowledge Infrastructure（CNKI）, China Biology Medical（CBM） database, Chinese Science and Technology Periodical Database（VIP）, Wan Fang Data, Pubmed and Cochrane Library were retrieved to search the randomized controlled trials（RCT） on heat-sensitive moxibustion in treatment of CSR, and Meta analysis was conducted by applying Rev Man 5.3 software. Results Eventually, 10 papers were included in this study, including 1008 subjects. Meta analysis result showed： the total effective rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.13, 95%CI（1.06, 1.21）, Z=3.54, P=0.000 4]; the cure rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.80, 95%CI（1.52, 2.13）, Z=6.82, P〈0.000 01]; the improvement of short-form Mc Gill pain questionnaire（SF-MPQ） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–4.44, 95%CI（–6.38,-2.50）, Z=4.49, P〈0.000 01]; visual analogue scale（VAS） of treatment group was lower than that of control group, and the difference was statistically significant [MD=-0.36, 95%CI（-0.50, –0.23）, Z=5.42, P〈0.00001]; and the improvement of interleukin-6（IL-6） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–7.32, 95%CI（-11.49, –3.14）, Z=3.44, P=0.000 6]. Conclusion It is indicated from the Meta analysis result that the clinical efficacy of heat-sensitive moxibustion or acupuncture combined with heat-sensitive moxibustion in treatment of CSR is superior to that of simple acupuncture or traditional suspended moxibustion, providing a new therapeutic method for treatment of CSR. However, the abovementioned conclusion still needs to be confirmed through randomized blind controlled trials with high quality and large sample size since the sample size of included studies was small, and the quality was low.展开更多
Objective To observe the effect of moxibustion on the expression levels of MCP-1 and NF-κB proteins in the colonic mucosa tissue of rats with Crohn＇s disease（CD）. Methods Morris method, which is internationally re...Objective To observe the effect of moxibustion on the expression levels of MCP-1 and NF-κB proteins in the colonic mucosa tissue of rats with Crohn＇s disease（CD）. Methods Morris method, which is internationally recognized, was adopted to establish CD rat models. The rats were randomly divided into blank control group, CD model group and moxa stick moxibustion group. In the moxa stick moxibustion group, the cigarette-like moxa sticks were used for suspended moxibustion at the locations 2 cm from Píshū（脾俞 BL 20） and Zhōngwǎn（中脘 CV 12）. The treatment was conducted once a day, lasted for 20 min at each time, and 7 times were needed; one acupoint was used for each time, and the two acupoints were used alternately. Under light microscope, HE staining was used to observe the pathological changes of colon, and immunohistochemical method was adopted to observe the expression levels of MCP-1, NF-κB p 65 and NF-κB p 50 proteins in colonic mucosa tissue of rats. Results Compared with the blank control group, in CD model group, mucosa and glands defect or disappearance, villus damage, submucosal congestion and edema, and elcosis were found; the average optical density of the expression of MCP-1, NF-κB p 50 and NF-κB p 65 proteins in the colonic mucosa tissue of rats significantly increased（P〈0.01）. Compared with the CD model group, in the moxa stick moxibustion group, the inflammatory response of colonic mucosa of rats improved significantly, mainly manifesting as relieved submucosal edema, a small amount of inflammatory cells infiltration, and regular intestinal glands distribution; the average optical density of the expression of MCP-1, NF-κB p 50 and NF-κB p 65 proteins in the colonic mucosa tissue of rats significantly decreased（P〈0.05）. Conclusions Moxibustion can down-regulate the expression levels of MCP-1 and NF-κB proteins in the colonic mucosa of CD rats.展开更多
Objective:To observe the influence of moxibustion on learning and memory ability in the rats with vascular dementia(VD) and explore the potential effect mechanism.Methods:A total of 80 rats,screened by Morris water ma...Objective:To observe the influence of moxibustion on learning and memory ability in the rats with vascular dementia(VD) and explore the potential effect mechanism.Methods:A total of 80 rats,screened by Morris water maze,were randomly divided into a shamoperation group,a model group,a neural stem cells(NSCs) group,a NSCs+piracetam group and a NSCs+moxibustion group,16 rats in each group.After corresponding treatments,Morris water maze and immunofluorescence technique were adopted to evaluate the therapeutic effect respectively.Results:Comparison among groups after modeling:compared with the sham-operation group,the escape latency was longer(P<0.01) and the times of crossing platform were reduced(P<0.01) in the rats of the model group.Comparison among groups after treatment:compared with the model group,the escape latency was shortened(P<0.01) and the times of crossing platform were increased(P<0.05) in the rats of the NSCs group.Compared with the NSCs group,the escape latency was shorter and the expressions of the hippocampus NR2B/EGFP and PKM ξ/EGFP expression level increased(all P<0.05) in the rats of the NSCs+piracetam group and the NSCs+moxibustion group(all P <0.05).Compared with the NSCs+piracetam group,the escape latency was shorter and the expressions of the hippocampus NR2B/EGFP and PKM ξ/EGFP expression level were higher in the rats of the moxibustion+NSCs group(all P<0.05).Conclusion:Moxibustion improves the spatial learning and memory ability of the VD rats and promotes the reconstruction of neurogenesis and synaptic function,which may be related to the up-regulation of the expressions of hippocampus NR2B and PKMξ expressions.展开更多
Objective： To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques.Methods： From March 2017 throu...Objective： To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques.Methods： From March 2017 through to September 2017, 60 outpatients of knee joint pain were collected from the Acupuncture-Moxibustion Department. They were randomly divided into the group A（treated with scraping combined with collateral bloodletting therapy） and the group B（treated with the simple needling therapy of acupuncture）, 30 cases in each one. Once treatment was given every day and10 times consist of one course, two courses of treatment were required. At the end of treatment, the visual analogue scale（VAS） was adopted to evaluate the pain index, tenderness index and the overall effect of the patients in the two groups. Based on the Lysholm knee scale, the scores were compared in the patients of the two groups before and after treatment.Results： The total effective rate was 96.7% in the group A and was 86.7% in the group B, indicating the significant difference（P〈0.05）. VAS value was 3.03 ± 0.62 in the group A and was 3.67 ± 0.74 in the group B after treatment, indicating that difference is statistically significant（P〈0.05）. The Lysholm knee score was 89.2 ± 4.8 in the group A and was 82.4 ± 2.6 in the group B after treatment, indicating that difference is statistically significant（P〈0.05）.Conclusion： The scraping combined with collateral bloodletting therapy is significant in the efficacy on knee joint pain and feasible in the clinical guidance.展开更多
Objective To observe the efficacy of 工-shaped acupuncture therapy for treatment of cervical spondylosis. Methods 工-shaped acupuncture therapy（penetration needling from Fēngchí（风池 GB 20） to Fēngfǔ（风府 ...Objective To observe the efficacy of 工-shaped acupuncture therapy for treatment of cervical spondylosis. Methods 工-shaped acupuncture therapy（penetration needling from Fēngchí（风池 GB 20） to Fēngfǔ（风府 GV 16）, under the C_3–C_6 spinous process, Dàzhuī（大椎 GV 14）, Jiānzhōngshù（肩中俞 SI 15）, Jiānwàishù（肩外俞 SI 14）, and 工-shaped acupoint selection way） was adopted for treatment of 80 cases of cervical spondylosis, needling manipulation was conducted for once every 10 min, and the needles were retained for 30 min. The treatment was carried out for once a day, and treatment for 10 times was considered as 1 course of treatment. Results Sixty-seven patients were cured, and thirteen were improved. Conclusion The efficacy of 工-shaped acupuncture therapy for treatment of cervical spondylosis was definite.展开更多
基金Supported by Anhui Provincial Colleges science research platform team building program:2015TD033Provincial demonstrating experiment and practice training center:20100541
文摘Objective To systematically evaluate the efficacy of heat-sensitive moxibustion in treatment of cervical spondylotic radiculopathy（CSR）. Methods Chinese National Knowledge Infrastructure（CNKI）, China Biology Medical（CBM） database, Chinese Science and Technology Periodical Database（VIP）, Wan Fang Data, Pubmed and Cochrane Library were retrieved to search the randomized controlled trials（RCT） on heat-sensitive moxibustion in treatment of CSR, and Meta analysis was conducted by applying Rev Man 5.3 software. Results Eventually, 10 papers were included in this study, including 1008 subjects. Meta analysis result showed： the total effective rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.13, 95%CI（1.06, 1.21）, Z=3.54, P=0.000 4]; the cure rate of treatment group was higher than that of control group, and the difference was statistically significant [RR=1.80, 95%CI（1.52, 2.13）, Z=6.82, P〈0.000 01]; the improvement of short-form Mc Gill pain questionnaire（SF-MPQ） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–4.44, 95%CI（–6.38,-2.50）, Z=4.49, P〈0.000 01]; visual analogue scale（VAS） of treatment group was lower than that of control group, and the difference was statistically significant [MD=-0.36, 95%CI（-0.50, –0.23）, Z=5.42, P〈0.00001]; and the improvement of interleukin-6（IL-6） of treatment group was superior to that of control group, and the difference was statistically significant [MD=–7.32, 95%CI（-11.49, –3.14）, Z=3.44, P=0.000 6]. Conclusion It is indicated from the Meta analysis result that the clinical efficacy of heat-sensitive moxibustion or acupuncture combined with heat-sensitive moxibustion in treatment of CSR is superior to that of simple acupuncture or traditional suspended moxibustion, providing a new therapeutic method for treatment of CSR. However, the abovementioned conclusion still needs to be confirmed through randomized blind controlled trials with high quality and large sample size since the sample size of included studies was small, and the quality was low.
基金Supported by:Shanghai Municipal Science and Technology Committee:13401903300Anhui Provincial Natural Science Foundation:1508085 QH 160+1 种基金Youth Scientific Research fund of Anhui University of Chinese Medicine:2014 qn 004Scientific Research Platform Innovation Team of Anhui Provincial Colleges and Universities:2015 TD 033
文摘Objective To observe the effect of moxibustion on the expression levels of MCP-1 and NF-κB proteins in the colonic mucosa tissue of rats with Crohn＇s disease（CD）. Methods Morris method, which is internationally recognized, was adopted to establish CD rat models. The rats were randomly divided into blank control group, CD model group and moxa stick moxibustion group. In the moxa stick moxibustion group, the cigarette-like moxa sticks were used for suspended moxibustion at the locations 2 cm from Píshū（脾俞 BL 20） and Zhōngwǎn（中脘 CV 12）. The treatment was conducted once a day, lasted for 20 min at each time, and 7 times were needed; one acupoint was used for each time, and the two acupoints were used alternately. Under light microscope, HE staining was used to observe the pathological changes of colon, and immunohistochemical method was adopted to observe the expression levels of MCP-1, NF-κB p 65 and NF-κB p 50 proteins in colonic mucosa tissue of rats. Results Compared with the blank control group, in CD model group, mucosa and glands defect or disappearance, villus damage, submucosal congestion and edema, and elcosis were found; the average optical density of the expression of MCP-1, NF-κB p 50 and NF-κB p 65 proteins in the colonic mucosa tissue of rats significantly increased（P〈0.01）. Compared with the CD model group, in the moxa stick moxibustion group, the inflammatory response of colonic mucosa of rats improved significantly, mainly manifesting as relieved submucosal edema, a small amount of inflammatory cells infiltration, and regular intestinal glands distribution; the average optical density of the expression of MCP-1, NF-κB p 50 and NF-κB p 65 proteins in the colonic mucosa tissue of rats significantly decreased（P〈0.05）. Conclusions Moxibustion can down-regulate the expression levels of MCP-1 and NF-κB proteins in the colonic mucosa of CD rats.
基金Supported by National Natural Science Foundation of China:81873370。
文摘Objective:To observe the influence of moxibustion on learning and memory ability in the rats with vascular dementia(VD) and explore the potential effect mechanism.Methods:A total of 80 rats,screened by Morris water maze,were randomly divided into a shamoperation group,a model group,a neural stem cells(NSCs) group,a NSCs+piracetam group and a NSCs+moxibustion group,16 rats in each group.After corresponding treatments,Morris water maze and immunofluorescence technique were adopted to evaluate the therapeutic effect respectively.Results:Comparison among groups after modeling:compared with the sham-operation group,the escape latency was longer(P<0.01) and the times of crossing platform were reduced(P<0.01) in the rats of the model group.Comparison among groups after treatment:compared with the model group,the escape latency was shortened(P<0.01) and the times of crossing platform were increased(P<0.05) in the rats of the NSCs group.Compared with the NSCs group,the escape latency was shorter and the expressions of the hippocampus NR2B/EGFP and PKM ξ/EGFP expression level increased(all P<0.05) in the rats of the NSCs+piracetam group and the NSCs+moxibustion group(all P <0.05).Compared with the NSCs+piracetam group,the escape latency was shorter and the expressions of the hippocampus NR2B/EGFP and PKM ξ/EGFP expression level were higher in the rats of the moxibustion+NSCs group(all P<0.05).Conclusion:Moxibustion improves the spatial learning and memory ability of the VD rats and promotes the reconstruction of neurogenesis and synaptic function,which may be related to the up-regulation of the expressions of hippocampus NR2B and PKMξ expressions.
基金Supported by Natural Science Foundation of 2017 Anhui University of Traditional Chinese Medicine:2017zrzd002
文摘Objective： To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques.Methods： From March 2017 through to September 2017, 60 outpatients of knee joint pain were collected from the Acupuncture-Moxibustion Department. They were randomly divided into the group A（treated with scraping combined with collateral bloodletting therapy） and the group B（treated with the simple needling therapy of acupuncture）, 30 cases in each one. Once treatment was given every day and10 times consist of one course, two courses of treatment were required. At the end of treatment, the visual analogue scale（VAS） was adopted to evaluate the pain index, tenderness index and the overall effect of the patients in the two groups. Based on the Lysholm knee scale, the scores were compared in the patients of the two groups before and after treatment.Results： The total effective rate was 96.7% in the group A and was 86.7% in the group B, indicating the significant difference（P〈0.05）. VAS value was 3.03 ± 0.62 in the group A and was 3.67 ± 0.74 in the group B after treatment, indicating that difference is statistically significant（P〈0.05）. The Lysholm knee score was 89.2 ± 4.8 in the group A and was 82.4 ± 2.6 in the group B after treatment, indicating that difference is statistically significant（P〈0.05）.Conclusion： The scraping combined with collateral bloodletting therapy is significant in the efficacy on knee joint pain and feasible in the clinical guidance.
基金Supported by Construction project of Anhui scientific research innovation platform of university:2015TD033key project of natural science research of Anhui University of Chinese Medicine in 2017:2017zrzd002
文摘Objective To observe the efficacy of 工-shaped acupuncture therapy for treatment of cervical spondylosis. Methods 工-shaped acupuncture therapy（penetration needling from Fēngchí（风池 GB 20） to Fēngfǔ（风府 GV 16）, under the C_3–C_6 spinous process, Dàzhuī（大椎 GV 14）, Jiānzhōngshù（肩中俞 SI 15）, Jiānwàishù（肩外俞 SI 14）, and 工-shaped acupoint selection way） was adopted for treatment of 80 cases of cervical spondylosis, needling manipulation was conducted for once every 10 min, and the needles were retained for 30 min. The treatment was carried out for once a day, and treatment for 10 times was considered as 1 course of treatment. Results Sixty-seven patients were cured, and thirteen were improved. Conclusion The efficacy of 工-shaped acupuncture therapy for treatment of cervical spondylosis was definite.
