衰老相关认知功能障碍发病率随着社会老龄化而逐年升高,严重影响老年人群的生活质量,已经成为全球关注的热点问题。本研究就衰老相关认知功能障碍的定义、诊断和评估、发病机制、预防和治疗手段进行归纳总结,以期为衰老相关认知功能障...衰老相关认知功能障碍发病率随着社会老龄化而逐年升高,严重影响老年人群的生活质量,已经成为全球关注的热点问题。本研究就衰老相关认知功能障碍的定义、诊断和评估、发病机制、预防和治疗手段进行归纳总结,以期为衰老相关认知功能障碍的早期发现、早期诊断、早期治疗提供理论基础。The incidence of aging-related cognitive dysfunction increases year by year with the aging of society, which seriously affects the quality of life of the elderly population and has become a hot issue of global concern. This study summarises the definition, diagnosis and assessment, pathogenesis, prevention and treatment of aging-related cognitive dysfunction, with a view to providing a theoretical basis for early detection, early diagnosis and early treatment of aging-related cognitive dysfunction.展开更多
目的:探讨甲状腺功能与2型糖尿病患者认知功能障碍的关系。方法:选取2023年4月至2023年08月山东大学第二医院健康查体中心收治的120例2型糖尿病患者作为研究组。根据2型糖尿病患者是否合并认知功能障碍分为非认知障碍组(n = 50)和认知...目的:探讨甲状腺功能与2型糖尿病患者认知功能障碍的关系。方法:选取2023年4月至2023年08月山东大学第二医院健康查体中心收治的120例2型糖尿病患者作为研究组。根据2型糖尿病患者是否合并认知功能障碍分为非认知障碍组(n = 50)和认知障碍组(n = 70)。比较两组间一般资料、甲状腺功能及生化指标水平的差异;采用线性相关分析探讨甲状腺相关激素、生化指标水平及一般资料与认知功能的相关性;采用多因素Logistic回归分析探讨2型糖尿病患者认知功能障碍的影响因素。结果:在一般资料中,认知障碍组的收缩压及年龄更高、舒张压及受教育程度更低(P P P P Objective: To investigate the relationship between thyroid function and cognitive dysfunction in patients with type 2 diabetes mellitus. Methods: 120 cases of type 2 diabetic patients admitted to the author’s Health Screening Center from April 2023 to August 2023 were selected as the study group. The patients with type 2 diabetes mellitus were divided into a non-cognitive impairment group (n = 50) and a cognitive impairment group (n = 70) according to whether or not they had cognitive impairment. We compared the differences in general information, thyroid function and biochemical index levels between the two groups;A linear correlation analysis was used to explore the correlation between the levels of thyroid-related hormones, biochemical indicators, general information and cognitive functions. The influencing factors of cognitive dysfunction in type 2 diabetes mellitus patients were investigated by using univariate and multivariate logistic regression analysis;Results: In the general information, the systolic blood pressure and age were higher while the diastolic blood pressure and educational level were lower in the cognitive impairment group (P P P < 0.001). Multifactorial regression analysis showed that education level (OR = 0.752, 95%CI: 0.639~0.884), FT3 (OR = 0.24, 95%CI: 0.081~0.712), and TSH (OR = 2.098, 95%CI: 1.165~3.778) were the influencing factors of cognitive dysfunction in type 2 diabetic patients. Conclusions: FT3 may be a protective factor for the development of cognitive impairment in patients with T2DM, whereas TSH may be a risk factor for the development of cognitive impairment in patients with T2DM.展开更多
目的:通过建立阻塞性睡眠呼吸暂停低通气综合征(OSAHS)大鼠模型,检测其vaspin的血清学以及mRNA、蛋白水平的表达特点,阐述脂肪因子vaspin在OSAHS发生过程中的作用机制。方法:用慢性间歇低氧(CIH)模拟OSAHS。健康雄性Wistar大鼠22只,随...目的:通过建立阻塞性睡眠呼吸暂停低通气综合征(OSAHS)大鼠模型,检测其vaspin的血清学以及mRNA、蛋白水平的表达特点,阐述脂肪因子vaspin在OSAHS发生过程中的作用机制。方法:用慢性间歇低氧(CIH)模拟OSAHS。健康雄性Wistar大鼠22只,随即分为空白对照(control)组和CIH组。每天将CIH组大鼠放入间歇性低氧舱内,共8周。实验前后应用大鼠尾压测量仪测量血压。实验结束后处死动物,检测空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、空腹胰岛素(FINS)、vaspin和脂联素。应用实时荧光定量PCR和蛋白印迹法(Western blotting)检测vaspin mRNA以及vaspin、Akt、p-Akt蛋白水平。结果:(1)慢性间歇性缺氧下血气结果:缺氧最低点时大鼠动脉血氧分压23.4 mm Hg^32.8 mm Hg,最低血氧饱和度范围为40.8%~65.9%,恢复舱内氧浓度至21%后,测得动脉血氧分压为74.5 mm Hg^102.9 mm Hg,动脉血氧饱和度为93.8%~98.9%。(2)实验前后2组大鼠之间比较体重均无显著差异;血压变化实验前2组大鼠尾动脉收缩压无显著差异,实验后2组大鼠之间比较,CIH组大鼠收缩压明显高于正常对照组。CIH组和control组比较,FPG、FINS、TG和TC均升高,差别有统计学意义(P<0.05)。(3)Pearson相关分析显示,血清vaspin水平与FPG、FINS、HOMA-IR和TC呈正相关。(4)CIH组大鼠脂肪组织的vaspin mRNA和蛋白质的表达水平均增加,差别有统计学意义(P<0.01);Akt mRNA表达水平无明显改变,但CIH组的p-Akt蛋白水平较control组降低。结论:OSAHS动物模型中vaspin;水平的改变可能在胰岛素抵抗发生过程中具有一定作用。展开更多
文摘衰老相关认知功能障碍发病率随着社会老龄化而逐年升高,严重影响老年人群的生活质量,已经成为全球关注的热点问题。本研究就衰老相关认知功能障碍的定义、诊断和评估、发病机制、预防和治疗手段进行归纳总结,以期为衰老相关认知功能障碍的早期发现、早期诊断、早期治疗提供理论基础。The incidence of aging-related cognitive dysfunction increases year by year with the aging of society, which seriously affects the quality of life of the elderly population and has become a hot issue of global concern. This study summarises the definition, diagnosis and assessment, pathogenesis, prevention and treatment of aging-related cognitive dysfunction, with a view to providing a theoretical basis for early detection, early diagnosis and early treatment of aging-related cognitive dysfunction.
文摘目的:探讨甲状腺功能与2型糖尿病患者认知功能障碍的关系。方法:选取2023年4月至2023年08月山东大学第二医院健康查体中心收治的120例2型糖尿病患者作为研究组。根据2型糖尿病患者是否合并认知功能障碍分为非认知障碍组(n = 50)和认知障碍组(n = 70)。比较两组间一般资料、甲状腺功能及生化指标水平的差异;采用线性相关分析探讨甲状腺相关激素、生化指标水平及一般资料与认知功能的相关性;采用多因素Logistic回归分析探讨2型糖尿病患者认知功能障碍的影响因素。结果:在一般资料中,认知障碍组的收缩压及年龄更高、舒张压及受教育程度更低(P P P P Objective: To investigate the relationship between thyroid function and cognitive dysfunction in patients with type 2 diabetes mellitus. Methods: 120 cases of type 2 diabetic patients admitted to the author’s Health Screening Center from April 2023 to August 2023 were selected as the study group. The patients with type 2 diabetes mellitus were divided into a non-cognitive impairment group (n = 50) and a cognitive impairment group (n = 70) according to whether or not they had cognitive impairment. We compared the differences in general information, thyroid function and biochemical index levels between the two groups;A linear correlation analysis was used to explore the correlation between the levels of thyroid-related hormones, biochemical indicators, general information and cognitive functions. The influencing factors of cognitive dysfunction in type 2 diabetes mellitus patients were investigated by using univariate and multivariate logistic regression analysis;Results: In the general information, the systolic blood pressure and age were higher while the diastolic blood pressure and educational level were lower in the cognitive impairment group (P P P < 0.001). Multifactorial regression analysis showed that education level (OR = 0.752, 95%CI: 0.639~0.884), FT3 (OR = 0.24, 95%CI: 0.081~0.712), and TSH (OR = 2.098, 95%CI: 1.165~3.778) were the influencing factors of cognitive dysfunction in type 2 diabetic patients. Conclusions: FT3 may be a protective factor for the development of cognitive impairment in patients with T2DM, whereas TSH may be a risk factor for the development of cognitive impairment in patients with T2DM.
文摘目的:通过建立阻塞性睡眠呼吸暂停低通气综合征(OSAHS)大鼠模型,检测其vaspin的血清学以及mRNA、蛋白水平的表达特点,阐述脂肪因子vaspin在OSAHS发生过程中的作用机制。方法:用慢性间歇低氧(CIH)模拟OSAHS。健康雄性Wistar大鼠22只,随即分为空白对照(control)组和CIH组。每天将CIH组大鼠放入间歇性低氧舱内,共8周。实验前后应用大鼠尾压测量仪测量血压。实验结束后处死动物,检测空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、空腹胰岛素(FINS)、vaspin和脂联素。应用实时荧光定量PCR和蛋白印迹法(Western blotting)检测vaspin mRNA以及vaspin、Akt、p-Akt蛋白水平。结果:(1)慢性间歇性缺氧下血气结果:缺氧最低点时大鼠动脉血氧分压23.4 mm Hg^32.8 mm Hg,最低血氧饱和度范围为40.8%~65.9%,恢复舱内氧浓度至21%后,测得动脉血氧分压为74.5 mm Hg^102.9 mm Hg,动脉血氧饱和度为93.8%~98.9%。(2)实验前后2组大鼠之间比较体重均无显著差异;血压变化实验前2组大鼠尾动脉收缩压无显著差异,实验后2组大鼠之间比较,CIH组大鼠收缩压明显高于正常对照组。CIH组和control组比较,FPG、FINS、TG和TC均升高,差别有统计学意义(P<0.05)。(3)Pearson相关分析显示,血清vaspin水平与FPG、FINS、HOMA-IR和TC呈正相关。(4)CIH组大鼠脂肪组织的vaspin mRNA和蛋白质的表达水平均增加,差别有统计学意义(P<0.01);Akt mRNA表达水平无明显改变,但CIH组的p-Akt蛋白水平较control组降低。结论:OSAHS动物模型中vaspin;水平的改变可能在胰岛素抵抗发生过程中具有一定作用。
