肝细胞癌(HCC)是最常见的肝脏恶性肿瘤,死亡率高且起病隐匿,多数患者就诊时已是中晚期。经动脉化疗栓塞(TACE)是中期肝细胞癌(HCC)的标准治疗方法。影像组学能从医学影像图像中挖掘高通量的定量图像特征,可以无创地对病灶进行评估,对预...肝细胞癌(HCC)是最常见的肝脏恶性肿瘤,死亡率高且起病隐匿,多数患者就诊时已是中晚期。经动脉化疗栓塞(TACE)是中期肝细胞癌(HCC)的标准治疗方法。影像组学能从医学影像图像中挖掘高通量的定量图像特征,可以无创地对病灶进行评估,对预测肝癌TACE治疗效果具有重要意义。本文就影像组学近年来在肝癌TACE治疗中的应用进行综述。Hepatocellular carcinoma (HCC) is the most common liver malignancy with high mortality and in-sidious onset, and most of the patients are in intermediate to advanced stages at the time of diagno-sis. Transarterial chemoembolization (TACE) is the standard treatment for intermediate stage hepatocellular carcinoma (HCC). Radiomics, which can mine high-throughput quantitative image features from medical imaging images, can noninvasively evaluate the lesions and is important for predicting the therapeutic effect of TACE in hepatocellular carcinoma. This article reviews the ap-plication of radiomics in TACE treatment of hepatocellular carcinoma in recent years.展开更多
探讨肝移植术后新发恶性肿瘤(De novo malignancies, DNMs)患者的预后影响因素,建立并验证列线图。方法 收集SEER(Surveillance, Epidemiology, and End Results)数据库中2004年至2015年接受肝移植的成年原发性肝细胞癌患者的临床资料,...探讨肝移植术后新发恶性肿瘤(De novo malignancies, DNMs)患者的预后影响因素,建立并验证列线图。方法 收集SEER(Surveillance, Epidemiology, and End Results)数据库中2004年至2015年接受肝移植的成年原发性肝细胞癌患者的临床资料,按7:3比例随机分为训练集(n=154)和验证集(n=67)。在训练集中,采用Cox回归分析筛选影响DNMs预后的独立因素,利用R语言构建DNMs预后列线图模型。采用一致性指数( C-index)和校准曲线评价预后模型的预测性能。结果 共纳入221例符合条件的DNMs患者。根据Cox回归分析相关结果,将年龄、诊断年份、婚姻状态、T分期以及潜伏期纳入列线图的构建。列线图C-index在训练集和验证集中分别为0.713 (95% CI: 0.667-0.759) 和0.729 (95% CI: 0.648-0.811),校准曲线显示列线图与实际观察结果非常吻合。结论 列线图可以准确预测DNMs患者的预后,具有良好的预测性能,能够为患者的个性化诊疗提供参考依据。展开更多
文摘肝细胞癌(HCC)是最常见的肝脏恶性肿瘤,死亡率高且起病隐匿,多数患者就诊时已是中晚期。经动脉化疗栓塞(TACE)是中期肝细胞癌(HCC)的标准治疗方法。影像组学能从医学影像图像中挖掘高通量的定量图像特征,可以无创地对病灶进行评估,对预测肝癌TACE治疗效果具有重要意义。本文就影像组学近年来在肝癌TACE治疗中的应用进行综述。Hepatocellular carcinoma (HCC) is the most common liver malignancy with high mortality and in-sidious onset, and most of the patients are in intermediate to advanced stages at the time of diagno-sis. Transarterial chemoembolization (TACE) is the standard treatment for intermediate stage hepatocellular carcinoma (HCC). Radiomics, which can mine high-throughput quantitative image features from medical imaging images, can noninvasively evaluate the lesions and is important for predicting the therapeutic effect of TACE in hepatocellular carcinoma. This article reviews the ap-plication of radiomics in TACE treatment of hepatocellular carcinoma in recent years.
文摘患者女,40岁。2019年10月,患者自己发现左乳有一大小约2 cm×2 cm肿物,质硬,活动度差,无其他伴随症状。3个月后,自觉该肿物较前明显增大,遂至外院就诊。2020年1月21日超声检查显示,左乳探及范围约4.5 cm×2.4 cm低回声,边界清,内有丰富血流信号,乳腺影像报告和数据系统(breast imaging reporting and data system,BI-RADS)4a类。医师建议手术治疗,患者拒绝,后自行至非正规医疗机构行中药及针灸治疗,治疗期间左乳肿物仍持续增大。
