目的通过Meta分析系统评价微波消融(MWA)和手术切除(HR)在肝细胞癌(HCC)合并肝硬化中的有效性及安全性。方法本研究根据PRISMA指南完成,PROSPERO注册号:CRD42024509185。检索Pub Med、Cochrane Library、EMBASE、Web of Science、中国...目的通过Meta分析系统评价微波消融(MWA)和手术切除(HR)在肝细胞癌(HCC)合并肝硬化中的有效性及安全性。方法本研究根据PRISMA指南完成,PROSPERO注册号:CRD42024509185。检索Pub Med、Cochrane Library、EMBASE、Web of Science、中国知网、维普、万方数据库,时间均为从建库至2023年11月,搜索MWA对比HR治疗HCC合并肝硬化的随机对照试验(RCT)和队列研究,采用Stata 12.0软件进行Meta分析。结果共纳入3项RCT和5项回顾性队列研究,共953例患者。Meta分析显示:MWA的1/2/3/5年总生存率(OS)与HR相比无统计学差异(P值均>0.05)。MWA的1/2/5年复发率与HR相比无统计学差异(P值均>0.05)。MWA的3年复发率高于HR(RR=1.59,95%CI:1.08~2.33,P=0.017)。MWA的1/3/5年无复发生存率(DFS)低于HR(RR=0.94,95%CI:0.89~0.99,P=0.018,I^(2)=0.0%;RR=0.84,95%CI:0.72~0.98,P=0.023,I^(2)=25.4%;RR=0.75,95%CI:0.58~0.98,P=0.032,I^(2)=34.6%)。但亚组分析表明,在RCT组,MWA的1/2/3年OS和1/3年DFS与HR相比无统计学差异(P值均>0.05)。MWA的术中出血量、手术时间、住院时间、不良反应及肝功能均优于HR(SMD=-2.31,95%CI:-2.64~-1.97,P<0.001,I^(2)=3.1%;SMD=-3.38,95%CI:-4.05~-2.71,P<0.001,I^(2)=73.8%;SMD=-2.54,95%CI:-3.27~-1.80,P<0.001,I^(2)=92.8%;RR=0.42,95%CI:0.30~0.59,P<0.001,I^(2)=0.0%;SMD=-1.43,95%CI:-1.89~-0.97,P<0.001)。结论MWA与HR在局部复发、DFS及OS方面无明显差异。MWA术中出血量更少,手术时间更短,不良反应更少,对肝功能影响更小,住院时间更短。展开更多
目的:对过去十年中医药治疗肝癌的文献进行可视化,探索肝癌治疗的研究热点、发展趋势。方法:选取2014年1月1日至2024年8月10日中国知网(CNKI)关于中医药治疗肝癌的研究,运用VOSviewer与CiteSpace对纳入的文献进行分析,并绘制相关图谱。...目的:对过去十年中医药治疗肝癌的文献进行可视化,探索肝癌治疗的研究热点、发展趋势。方法:选取2014年1月1日至2024年8月10日中国知网(CNKI)关于中医药治疗肝癌的研究,运用VOSviewer与CiteSpace对纳入的文献进行分析,并绘制相关图谱。结果:共有2954篇文献最终被纳入,近十年发文量缓慢上升;形成了以曾普华、吴孝雄、翟笑枫等研究团队;广西中医药大学、广州中医药大学、湖南中医药大学是发文量最多的机构;高频关键词为肝癌、中药、中医药、肝细胞癌、综述,共形成9个聚类,研究热点主要集中在中医药治疗肝癌的临床研究、基础研究、学术经验总结;近两年的研究热点为数据挖掘、作用机制、肝细胞、肠道菌群。结论:通过文献计量学的方法,展示了中医药治疗肝癌的研究热点、研究进展、研究前沿,对该领域进一步的发展具有重要指导作用。Objective: To visualize the literature on the treatment of liver cancer with traditional Chinese medicine (TCM) over the past decade and explore the research hotspots and development trends in the treatment of liver cancer. Methods: Selected research on TCM treatment of liver cancer from the China National Knowledge Infrastructure (CNKI) database from January 1, 2014, to August 10, 2024. VOSviewer and CiteSpace were used to analyze the included literature and to create relevant graphs. Results: A total of 2954 articles were ultimately included, with a slow increase in the number of publications over the past decade;research teams led by Zeng Puhua, Wu Xiaoxiong, and Zhai Xiaofeng were formed;Guangxi University of Chinese Medicine, Guangzhou University of Chinese Medicine, and Hunan University of Chinese Medicine were the institutions with the most publications;high-frequency keywords were liver cancer, Chinese herbal medicine, TCM, hepatocellular carcinoma, and review, forming a total of 9 clusters, with research hotspots mainly focused on clinical research, basic research, and academic experience summarization of TCM treatment for liver cancer;research hotspots in the past two years have been data mining, mechanisms of action, hepatocytes, and gut microbiota. Conclusion: By using bibliometric methods, this study presents the research hotspots, progress, and frontiers in the treatment of liver cancer with TCM, which plays an important guiding role in the further development of this field.展开更多
目的:从microRNAs(miRNAs)调控角度揭示慢性乙型肝炎病毒(hepatitis B virus,HBV)感染的分子机制.方法:将符合标准的病例分为慢性HBV感染者组(含慢性乙型肝炎及慢性HBV携带者)与正常组,借助Agilent Human miRNA 8×60k微阵列芯片检...目的:从microRNAs(miRNAs)调控角度揭示慢性乙型肝炎病毒(hepatitis B virus,HBV)感染的分子机制.方法:将符合标准的病例分为慢性HBV感染者组(含慢性乙型肝炎及慢性HBV携带者)与正常组,借助Agilent Human miRNA 8×60k微阵列芯片检测血浆中miRNAs表达谱,求得两组间的差异表达miRNAs谱(P<0.05),借助miRNA生物信息学分析软件预测其靶基因并对靶基因进行GO功能富集分析和Pathway分析.结果:两组间的差异表达miRNAs共69条(P<0.05),28条上调,41条下调;GO分析及Pathway分析得到其功能主要涉及生物黏附、转录正/负调控、生物合成过程的正/负调控、氮化合物的代谢过程的正/负调控、蛋白质定位、蛋白氨基酸的磷酸化、Notch信号传导途径、细胞凋亡、Wnt信号通路、Hedgehog信号通路、T细胞受体信号通路、MAPK信号通路、转化生长因子b信号通路、B细胞受体信号通路、ErbB信号通路、p53信号通路等.结论:慢性HBV感染受特异性mi RNAs调控,其调控涉及多个生命过程和信号通路.展开更多
文摘目的:对过去十年中医药治疗肝癌的文献进行可视化,探索肝癌治疗的研究热点、发展趋势。方法:选取2014年1月1日至2024年8月10日中国知网(CNKI)关于中医药治疗肝癌的研究,运用VOSviewer与CiteSpace对纳入的文献进行分析,并绘制相关图谱。结果:共有2954篇文献最终被纳入,近十年发文量缓慢上升;形成了以曾普华、吴孝雄、翟笑枫等研究团队;广西中医药大学、广州中医药大学、湖南中医药大学是发文量最多的机构;高频关键词为肝癌、中药、中医药、肝细胞癌、综述,共形成9个聚类,研究热点主要集中在中医药治疗肝癌的临床研究、基础研究、学术经验总结;近两年的研究热点为数据挖掘、作用机制、肝细胞、肠道菌群。结论:通过文献计量学的方法,展示了中医药治疗肝癌的研究热点、研究进展、研究前沿,对该领域进一步的发展具有重要指导作用。Objective: To visualize the literature on the treatment of liver cancer with traditional Chinese medicine (TCM) over the past decade and explore the research hotspots and development trends in the treatment of liver cancer. Methods: Selected research on TCM treatment of liver cancer from the China National Knowledge Infrastructure (CNKI) database from January 1, 2014, to August 10, 2024. VOSviewer and CiteSpace were used to analyze the included literature and to create relevant graphs. Results: A total of 2954 articles were ultimately included, with a slow increase in the number of publications over the past decade;research teams led by Zeng Puhua, Wu Xiaoxiong, and Zhai Xiaofeng were formed;Guangxi University of Chinese Medicine, Guangzhou University of Chinese Medicine, and Hunan University of Chinese Medicine were the institutions with the most publications;high-frequency keywords were liver cancer, Chinese herbal medicine, TCM, hepatocellular carcinoma, and review, forming a total of 9 clusters, with research hotspots mainly focused on clinical research, basic research, and academic experience summarization of TCM treatment for liver cancer;research hotspots in the past two years have been data mining, mechanisms of action, hepatocytes, and gut microbiota. Conclusion: By using bibliometric methods, this study presents the research hotspots, progress, and frontiers in the treatment of liver cancer with TCM, which plays an important guiding role in the further development of this field.
文摘目的:从microRNAs(miRNAs)调控角度揭示慢性乙型肝炎病毒(hepatitis B virus,HBV)感染的分子机制.方法:将符合标准的病例分为慢性HBV感染者组(含慢性乙型肝炎及慢性HBV携带者)与正常组,借助Agilent Human miRNA 8×60k微阵列芯片检测血浆中miRNAs表达谱,求得两组间的差异表达miRNAs谱(P<0.05),借助miRNA生物信息学分析软件预测其靶基因并对靶基因进行GO功能富集分析和Pathway分析.结果:两组间的差异表达miRNAs共69条(P<0.05),28条上调,41条下调;GO分析及Pathway分析得到其功能主要涉及生物黏附、转录正/负调控、生物合成过程的正/负调控、氮化合物的代谢过程的正/负调控、蛋白质定位、蛋白氨基酸的磷酸化、Notch信号传导途径、细胞凋亡、Wnt信号通路、Hedgehog信号通路、T细胞受体信号通路、MAPK信号通路、转化生长因子b信号通路、B细胞受体信号通路、ErbB信号通路、p53信号通路等.结论:慢性HBV感染受特异性mi RNAs调控,其调控涉及多个生命过程和信号通路.
