Objective To observe changes of plain MR T1WI signal intensity of dentate nucleus in nasopharyngeal carcinoma patients after radiotherapy and multiple times of intravenous injection of gadolinium-based contrast agent(...Objective To observe changes of plain MR T1WI signal intensity of dentate nucleus in nasopharyngeal carcinoma patients after radiotherapy and multiple times of intravenous injection of gadolinium-based contrast agent(GBCA).Methods Fifty patients with pathologically confirmed nasopharyngeal carcinoma and received intensity-modulated radiotherapy were retrospectively enrolled as the nasopharyngeal carcinoma group,and 50 patients with other malignant tumors and without history of brain radiotherapy were retrospectively enrolled as the control group.All patients received yearly GBCA enhanced MR examinations for the nasopharynx or the head.T1WI signal intensities of the dentate nucleus and the pons on same plane were measured based on images in the year of confirmed diagnosis(recorded as the first year)and in the second to the fifth years.T1WI signal intensity ratio of year i(ranging from 1 to 5)was calculated with values of dentate nucleus divided by values of the pons(ΔSI i),while the percentage of relative changes of year j(ranging from 2 to 5)was calculated withΔSI j compared toΔSI 1(Rchange j).The values of these two parameters were compared,and the correlation ofΔSI and GBCA injection year-time was evaluated within each group.Results No significant difference of gender,age norΔSI 1 was found between groups(all P>0.05).The second to the fifth yearΔSI and Rchange in nasopharyngeal carcinoma group were all higher than those in control group(all P<0.05).Within both groups,ΔSI was positively correlated with GBCA injection year-time(both P<0.05).Conclusion Patients with nasopharyngeal carcinoma who underwent radiotherapy and multiple times of intravenous injection of GBCA tended to be found with gradually worsening GBCA deposition in dentate nucleus,for which radiotherapy might be a risk factor.展开更多
乳腺癌缺失基因2（deleted in breast cancer， DBC2）属于一种抑癌基因，定位于人类染色体8p21，全长20.5Kbp，又名Rhobtb2（rho-related BTB do-main-containing@2），即Ras同源蛋白相关的包含两个BTB结构域的基因2。2002年由Hamaguch...乳腺癌缺失基因2（deleted in breast cancer， DBC2）属于一种抑癌基因，定位于人类染色体8p21，全长20.5Kbp，又名Rhobtb2（rho-related BTB do-main-containing@2），即Ras同源蛋白相关的包含两个BTB结构域的基因2。2002年由Hamaguchi等[1]应用表象差异分析法分离得到。DBC2肿瘤抑制基因是目前与90﹪的散发性，非家族性乳腺癌相关的少数基因之一。现就其研究进展综述如下。展开更多
热疗是继手术、放疗、化疗及生物治疗之后的第5种肿瘤治疗手段,亦是重要的肿瘤辅助治疗方法之一,临床应用无毒、安全,被称为绿色治疗。近年来,肿瘤的热疗越来越受到重视,全国许多地市级医院甚至县级医院都普遍开展肿瘤热疗,并取得很好...热疗是继手术、放疗、化疗及生物治疗之后的第5种肿瘤治疗手段,亦是重要的肿瘤辅助治疗方法之一,临床应用无毒、安全,被称为绿色治疗。近年来,肿瘤的热疗越来越受到重视,全国许多地市级医院甚至县级医院都普遍开展肿瘤热疗,并取得很好的治疗效果。2017年中国制定第1版热疗指南,为热疗工作的开展提供标准和方向。时隔2年,中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)热疗专家委员会根据新的证据,在适应证、禁忌证和操作程序等方面,在原指南的基础上进行再次修订,期望修订后的共识能给热疗工作者带来更多规范化的指导,更好地为肿瘤患者服务。展开更多
基金supported by the National Natural Science Foundation of China(No.8127261181301927)+1 种基金Zhejiang Provincial Natural Science Foundation(No.LY13H160023)the Medical and Scientific Research Projects of Hangzhou City(No.20150633B42)
文摘Objective To observe changes of plain MR T1WI signal intensity of dentate nucleus in nasopharyngeal carcinoma patients after radiotherapy and multiple times of intravenous injection of gadolinium-based contrast agent(GBCA).Methods Fifty patients with pathologically confirmed nasopharyngeal carcinoma and received intensity-modulated radiotherapy were retrospectively enrolled as the nasopharyngeal carcinoma group,and 50 patients with other malignant tumors and without history of brain radiotherapy were retrospectively enrolled as the control group.All patients received yearly GBCA enhanced MR examinations for the nasopharynx or the head.T1WI signal intensities of the dentate nucleus and the pons on same plane were measured based on images in the year of confirmed diagnosis(recorded as the first year)and in the second to the fifth years.T1WI signal intensity ratio of year i(ranging from 1 to 5)was calculated with values of dentate nucleus divided by values of the pons(ΔSI i),while the percentage of relative changes of year j(ranging from 2 to 5)was calculated withΔSI j compared toΔSI 1(Rchange j).The values of these two parameters were compared,and the correlation ofΔSI and GBCA injection year-time was evaluated within each group.Results No significant difference of gender,age norΔSI 1 was found between groups(all P>0.05).The second to the fifth yearΔSI and Rchange in nasopharyngeal carcinoma group were all higher than those in control group(all P<0.05).Within both groups,ΔSI was positively correlated with GBCA injection year-time(both P<0.05).Conclusion Patients with nasopharyngeal carcinoma who underwent radiotherapy and multiple times of intravenous injection of GBCA tended to be found with gradually worsening GBCA deposition in dentate nucleus,for which radiotherapy might be a risk factor.
文摘乳腺癌缺失基因2（deleted in breast cancer， DBC2）属于一种抑癌基因，定位于人类染色体8p21，全长20.5Kbp，又名Rhobtb2（rho-related BTB do-main-containing@2），即Ras同源蛋白相关的包含两个BTB结构域的基因2。2002年由Hamaguchi等[1]应用表象差异分析法分离得到。DBC2肿瘤抑制基因是目前与90﹪的散发性，非家族性乳腺癌相关的少数基因之一。现就其研究进展综述如下。
文摘热疗是继手术、放疗、化疗及生物治疗之后的第5种肿瘤治疗手段,亦是重要的肿瘤辅助治疗方法之一,临床应用无毒、安全,被称为绿色治疗。近年来,肿瘤的热疗越来越受到重视,全国许多地市级医院甚至县级医院都普遍开展肿瘤热疗,并取得很好的治疗效果。2017年中国制定第1版热疗指南,为热疗工作的开展提供标准和方向。时隔2年,中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)热疗专家委员会根据新的证据,在适应证、禁忌证和操作程序等方面,在原指南的基础上进行再次修订,期望修订后的共识能给热疗工作者带来更多规范化的指导,更好地为肿瘤患者服务。
